Mining the Plasmodium genome database to define organellar function: What does the apicoplast do?

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 357, Issue 1417, 2002, Pages 35-46

  Roos, David S ^a   Crawford, Michael J ^a   Donald, Robert G K ^a   Fraunholz, Martin ^a   Harb, Omar S ^a   He, Cynthia Y ^a   Kissinger, Jessica C ^a   Shaw, Michael K ^a   Striepen, Boris ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Apicomplexan parasites; Functional genomics; Organellar genomes; Plastid evolution; Toxoplasma gondi

Indexed keywords

GENOME;

ALGAE; EIMERIA; PLASMODIUM FALCIPARUM; PROTOZOA; TOXOPLASMA;

PROTOZOAL DNA; PROTOZOAL PROTEIN;

ALGA; ANIMAL; ARTICLE; BIOLOGY; CELL COMPARTMENTALIZATION; CELL ORGANELLE; CYTOLOGY; ENDOCYTOSIS; GENE; GENETIC DATABASE; GENETICS; GENOME; HORIZONTAL GENE TRANSFER; METABOLISM; METHODOLOGY; MOLECULAR EVOLUTION; PHYLOGENY; PHYSIOLOGY; PLASMODIUM FALCIPARUM; SYMBIOSIS;

ALGAE; ANIMALS; CELL COMPARTMENTATION; COMPUTATIONAL BIOLOGY; DATABASES, GENETIC; DNA, PROTOZOAN; ENDOCYTOSIS; EVOLUTION, MOLECULAR; GENE TRANSFER, HORIZONTAL; GENES, PROTOZOAN; GENOME, PROTOZOAN; ORGANELLES; PHYLOGENY; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; SYMBIOSIS;

EID: 0037192109     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.2001.1047     Document Type: Conference Paper

References (90)

