메뉴 건너뛰기




Volumn 93, Issue 7, 1999, Pages 2369-2379

Constitutive activation of the JAK2/STAT5 signal transduction pathway correlates with growth factor independence of megakaryocytic leukemic cell lines

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH FACTOR; HEMOPOIETIC GROWTH FACTOR; INTERLEUKIN 3; INTERLEUKIN 6; PROTEIN TYROSINE KINASE; RAF PROTEIN; STAT5 PROTEIN; THROMBOPOIETIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 0033120870     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.7.2369.407k18_2369_2379     Document Type: Article
Times cited : (62)

References (48)
  • 1
    • 0028832719 scopus 로고
    • Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity
    • Alexander WS, Metcalf D, Dunn AR: Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity. EMBO J 14:5569, 1995
    • (1995) EMBO J , vol.14 , pp. 5569
    • Alexander, W.S.1    Metcalf, D.2    Dunn, A.R.3
  • 2
    • 0028332086 scopus 로고
    • Activation and inhibition of erythropoietin receptor function: Role of receptor dimerization
    • Watowich SS, Hilton DJ, Lodish HF: Activation and inhibition of erythropoietin receptor function: Role of receptor dimerization. Mol Cell Biol 14:3535, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 3535
    • Watowich, S.S.1    Hilton, D.J.2    Lodish, H.F.3
  • 3
    • 0028959163 scopus 로고
    • Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines
    • Kitayama H, Kanakura Y, Furitsu T, Tsujimura T, Oritani K, Ikeda H, Sugahara H, Mitsui H, Kanayamu Y, Kitamura Y: Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines. Blood 85:790, 1995
    • (1995) Blood , vol.85 , pp. 790
    • Kitayama, H.1    Kanakura, Y.2    Furitsu, T.3    Tsujimura, T.4    Oritani, K.5    Ikeda, H.6    Sugahara, H.7    Mitsui, H.8    Kanayamu, Y.9    Kitamura, Y.10
  • 4
    • 0028935483 scopus 로고
    • Constitutive activation of a variant of the env-mpl oncogene product by disulfide-linked homodimerization
    • Courtois G, Benit L, Mikaeloff Y, Pauchard M, Charon M, Varlet P, Gisselbrecht S: Constitutive activation of a variant of the env-mpl oncogene product by disulfide-linked homodimerization. J Virol 69: 2794, 1995
    • (1995) J Virol , vol.69 , pp. 2794
    • Courtois, G.1    Benit, L.2    Mikaeloff, Y.3    Pauchard, M.4    Charon, M.5    Varlet, P.6    Gisselbrecht, S.7
  • 5
    • 0028073748 scopus 로고
    • Interleukin-3 is an autocrine growth factor of human megakaryoblasts, the DAMI and MEG-01 cells
    • Chen YZ, Gu XF, Caen JP, Han ZC: Interleukin-3 is an autocrine growth factor of human megakaryoblasts, the DAMI and MEG-01 cells. Br J Haematol 88:481, 1994
    • (1994) Br J Haematol , vol.88 , pp. 481
    • Chen, Y.Z.1    Gu, X.F.2    Caen, J.P.3    Han, Z.C.4
  • 6
    • 0023108264 scopus 로고
    • Constitutive expression of the granulocyte-macrophage colony-stimulating factor gene in acute myeloblastic leukemia
    • Young DC, Wagner K, Griffin JD: Constitutive expression of the granulocyte-macrophage colony-stimulating factor gene in acute myeloblastic leukemia. J Clin Invest 79:100, 1987
    • (1987) J Clin Invest , vol.79 , pp. 100
    • Young, D.C.1    Wagner, K.2    Griffin, J.D.3
  • 7
    • 0022811277 scopus 로고
    • Autocrine secretion of GM-CSF in acute myeloblastic leukemia
    • Young DC, Griffin JD: Autocrine secretion of GM-CSF in acute myeloblastic leukemia. Blood 68:1178, 1986
    • (1986) Blood , vol.68 , pp. 1178
    • Young, D.C.1    Griffin, J.D.2
  • 9
    • 0030052617 scopus 로고    scopus 로고
    • Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets
    • Miyakawa Y, Oda A, Druker BJ, Miyazaki H, Handa M, Ohashi H, Ikeda Y: Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets. Blood 87:439, 1996
    • (1996) Blood , vol.87 , pp. 439
    • Miyakawa, Y.1    Oda, A.2    Druker, B.J.3    Miyazaki, H.4    Handa, M.5    Ohashi, H.6    Ikeda, Y.7
  • 11
    • 0029588429 scopus 로고
