Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives

Journal of Medicinal Chemistry

Volumn 45, Issue 16, 2002, Pages 3497-3508

  Jonckers, Tim H M ^a   Van Miert, Sabine ^a   Cimanga, Kanyanga ^a   Bailly, Christian ^b   Colson, Pierre ^c   De Pauw Gillet, Marie Claire ^c   Van den Heuvel, Hilde ^a   Claeys, Magda ^a   Lemière, Filip ^a   Esmans, Eddy L ^a   Rozenski, Jef ^d   Quirijnen, Ludo ^e   Maes, Louis ^e   Dommisse, Roger ^a   Lemière, Guy L F ^a   Vlietinck, Arnold ^a   Pieters, Luc ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b Institut de Recherche sur le Cancer de Lille   (France)

^c UNIVERSITY OF LIÈGE   (Belgium)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^e Virco BVBA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2 BROMO 9 CYANONEOCRYPTOLEPINE; 2 BROMONEOCRYPTOLEPINE; 2 METHOXY 9 CYANONEOCRYPTOLEPINE; 2 NITRO 9 CYANONEOCRYPTOLEPINE; 5 METHYL 5H INDOLO[2,3,B]QUINOLINE; ALKALOID; ANTIMALARIAL AGENT; ANTITRYPANOSOMAL AGENT; BETA HEMATIN; CRYPTOLEPINE DERIVATIVE; CYANAMIDE; CYTOTOXIC AGENT; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); HEMATIN; N' [2 (2 TRIMETHYLSILYLETHYNYL)PHENYL]CARBODIIMIDE DERIVATIVE; NEOCRYPTOLEPINE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYPTOLEPIS SANGUINOLENTA; CYCLIZATION; CYTOTOXICITY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG MECHANISM; DRUG RESISTANCE; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; ISOMERISM; LINEAR DICHROISM; NONHUMAN; PLANT ROOT; PLASMODIUM FALCIPARUM; PROTEIN DNA INTERACTION; STEREOSPECIFICITY; STRAIN DIFFERENCE; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

ALKALOIDS; ANIMALS; ANTIMALARIALS; CELL LINE; DNA; DNA TOPOISOMERASES, TYPE II; HEME; HEMIN; HUMANS; INTERCALATING AGENTS; PLASMODIUM FALCIPARUM; POLYMERS; QUINOLINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

EID: 0036682302     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm011102i     Document Type: Article

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