The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice

Psychopharmacology

Volumn 167, Issue 3, 2003, Pages 257-264

  Paterson, Neil E ^a   Semenova, Svetlana ^a   Gasparini, Fabrizio ^b   Markou, Athina ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

mGluR5; Mice; MPEP; Nicotine; Rats; Self administration

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; COCAINE; DOPAMINE; GLUTAMIC ACID; METABOTROPIC RECEPTOR; NICOTINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG SELF ADMINISTRATION; FOOD INTAKE; MALE; MESOLIMBIC DOPAMINERGIC SYSTEM; MOUSE; NEUROMODULATION; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; REINFORCEMENT; REWARD; VENTRAL TEGMENTUM;

EID: 0038240644     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-003-1432-z     Document Type: Article

References (57)

1. Battaglia G, Bruno V, Pisani A, Centonze D, Catania MV, Calabresi P, Nicoletti F (2001) Selective blockade of type-1 metabotropic glutamate receptors induces neuroprotection by enhancing GABAergic neurotransmission. Mol Cell Neurosci 17:1071-1083
2. Battaglia G, Fornai F, Busceti CL, Aloisi G, Cerrito F, De Blasi A, Melchiorri D, Nicoletti F (2002) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against methamphetamine neurotoxicity. J Neurosci 22:2135-2141
3. Breysse N, Baunez C, Spooren W, Gasparini F, Amalric M (2002) Chronic but not acute treatment with a metabotropic glutamate 5 receptor antagonist reverses the akinetic deficits in a rat model of Parkinsonism. J Neurosci 22:5669-5678
4. 2 receptor antagonists. J Neurosci 22:2977-2988
5. Cartmell J, Schoepp DD (2000) Regulation of neurotransmitter release by metabotropic glutamate receptors. J Neurochem 75:889-907
6. Chapman AG, Nanan K, Williams M, Meldrum BS (2000) Anticonvulsant activity of two metabotropic glutamate receptor group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-piperidine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893). Neuropharmacology 39:1567-1574
7. Chiamulera C, Epping-Jordan MP, Zocchi A, Marcon C, Cottiny C, Tacconi S, Corsi M, Orzi F, Conquet F (2001) Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nature Neurosci 4:873-874
8. Conn PJ, Pin J-P (1997) Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 37:205-37
9. Corrigall WA, Coen KM (1991) Selective dopamine antagonists reduce nicotine self-administration. Psychopharmacology 104:171-176
10. Corrigall WA, Coen KM, Zhang J, Adamson L (2002) Pharmacological manipulations of the pedunculopontine tegmental nucleus in the rat reduce self-administration of both nicotine and cocaine. Psychopharmacology 160:198-205
11. 1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse. Behav Brain Res 118:61-65
12. 2-like, dopamine receptors in the rat nucleus accumbens. Eur J Neurosci 13:2157-2164
13. Dewey SL, Brodie JD, Gerasimov M, Horan B, Gardner EL, Ashby CR Jr (1999) A pharmacologic strategy for the treatment of nicotine addiction. Synapse 31:76-86
14. Fattore L, Cossu G, Martellotta MC, Fratta W (2002) Baclofen antagonizes intravenous self-administration of nicotine in mice and rats. Alcohol Alcohol 37:495-498
15. File SE, Kenny PJ, Ouagazzal A-M (1998) Bimodal modulation by nicotine of anxiety in the social interaction test: role of the dorsal hippocampus. Behav Neurosci 112:1423-1429
16. Gasparini F, Lingenhohl K, Stoehr N, Flor PJ, Heinrich M, Vranesic I, Biollaz M, Allgeier H, Heckendorn R, Urwyler S, Varney MA, Johnson EC, Hess SD, Rao SP, Sacaan AI, Santori EM, Velicelebi G, Kuhn R (1999) 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology 38:1493-1503
17. Ghasemzadeh MB, Nelson LC, Lu X-Y, Kalivas PW (1999) Neuroadaptations in ionotropic and metabotropic glutamate receptor mRNA produced by cocaine treatment. J Neurochem 72:157-165
18. Goeders NE (1997) A neuroendocrine role in cocaine reinforcement. Psychoneuroendocrinology 22:237-259
19. Goeders NE, McNulty MA, Mirkis S, McAllister KH (1989) Chlordiazepoxide alters intravenous cocaine self-administration in rats. Pharmacol Biochem Behav 33:859-866
20. Goeders NE, McNulty MA, Guerin GF (1993) Effects of alprazo-lam on intravenous cocaine self-administration in rats. Pharmacol Biochem Behav 44:471-474
21. Harrison AA, Gasparini F, Markou A (2002) Nicotine potentiation of brain stimulation reward reversed by DHβE and SCH23390, but not by eticlopride, LY 314582 or MPEP in rats. Psychopharmacology 160:56-66
22. Henry SA, Lehmann-Masten V, Gasparini F, Geyer MA, Markou A (2002) The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects in prepulse inhibition and locomotor activity. Neuropharmacology 43:1199-1209
23. Holscher C, Gigg J, O'Mara SM (2001) Metabotropic glutamate receptor activation and blockade: their role in long-term potentiation, learning and neurotoxicity. Neurosci Biobehav Rev 23:399-410
24. Irvine EE, Bagnalasta M, Marcon C, Motta C, Tessari M, File SE, Chiamulera C (2001) Nicotine self-administration and withdrawal: modulation of anxiety in the social interaction test in rats. Psychopharmacology 153:315-320
25. Kuzmin A, Semenova S, Zvartau EE, van Ree JM (1996a) Enhancement of morphine self-administration in drug-naive, inbred strains of mice by acute emotional stress. Eur Neuropsychopharmacol 6:63-68
