Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum

Science

Volumn 299, Issue 5607, 2003, Pages 705-708

  Foth, Bernardo J ^a   Ralph, Stuart A ^a   Tonkin, Christopher J ^a   Struck, Nicole S ^a,d   Fraunholz, Martin ^b   Roos, David S ^b   Cowman, Alan F ^c   McFadden, Geoffrey I ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF HAMBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DISEASES; EXTRACTION;

SITE-DIRECTED MUTAGENESIS;

PROTEINS;

HEAT SHOCK PROTEIN 70; PEPTIDE DERIVATIVE;

MALARIA; PARASITE; PEPTIDE;

AMINO ACID ANALYSIS; APICOPLAST; ARTICLE; BINDING SITE; GENE DISRUPTION; GENOME; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; PLASTID; PRIORITY JOURNAL; PROTEIN TARGETING; SITE DIRECTED MUTAGENESIS;

ACYL CARRIER PROTEIN; ALGORITHMS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO ACIDS; ANIMALS; ASPARAGINE; BINDING SITES; COMPUTATIONAL BIOLOGY; GREEN FLUORESCENT PROTEINS; HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; LUMINESCENT PROTEINS; LYSINE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEURAL NETWORKS (COMPUTER); ORGANELLES; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN SORTING SIGNALS; PROTEIN TRANSPORT; PROTOZOAN PROTEINS; VACUOLES;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0037474121     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1078599     Document Type: Article

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31. We thank R. Good and T. Speed for bioinformatic assistance and suggestions on Plasmo AP, M. McCarthy and R. Gleadow for assistance with statistical analysis, and G. van Dooren for critical reading of the manuscript. B.J.F. is supported by a Melbourne International Research Scholarship and a Melbourne International Fee Remission Scholarship. S.A.R. and C.J.T. are supported by Melbourne Research Scholarships. D.S.R. is a Burroughs Wellcome Scholar and an Ellison Foundation Senior Scholar in Global Infectious Diseases. G.I.M. and A.F.C. are HHMI International Scholars, and G.I.M. is an Australian Research Council Professorial Fellow. Support from U.S. NIH and the Australian Research Council and a program grant from the National Health and Medical Research Council of Australia are gratefully acknowledged.