Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents

Journal of Medicinal Chemistry

Volumn 44, Issue 19, 2001, Pages 3187-3194

  Wright, C W ^a   Addae Kyereme, J ^a,b   Breen, A G ^a   Brown, J E ^a   Cox, M F ^a,c   Croft, S L ^d   Gokcek Y ^a   Kendrick, H ^d   Phillips, R M ^a   Pollet, P L ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

^c UNIVERSITY OF GUYANA   (Guyana)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,7 DIBROMOCRYPTOLEPINE; ANTIMALARIAL AGENT; CHLOROQUINE; CRYPTOLEPINE DERIVATIVE; HEMATIN; HEMOZOIN; INTERCALATING AGENT; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CELL FREE SYSTEM; DERIVATIZATION; DNA SYNTHESIS; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; MALARIA; PARASITEMIA; TOXICITY TESTING; TRADITIONAL MEDICINE;

ALKALOIDS; ANIMALS; ANTIMALARIALS; ANTINEOPLASTIC AGENTS; CATTLE; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; HEATING; HEMIN; INDOLES; MALARIA; MICE; NUCLEIC ACID DENATURATION; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0035855878     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010929+     Document Type: Article

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