    • Thrombopoietin induces activation of at least two distinct signaling pathways
    • Nagata Y, Todokoro K: Thrombopoietin induces activation of at least two distinct signaling pathways. FEBS Lett 377:497, 1995
    • (1995) FEBS Lett , vol.377 , pp. 497
    • Nagata, Y.1    Todokoro, K.2
  • 12
    • 0029584186 scopus 로고
    • Thrombopoietin induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in a human thrombopoietin-dependent cell line
    • Yamada M, Komatsu N, Okada K, Kato T, Miyazaki H, Miura Y: Thrombopoietin induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in a human thrombopoietin-dependent cell line. Biochem Biophys Res Commun 217:230, 1995
    • (1995) Biochem Biophys Res Commun , vol.217 , pp. 230
    • Yamada, M.1    Komatsu, N.2    Okada, K.3    Kato, T.4    Miyazaki, H.5    Miura, Y.6
  • 13
    • 0028910991 scopus 로고
    • The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl
    • Drachman JG, Griffin JD, Kaushansky K: The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl. J Biol Chem 270:4979, 1995
    • (1995) J Biol Chem , vol.270 , pp. 4979
    • Drachman, J.G.1    Griffin, J.D.2    Kaushansky, K.3
  • 17
    • 0029115640 scopus 로고
    • Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue
    • Liu X, Robinson GW, Gouilleux F, Groner B, Hennighausen L: Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc Natl Acad Sci USA 92:8831, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8831
    • Liu, X.1    Robinson, G.W.2    Gouilleux, F.3    Groner, B.4    Hennighausen, L.5
  • 18
    • 0028217452 scopus 로고
    • Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
    • published erratum appears in EMBO J 14:854, 1995
    • Wakao H, Gouilleux F, Groner B: Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response (published erratum appears in EMBO J 14:854, 1995). EMBO J 13:2182, 1994
    • (1994) EMBO J , vol.13 , pp. 2182
    • Wakao, H.1    Gouilleux, F.2    Groner, B.3
  • 19
    • 0027993605 scopus 로고
    • Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription
    • Gouilleux F, Wakao H, Mundt M, Groner B: Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J 13:4361, 1994
    • (1994) EMBO J , vol.13 , pp. 4361
    • Gouilleux, F.1    Wakao, H.2    Mundt, M.3    Groner, B.4
  • 20
    • 0345599129 scopus 로고
    • The Bmx tyrosine-kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase
    • Saharinen P, Ekman N, Sarvas K, Alitalo K, Silvennoinen O: The Bmx tyrosine-kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase. Mol Endocrinol 8:469, 1994
    • (1994) Mol Endocrinol , vol.8 , pp. 469
    • Saharinen, P.1    Ekman, N.2    Sarvas, K.3    Alitalo, K.4    Silvennoinen, O.5
  • 21
    • 0028097932 scopus 로고
    • Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the P91 gene
    • Pine R, Canova A, Schindler C: Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the P91 gene. EMBO J 13:158, 1994
    • (1994) EMBO J , vol.13 , pp. 158
    • Pine, R.1    Canova, A.2    Schindler, C.3
  • 22
    • 0028075831 scopus 로고
    • Growth hormone specifically regulates serine protease inhibitor gene transcription via gamma-activated sequence-like DNA elements
    • Sliva D, Wood TJ, Schindler C, Lobie PE, Norstedt G: Growth hormone specifically regulates serine protease inhibitor gene transcription via gamma-activated sequence-like DNA elements. J Biol Chem 269:26208, 1994
    • (1994) J Biol Chem , vol.269 , pp. 26208
    • Sliva, D.1    Wood, T.J.2    Schindler, C.3    Lobie, P.E.4    Norstedt, G.5
  • 26
    • 0020321974 scopus 로고
    • HEL cells: A new human erythroleukemia cell line with spontaneous and induced globin expression
    • Martin P, Papayannopoulou T: HEL cells: A new human erythroleukemia cell line with spontaneous and induced globin expression. Science 216:1233, 1982
    • (1982) Science , vol.216 , pp. 1233
    • Martin, P.1    Papayannopoulou, T.2
  • 27
    • 13344276586 scopus 로고    scopus 로고
