Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

British Journal of Pharmacology

Volumn 132, Issue 7, 2001, Pages 1423-1430

  Tatarczyńska, Ewa ^a   Kłodzińska, Aleksandra ^a   Chojnacka Wójcik, Ewa ^a   Pałucha, Agnieszka ^a   Gasparini, Fabrizio ^b   Kuhn, Rainer ^b   Pilc, Andrzej ^a,c  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Anxiety; Conflict drinking test; Depression; Four plate test; MGlu5 receptors; MPEP; Plus maze test; Tail suspension test

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 5 HYDROXYTRYPTOPHAN; DIAZEPAM; IMIPRAMINE; METABOTROPIC RECEPTOR ANTAGONIST;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY NEUROSIS; ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; LOCOMOTION; MALE; MAZE TEST; MOTOR COORDINATION; MOUSE; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; TRANQUILIZING ACTIVITY;

EID: 0035069188     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703923     Document Type: Article

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