Pharmacological and anatomical evidence for an interaction between mGluR5- and GABAA α1-containing receptors in the discriminative stimulus effects of ethanol

Neuropsychopharmacology

Volumn 30, Issue 4, 2005, Pages 747-757

  Besheer, Joyce ^a   Hodge, Clyde W ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Benzodiazepine; Confocal; Diazepam; Discriminative stimulus; Ethanol; GABAA; Immunohistochemistry; mGluR5; MPEP

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; DIAZEPAM; GLUTAMATE RECEPTOR 5; GLUTAMATE RECEPTOR ANTAGONIST; PENTOBARBITAL; WATER;

ALCOHOLISM; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN REGION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DRUG EFFECT; DRUG SUBSTITUTION; FLUORESCENCE ANALYSIS; GLOBUS PALLIDUS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LIMBIC SYSTEM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; STATISTICAL SIGNIFICANCE; TRAINING;

ALCOHOLISM; ANIMALS; DIAZEPAM; DISCRIMINATION (PSYCHOLOGY); DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; ETHANOL; EXCITATORY AMINO ACID ANTAGONISTS; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; IMMUNOHISTOCHEMISTRY; MALE; NEURONS; PENTOBARBITAL; PYRIDINES; RATS; RATS, LONG-EVANS; RECEPTORS, GABA-A; RECEPTORS, METABOTROPIC GLUTAMATE; SYNAPTIC TRANSMISSION; TELENCEPHALON;

EID: 15444362811     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300616     Document Type: Article

References (67)