    • Inhibition of protein kinase C suppresses megakaryocytic differentiation and stimulates erythroid differentiation in HEL cells
    • Hong Y, Martin JF, Vainchenker W, Erusalimsky JD: Inhibition of protein kinase C suppresses megakaryocytic differentiation and stimulates erythroid differentiation in HEL cells. Blood 87:123, 1996
    • (1996) Blood , vol.87 , pp. 123
    • Hong, Y.1    Martin, J.F.2    Vainchenker, W.3    Erusalimsky, J.D.4
  • 28
    • 0022353446 scopus 로고
    • Establishment of a novel human megakaryoblastic leukemia cell line, MEG-01, with positive Philadelphia chromosome
    • Ogura M, Morishima Y, Ohno R, Kato Y, Hirabayashi N, Nagura H, Saito H: Establishment of a novel human megakaryoblastic leukemia cell line, MEG-01, with positive Philadelphia chromosome. Blood 66:1384, 1985
    • (1985) Blood , vol.66 , pp. 1384
    • Ogura, M.1    Morishima, Y.2    Ohno, R.3    Kato, Y.4    Hirabayashi, N.5    Nagura, H.6    Saito, H.7
  • 30
    • 0028342870 scopus 로고
    • Identification of JAK protein tyrosine kinases as signaling molecules for prolactin. Functional analysis of prolactin receptor and prolactin-erythropoietin receptor chimera expressed in lymphoid cells
    • Dusanter-Fourt I, Muller O, Ziemiecki A, Mayeux P, Drucker B, Djiane J, Wilks A, Harpur AG, Fischer S, Gisselbrecht S: Identification of JAK protein tyrosine kinases as signaling molecules for prolactin. Functional analysis of prolactin receptor and prolactin-erythropoietin receptor chimera expressed in lymphoid cells. EMBO J 13:2583, 1994
    • (1994) EMBO J , vol.13 , pp. 2583
    • Dusanter-Fourt, I.1    Muller, O.2    Ziemiecki, A.3    Mayeux, P.4    Drucker, B.5    Djiane, J.6    Wilks, A.7    Harpur, A.G.8    Fischer, S.9    Gisselbrecht, S.10
  • 31
    • 0026734257 scopus 로고
    • Expression of human hsp70 in rat fibroblasts enhances cell survival and facilitates recovery from translational and transcriptional inhibition following heat shock
    • Liu RY, Li X, Li L, Li GC: Expression of human hsp70 in rat fibroblasts enhances cell survival and facilitates recovery from translational and transcriptional inhibition following heat shock. Cancer Res 52:3667, 1992
    • (1992) Cancer Res , vol.52 , pp. 3667
    • Liu, R.Y.1    Li, X.2    Li, L.3    Li, G.C.4
  • 32
    • 0019057560 scopus 로고
    • A rapid single step staining technique for DNA analysis by flow microfluorimetry
    • Taylor IW: A rapid single step staining technique for DNA analysis by flow microfluorimetry. J Histochem Cytochem 28:1021, 1980
    • (1980) J Histochem Cytochem , vol.28 , pp. 1021
    • Taylor, I.W.1
  • 33
    • 0026061602 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor-dependent myeloid cell line
    • Kanakura Y, Druker B, Wood KW, Mamon HJ, Okuda K, Roberts TM, Griffin JD: Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor-dependent myeloid cell line. Blood 77:243, 1991
    • (1991) Blood , vol.77 , pp. 243
    • Kanakura, Y.1    Druker, B.2    Wood, K.W.3    Mamon, H.J.4    Okuda, K.5    Roberts, T.M.6    Griffin, J.D.7
  • 34
    • 0027534989 scopus 로고
    • Attenuation of serum inducibility of immediate early genes by oncoproteins in tyrosine kinase signaling pathways
    • Yu CL, Prochownik EV, Imperiale MJ, Jove R: Attenuation of serum inducibility of immediate early genes by oncoproteins in tyrosine kinase signaling pathways. Mol Cell Biol 13:2011, 1993
    • (1993) Mol Cell Biol , vol.13 , pp. 2011
    • Yu, C.L.1    Prochownik, E.V.2    Imperiale, M.J.3    Jove, R.4
  • 35
    • 0023883585 scopus 로고
    • Isolation and characterization of the Bos taurus beta-casein gene
    • Gorodetsky SI, Tkach TM, Kapelinskaya TV: Isolation and characterization of the Bos taurus beta-casein gene. Gene 66:87, 1988
    • (1988) Gene , vol.66 , pp. 87
    • Gorodetsky, S.I.1    Tkach, T.M.2    Kapelinskaya, T.V.3
  • 36
    • 0031953831 scopus 로고    scopus 로고
    • Stat3 activation by Src induces specific gene regulation and is required for cell transformation
