Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats

Psychopharmacology

Volumn 179, Issue 1, 2005, Pages 247-254

  Kenny, Paul J ^a   Boutrel, Benjamin ^a   Gasparini, Fabrizio ^b   Koob, George F ^a   Markou, Athina ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Addiction; Cocaine; Dependence; Escalation; Glutamate; Intracranial self stimulation; Metabotropic glutamate 5 (mGlu5) receptor; Rat; Reward; Self administration

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; COCAINE; METABOTROPIC RECEPTOR 5 ANTAGONIST; METABOTROPIC RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

AFFECT; ANIMAL EXPERIMENT; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG EFFECT; DRUG SELF ADMINISTRATION; DRUG USE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; REINFORCEMENT; REWARD; SELF STIMULATION;

ANIMALS; BRAIN; CHOICE BEHAVIOR; COCAINE; CONDITIONING (PSYCHOLOGY); EXCITATORY AMINO ACID ANTAGONISTS; MALE; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; REWARD; SELF ADMINISTRATION; SELF STIMULATION;

EID: 17744400697     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-004-2069-2     Document Type: Article

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