1. Akk G, Steinbach JH (2000). Activation and block of recombinant GABA(A) receptors by pentobarbitone: a single-channel study. Br J Pharmacol 130: 249-258.
2. Aschner M, Mutkus L, Allen JW (2001). Aspartate and glutamate transport in acutely and chronically ethanol exposed neonatal rat primary astrocyte cultures. Neurotoxicology 22: 601-605.
3. Ator NA, Grant KA, Purdy RH, Paul SM, Griffiths RR (1993). Drug discrimination analysis of endogenous neuroactive steroids in rats. Eur J Pharmacol 241: 237-243.
4. Awad H, Hubert GW, Smith Y, Levey AI, Conn PJ (2000). Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus. J Neurosci 20: 7871-7879.
5. Bäckström P, Bachteler D, Koch S, Hyytiä P, Spanagel R, National Public Health Institute HFdz-md (2004). mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology 29: 921-928.
6. Barry M (1991). Interactions of drugs with alcohol. Practitioner 235: 270-272.
7. Benquet P, Gee CE, Gerber U (2002). Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes. J Neurosci 22: 9679-9686.
8. Besheer J, Cox AA, Hodge CW (2003). Coregulation of ethanol discrimination by the nucleus accumbens and amygdala. Alcohol Clin Exp Res 27: 450-456.
9. Bordi F, Ugolini A (1999). Group I metabotropic glutamate receptors: implications for brain diseases. Prog Neurobiol 59: 55-79.
10. Bormann J (1988). Electrophysiology of GABAA and GABAB receptor subtypes. Trends Neurosci 11: 112-116.
11. Chiamulera C, Epping-Jordan MP, Zocchi A, Marcon C, Cottiny C, Tacconi S et al (2001). Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nat Neurosci 4: 873-874.
12. Costa ET, Savage DD, Valenzuela CF (2000). A review of the effects of prenatal or early postnatal ethanol exposure on brain ligand-gated ion channels. Alcohol Clin Exp Res 24: 706-715.
13. de Novellis V, Marabese I, Palazzo E, Rossi F, Berrino L, Rodella L et al (2003). Group I metabotropic glutamate receptors modulate glutamate and gamma-aminobutyric acid release in the periaqueductal grey of rats. Eur J Pharmacol 462: 73-81.
14. Diaz-Cabiale Z, Vivo M, Del Arco A, O'Connor WT, Harte MK, Muller CE et al (2002). Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Interactions with adenosine A(2A) and dopamine D(2) receptors. Neurosci Lett 324: 154-158.
15. Dodd PR, Beckmann AM, Davidson MS, Wilce PA (2000). Glutamate-mediated transmission, alcohol, and alcoholism. Neurochem Int 37: 509-533.
16. Evans EB, Balster RL (1991). CNS depressant effects of volatile organic solvents. Neurosci Biobehav Rev 15: 233-241.
17. 3H]flunitrazepam, are distinct alpha-subunits of the GABA-benzodiazepine receptor complex. Neurosci Lett 90: 314-319.
18. Gasparini F, Lingenhohl K, Stoehr N, Flor PJ, Heinrich M, Vranesic I et al (1999). 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology 38: 1493-1503.
19. Gereau RWT, Conn PJ (1995). Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1. J Neurosci 15: 6879-6889.
20. Gonzales RA, Theiss C, Crews FT (1986). Effects of ethanol on stimulated inositol phospholipid hydrolysis in rat brain. J Pharmacol Exp Ther 237: 92-98.
21. Grant KA, Azarov A, Bowen CA, Mirkis S, Purdy RH (1996). Ethanol-like discriminative stimulus effects of the neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one in female Macaca fascicularis monkeys. Psychopharmacology 124: 340-346.
22. Grant KA, Azarov A, Shively CA, Purdy RH (1997). Discriminative stimulus effects of ethanol and 3 alpha-hydroxy-5 alpha-pregnan-20-one in relation to menstrual cycle phase in cynomolgus monkeys (Macaca fascicularis). Psychopharmacology 130: 59-68.
23. Grant KA, Colombo G (1993). Pharmacological analysis of the mixed discriminative stimulus effects of ethanol. Alcohol Alcoholism Suppl 2: 445-449.
24. Grant KA, Lovinger DM (1995). Cellular and behavioral neurobiology of alcohol: receptor-mediated neuronal processes. Clin Neurosci 3: 155-164.
25. Green-Jordan K, Grant KA (2000). Modulation of the ethanol-like discriminative stimulus effects of diazepam and phencyclidine by L-type voltage-gated calcium-channel ligands in rats. Psychopharmacology 149: 84-92.
26. + depolarization in cultured cerebellar Purkinje neurons. Brain Res 773: 82-89.
27. Härtig W, Brauer K, Fritschy JM, Bruckner G, Bigl V (1995). Regional and cellular expression sites of the alpha 1 subunit of GABAA receptors in the rat basal forebrain: a cytochemical study with glutamic acid decarboxylase, choline acetyltransferase, calcium-binding proteins and nitric oxide synthase as second markers. Brain Res 692: 215-226.
28. Hodge CW, Cox AA (1998). The discriminative stimulus effects of ethanol are mediated by NMDA and GABA(A) receptors in specific limbic brain regions. Psychopharmacology 139: 95-107.
29. Hodge CW, Mehmert KK, Kelley SP, McMahon T, Haywood A, Olive MF et al (1999). Supersensitivity to allosteric GABA(A) receptor modulators and alcohol in mice lacking PKCepsilon. Nat Neurosci 2: 997-1002.
30. Hodge CW, Nannini MA, Olive MF, Kelley SP, Mehmert KK (2001). Allopregnanolone and pentobarbital infused into the nucleus accumbens substitute for the discriminative stimulus effects of ethanol. Alcohol Clin Exp Res 25: 1441-1447.
31. Hoffpauir BK, Gleason EL (2002). Activation of mGluR5 modulates GABA(A) receptor function in retinal amacrine cells. J Neurophysiol 88: 1766-1776.
32. Jarbe TU, McMillan DE (1983). Interaction of the discriminative stimulus properties of diazepam and ethanol in pigeons. Pharmacol Biochem Behav 18: 73-80.
33. June HL, Foster KL, McKay PF, Seyoum R, Woods JE, Harvey SC et al (2003). The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum. Neuropsychopharmacology 28: 2124-2137.