    • Turkson J, Bowman T, Garcia R, Caldenhoven E, De Groot RP, Jove R: Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol Cell Biol 18:2545, 1998
    • (1998) Mol Cell Biol , vol.18 , pp. 2545
    • Turkson, J.1    Bowman, T.2    Garcia, R.3    Caldenhoven, E.4    De Groot, R.P.5    Jove, R.6
  • 37
    • 0027998224 scopus 로고
    • Factor independence of human myeloid leukemia cell lines is associated with increased phosphorylation of the proto-oncogene Raf-1
    • Okuda K, Matulonis U, Salgia R, Kanakura Y, Druker B, Griffin JD: Factor independence of human myeloid leukemia cell lines is associated with increased phosphorylation of the proto-oncogene Raf-1. Exp Hematol 22:1111, 1994
    • (1994) Exp Hematol , vol.22 , pp. 1111
    • Okuda, K.1    Matulonis, U.2    Salgia, R.3    Kanakura, Y.4    Druker, B.5    Griffin, J.D.6
  • 38
    • 0030471795 scopus 로고    scopus 로고
    • The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway
    • Cortez D, Stoica G, Pierce JH, Pendergast AM: The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway. Oncogene 13:2589, 1996
    • (1996) Oncogene , vol.13 , pp. 2589
    • Cortez, D.1    Stoica, G.2    Pierce, J.H.3    Pendergast, A.M.4
  • 39
    • 0028274049 scopus 로고
    • Expression of bcr-abl abrogates factor-dependent growth of human hematopoietic M07E cells by an autocrine mechanism
    • Sirard C, Laneuville P, Dick JE: Expression of bcr-abl abrogates factor-dependent growth of human hematopoietic M07E cells by an autocrine mechanism. Blood 83:1575, 1994
    • (1994) Blood , vol.83 , pp. 1575
    • Sirard, C.1    Laneuville, P.2    Dick, J.E.3
  • 40
    • 0031105070 scopus 로고    scopus 로고
    • Activation of hematopoietic growth factor signal transduction pathways by the human oncogene BCR/ABL
    • Sattler M, Salgia R: Activation of hematopoietic growth factor signal transduction pathways by the human oncogene BCR/ABL. Cytokine Growth Factor Rev 8:63, 1997
    • (1997) Cytokine Growth Factor Rev , vol.8 , pp. 63
    • Sattler, M.1    Salgia, R.2
  • 41
    • 0344304636 scopus 로고    scopus 로고
    • Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia
    • Shuai K, Halpern J, ten Hoeve J, Rao X, Sawyers CL: Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene 18:13, 1996
    • (1996) Oncogene , vol.18 , pp. 13
    • Shuai, K.1    Halpern, J.2    Ten Hoeve, J.3    Rao, X.4    Sawyers, C.L.5
  • 45
    • 0030843270 scopus 로고    scopus 로고
    • P210 Bcr-Abl interacts with the interleukin-3 beta c subunit and constitutively activates Jak2
    • Wilson-Rawls J, Liu J, Laneuville P, Arlinghaus RB: P210 Bcr-Abl interacts with the interleukin-3 beta c subunit and constitutively activates Jak2. Leukemia 3:428, 1997
    • (1997) Leukemia , vol.3 , pp. 428
    • Wilson-Rawls, J.1    Liu, J.2    Laneuville, P.3    Arlinghaus, R.B.4
  • 46
    • 0029863169 scopus 로고    scopus 로고
    • Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl
    • Carlesso N, Frank DA, Griffin JD: Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. J Exp Med 183:811, 1996
    • (1996) J Exp Med , vol.183 , pp. 811
    • Carlesso, N.1    Frank, D.A.2    Griffin, J.D.3
  • 47
    • 0028817880 scopus 로고
    • Jak-STAT signaling induced by the v-able oncogene
    • Danial NN, Pernis A, Rothman PB: Jak-STAT signaling induced by the v-able oncogene. Science 269:1875, 1995
    • (1995) Science , vol.269 , pp. 1875
    • Danial, N.N.1    Pernis, A.2    Rothman, P.B.3
  • 48
    • 0029069540 scopus 로고
    • Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
    • Yu CL, Meyer DJ, Campbell GS, Larner AC, Carter-Su C, Schwartz J, Jove R: Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269:81, 1995
    • (1995) Science , vol.269 , pp. 81
    • Yu, C.L.1    Meyer, D.J.2    Campbell, G.S.3    Larner, A.C.4    Carter-Su, C.5    Schwartz, J.6    Jove, R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.