Synthesis and in vitro studies of novel pyrimidinyl peptidomimetics as potential antimalarial therapeutic agents

Journal of Medicinal Chemistry

Volumn 45, Issue 16, 2002, Pages 3491-3496

  Zhu, Shuren ^a   Hudson, Thomas H ^a   Kyle, Dennis E ^a   Lin, Ai J ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAZABICYCLO[2.2.2]OCTANE; 2 ACETOXYMETHYL 4 (5 BENZYLOXYCARBONYLAMINO 6 OXO 2 PHENYL 6H PYRIMIDIN 1 YL)BUT 2 ENOIC ACID METHYL ESTER; 2 ACETOXYMETHYL 4 [2 (5 BENZYLOXYCARBONYLAMINO 6 OXO 2 PHENYL 6H PYRIMIDIN 1 YL)ACETY]AMINO]PENT 2 ENOIC ACID METHYL ESTER; ANTIMALARIAL AGENT; BENZENE DERIVATIVE; CHLOROQUINE; DICARBOXYLIC ACID; DIETHYL AZADICARBOXYLATE; METHYL 2 HYDROXYMETHYLBUT 2 ENOATE; NICOTINYL ALCOHOL; PYRIMIDINE DERIVATIVE; TRIPHENYLPHOSPHINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIMALARIAL ACTIVITY; ARTICLE; CATALYSIS; CHEMICAL REACTION KINETICS; COLON; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG RESISTANCE; DRUG SYNTHESIS; EVALUATION; GROWTH INHIBITION; IC 50; LIFESPAN; MACROPHAGE; MOLECULAR CLONING; MOUSE; NERVE CELL; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; CELL LINE; CHLOROQUINE; DRUG RESISTANCE; HUMANS; INHIBITORY CONCENTRATION 50; MACROPHAGES; MALARIA; MICE; MOLECULAR MIMICRY; NEURONS; PEPTIDES; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036682237     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020104f     Document Type: Article

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