Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function - I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain

Neuropharmacology

Volumn 40, Issue 1, 2001, Pages 1-9

  Walker, K ^a,b   Bowes, M ^a,b   Panesar, M ^a,b   Davis, A ^a,b   Gentry, C ^a,b   Kesingland, A ^a,b   Gasparini, F ^a   Spooren, W ^a   Stoehr, N ^a   Pagano, A ^a,d   Flor, P J ^a   Vranesic, I ^a   Lingenhoehl, K ^a   Johnson, E C ^c   Varney, M ^c   Urban, L ^a,b   Kuhn, R ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Life Sciences Group   (United Kingdom)

^c SIBIA Corp   (United States)

^d UNIVERSITY OF CATANIA   (Italy)

Author keywords

Inflammatory hyperalgesia; Metabotropic glutamate receptor; mGlu5 antagonist; MPEP; Pain

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL) PYRIDINE; DICLOFENAC; GLUTAMATE 5 RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; INDOMETACIN; LAMOTRIGINE; METABOTROPIC RECEPTOR; MORPHINE SULFATE; NONSTEROID ANTIINFLAMMATORY AGENT; RECEPTOR SUBTYPE; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; LOCOMOTION; MALE; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; STOMACH EROSION;

EID: 0033758569     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(00)00113-1     Document Type: Article

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