Parallel Solution-Phase Synthesis of Conformationally Restricted Congeners of Pentamidine and Evaluation of Their Antiplasmodial Activities

Journal of Medicinal Chemistry

Volumn 47, Issue 10, 2004, Pages 2700-2705

  Mayence, Annie ^a   Vanden Eynde, Jean Jacques ^a   Krogstad, Fran M ^b   Krogstad, Donald J ^b   Cushion, Melanie T ^c   Huang, Tien L ^a  

^a XAVIER UNIVERSITY OF LOUISIANA   (United States)

^b TULANE UNIVERSITY   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BIS(1,3 DIMETHYLIMIDAZOLINE 2 YL)PIPERAZINE; 1,4 BIS[4 (1,4,5,6 TETRAHYDROPYRIMIDIN 2 YL)PHENYL]PIPERAZINE; 4,4' (1,4 PIPERAZINEDIYL)BIS(N BUTYLBENZENECARBOXIMIDAMIDE); 4,4' (1,4 PIPERAZINEDIYL)BIS(N CYCLOHEXYLBENZENECARBOXIMIDAMIDE; 4,4' (1,4 PIPERAZINEDIYL)BIS(N CYCLOPENTYLBENZENECARBOXIMIDAMIDE); 4,4' (1,4 PIPERAZINEDIYL)BIS[N (1 METHYLETHYL)BENZENECARBOXIMIDAMIDE]; 4,4' (1,4 PIPERAZINEDIYL)BIS[N (PHENYLMETHYL)BENZENECARBOXIMIDAMIDE; ANTIMALARIAL AGENT; BISBENZAMIDINE DERIVATIVE; CHLOROQUINE; PENTAMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CELL FREE SYSTEM; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; DNA BINDING; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; CELL LINE, TUMOR; CELL-FREE SYSTEM; CHLOROQUINE; DRUG RESISTANCE; HEMIN; HUMANS; MOLECULAR CONFORMATION; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2342614821     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030545e     Document Type: Article

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