The Fawn-Hooded (FH/Wjd) rat: A genetic animal model of comorbid depression and alcoholism

Psychiatric Genetics

Volumn 12, Issue 1, 2002, Pages 1-16

  Rezvani, Amir H ^a   Parsian, Abbas ^b   Overstreet, David H ^c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Alcoholism; Depression; Fawn Hooded (FH Wjd) rats; Forced swim test; Saccharin intake; Voluntary alcohol intake

Indexed keywords

ALCOHOL; ANTIDEPRESSANT AGENT; SACCHARIN;

ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ALCOHOLISM; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; CHI SQUARE DISTRIBUTION; CONTROLLED STUDY; DEPRESSION; FORCED SWIMMING TEST; GENETIC MODEL; IMMOBILIZATION; INBRED STRAIN; MAZE TEST; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGENY; RAT; SOCIAL INTERACTION; VOCALIZATION;

ALCOHOLISM; ANIMALS; DEPRESSION; DISEASE MODELS, ANIMAL; MAZE LEARNING; PHENOTYPE; RATS; RATS, INBRED STRAINS; RESTRAINT, PHYSICAL; SACCHARIN; SOCIAL BEHAVIOR; STRESS, PSYCHOLOGICAL;

ANIMALIA;

EID: 0036218274     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041444-200203000-00001     Document Type: Article

References (98)

