The development of a multivalent DNA vaccine for malaria

Springer Seminars in Immunopathology

Volumn 19, Issue 2, 1997, Pages 147-159

  Hedstrom, Richard C ^a,d   Doolan, Denise L ^a   Wang, Ruobing ^a   Gardner, Malcolm J ^a,b   Kumar, Anita ^a   Sedegah, Martha ^a,b   Gramzinski, Robert A ^a   Sacci Jr , John B ^a,b   Charoenvit, Yupin ^a   Weiss, Walter R ^a   Margalith, Michal ^c   Norman, Jon A ^c   Hobart, Peter ^c   Hoffman, Stephen L ^a  

^a NAVAL MEDICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c VICAL INC   (United States)

^d J CRAIG VENTER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; MALARIA VACCINE; PARASITE ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; IMMUNIZATION; IMMUNOGENICITY; INTRADERMAL DRUG ADMINISTRATION; INTRAMUSCULAR DRUG ADMINISTRATION; MALARIA; NONHUMAN; PLASMODIUM; PRIORITY JOURNAL; REVIEW; VACCINATION;

ANIMALS; ANTIGENS, PROTOZOAN; CD8-POSITIVE T-LYMPHOCYTES; CLINICAL TRIALS; FORECASTING; LIVER; MACACA MULATTA; MALARIA; MALARIA VACCINES; MALARIA, FALCIPARUM; MICE; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PROTOZOAN PROTEINS; VACCINATION; VACCINES, COMBINED; VACCINES, DNA; WORLD HEALTH;

EID: 9844223400     PISSN: 03444325     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00870265     Document Type: Review

References (62)

