In vitro antimalarial activity of a series of cationic 2,2′ -bipyridyl- and 1,10-phenanthrolineplatinum(II) benzoylthiourea complexes

Journal of Medicinal Chemistry

Volumn 47, Issue 11, 2004, Pages 2926-2934

  Egan, Timothy J ^a   Koch, Klaus R ^b   Swan, Paul L ^a   Clarkson, Cailean ^a   Van Schalkwyk, Donelly A ^a   Smith, Peter J ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

1,10 PHENANTHROLINEPLATINUM BENZOYLTHIOUREA COMPLEX; 2,2' BIPYRIDINE DERIVATIVE; [N BENZOYL N',N' BIS(2 HYDROXYETHYL)THIOUREATO](4 METHYL 1,10 PHENANTHROLINE)PLATINUM CHLORIDE; [N BENZOYL N',N' BIS(2 HYDROXYETHYL)THIOUREATO](4,4' DI TERT BUTYL 2,2' BIPYRIDYL)PLATINUM CHLORIDE; [N BENZOYL N',N' BIS(2 HYDROXYETHYL)THIOUREATO](4,4' DIMETHYL 2,2' BIPYRIDYL)PLATINUM CHLORIDE; ANTIMALARIAL AGENT; CHLOROQUINE; DIMETHYL SULFOXIDE; EMETINE; HEMATIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN;

2,2'-DIPYRIDYL; ANIMALS; ANTIMALARIALS; CHO CELLS; CRICETINAE; HEMIN; ORGANOPLATINUM COMPOUNDS; PHENANTHROLINES; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA;

EID: 2542457563     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm031132g     Document Type: Article

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