Plasmodium falciparum-Based Bioassay for Measurement of Artemisinin Derivatives in Plasma or Serum

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 3, 2004, Pages 954-960

  Teja Isavadharm, Paktiya ^a   Peggins, James O ^c,e   Brewer, Thomas G ^c,f   White, Nicholas J ^b,d   Webster, H Kyle ^a,g   Kyle, Dennis E ^a,c,h  

^a ARMED FORCES RESEARCH INSTITUTE OF MEDICAL SCIENCES   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^d JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^e NATIONAL CANCER INSTITUTE   (United States)

^f BILL AND MELINDA GATES FOUNDATION   (United States)

^g BD Technologies   (United States)

^h AUSTRALIAN ARMY MALARIA INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTEMETHER; ARTEMISININ; ARTEMISININ DERIVATIVE; ARTESUNATE; DIHYDROARTEMISININ;

ACCURACY; ANTIBIOTIC SENSITIVITY; ANTIMALARIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; BIOASSAY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DETERMINATION; ELECTROCHEMICAL DETECTION; HEAT TREATMENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALARIA; MULTIDRUG RESISTANCE; NONHUMAN; NORMAL HUMAN; PLASMA; PLASMA VOLUME; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; REPRODUCIBILITY; SERUM;

ANIMALS; ANTIMALARIALS; ARTEMISININS; BIOLOGICAL ASSAY; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCHEMISTRY; HEAT; HUMANS; MACACA MULATTA; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; REPRODUCIBILITY OF RESULTS; SESQUITERPENES;

EID: 1442324699     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.3.954-960.2004     Document Type: Article

References (45)

