Coexistence of High Levels of Apoptotic Signaling and Inhibitor of Apoptosis Proteins in Human Tumor Cells: Implication for Cancer Specific Therapy

Cancer Research

Volumn 63, Issue 20, 2003, Pages 6815-6824

  Yang, Lily ^a   Cao, Zehong ^a   Yan, Hui ^a,b   Wood, William C ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INHIBITOR; CASPASE 3; CASPASE 8; CASPASE INHIBITOR; INHIBITOR OF APOPTOSIS PROTEIN; SURVIVIN; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL CULTURE; COLON CARCINOMA; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY;

APOPTOSIS; CASPASES; CELL LINE, TUMOR; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; HUMANS; ISOENZYMES; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; NEOPLASMS; PROTEIN BIOSYNTHESIS; PROTEINS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 0142188706     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Hickman, J. A. Apoptosis and tumourigenesis. Curr. Opin. Genet. Dev., 12: 67-72, 2002.
2. Reed, J. C. Mechanisms of apoptosis avoidance in cancer. Curr. Opin. Oncol., 11: 68-75, 1999.
3. LaCasse, E. C., Baird, S., Korneluk, R. G., and MacKenzic, A. E. The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene, 17: 3247-3259, 1998.
4. Satoh, K., Kaneko, K., Hirota, M., Masamune, A., Satoh, A., and Shimosegawa, T. Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors. Cancer (Phila.), 92: 271-278, 2001.
5. Kaufmann, S. H., and Earnshaw, W. C. Induction of apoptosis by cancer chemotherapy. Exp. Cell Res., 256: 42-49, 2000.
6. Dive, C. Avoidance of apoptosis as a mechanism of drug resistance. J. Intern. Med. Suppl., 740: 139-145, 1997.
7. Makin, G., and Hickman, J. A. Apoptosis and cancer chemotherapy. Cell Tissue Res., 301: 143-152, 2000.
8. Haq, R., and Zanke, B. Inhibition of apoptotic signaling pathways in cancer cells as a mechanism of chemotherapy resistance. Cancer Metastasis Rev., 17: 233-239, 1998.
9. Budihardjo, I., Oliver, H., Lutter, M., Luo, X., and Wang, X. Biochemical pathways of caspase activation during apoptosis. Annu. Rev. Cell Dev. Biol., 15: 269-290, 1999.
10. Stroh, C., and Schulze-Osthoff, K. Death by a thousand cuts: an ever increasing list of caspase substrates. Cell Death Differ, 5: 997-1000, 1998.
11. Liu, X., Zou, H., Slaughter, C., and Wang, X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell, 89: 175-184, 1997.
12. Miller, L. K. An exegesis of IAPs: salvation and surprises from BIR motifs. Trends Cell Biol., 9: 323-328, 1999.
13. Ambrosini, G., Adida, C., and Alticri, D. C. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med., 3: 917-921, 1997.
14. Reed, J. C. The Survivin saga goes in vivo. J. Clin. Investig., 108: 965-969, 2001.
15. Huang, Y., Park, Y. C., Rich, R. L., Segal, D., Myszka, D. G., and Wu, H. Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. Cell, 104: 781-790, 2001.
16. Srinivasula, S. M., Hegde, R., Saleh, A., Datta, P., Shiozaki, E., Chai, J., Lee, R. A., Robbins, P. D., Fernandes-Alnemri, T., Shi, Y., and Alnemri, E. S. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature (Lond.), 410: 112-116, 2001.
17. Tamm, I., Wang, Y., Sausville, E., Scudiero, D. A., Vigna, N., Oltersdorf, T., and Reed, J. C. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res., 58: 5315-5320, 1998.
18. Riedl, S. J., Renatus, M., Schwarzenbacher, R., Zhou, Q., Sun, C., Fesik, S. W., Liddington, R. C., and Salvesen, G. S. Structural basis for the inhibition of caspase-3 by XIAP. Cell, 104: 791-800, 2001.
19. Altieri, D. C. The molecular basis and potential role of survivin in cancer diagnosis and therapy. Trends Mol. Med., 7: 542-547, 2001.