34. Kostowski W, Bienkowski P (1999). Discriminative stimulus effects of ethanol: neuropharmacological characterization. Alcohol 17: 63-80.
35. Krasowski MD, Harrison NL (1999). General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci 55: 1278-1303.
36. Littleton JM, Lovinger D, Liljequist S, Ticku R, Matsumoto I, Barron S (2001). Role of polyamines and NMDA receptors in ethanol dependence and withdrawal. Alcohol Clin Exp Res 25: 132S-136S.
37. Lu XY, Ghasemzadeh MB, Kalivas PW (1999). Expression of glutamate receptor subunit/subtype messenger RNAS for NMDAR1, GLuR1, GLuR2 and mGLuR5 by accumbal projection neurons. Brain Res Mol Brain Res 63: 287-296.
38. McGeehan AJ, Olive MF (2003). The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse. Synapse 47: 240-242.
39. McKernan RM, Whiting PJ (1996). Which GABAA-receptor subtypes really occur in the brain? Trends Neurosci 19: 139-143.
40. Mihic SJ (1999). Acute effects of ethanol on GABAA and glycine receptor function. Neurochem Int 35: 115-123.
41. Minami K, Gereau RWT, Minami M, Heinemann SF, Harris RA (1998). Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes. Mol Pharmacol 53: 148-156.
42. Mohler H, Benke D, Benson J, Luscher B, Rudolph U, Fritschy JM (1997). Diversity in structure, pharmacology, and regulation of GABA(A) receptors. Bowery NG, Enna SJ (ed). The GABA Receptors. Humana Press Inc.: Totowa, NJ, pp 11-36.
43. Netzeband JG, Gruol DL (1995). Modulatory effects of acute ethanol on metabotropic glutamate responses in cultured Purkinje neurons. Brain Res 688: 105-113.
44. Netzeband JG, Schneeloch JR, Trotter C, Caguioa-Aquino JN, Gruol DL (2002). Chronic ethanol treatment and withdrawal alter ACPD-evoked calcium signals in developing Purkinje neurons. Alcohol Clin Exp Res 26: 386-393.
45. 2+ changes in heterologous cell types and neurons. J Biol Chem 278: 28210-28219.
46. Pintor A, Pezzola A, Reggio R, Quarta D, Popoli P (2000). The mGlu5 receptor agonist CHPG stimulates striatal glutamate release: possible involvement of A2A receptors. Neuroreport 11: 3611-3614.
47. Pirker S, Schwarzer C, Wieselthaler A, Sieghart W, Sperk G (2000). GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 101: 815-850.
48. Pisani A, Gubellini P, Bonsi P, Conquet F, Picconi B, Centonze D et al (2001). Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons. Neuroscience 106: 579-587.
49. Poisik OV, Mannaioni G, Traynelis S, Smith Y, Conn PJ (2003). Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus. J Neurosci 23: 122-130.
50. Popik P, Wrobel M (2002). Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist. Neuropharmacology 43: 1210-1217.
51. Romano C, Sesma MA, McDonald CT, O'Malley K, Van den Pol AN, Olney JW (1995). Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain. J Comp Neurol 355: 455-469.
52. Schwarzer C, Berresheim U, Pirker S, Wieselthaler A, Fuchs K, Sieghart W et al (2001). Distribution of the major gamma-aminobutyric acid(A) receptor subunits in the basal ganglia and associated limbic brain areas of the adult rat. J Comp Neurol 433: 526-549.
53. Serafini R, Bracamontes J, Steinbach JH (2000). Structural domains of the human GABAA receptor 3 subunit involved in the actions of pentobarbital. J Physiol 524: 649-676.
54. Sharko AC, Iller K, Koening H, Lau K, Ou CJ, Olive MF et al (2002). Involvement of metabotropic glutamate receptor subtype 5 (mGlu5) in alcohol self-administration. Alcohol Clin Exp Res Suppl 26: 112A.
55. Shelton KL, Grant KA (2002). Discriminative stimulus effects of ethanol in C57BL/6J and DBA/2J inbred mice. Alcohol Clin Exp Res 26: 747-757.
56. Simonyi A, Zhang JP, Sun AY, Sun GY (1996). Chronic ethanol on mRNA levels of IP3R1, IP3 3-kinase and mGluR1 in mouse Purkinje neurons. Neuroreport 7: 2115-2118.
57. Skerritt JH, Macdonald RL (1984). Benzodiazepine receptor ligand actions on GABA responses. Benzodiazepines, CL 218872, zopiclone. Eur J Pharmacol 101: 127-134.
58. Spooren WP, Gasparini F, Bergmann R, Kuhn R (2000). Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats. Europ J Pharmacol 406: 403-410.
59. Spooren WP, Gasparini F, Salt TE, Kühn R (2001). Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders. Trends Pharmacol Sci 22: 331-337.
60. Steinbach JH, Akk G (2001). Modulation of GABA(A) receptor channel gating by pentobarbital. J Physiol 537: 715-733.
61. Stephenson FA, Duggan MJ, Pollard S (1990). The gamma 2 subunit is an integral component of the gamma-aminobutyric acidA receptor but the alpha 1 polypeptide is the principal site of the agonist benzodiazepine photoaffinity labeling reaction. J Biol Chem 265: 21160-21165.
62. Stolerman I (1992). Drugs of abuse: behavioural principles, methods and terms. Trends in Pharmacol Sci 13: 170-176.
63. Study RE, Barker JL (1981). Diazepam and (-)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons. Proc Natl Acad Sci USA 78: 7180-7184.
64. Sung KW, Choi S, Lovinger DM (2001). Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses. J Neurophysiol 86: 2405-2412.
65. Tabakoff B, Hoffman PL (1993). Ethanol, sedative hypnotics, and glutamate receptor function in brain and cultured cells. Behav Genet 23: 231-236.
66. Weight FF, Peoples RW, Wright JM, Lovinger DM, White G (1993). Ethanol action on excitatory amino acid activated ion channels. Alcohol Alcoholism Suppl 2: 353-358.
67. Woodward JJ (1999). Ionotropic glutamate receptors as sites of action for ethanol in the brain. Neurochem Int 35: 107-113.