1. Acton, N., D. L. Klayman, and I. J. Rollman. 1985. Reductive electrochemical HPLC assay for artemisinin (qinghaosu). Planta Med. 4:445-446.
2. Baker, J. K., R. H. Yarber, C. D. Hufford, I. S. Lee, H. N. ElSohly, and J. D. McChesney. 1989. Thermospray mass spectroscopy/high performance liquid chromatographic identification of the metabolites formed from arteether using a rat liver microsome preparation. Biomed. Environ. Mass Spectrom. 18:337-351.
3. Batty, K. T., T. M. E. Davis, L. T. A. Thu, T. Q. Binh, T. K. Anh, and K. F. Ilett. 1996. Selective high-performance liquid chromatographic determination of artesunate and alpha- and beta-dihydroartemisinin in patients with falciparum malaria. J. Chromatogr. B Biomed. Appl. 677:345-350.
4. Benakis, A., C. Schopfer, M. Paris, C. T. Plessas, P. E. Karayannakos, I. Dondas, D. Kotsarelis, S. T. Plessas, and G. Skalkeas. 1991. Pharmacokinetics of arteether in dog. Eur. J. Drug Metab. Pharmacokinet. 16:325-328.
5. Bethell, D. B., P. Teja-Isavadharm, X. T. Cao, T. T. Pham, T. T. Ta, T. N. Tran, T. T. Nguyen, T. P. Pham, D. E. Kyle, N. P. Day, and N. J. White. 1997. Pharmacokinetics of oral artesunate in children with moderately severe Plasmodium falciparum malaria. Trans. R. Soc. Trop. Med. Hyg. 91:195-198.
6. Bilia, A. R., D. Lazari, L. Messori, V. Taglioli, C. Temperini, and F. F. Vincieri. 2002. Simple and rapid physico-chemical methods to examine action of antimalarial drugs with hemin: its application to Artemisia annua constituents. Life Sci. 70:769-778.
7. Bland, J. M., and D. G. Altman. 1986. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet i:307-310.
8. Chan, K. L., K. H. Yuen, S. Jinadasa, K. K. Peb, and W. T. Toh. 1997. A high-performance liquid chromatography analysis of plasma artemisinin using a glassy carbon electrode for reductive electrochemical detection. Planta Med. 63:66-69.
9. Chimanuka, B., M. Gabriels, M. R. Detaevernier, and J. A. Plaizier-Vercammen. 2002. Preparation of beta-artemether liposomes, their HPLC-UV evaluation and relevance for clearing recrudescent parasitaemia in Plasmodium chabaudi malaria-infected mice. J. Pharm. Biomed. Anal. 28:13-22.
10. Desjardins, R. E., C. J. Canfield, J. D. Haynes, and J. D. Chulay. 1979. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob. Agents Chemother. 16:710-718.
11. Hein, T. T., and N. J. White. 1993. Qinghaosu. Lancet 341:603-608.
12. Idowu, O. R., G. Edwards, S. A. Ward, M. L. Orme, and A. M. Breckenridge. 1989. Determination of arteether in blood plasma by high-performance liquid chromatography with ultraviolet detection after hydrolysis acid. J. Chromatogr. 493:125-136.
13. Ilett, K. F., B. T. Ethell, J. L. Maggs, T. M. Davis, K. T. Batty, B. Burchell, T. Q. Binh, T. A. Thu le, N. C. Hung, M. Pirmohamed, B. K. Park, and G. Edwards. 2002. Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases. Drug Metab. Dispos. 30:1005-1012.
14. Ittarat, W., S. Looareesuwan, P. Pootrakul, P. Sumpunsirikul, P. Vattanavibool, and S. R. Meshnick. 1998. Effects of α-thalassemia on pharmacokinetics of the antimalarial agent artesunate. Antimicrob. Agents Chemother. 42:2332-2335.
15. Karbwang, J., K. Na-Bangchang, P. Molunto, V. Banmairuroi, and K. Congpuong. 1997. Determination of artemether and its major metabolite, dihydroartemisinin, in plasma using high-performance liquid chromatography with electrochemical detection. J. Chromatogr. B Biomed. Sci. Appl. 690:259-265.
16. Kotecka, B. M., and K. H. Rieckmann. 1993. Chloroquine bioassay using malaria microcultures. Am. J. Trop. Med. Hyg. 49:460-464.
17. Li, Q. G., J. O. Peggins, L. L. Fleckenstein, K. Masonic, M. H. Heiffer, and T. G. Brewer. 1998. The pharmacokinetics and bioavailability of dihydroartemisinin, arteether, artemether, artesunic acid and artelinic acid in rats. J. Pharm. Pharmacol. 50:173-182.
18. Li, X., and K. Rieckmann. 1992. A bioassay for derivatives of qinghaosu (artemisinin). Trop. Med. Parasitol. 43:195-196.
19. Maggs, J. L., S. Madden, L. P. Bishop, P. M. O'Neill, and B. K. Park. 1997. The rat biliary metabolites of dihydroartemisinin, an antimalarial endoperoxide. Drug Metab. Dispos. 25:1200-1204.
20. Melendez, V., J. O. Peggins, T. G. Brewer, and A. D. Theoharides. 1991. Determination of the antimalarial arteether and its deethylated metabolite dihydroartemisinin in plasma by high-performance liquid chromatography with reductive electrochemical detection. J. Pharm. Sci. 80:132-138.
21. Muhia, D. K., C. G. Thomas, S. A. Ward, G. Edwards, E. K. Mberu, and W. M. Watkins. 1994. Ferriprotoporphyrin catalysed decomposition of artemether: analytical and pharmacological implications. Biochem. Pharmacol. 48:889-895.
22. Murphy, S. A., E. Mberu, D. Muhia, M. English, J. Crawley, C. Waruiru, B. Lowe, C. R. Newton, P. Winstanley, K. Marsh, and W. M. Watkins. 1997. The disposition of intramuscular artemether in children with cerebral malaria; a preliminary study. Trans. R. Soc. Trop. Med. Hyg. 91:331-334.
23. Navaratnam, V., S. M. Mansor, L. K. Chin, M. N. Mordi, M. Asokan, and N. K. Nair. 1995. Determination of artemether and dihydroartemisinin in blood plasma by high-performance liquid chromatography for application in clinical pharmacological studies. J. Chromatogr. B Biomed. Appl. 669:289-294.
24. Newton, P., Y. Suputtamongkol, P. Teja-Isavadharm, S. Pukrittayakamee, V. Navaratnam, I. Bates, and N. J. White. 2000. Antimalarial bioavailability and disposition of artesunate in acute falciparum malaria. Antimicrob. Agents Chemother. 44:972-977.