20. Sarela, A. I., Scott, N., Ramsdale, J., Markham, A. F., and Guillou, P. J. Immunohistochemical detection of the anti-apoptosis protein, survivin, predicts survival after curative resection of stage II colorectal carcinomas. Ann. Surg. Oncol., 8: 305-310, 2001.
21. Tanaka, K., Iwamoto, S., Gon, G., Nohara, T., Iwamoto, M., and Tanigawa, N. Expression of survivin and its relationship to loss of apoptosis in breast carcinomas. Clin. Cancer Res., 6: 127-134, 2000.
22. Ferreira, C. G., van der Valk, P., Span, S. W., Jonker, J. M., Postmus, P. E., Kruyt, F. A., and Giaccone, G. Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small cell lung cancer patients. Ann. Oncol., 12: 799-805, 2001.
23. Li, J., Feng, Q., Kim, J. M., Schneiderman, D., Liston, P., Li, M., Vanderhyden, B., Faught, W., Fung, M. F., Senterman, M., Korneluk, R. G., and Tsang, B. K. Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins. Endocrinology, 142: 370-380, 2001.
24. Sasaki, H., Sheng, Y., Kotsuji, F., and Tsang, B. K. Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells. Cancer Res., 60: 5659-5666, 2000.
25. Bargou, R. C., Wagener, C., Bommert, K., Mapara, M. Y., Daniel, P. T., Arnold, W., Dietel, M., Guski, H., Feller, A., Royer, H. D., and Dorken, B. Overexpression of the death-promoting gene bax-α, which is down-regulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice. J. Clin. Investig., 97: 2651-2659, 1996.
26. Arai, H., Gordon, D., Nabel, E. G., and Nabel, G. J. Gene transfer of Fas ligand induces tumor regression in vivo. Proc. Natl. Acad. Sci. USA, 94: 13862-13867, 1997.
27. Komata, T., Kondo, Y., Kanzawa, T., Ito, H., Hirohata, S., Koga, S., Sumiyoshi, H., Takakura, M., Inoue, M., Barna, B. P., Germano, I. M., Kyo, S., and Kondo, S. Caspase-8 gene therapy using the human telomcrase reverse transcriptase promoter for malignant glioma cells. Hum. Gene Ther., 13: 1015-1025, 2002.
28. Shinoura, N., Sakurai, S., Asai, A., Kirino, T., and Hamada, H. Transduction of Apaf-1 or caspase-9 induces apoptosis in A-172 cells that are resistant to p53-mediated apoptosis. Biochem. Biophys. Res. Commun., 272: 667-673, 2000.
29. Fong, W. G., Liston, P., Rajcan-Separovic, E., St. Jean, M., Craig, C., and Korneluk, R. G. Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines. Genomics, 70: 113-122, 2000.
30. Liston, P., Fong, W. G., Kelly, N. L., Toji, S., Miyazaki, T., Conte, D., Tamai, K., Craig, C. G., McBurney, M. W., and Korneluk, R. G. Identification of XAF1 as an antagonist of XIAP anti-caspase activity. Nat. Cell Biol., 3: 128-133, 2001.
31. Mesri, M., Wall, N. R., Li, J., Kim, R. W., and Altieri, D. C. Cancer gene therapy using a survivin mutant adenovirus. J. Clin. Investig., 108: 981-990, 2001.
32. O'Connor, D. S., Grossman, D., Plescia, J., Li, F., Zhang, H., Villa, A., Tognin, S., Marchisio, P. C., and Altieri, D. C. Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc. Natl. Acad. Sci. USA, 97: 13103-13107, 2000.
33. Srinivasula, S. M., Ahmad, M., MacFarlane, M., Luo, Z., Huang, Z., Fernandes-Alnemri, T., and Alnemri, E. S. Generation of constitutively active recombinant caspases-3 and -6 by rearrangement of their subunits. J. Biol. Chem., 273: 10107-10111, 1998.
34. He, T. C., Zhou, S., da Costa, L. T., Yu, J., Kinzler, K. W., and Vogelstein, B. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. USA, 95: 2509-2514, 1998.