1. Alonso PL, Lindsay SW, Armstrong Schellenberg JRM, Keita K, Gomez P, Shenton FC, Hill AG, David PH, Fegan G, Cham K, Greenwood BM (1993) A malaria control trial using insecticide-trealed bed nets and targeted chemoprophylaxis in a rural area of The Gambia, West Africa. Trans R Soc Trop Med Hyg 87 : 37
2. Baird J (1995) Host age as a determinant of naturally acquired immunity to Plasmodium falciparum. Parasitol Today 11 : 105
3. Beach RF, Ruebush TK, Sexton JD, Bright PL, Hightower AW, Breman JG, Mount DL, Oloo AJ (1993) Effectiveness of permethrin-impregnated bed nets and curtains for malaria control in holoendemic area of western Kenya. Am J Trop Med Hyg 49 : 290
4. Beadle C, McElroy PD, Oster CN, Beier JC, Oloo AJ, Onyango FK, Chumo DK, Bales JD, Sherwood JA, Hoffman SL (1995) Impact of transmission intensity and age on Plasmodium falcipanun density and associated fever: implications for malaria vaccine design. J Infect Dis 172 : 1047
5. Blackman MJ, Heidrich HG, Donachie S, McBride JS, Holder AA (1990) A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies. J Exp Med 172 : 379
6. Burns JM, Majarian WR, Young JF, Daly TM, Long CA (1989) A protective monoclonal antibody recognizes an epitope in the carboxyl-terminal cysteine-rich domain in the precursor of the major merozoite surface antigen of the rodent malarial parasite, Plasmodium yoelii. J Immunol Methods 143 : 2670
7. Campbell JR (1989) DNA sequence of the gene encoding a Plasmodium falciparum malaria candidate vaccine antigen. Nucleic Acids Res 17 : 5854
8. Charoenvit Y, Leef ML, Yuan LF, Sedegah M, Beaudoin RL (1987) Characterization of Plasmodium yoelii monoclonal antibodies directed against stage-specific sporozoite antigens. Infect Immun 55 : 604
9. Charoenvit Y, Mellouk S, Sedegah M, Toyoshima T, Leef MF, De la Vega P, Beaudoin RL, Aikawa M, Fallarme V, Hoffman SL (1995) Plasmodium yoelii: 17-kDa hepatic and erythrocytic stage protein is the target of an inhibitory monoclonal antibody. Exp Parasitol 80 : 419
10. Church LWP, Le TP, Bryan JP, Gordon DM, Edelman R, Fries L, Davis JR, Herrington DA, Clyde DF, Shmuklarsky MJ, Schneider I, McGovern TW, Chulay JD, Ballou WR, Hoffman SL (1997) Clinical manifestations of Plasmodium falciparum malaria experimentally induced by mosquito challenge. J Infect Dis 175 : 915
11. Cohen S, McGregor IA, Carrington S (1961) Gamma-globulin and acquired immunity to human malaria. Nature 192 : 733
12. Daly TM, Long CA (1993) A recombinant 15-kilodalton carboxyl-terminal fragment of Plasmodium yoelii yoelii 17XL merozoite surface protein 1 induces a protective immune response in mice. Infect Immun 61 : 2462
13. Daly TM, Long CA (1995) Humoral response to a carboxyl-terminal region of the merozoite surface protein-1 plays a predominant role in controlling blood-stage infection in rodent malaria. J Immunol 155 : 236
14. Degen SJ, Rajput B, Reich E (1986) The human tissue plasminogen activator gene. J Biol Chem 261 : 6972
15. Diggs CL, Ballou WR, Miller LH (1993) The major merozoite surface protein as a malaria vaccine target. Parasitol Today 9 : 300
16. Doolan DL, Hoffman SL (1997) Multi-gene vaccination against malaria: a multi-stage, multi-immune response approach. Parasitol Today 13 : 171
17. Doolan DL, Hedstrom RC, Rogers WO, Charoenvit Y, Rogers M, de la Vega P, Hoffman SL (1996) Characterization of the protective hepatocyte erythrocyte protein 17-kDa gene of Plasmodium yoelii: homolog of P. falciparum exported protein-1. J Biol Chem 271 : 17861
18. + T cell, interferon-γ, nitric oxide-dependent immunity. J Exp Med 183 : 1739
19. Etlinger HM, Caspers P, Matile H, Schoenfeld HJ, Stueber D, Takacs B (1991) Ability of recombinant or native proteins to protect monkeys against heterologous challenge with Plasmodium falicparium. Infect Immun 59 : 3498
20. Flynn JL, Weiss WR, Norris KA, Seifert HS, Kumar S, So M (1990) Generation of a cytotoxic T-lymphocyte response using a Salmonella antigen-delivery system. Mol Microbiol 4 : 2111
