메뉴 건너뛰기




Volumn 16, Issue 11, 2002, Pages 2241-2244

Reduced stress-induced hyperthermia in mGluR5 knockout mice

Author keywords

Anxiety; Knockout; Metabotropic glutamate receptor 5; MTEP; Radiotelemetry

Indexed keywords

3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; ANXIOLYTIC AGENT; METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 5; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR ANTAGONIST; PYRIDINE DERIVATIVE; RECEPTOR SUBTYPE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

EID: 0036458839     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2002.02294.x     Document Type: Article
Times cited : (76)

References (18)
  • 2
    • 0035996363 scopus 로고    scopus 로고
    • Anxiolytic-like activity of the mGluR5 antagonist MPEP. A comparison with diazepam and buspirone
    • Brodkin, J., Busse, C., Sukoff, S. & Varney, M. (2002) Anxiolytic-like activity of the mGluR5 antagonist MPEP. A comparison with diazepam and buspirone. Pharmacol. Biochem. Behav., 73, 1-8.
    • (2002) Pharmacol. Biochem. Behav. , vol.73 , pp. 1-8
    • Brodkin, J.1    Busse, C.2    Sukoff, S.3    Varney, M.4
  • 4
    • 0025850398 scopus 로고
    • Acute and chronic administration of cocaine produces hyperthermia in the rat
    • Chung, L.L., Pechnick, R.N., Bova, M.P. & George, R. (1991) Acute and chronic administration of cocaine produces hyperthermia in the rat. Proc. West. Pharmacol. Soc., 34, 27-28.
    • (1991) Proc. West. Pharmacol. Soc. , vol.34 , pp. 27-28
    • Chung, L.L.1    Pechnick, R.N.2    Bova, M.P.3    George, R.4
  • 5
    • 0343750698 scopus 로고    scopus 로고
    • Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy
    • Conrad, C.D., LeDoux, J.E., Magarinos, A.M. & McEwen, B.S. (1999) Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy. Behav. Neurosci., 113, 902-913.
    • (1999) Behav. Neurosci. , vol.113 , pp. 902-913
    • Conrad, C.D.1    LeDoux, J.E.2    Magarinos, A.M.3    McEwen, B.S.4
  • 6
    • 18744383965 scopus 로고    scopus 로고
    • 3-[(2-Methyl-1,3-thiazol-4-yl) ethynyl]pyridine (MTEP): A potent and highly selective metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity
    • in press
    • Cosford, N., Tehrani, L., Roppe, J., Schweiger, E., Smith, N.D., Anderson, J., Brodkin, J., Jiang, X., Washburn, M. & Varney, M. (in press) 3-[(2-Methyl-1,3-thiazol-4-yl) ethynyl]pyridine (MTEP): A potent and highly selective metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity. J. Med. Chem. Lett., in press.
    • J. Med. Chem. Lett.
    • Cosford, N.1    Tehrani, L.2    Roppe, J.3    Schweiger, E.4    Smith, N.D.5    Anderson, J.6    Brodkin, J.7    Jiang, X.8    Washburn, M.9    Varney, M.10
  • 8
    • 0030954048 scopus 로고    scopus 로고
    • Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP
    • Lu, Y., Jia, Z., Janus, C., Henderson, J.T., Gerlai, R., Wojtowicz, J.M. & Roder, J.C. (1997) Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J. Neurosci., 17, 5196-5205.
    • (1997) J. Neurosci. , vol.17 , pp. 5196-5205
    • Lu, Y.1    Jia, Z.2    Janus, C.3    Henderson, J.T.4    Gerlai, R.5    Wojtowicz, J.M.6    Roder, J.C.7
  • 9
    • 0026761061 scopus 로고
    • Psychological stress and body temperature changes in humans
    • Marazzati, D., Di Muro, A. & Castrogiovanni, P. (1992) Psychological stress and body temperature changes in humans. Phys. Behav., 52, 393-395.
    • (1992) Phys. Behav. , vol.52 , pp. 393-395