1. Plasmodium: The fine structure of malarial parasites
2. Gene discovery by EST sequencing in Toxoplasma gondii reveals sequences restricted to the apicomplexa
3. The gene family encoding the fucoxanthin chlorophyll proteins from the brown alga Macrocystis pyrifera
4. Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii: Implications for the target of macrolide antibiotics
5. Development of a stable episomal shuttle vector for Toxoplasma gondii
6. The non-photosynthetic plastid in malaria parasites and other apicomplexans is derived from outside the green plastid lineage
7. Mechanism of protein targeting to the chlorarachniophyte plastids and the evolution of complex plastids with four membranes: A hypothesis
8. Forward and reverse genetics in the study of the obligate intracellular parasite Toxoplasma gondii
9. The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum
10. Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblasts
11. Kingdom protozoa and its 18 phyla
12. Ultrastructure
13. Import and routing of nucleus-encoded chloroplast proteins
14. Toxoplasma gondii exploits host low-density lipoprotein receptor-mediated endocytosis for cholesterol acquisition
15. Recognition sites for antibiotics within rRNA
16. K2/Klesli and GUS: Experiments in integrated access to genomic data sources
17. Phylogeneric analysis of tufA sequences indicates a cyanobacterial origin of all plastids
18. Analysis of targeting sequences demonstrates that trafficking to the Toxoplasma gondii plastid branches off the secretory system
19. Two conserved amino acid motifs mediate protein targeting to the micronemes of the apicomplexan parasite Toxoplasma gondii
20. Homologous recombination and gene replacement at the dihydrofolate reductase/thymidylate synthase locus in Toxoplasma gondii
21. Gene knock-outs and allelic replacements in Toxoplasma gondii: HXGPRT as a selectable marker for 'hit-and-run' mutagenesis
22. Deoxyxylulose phosphate pathway to terpenoids
23. Nuclear-encoded, plastid-targeted genes suggest a single common origin for apicomplexan and dinoflagellate plastids
24. The extrachromosomal DNAs of apicomplexan parasites
25. A plastid organelle as a drug target in apicomplexan parasites
26. In vitro assays elucidate peculiar kinetics of clindamycin action against Toxoplasma gondii
27. The Plasmodium falciparum genome project
28. Toxoplasmosis. A parasite life cycle, pathology, and immunology
29. Ribosomal RNA sequences of Sarcocystis muris, Theileria annulata and Crypthecodinium cohnii reveal evolutionary, relationships among apicomplexans, dinoflagellates, and ciliates
30. Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum
31. Effect of fetal bovine serum glycoproteins on the in vitro proliferation of the oyster parasite Perkinsus marinus: Development of a fully defined medium
32. Stage specific actions of antimalarial drugs on Plasmodium falciparum in culture
33. The nuclear envelope serves as an intermediary between the ER and Golgi complex in the intracellular parasite Toxoplasma gondii
34. Import of proteins into mitochondria and chloroplasts
35. A plastid segregation defect in the protozoan parasite Toxoplasma gondii
36. Targeting and processing of nuclear-encoded apicoplast proteins in plastid segregation mutants of Toxoplasma gondii
37. Subcellular localization of acetyl-CoA carboxylase in the apicomplexan parasite Toxoplasma gondii
38. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
39. A plastid of probable green algal origin in apicomplexan parasites
40. Protein transport into 'complex' diatom plastids utilizes two different targeting signals
41. Summary of the workshop on future directions in discovery and development of therapeutic agents for opportunistic infections associated with AIDS
42. Progress in taxonomy of the apicomplexan protozoa
43. The parasitophorous vacuole membrane surrounding Plasmodium and Toxoplasma: An unusual compartment in infected cells
44. Toxoplasmic encephalitis in AIDS patients
45. Early and longitudinal evaluations of treated infants and children and untreated historical patients with congenital toxoplasmosis: The Chicago Collaborative Treatment Trial
46. Plastids and protein targeting
47. Apicomplexan plastids as drug targets
48. Plastid in human parasites
49. Plastids in apicomplexan parasites
50. Gene transfer from organelles to the nucleus: How much, what happens, and why?
51. Gene transfer to the nucleus and the evolution of chloroplasts
52. Protein import into mitochondria
53. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
54. Second-hand chloroplasts and the case of the disappearing nucleus
55. Toxoplasma gondii as viewed from a virological perspective
56. Toxoplasma gondii: Genetic recombination between drug resistant mutants
57. Functional domains of the ferredoxin transit sequence involved in chloroplast import
58. The Plasmodium Genome Database Collaborative PlasmoDB: An integrative database of the Plasmodium falciparum genome. Tools for accessing and analyzing finished and unfinished sequence data
59. Toxoplasmosis
60. Bioinformatics - Trying to swim in a sea of data
61. Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii
62. Tagging genes and trapping promoters in Toxoplasma gondii by insertional mutagenesis
63. Transport and trafficking: Toxoplasma as a model for Plasmodium
64. Origin, targeting, and function of the apicomplexan plastid
65. Toxoplasma as a model parasite: Apicomplexan biochemistry, cell biology, molecular genetics...and beyond
66. The mannitol cycle in Eimeria
67. Protein import into cyanelles and complex chloroplasts
68. How individual cells develop from a syncytium: Merogony in Theileria parva (Apicomplexa)
69. The fine structure and reproduction of Toxoplasma gondii
70. Hohlzylinders
71. The cell biology of sexual development in Plasmodium
72. Protein translocation into and across the chloroplastic envelope membranes
73. Plant lipids: Metabolism, mutants, and membranes
74. Expression, selection, and organellar targeting of the Green Fluorescent Protein in Toxoplasma gondii
75. The plastid of Toxoplasma gondii is divided by association with the centrosomes
76. Targeting of soluble proteins to the rhoptries and micronemes in Toxoplasma gondii
77. Parasite genomics: Current status and future prospects
78. Hypoxanthine-guanine phosphoribosyltransferase as a therapeutic target in protozoal infections
79. Apicomplexan parasites possess distinct nuclear-encoded, but apicoplast-localized, plant-type ferredoxin-NADP(+) reductase and ferredoxin
80. Chloroplast transit peptides: The perfect random coil?
81. Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum
82. Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway
83. Topoisomerase II inhibitors induce cleavage of nuclear and 35-kb plastid DNAs in the malarial parasite Plasmodium falciparum
84. Molecular genetics of drug resistance in Plasmodium falciparum malaria
85. Extrachromosomal DNA in the Apicomplexa
86. World malaria situation in 1994
87. Analysis of apicoplast targeting and transit peptide processing in Toxoplasma gondii by deletional and insertional mutagenesis
88. Cryptosporidium parvum appears to lack a plastid genome