21. Freeman RR, Holder AA (1983) Characteristics of the protective response of BALB/c mice immunized with a purified Plasmodium yoelii schizont antigen. Clin Exp Immunol 54 : 609
22. Gramzinski RA, Maris DC, Obaldia N, Rossan R, Sedegah M, Wang R, Hobart P, Margalith M, Hoffman S (1996) Optimization of antibody responses of a malaria DNA vaccine in Aotus monkeys. Vaccine Res 5 : 173
23. Hedstrom RC, Campbell JR, Leef ML, Charoenvit Y, Carter M, Sedegah M, Beaudoin RL, Hoffman SL (1990) A malaria sporozoite surface antigen distinct from the circumsporozoite protein. Bull World Health Org 68 : 152
24. Hedstrom RC, Sedegah M, Hoffman SL (1944) Prospects and strategics for development of DNA vaccines against malaria. Res Immunol 145 : 476
25. Hill AVS, Allsopp CEM, Kwialkowki D, Anstey NM, Twumasi P, Rowe PA, Bennett S, Brewster D, McMichael A, Greenwood BM (1991) Common West African HLA antigens are associated with protection from severe malaria. Nature 352 : 595
26. Hoffman SL (1997) Experimental challenge of volunteers with malaria. Ann Int Med 127 : 233
27. Hoffman SL, Oster CN, Plowe CV, Woollett GR, Beier JC, Chulay JD, Wirtz RA, Hollingdale MR, Mugambi M (1987) Naturally acquired antibodies to sporozoites do not prevent malaria: vaccine development implications. Science 237 : 639
28. Hoffman SL, Isenbarger D, Long GW, Sedegah M, Szarfman A, Waters L, Hollingdale MR, Miede PH van der, Finbloom DS, Ballou WR (1989) Sporozoite vaccine induces genetically restricted T cell elimination of malaria from hepatocytes. Science 244 : 1078
29. Hoffman SL, Weiss W, Mellouk S, Sedegah M (1990) Irradiated sporozoite vaccine induces cytotoxic T lymphocytes that recognize malaria antigens on the surface of infected hepatocytes. Immunol Lett 25 : 33
30. Hoffman SL, Franke ED, Hollingdale MR, Druilhe P (1996) Attacking the infected hepalocyte. In: Holfman SL (ed) Malaria vaccine development. ASM Press, Washington DC, pp 35-75
31. Holder AA, Freeman RR (1981) Immunization against blood-stage rodent malaria using purified parasite antigens. Nature 294 : 361
32. Khusmith S, Charoenvit Y, Kumar S, Sedegah M, Beaudoin RL, Hoffman SL (1991) Protection against malaria by vaccination with sporozoite surface protein 2 plus CS protein. Science 252 : 715
33. + cytotoxic T cell clone recognizing sporozoite surface protein 2. Infect Immun 62 : 2979
34. Lal AA, De la Cruz VF, Welsh JA, Charoenvit Y, Maloy WL, McCutchan TF (1987) Structure of the gene encoding the circumsporozoite protein of Plasmodium yoelii. J Biol Chem 262 : 2937
35. + T-cell-mediated protective immunity against malaria. Proc Natl Acad Sci USA 90 : 5214
36. Ling IT, Ogun SA, Holder AA (1994) Immunization against malaria with a recombinant protein. Parasite Immunol 16 : 63
37. McElroy PD, Beier JC, Oster CN, Beadle C, Sherwood JA, Oloo AJ, Hoffman SL (1994) Predicting outcome in malaria: correlation between rate of exposure to infected mosquitoes and level of Plasmodium falriparum parasitemia. Am J Trop Med Hyg 51 : 523
38. Mitchell GH, Butcher GA, Cohen S (1975) Merozoite vaccination against Plasmodium knowlesi malaria. Immunology 29 : 397
39. Panina Bordignon P, Tan A, Termijtelen A, Demotz S, Corradin G, Lanzavecchia A (1989) Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. Eur J Immunol 19 : 2237
40. Perrin LH, Merkli B, Loche M, Chizzolini C, Smart J, Richle R (1984) Antimalarial immunity in Saimiri monkeys. Immunization with surface components of asexual blood stages. J Exp Med 160 : 441
41. + T cell clones against Plasmodium yoelii liver stages. J Immunol 150 : 1471
42. Robson KJ, Hall JR, Jennings MW, Harris TJ, Marsh K, Newhold CI, Tate VE, Weatherall DJ (1988) A highly conserved amino acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite. Nature 335 : 79
43. + T and B cell epitopes. Comaprison of thrir immunogenicity and capacity to induce protective immunity. J Immunol 153 : 4636