1. Serotonin uptake and imipramine binding in blood platelets and brain of Fawn-Hooded and Sprague-Dawley rats
2. Differential neuroendocrine response to the 5-HT agonist m-CPP in Fawn-Hooded rats relative to Wistar and Sprague-Dawley rats
3. A comparison of feeding and locomotion responses to serotonin agonists in three rat strains
4. Attenuation of hypercortisolemia in Fawn-Hooded rats by antidepressant drugs
5. Functional and biochemical evidence for altered serotonergic function in the Fawn-Hooded rat strain
6. Single-locus control of saccharine intake in BXD/Ty recombinant inbred (RI) mice: Some methodological implications for RI strain analysis
7. The role of putative 5-HT1A and 5-HT1B receptors in the control of feeding in rats
8. Is the forced swimming test a valid predictor of antidepressant action?
9. Renal disease susceptibility and hypertension are under independent genetic control in the Fawn-Hooded rat
10. Peculiarities of forming experimental alcoholism in noninbred rats
11. A QTL trait locus for alcohol consumption in selectively bred rat lines
12. 5-HT transporter sites and 5-HT1A and 5-HT3 receptors in Fawn-Hooded rats: A quantitative autoradiography study
13. Alcoholism and affective disorders: Familial associations and genetic models
14. Sardinian alcohol preferring rats: A genetic animal model of anxiety
15. Alcoholism and primary major depression: A family study approach to co-existing disorders
16. 3H-serotonin uptake I: A study in Fawn-Hooded rats
17. 3H]-imipramine binding in platelets and cerebral cortex of Fawn-Hooded rats
18. A family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence
19. The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs
20. 1A receptor function
21. Early-onset alcoholics have lower cerebrospinal fluid 5-hydroxyindoleacetic acid levels than late-onset alcoholics
22. Identification of quantitative trait loci influencing alcohol consumption in the high alcohol drinking and low alcohol drinking rat lines
23. Combination of naltrexone and fluoxetine on rats' propensity to take alcoholic beverage
24. Selectively bred lines of rat differ in social interaction and hippocampal 5-HT1A receptor function: A link between anxiety and depression?
25. Prevalence of SDM-IV alcohol abuse and dependence: United States, 1992
26. The effects of social isolation on the forced swim test in Fawn-Hooded and Wistar rats
27. Effects of isolation rearing on locomotion, anxiety and responses to ethanol in Fawn-Hooded and Wistar rats
28. Effects of isolation-rearing on voluntary consumption of ethanol, sucrose and saccharin solutions in Fawn-Hooded and Wistar rats
29. Reduced serotonin transporters in alcoholism
30. Serotonergic dysfunction, negative mood states, and response to alcohol
31. 2 receptors in the Fawn-Hooded rat
32. 1C receptor and the serotonin uptake site in Fawn-Hooded rat brain
33. Suppression of ethanol intake in alcohol-preferring rats by prior voluntary saccharin consumption
34. P rats develop physical dependence on alcohol via voluntary drinking: Changes in seizure thresholds, anxiety, and patterns of alcohol drinking
35. An air puff stimulus protocol for elicitation of ultrasonic vocalizations in rats
36. Ultrasonic vocalizations in alcohol-preferring and-nonpreferring rat strains
37. Brain regional and adrenal monoamine concentrations and behavioral responses to stress in alcohol-preferring AA and alcohol-avoiding ANA rats
38. Binding of serotonergic ligands to brain membranes of alcohol-preferring AA and alcohol-avoiding ANA rats
39. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps
40. Serotonin and alcohol intake, abuse and dependence: Clinical evidence
41. Criteria for an animal model of alcoholism
42. Alcohol preference and voluntary alcohol intakes of inbred rat strains and the NIH heterogeneous stock rats
43. Selective breeding for alcohol preference and associated responses
44. St. John's wort for depression - An overview and meta-analysis of randomised clinical trials
45. The serotonin hypothesis of major depression
46. Experimentally induced changes in the free selection of ethanol
47. The thyrotropin releasing hormone analog TA-0910 reduces voluntary alcohol intake of P rats subchronically in a limited scheduled access paradigm
48. Volitional consumption of ethanol by Fawn-Hooded rats: Effects of alternative solutions and drug treatments
49. Comorbidity for alcoholism and depression
50. Familial transmission of depression and alcoholism
51. Regional brain levels of monoamines in alcohol-preferring and -nonpreferring lines of rats
52. Contents of monoamines in forebrain regions of alcohol-preferring P and -nonpreferring NP lines of rats
53. Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorders
54. The Flinders sensitive line rats: A genetic animal model of depression
55. Behavioral differences between two inbred strains of Fawn-Hooded rats: A model of serotonin dysfunction
56. Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholism
57. Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains
58. Biological correlates of ethanol drinking in Fawn-Hooded-derived rats
59. Swim test immobility cosegregates with serotonergic but not cholinergic sensitivity in cross breeds of Flinders line rats
60. Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders sensitive line rats as an animal model of depression
61. Behavioral similarities and differences among alcohol preferring and nonpreferring rats: Confirmation by factor analysis and extension to additional groups
62. 2A antagonists amperozide and FG 5974
63. Suppression of alcohol intake by chronic naloxone treatment in P rats: Tolerance development and elevation of opiate receptor binding
64. Behavioural features of alcohol-preferring rats: Focus on inbred strains
65. Role of serotonin in the pathophysiology of depression: Focus on the serotonin transporter
66. Effects of Hypericum perforatum extract on ethanol intake, and on behavioral despair: A search for the neurochemical systems involved
67. Validation of open-closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
68. Effects of Hypericum peforatum extraction on alcohol intake in Marchigian Sardininian alcohol-preferring rats
69. Localization of genes affecting alcohol drinking in mice
70. Sex-specific genetic influences on the comorbidity of alcoholism and major depression in a population-based sample of US twins
71. Genetics of the Fawn-Hooded rat strain. The coat color dilution and platelet storage pool deficiency are pleiotropic effects of the autosomal recessive red-eyed dilution gene
72. Role of taste aversion in calcium channel inhibitor-induced suppression of saccharin and alcohol drinking in rats
73. Effects of sertraline on ethanol intake and model depressive behavior in Fawn-Hooded rats
74. Suppression of alcohol consumption by fenfluramine in Fawn-Hooded rats with serotonin dysfunction
75. Genetic serotonin deficiency and alcohol preference in the Fawn-Hooded rats
76. Drug-induced reductions in ethanol intake in alcohol preferring and Fawn-Hooded rats
77. Attenuation of alcohol preference in alcohol preferring rats by a novel TRH analogue TA-0910
78. Reduction of tolerance to anti-craving drugs for alcohol
79. Attenuation of alcohol intake by Ibogaine in three strains of alcohol preferring rats
80. Attenuation of alcohol consumption by a novel non-toxic ibogaine analog (18-methozycoronaridine) in alcohol preferring rats
81. Attenuation of alcohol intake by the extract of Hypericum Perforatum (St. John's Wort) in two different strains of alcohol-preferring rats
82. Combination pharmacotherapy: A mixture of small doses of naltrexone, fluoxetine, and a thyrotropin-releasing hormone analogue reduces alcohol intake in three strains of alcohol-preferring rats
83. Alcohol taste threshold and concentrations of solution preferred by rats
84. Ethanol discrimination is Fawn-Hooded rats is compromised when compared to other strains
85. Genetic and clinical implications of alcoholism and affective disorder
86. Biological, psychological and environmental predictors of alcoholism risk: A longitudinal study
87. Alcohol intoxication and withdrawal
88. Long and short alcohol deprivation: Effects on AA and alcohol-preferring rats
89. The AA and ANA rat lines, selected for differences in voluntary alcohol consumption
90. Intake of saccharin solution in selectively bred high and low alcohol drinking (HAD & LAD) lines of rats and in the F2 progeny of HAD and LAD rat crosses
91. Platelet storage pool disease in hybrid rats. F1 Fawn-Hooded rats derived from crosses with their putative ancestors (Rattus norvegicus)
92. Hereditary defect in platelet function in rats
93. Induction of dependence on ethanol by free choice drinking in alcohol-preferring rats
94. Fawn-Hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists
95. Psychiatric disorders in the relatives of probands with affective disorders: The Yale University National Institute of Mental Health collaborative study
96. Validity, reliability, and utility of the chronic mild stress model of depression
97. Familial alcoholism in primary major depressive disorder
98. Immunostained serotonergic fibers are decreased in selected brain regions of alcohol-preferring rats