Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 19, 1996, Pages 10034-10039

  Silva, A M ^a   Lee, A Y ^a   Gulnik, S V ^a   Majer, P ^a   Collins, J ^a   Bhat, T N ^a   Collins, P J ^a   Cachau, R E ^a   Luker, K E ^b   Gluzman, I Y ^b   Francis, S E ^b   Oksman, A ^b   Goldberg, D E ^b   Erickson, J W ^a  

^a SAIC FREDERICK INC   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

aspartic protease; cathepsin D; crystallography; drug design; malaria

Indexed keywords

ANTIMALARIAL AGENT; ASPARTIC PROTEINASE; ASPARTIC PROTEINASE INHIBITOR; PEPSTATIN; RECOMBINANT PROTEIN;

ANTIMALARIAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG DESIGN; DRUG POTENCY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STRUCTURE; INHIBITION KINETICS; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ASPARTIC ENDOPEPTIDASES; CATHEPSIN D; CLONING, MOLECULAR; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; HEMOGLOBINS; HUMANS; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PROTEASE INHIBITORS; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

PLASMODIUM FALCIPARUM;

EID: 16044374702     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.19.10034     Document Type: Article

References (28)

1. Sturchler, D. (1989) Parasitol. Today 5, 39-40.
2. Scheibel, L. W. & Sherman, I. W. (1988) in Malaria, eds. Wernsdofer, W. H. & McGregor, I. (Churchill Livingstone, London), pp. 219-252.
3. Olliaro, P. I. & Goldberg, D. E. (1995) Parasitol. Today 11, 294-297.
4. Slater, A. F. G. (1993) Pharmacol. Ther. 57, 203-235.
5. Rosenthal, P. J., Wollish, W. S., Palmer, J. T. & Rasnick, D. (1991) J. Clin. Invest. 88, 1467-1472.
6. Francis, S. E., Gluzman, I. Y., Oksman, A., Knickerbocker, A., Mueller, R., Bryant, M., Sherman, D. R., Russell, D. G. & Goldberg, D. E. (1994) EMBO J. 13, 306-317.
7. Gluzman, I. Y., Francis, S. E., Oksman, A., Smith, C. E., Duffin, K. L. & Goldberg, D. E. (1994) J. Clin. Invest. 93, 1602-1608.
8. Dame, J. B., Reddy, G. R., G., Yowell, C. A., Dunn, B. M., Kay, J. & Berry, C. (1994) Mol. Biochem. Parasitol. 64, 177-190.
9. Umezawa, H., Aoyagi, T., Morishima, H., Matsuzaki, M., Hamada, M. & Takeuchi, T. (1970) J. Antibiot. (Tokyo) 23, 259-262.
10. Hill, J., Tyas, L., Phylip, L. H., Kay, J., Dunn, B. M. & Berry, C. (1994) FEBS Lett. 352, 155-158.
11. Luker, K. L., Francis, S. E., Gluzman, I. Y. & Goldberg, D. E. (1996) Mol. Biochem. Parasitol., in press.
12. Matayoshi, E. D., Wang, G. T., Krafft, G. A. & Erickson, J. (1990) Science 247, 954-958.
13. William, J. W. & Morrison, J. F. (1979) Methods Enzymol. 63, 437-467.
14. Otwinowski, Z. (1993) DENZO: An Oscillation Data Processing Program for Macromolecular Crystallography (Yale Univ. Press, New Haven, CT).
15. Otwinowski, Z. (1993) SCALEPACK: Software for the Scaling Together of Integrated Intensities Measured on a Number of Separate Diffraction Images (Yale Univ. Press, New Haven, CT).
16. Navaza, J. (1994) Acta Crystallogr. A 50, 157-163.
17. Baldwin, E. T., Bhat, T. N., Gulnik, S., Hosur, M. V., Sowder, R. C., Cachau, R. E., Collins, J., Silva, A. M. & Erickson, J. W. (1993) Proc. Natl. Acad. Sci. USA 90, 6796-6800.
18. Brünger, A. T., (1992) X-PLOR: A System for X-ray Crystallography and NMR (Yale Univ. Press, New Haven, CT), Version 3.1.
19. Davies, D. (1990) Annu. Rev. Biophys. Biophys. Chem. 19, 189-215.
20. Diamond, R. (1976) Acta Crystallogr. A 32, 1-10.
21. Gerstein, M., Lesk, A. M. & Chothia, C. (1994) Biochemistry 33, 6739-6749.
22. Chu, A. H. & Ackers, G. K. (1981) J. Biol. Chem. 256, 1199-1205.
23. Erickson, J. W., Baldwin, E. T., Bhat, T. N. & Gulnik, S. (1995) in Aspartic Proteinases: Structure, Function, Biology and Biomedical Implications, ed. Takahashi, K. (Plenum, New York), pp. 181-192.
24. Abad-Zapatero, C., Rydel, T. J. & Erickson, J. W. (1990) Proteins 8, 62-81.
25. Sali, A., Veerapandi, J. B., Cooper, S. I., Foundling, S. I., Hoover, D. J. & Blundel, T. L. (1987) EMBO J. 8, 2179-2188.
26. Schlechter, I. & Berger, A. (1967) Biochem. Biophys. Res. Commun. 27, 157-163.
27. Cachau, R. E. (1994) Biophys. Chem. 51, 1-17.
28. Sielicki, A. R., Hayakawa, K., Fujinaga, M., Murphy, E. P., Fraser, M., Muir, A. K., Carilli, C. T., Lewicki, J. A., Baxter, J. D. & James, M. N. G., (1989) Science 243, 1346-1351.