44. + cytolytic T cell clones derived against the Plasmodium yoelii circumsporozoite protein protect against malaria. Int Immunol 3 : 579
45. Rogers WO, Malik A, Mellouk S, Nakamura K, Rogers MD, Szarfman A, Gordon DM, Nussler AK, Aikawa M, Hoffman SL (1992) Characterization of Plasmodium falciparum sporozoite surface protein 2. Proc Natl Acad Sci USA 89 : 9176
46. Rogers WO, Rogers MD, Hedstrom RC, Hoffman SL (1992) Characterization of the gene encoding sporozoite surface protein 2, a protective Plasmodium yoelii sprozoite antigen. Mol Biochem Parasitol 53 : 45
47. Romero P, Maryanski JL, Corradin G, Nussenzweig RS, Nussenzweig V, Zavala F (1989) Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria. Nature 341 : 323
48. Sabchareon A, Burnouf T, Quattara D, Attanath P, Bouharoun Tayoun H, Chantavanich P, Foucault C, Chongsuphajaisiddhi T, Druilhe P (1991) Parasitologic and clinical human response to immunoglobulin administration in falciparum malaria. Am J Trop Med Hyg 45 : 297
49. Sanchez GI, Rogers WO, Mellouk S, Hoffman SL (1994) Plasmodium falciparum: exported protein-1, a blood stage antigen, is expressed in liver stage parasites. Exp Parasitol 79 : 59
50. + T cells and antibodies required for immunity to malaria sporozoites. Nature 330 : 664
51. Sedegah M, Beaudoin RL, De la Vega P, Leef MF, Ozcel MA, Jones E, Charoenvit Y, Yuan LF, Gross M, Majarian WR, Robey FA, Weiss W, Hoffman SL (1988) Use of a vaccinia construct expressing the circumsporozoite protein in the analysis of protective immunity to Plasmodium yoelii. In: Lasky L (ed) Technological advances in vaccine development. Liss, New York, pp 295-309
52. Sedegah M, Beaudoin RL, Majarian WR, Cochran MD, Chiang CH, Sadoff J, Aggarwal A, Charoenvit Y, Hoffman SL (1990) Evaluation of vaccines designed to induce protective cellular immunity against the Plasmodium yoelii circumsporozoite protein: vaccinia, pseudorabies, and salmonella transformed with circumsporozoite gene. Bull World Health Org 68 : 109
53. Sedegah M, Chiang CH, Weiss WR, Mellouk S, Cochran MD, Houghton RA, Beaudoin RL, Smith D, Hoffman SL (1992) Recombinant pseudorabies virus carrying a plasmodium gene: herpes virus as a new live viral vector for inducing T- and B-cell immunity. Vaccine 10 : 578
54. Sedegah M, Hedstrom RC, Hobart P, Hoffman SL (1994) Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc Natl Acad Sci USA 91 : 9866
55. Siddiqui WA, Tam LQ, Kramer KJ, Hui GS, Case SE, Yamaga KM, Chang SP, Chan EB, Kan SC (1987) Merozoite surface coat precursor protein completely protects Aotus monkeys against Plasmodium falciparum malaria. Proc Natl Acad Sci USA 84 : 3014
56. Stoute JA, Slaoui M, Heppner DG, Monin P, Kester K, Desmons P, Wellde BT, Garcon N, Krzych U, Marchand M, Ballou WR, Cohen JD, for the RTS,S Malaria Vaccine Evaluation Group (1997) A preliminary evaluation of a recombinant circumsporozoite vaccine against Plasmodium falciparum malaria. N Engl J Med 336 : 86
57. Valmori D, Pessi A, Bianchi E, Corradin G (1992) Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human vaccination. J Immunol Methods 149 : 717
58. + T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites. Proc Natl Acad Sci USA 85 : 573
59. Weiss WR, Good MF, Hollingdale MR, Miller LH, Berzofsky JA (1989) Genetic control of immunity to Plasmodium yoelii sporozoites. J Immunol 143 : 4263
60. Weiss WR, Mellouk S, Houghten RA, Sedegah M, Kumar S, Good MF, Berzofsky JA, Miller LH, Hoffman SL (1990) Cytotoxic T cells recognize a peptide from the circumsporozoite protein on malaria-infected hepatocytes. J Exp Med 171 : 763
61. Weiss WR, Berzovsky JA, Houghten R, Sedegah M, Hollingdale M, Hoffman SL (1992) A T cell clone directed at the circumsporozoite protein which protects mice against both P. yoelii and P. berghei. J Immunol 149 : 2103
62. Zhu J, Hollingdale MR (1991) Structure of Plasmodium fulciparum liver stage antigen-1. Mol Biochem Parasitol 48 : 223