The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse

Synapse

Volumn 47, Issue 3, 2003, Pages 240-242

  McGeehan, Andrew J ^a   Olive, M Foster ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amphetamine; Cocaine; Conditioned place preference; Ethanol; Glutamate; mGluR5; Morphine; Nicotine; Reward

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; ALCOHOL; AMPHETAMINE; COCAINE; GLUTAMIC ACID; METABOTROPIC RECEPTOR ANTAGONIST; NICOTINE;

ANIMAL EXPERIMENT; ARTICLE; AVERSION; CONDITIONING; CONTROLLED STUDY; DOSE RESPONSE; MALE; MOUSE; NEUROTRANSMISSION; NONHUMAN; PLACE PREFERENCE; PRIORITY JOURNAL; REWARD;

EID: 0037337238     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.10166     Document Type: Article

References (18)

1. Chiamulera C, Epping-Jordan MP, Zocchi A, Marcon C, Cottiny C, Tacconi S, Corsi M, Orzi F, Conquet F. 2001. Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nat Neurosci 4:873-874.
2. Cornish JL, Kalivas PW. 2000. Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction. J Neurosci 20:RC89 (1-5).
3. Cornish JL, Duffy P, Kalivas PW. 1999. A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior. Neuroscience 92:1359-1367.
4. Cunningham CL, Prather LK. 1992. Conditioning trial duration affects ethanol-induced conditioned place preference in mice. Anim Learn Behav 20:187-194.
5. Cunningham CL, Niehus DR, Malott DH, Prather LK. 1992. Genetic differences in the rewarding and activating effects of morphine and ethanol. Psychopharmacology 107:385-393.
6. Di Ciano P, Everitt BJ. 2001. Dissociable effects of antagonism of NMDA and AMPA/KA receptors in the nucleus accumbens core and shell on cocaine-seeking behavior. Neuropsychopharmacology 25:341-360.
7. Diaz-Cabiale Z, Vivó M, Del Arco A, O'Connor WT, Harte MK, Müller CE, Martínez E, Popoli P, Fuxe K, Ferré S. 2002. Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Interactions with adenosine A2A and dopamine D2 receptors. Neurosci Lett 324:154-158.
8. Gasparini F, Lingenhohl K, Stoehr N, Flor PJ, Heinrich M, Vranesic I, Biollaz M, Allgeier H, Heckendorn R, Urwyler S, Varney MA, Johnson EC, Hess SD, Rao SP, Sacaan AI, Santori EM, Velicelebi G, Kuhn R. 1999. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology 38:1493-1503.
9. Kalivas PW. 2000. A role for glutamate transmission in addiction to psychostimulants. Addict Biol 5:325-329.
10. Lu XY, Ghasemzadeh MB, Kalivas PW. 1999. Expression of glutamate receptor subunit/subtype messenger RNAS for NMDAR1, GLuR1, GLuR2 and mGLuR5 by accumbal projection neurons. Brain Res Mol Brain Res 63:287-296.
11. Pulvirenti L, Swerdlow NR, Koob GF. 1989. Microinjection of a gluatamate antagonist into the nucleus accumbens reduces psychostimulant locomotion in rats. Neurosci Lett 103:213-218.
12. Pulvirenti L, Swerdlow NR, Koob GF. 1991. Nucleus accumbens NMDA antagonist decreases locomotor activity produced by cocaine, heroin or accumbens dopamine, but not caffeine. Pharmacol Biochem Behav 40:841-845.
13. Pulvirenti L, Maldonado-Lopez R, Koob GF. 1992. NMDA receptors in the nucleus accumbens modulate intravenous cocaine but not heroin self-administration in the rat. Brain Res 594:327-330.
14. Rockhold RW. 1998. Glutamatergic involvement in psychomotor stimulant action. Prog Drug Res 50:155-192.
15. Romano C, Sesma MA, McDonald CT, O'Malley K, Van den Pol AN, Olney JW. 1995. Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain. J Comp Neurol 355:455-469.
16. Shigemoto R, Nomura S, Ohishi H, Sugihara H, Nakanishi S, Mizuno N. 1993. Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neurosci Lett 163:53-57.
17. Witkin JM. 1993. Blockade of the locomotor stimulant effects of cocaine and methamphetamine by glutamate antagonists. Life Sci 53:L405-410.
18. Wolf ME. 1998. The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants. Prog Neurobiol 54:679-720.