    • Marazzati, D.1    Di Muro, A.2    Castrogiovanni, P.3
  • 10
    • 0032794754 scopus 로고    scopus 로고
    • Cocaine-induced hypertension: Role of the peripheral sympathetic system
    • Mo, W., Arruda, J.A., Dunea, G. & Singh, A.K. (1999) Cocaine-induced hypertension: Role of the peripheral sympathetic system. Pharmacol. Res., 40, 139-145.
    • (1999) Pharmacol. Res. , vol.40 , pp. 139-145
    • Mo, W.1    Arruda, J.A.2    Dunea, G.3    Singh, A.K.4
  • 11
    • 0032501231 scopus 로고    scopus 로고
    • Behavioral senstitization to cocaine after a brief social stress is accompanied by changes in fos expression in the murine brainstem
    • Nikulina, E.M., Marchand, J.E., Kream, R.M. & Miczek, K.A. (1998) Behavioral senstitization to cocaine after a brief social stress is accompanied by changes in fos expression in the murine brainstem. Brain Res., 810, 200-210.
    • (1998) Brain Res. , vol.810 , pp. 200-210
    • Nikulina, E.M.1    Marchand, J.E.2    Kream, R.M.3    Miczek, K.A.4
  • 14
    • 0022294084 scopus 로고
    • Endogenous hyperthermia in normal human subjects: Experimental study of emotional states (II)
    • Reeves, D., Levinson, D., Justesen, S. & Lubin, B. (1985) Endogenous hyperthermia in normal human subjects: Experimental study of emotional states (II). Int. J. Psychosom., 32, 18-23.
    • (1985) Int. J. Psychosom. , vol.32 , pp. 18-23
    • Reeves, D.1    Levinson, D.2    Justesen, S.3    Lubin, B.4
  • 15
    • 0035397917 scopus 로고    scopus 로고
    • Novel allosteric antagonists shed light on mGlu5 receptors and CNS disorders
    • Spooren, W., Gasparini, F., Salt, T. & Kuhn, R. (2001) Novel allosteric antagonists shed light on mGlu5 receptors and CNS disorders. Trends Pharmacol. Sci., 22, 331-337.
    • (2001) Trends Pharmacol. Sci. , vol.22 , pp. 331-337
    • Spooren, W.1    Gasparini, F.2    Salt, T.3    Kuhn, R.4
  • 16
    • 0037169165 scopus 로고    scopus 로고
    • Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608)
    • Spooren, W.P.J.M., Schoeffter, P., Gasparini, F., Kuhn, R. & Gentsch, C. (2002) Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608). Eur. J. Pharmacol., 435, 161-170.
    • (2002) Eur. J. Pharmacol. , vol.435 , pp. 161-170
    • Spooren, W.P.J.M.1    Schoeffter, P.2    Gasparini, F.3    Kuhn, R.4    Gentsch, C.5
  • 17
    • 0033680311 scopus 로고    scopus 로고
    • Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl) pyridine in rodents
    • Spooren, W., Vassout, A., Neijt, H., Kuhn, R., Gasparini, F., Roux, S., Porsolt, R. & Gentsch, C. (2000) Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl) pyridine in rodents. J. Pharmacol. Exp. Ther., 295, 1267-1275.
    • (2000) J. Pharmacol. Exp. Ther. , vol.295 , pp. 1267-1275
    • Spooren, W.1    Vassout, A.2    Neijt, H.3    Kuhn, R.4    Gasparini, F.5    Roux, S.6    Porsolt, R.7    Gentsch, C.8
  • 18
    • 0035069188 scopus 로고    scopus 로고
    • Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
    • Tatarczynska, E., Klodzinska, A., Chojnacka-Wojcik, E., Palucha, A., Gasparini, F., Kuhn, R. & Plic, A. (2001) Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. Br. J. Pharmacol., 132, 1423-1430.
    • (2001) Br. J. Pharmacol. , vol.132 , pp. 1423-1430
    • Tatarczynska, E.1    Klodzinska, A.2    Chojnacka-Wojcik, E.3    Palucha, A.4    Gasparini, F.5    Kuhn, R.6    Plic, A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.