25. Newton, P., M. Vugt, P. Teja-Isavadharm, D. Siriyanonda, M. Rasameesoraj, P. Teerapong, R. Ruangveerayuth, T. Slight, F. Nosten, Y. Suputtamongkol, S. Looareesuwan, and N. J. White. 2002. Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria. Antimicrob. Agents Chemother. 46:1125-1127.
26. Ramu, K., and J. K. Baker. 1997. Identification of the glucuronides of the hydroxylated metabolites of the antimalarial arteether in rat plasma and urine by thermospray high-performance liquid chromatography/mass spectrometry. J. Pharm. Sci. 86:915-920.
27. Sabarinath, S., M. Rajanikanth, K. P. Madhusudanan, and R. C. Gupta. 2003. A sensitive and selective liquid chromatographic/electrospray ionization tandem mass spectrometric assay for the simultaneous quantification of alpha-, beta-arteether and its metabolite dihydroartemisinin in plasma, useful for pharmacokinetic studies. J. Mass Spectrom. 38:732-742.
28. Sandrenan, N., A. Sioufi, J. Godbillon, C. Netter, M. Donker, and C. van Valkenburg. 1997. Determination of artemether and its metabolite, dihydroartemisinin, in plasma by high-performance liquid chromatography and electrochemical detection in the reductive mode. J. Chromatogr. B Biomed. Sci. Appl. 691:145-153.
29. Scott, H. V., M. D. Edstein, J. R. Veenendall, and K. H. Rieckmann. 1988. A sensitive bioassay for serum cycloguanil using Plasmodium falciparum in vitro. Int. J. Parasitol. 18:605-609.
30. Sipahimalani, A. T., D. P. Fulzele, and M. R. Heble. 1991. Rapid method for the detection and determination of artemisinin by gas chromatography. J. Chromatogr. 538:452-455.
31. Souppart, C., N. Gauducheau, N. Sandrenan, and F. Richard. 2002. Development and validation of a high-performance liquid chromatography-mass spectrometry assay for the determination of artemether and its metabolite dihydroartemisinin in human plasma. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 774:195-203.
32. Suputtamongkol, Y., P. N. Newton, B. Angus, P. Teja-Isavadharm, D. Keeratithakul, M. Rasameesoraj, S. Pukrittayakamee, and N. J. White. 2001. A comparison of oral artesunate and artemether antimalarial bioactivities in acute falciparum malaria. Br. J. Clin. Pharmacol. 52:655-661.
33. Taylor, R. B., M. I. Awad, R. Reid, and R. R. Moody. 2000. Determination of sodium artesunate in plasma using ion-pairing high-performance liquid chromatography. J. Chromatogr. B Biomed. Sci. Appl. 744:415-421.
34. Teja-Isavadharm, P., F. Nosten, D. E. Kyle, C. Luxemburger, F. ter Kuile, J. O. Peggins, T. G. Brewer, and N. J. White. 1996. Comparative bioavailability of oral, rectal and intramuscular artemether in healthy subjects-use of simultaneous measurement by high performance liquid chromatography and bioassay. Br. J. Clin. Pharmacol. 42:599-604.
35. Teja-Isavadharm, P., G. Watt, C. Eamsila, K. Jongsakul, Q. Li, D. Keeratithakul, N. Sirisopana, L. Loesuttiviboon, T. G. Brewer, and D. E. Kyle. 2001. Comparative pharmacokinetic-effect kinetics of oral sodium artesunate in healthy volunteers and patients with uncomplicated falciparum malaria. Am. J. Trop. Med. Hyg. 65:717-721.
36. Theoharides, A. D., M. H. Smyth, R. W. Ashmore, J. M. Halverson, Z. M. Zhou, W. E. Ridder, and A. J. Lin. 1988. Determination of dihydroqinghaosu in blood by pyrolysis gas chromatography/mass spectrometry. Anal. Chem. 60:115-130.
37. Thomas, C. G., S. A. Ward, and G. Edwards. 1992. Selective determination, in plasma, of artemether and its major metabolite, dihydroartemisinin, by high-performance liquid chromatography with ultraviolet detection. J. Chromatogr. 583:131-136.
38. Titulaer, H. A. C., J. Zuidema, P. A. Kager, J. C. F. M. Wetstyn, C. B. Lugt, and F. W. H. M. Merkus. 1990. The pharmacokinetics of artemisinin after oral, intramuscular and rectal administration to human volunteers. J. Pharm. Pharmacol. 42:810-813.
39. Traore, B., E. Lazaro, and F. Gay. 1997. A bioassay for evaluating antimalarial activity and for measuring concentration in plasma. Trop. Med. Int. Health 2:929-933.
40. van Agtmael, M. A., J. J Butter, E. J. Portier, and C. J. van Boxtel. 1998. Validation of an improved reversed-phase high-performance liquid chromatography assay with reductive electrochemical detection for the determination of artemisinin derivatives in man. Ther. Drug Monit. 20:109-116.
41. Webster, H. K., E. F. Boudreau, K. Pavanand, K. Yongvanitchit, and L. W. Pang. 1985. Antimalarial drug susceptiblity testing Plasmodium falciparum in Thailand using a microdilution radioisotope method. Am. J. Trop. Med. Hyg. 34:228-235.
42. White, N. J. 1993. Clinical pharmacokinetics and pharmacodynamics of artemisinin and derivatives. Trans. R. Soc. Trop. Med. Hyg. 88(Suppl. 1):S41-S43.
43. Yang, S. D., J. M. Ma, J. H. Sun, and Z. Y. Song. 1985. Determination of artesunate and dihydroqinghaosu in human plasma by high performance liquid chromatography with a reductive mode electrochemical detection. Yao Xue Xue Bao 20:457-462.
44. Yeo, A. E., and K. H. Rieckman. 1992. A bioassay for mefloquine. J. Parasitol. 78:1096-1097.
45. Zhou, Z. M., J. C. Anders, H. Chung, and A. D. Theoharides. 1987. Analysis of artesunic acid and dihydroqinghaosu in blood by high-performance liquid chromatography with reductive electrochemical detection. J. Chromatogr. 414:77-90.