26. 2+ channel modulators. Eur J Pharmacol 295:19-25
27. Kuzmin AV, Semenova S, Gerrits MA, Zvartau EE, van Ree JM (1997) Kappa-opioid receptor agonist U50,488H modulates cocaine and morphine self-administration in drug naive rats and mice. Eur J Pharmacol 321:265-271
28. Kuzmin A, Semenova S, Zvartau E, De Vry J (1999) Effects of calcium channel blockade on intravenous self-administration of ethanol in rats. Eur Neuropsychopharmacol 9:197-203
29. Mansvelder HD, Keath JR, McGehee DS (2002) Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas. Neuron 33:905-919
30. Markou A, Paterson NE (2001) The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat. Nicotine Tob Res 3:361-373
31. Martellotta MC, Cossu G, Fattore L, Gessa GL, Fratta W (1998) Intravenous self-administration of gamma-hydroxybutyric acid in drug-naive mice. Eur Neuropsychopharmacol 8:293-296
32. McGehee DS, Heath MJS, Gelber S, Devay P, Role LW (1995) Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science 269:1692-1696
33. 1 receptor deficient mice. Neuroreport 6:2314-2316
34. Ossowska K, Konieczny J, Wolfarth S, Wieronska J, Pilc A (2001) Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats. Neuropharmacology 41:413-420
35. Paterson NE, Markou A (2002) Increased GABA neurotransmission via administration of gamma-vinylGABA decreased nicotine self-administration in the rat. Synapse 44:252-253
36. Piazza PV, Deminiere JM, Le Moal M, Simon H (1990) Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration. Brain Res 514:22-26
37. Picciotto MR, Corrigall WA (2002) Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics. J Neurosci 22:3338-3341
38. Ramsay NF, Van Ree JM (1993) Emotional but not physical stress enhances intravenous cocaine self-administration in drug-naive rats. Brain Res 608:216-222
39. Reid MS, Fox L, Ho LB, Berger SP (2000) Nicotine stimulation of extracellular glutamate levels in the nucleus accumbens: neuropharmacological characterization. Synapse 35:129-136
40. Sarnyai Z, Shaham Y, Heinrichs SC (2001) The role of cortico-tropin-releasing factor in drug addiction. Pharmacol Rev 53:209-243
41. Schilstrom B, Fagerquist MV, Zhang X, Hertel P, Panagis G, Nomikos GG, Svensson TH (2000) Putative role of presynaptic alpha7 nicotinic receptors in nicotine stimulated increases of extracellular levels of glutamate and aspartate in the ventral tegmental area. Synapse 38:375-383
42. Schoepp DD (2001) Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J Pharmacol Exp Ther 299:12-20
43. Schulz B, Fendt M, Gaparini F, Lingenhohl K, Kuhn R, Koch M (2001) The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-piperidine (MPEP) blocks fear conditioning in rats. Neuropharmacology 41:1-7
44. Semenova S, Kuzmin A, Zvartau E (1995) Strain differences in the analgesic and reinforcing action of morphine in mice. Pharmacol Biochem Behav 50:17-21
45. Semenova S, Danysz W, Bespalov A (1999) Low-affinity NMDA receptor channel blockers inhibit acquisition of intravenous morphine self-administration in naive mice. Eur J Pharmacol 378:1-8
46. Shaham Y, Alvares K, Nespor SM, Grunberg NE (1992) Effect of stress on oral morphine and fentanyl self-administration in rats. Pharmacol Biochem Behav 41:615-619
47. Shigemoto R, Nomura S, Ohishi H, Sugihara H, Nakanishi S, Mizuno N (1993) Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neurosci Lett 163:53-57
48. Spooren WPJM, Gasparini F, Bergmann R, Kuhn R (2000a) Effects of the prototypical mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)-piperidine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats. Eur J Pharmacol 406:403-410
49. Spooren WPJM, Vassout A, Neijt HC, Kuhn R, Gasparini F, Roux S, Porsolt RD, Gentsch C (2000b) Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)-pyridine in rodents. J Pharmacol Exp Ther 295:1267-1275
50. Spooren WPJM, Gaparini F, Salt TE, Kuhn R (2001) Novel allosteric antagonists shed light on mGlu5 receptors and CNS disorders. Trends Pharmacol Sci 22:331-337
51. Stolerman IP, Naylor C, Elmer GI, Goldberg SR (1999) Discrimination and self-administration of nicotine by inbred strains of mice. Psychopharmacology 141:297-306
52. Szyndler J, Sienkiewicz-Jarosz H, Maciejak P, Siemiatkowski M, Rokicki D, Czlonkowska AI, Plaznik A (2001) The anxiolytic-like effect of nicotine undergoes rapid tolerance in a model of contextual fear conditioning in rats. Pharmacol Biochem Behav 69:511-518
53. Tallaksen-Greene SJ, Kaatz KW, Romano C, Albin RL (1998) Localization of mGluR1a-like immunoreactivity and mGluR5-like immunoreactivity in identified populations of striatal neurons. Brain Res 780:210-217
54. Tatarczynska E, Klodzinska A, Chojnacka-Wojcik E, Palucha A, Gasparini F, Kuhn R, Pilc A (2001) Potential anxiolytic- and anti-depressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. Br J Pharmacol 132:1423-1430
55. Vezina P, Kim J-H (1999) Metabotropic glutamate receptors and the generation of locomotor activity: interactions with midbrain dopamine. Neurosci Biobehav Rev 23:577-589
56. Watkins SS, Koob GF, Markou A (2000) Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal. Nicotine Tob Res 2:19-37
57. Zhang Y, Loonam TM, Noailles PA, Angulo JA (2001) Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Ann NY Acad Sci 937:93-120