Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608)

European Journal of Pharmacology

Volumn 435, Issue 2-3, 2002, Pages 161-170

  Spooren, Will P J M ^a   Schoeffter, Philippe ^a   Gasparini, Fabrizio ^a   Kuhn, Rainer ^a   Gentsch, Conrad ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

(Mouse); ACTH (adrenocorticotropin); Anxiolytic; Benzodiazepine; Buspirone; Corticosterone; MGlu2 receptor agonist; MGlu5 receptor antagonist; NK1 receptor antagonist; Stress induced hyperthermia; Tachykinin

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; ALCOHOL; ANXIOLYTIC AGENT; BENZODIAZEPINE DERIVATIVE; BUSPIRONE; CHLORDIAZEPOXIDE; CLOBAZAM; CORTICOSTERONE; CORTICOTROPIN; DIAZEPAM; EGLUMETAD; LY 314582; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR ANTAGONIST; NEUROKININ 1 RECEPTOR ANTAGONIST; OXAZEPAM; QUINOLINE 4 CARBOXYLIC ACID [1 [3,5 BIS(TRIFLUOROMETHYLBENZOYL)] 2 (4 CHLOROBENZYL)PIPERIDIN 4 YL]AMIDE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORE TEMPERATURE; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN BLOOD LEVEL; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG EFFECT; HYPERTHERMIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RACEMIC MIXTURE; TRANQUILIZING ACTIVITY; VALIDATION PROCESS;

ADRENOCORTICOTROPIC HORMONE; ANALYSIS OF VARIANCE; ANIMALS; ANTI-ANXIETY AGENTS; BENZODIAZEPINES; BICYCLO COMPOUNDS; BODY TEMPERATURE; BUSPIRONE; CHLORDIAZEPOXIDE; CORTICOSTERONE; DIAZEPAM; ETHANOL; HYPERTHERMIA, INDUCED; MALE; MICE; MICE, INBRED ICR; OXAZEPAM; PIPERIDINES; PYRIDINES; QUINOLINES; REPRODUCIBILITY OF RESULTS; STRESS;

EID: 0037169165     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01562-X     Document Type: Article

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