35. Holcik, M., Gibson, H., and Korneluk, R. G. XIAP: apoptotic brake and promising therapeutic target. Apoptosis, 6: 253-261, 2001.
36. Deveraux, Q. L., Leo, E., Stennicke, H. R., Welsh, K., Salvesen, G. S., and Reed, J. C. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J., 18: 5242-5251, 1999.
37. Du, C., Fang, M., Li, Y., Li, L., and Wang, X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell, 102: 33-42, 2000.
38. Shinoura, N., Muramatsu, Y., Yoshida, Y., Asai, A., Kirino, T., and Hamada, H. Adenovirus-mediated transfer of caspase-3 with Fas ligand induces drastic apoptosis in U-373MG glioma cells. Exp. Cell Res., 256: 423-433, 2000.
39. Keaue, M. M., Ettenberg, S. A., Lowrey, G. A., Russell, E. K., and Lipkowitz, S. Fas expression and function in normal and malignant breast cell lines. Cancer Res., 56: 4791-4798, 1996.
40. Bargou, R. C., Daniel, P. T., Mapara, M. Y., Bommert, K., Wagener, C., Kallinich, B., Royer, H. D., and Dorken, B. Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-α expression in tumor cells correlates with resistance towards apoptosis. Int. J. Cancer, 60: 854-859, 1995.
41. Teitz, T., Wei, T., Valentine, M. B., Vanin, E. F., Grenet, J., Valentine, V. A., Behm, F. G., Look, A. T., Lahti, J. M., and Kidd, V. J. Caspase-8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat. Med., 6: 529-535, 2000.
42. Vakkala, M., Paakko, P., and Soini, Y. Expression of caspases 3, 6, and 8 is increased in parallel with apoptosis and histological aggressiveness of the breast lesion. Br. J. Cancer, 81: 592-599, 1999.
43. Nakopoulou, L., Alexandrou, P., Stefanaki, K., Panayotopoulou, E., Lazaris, A. C., and Davaris, P. S. Immunohistochemical expression of caspase-3 as an adverse indicator of the clinical outcome in human breast cancer. Pathobiology, 69: 266-273, 2001.
44. Krajewski, S., Krajewska, M., Turner, B. C., Pratt, C., Howard, B., Zapata, J. M., Frenkel, V., Robertson, S., Ionov, Y., Yamamoto, H., Perucho, M., Takayama, S., and Reed, J. C. Prognostic significance of apoptosis regulators in breast cancer. Endocr. Relat. Cancer, 6: 29-40, 1999.
45. Parton, M., Krajewski, S., Smith, I., Krajewska, M., Archer, C., Naito, M., Ahern, R., Reed, J., and Dowsett, M. Coordinate expression of apoptosis-associated proteins in human breast cancer before and during chemotherapy. Clin. Cancer Res., 8: 2100-2108, 2002.
46. Marusawa, H., Matsuzawa, S., Welsh, K., Zou, H., Armstrong, R., Tamm, I., and Reed, J. C. HBXIP functions as a cofactor of survivin in apoptosis suppression. EMBO J., 22: 2729-2740, 2003.
47. Wall, N. R., O'Connor, D. S., Plescia, J., Pommier, Y., and Altieri, D. C. Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis. Cancer Res., 63: 230-235, 2003.
48. Wittmann, S., Bali, P., Donapaty, S., Nimmanapalli, R., Guo, F., Yumaguchi, H., Huang, M., Jove, R., Wang, H. G., and Bhalla, K. Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis. Cancer Res., 63: 93-99, 2003.
49. Wei, S. J., Chao, Y., Shih, Y. L., Yang, D. M., Hung, Y. M., and Yang, W. K. Involvement of Fas (CD95/APO-1) and Fas ligand in apoptosis induced by ganciclovir treatment of tumor cells transduced with herpes simplex virus thymidine kinase. Gene Ther., 6: 420-431, 1999.
50. Kurokawa, H., Nishio, K., Fukumoto, H., Tomonari, A., Suzuki, T., and Saijo, N. Alteration of caspase-3 (cpp32/yama/apopain) in wild type MCF-7 breast cancer cell. Oncol. Rep., 6: 33-37, 1999.