Anxiolytic-like activity of the mGluR5 antagonist MPEP: A comparison with diazepam and buspirone

Pharmacology Biochemistry and Behavior

Volumn 73, Issue 2, 2002, Pages 359-366

  Brodkin, Jesse ^a   Busse, Chris ^a   Sukoff, Stacey J ^a   Varney, Mark A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Anxiety; MPEP; Rat; Ultrasonic vocalizations

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 6 METHYL 2 (PHENYLETHYNYL)PYRIDINE; 6-METHYL-2-(PHENYLETHYNYL)PYRIDINE; AMINO ACID RECEPTOR BLOCKING AGENT; ANXIOLYTIC AGENT; BUSPIRONE; DIAZEPAM; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 5; PYRIDINE DERIVATIVE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; METABOTROPIC RECEPTOR ANTAGONIST;

ANIMAL; ARTICLE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; FEAR; MALE; PSYCHOLOGICAL ASPECT; PUNISHMENT; RAT; STARTLE REFLEX; VOCALIZATION; WISTAR RAT; ANIMAL EXPERIMENT; ANXIETY; ANXIETY NEUROSIS; CONDITIONING; CONTROLLED STUDY; DRUG ACTIVITY; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; STIMULUS RESPONSE; TRANQUILIZING ACTIVITY; TREATMENT INDICATION;

ANIMALS; ANTI-ANXIETY AGENTS; BUSPIRONE; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; FEAR; MALE; PUNISHMENT; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, GABA-A; RECEPTORS, METABOTROPIC GLUTAMATE; STARTLE REACTION; VOCALIZATION, ANIMAL; ANIMAL; ANTI-ANXIETY AGENTS, BENZODIAZEPINE; COMPARATIVE STUDY;

RODENTIA;

EID: 0035996363     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(02)00828-6     Document Type: Article

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