Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (I12R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery

Leukemia and Lymphoma

Volumn 32, Issue 3-4, 1999, Pages 289-297

  Witthuhn, Bruce A ^a   Williams, Mark D ^a   Kerawalla, Hoshnuwar ^a   Uckun, Fatih M ^a  

^a Department of Genetics   (United States)

Author keywords

Baculovirus; IL2 receptor; Janus kinase (Jak); STAT; Transphosphorylation

Indexed keywords

INTERLEUKIN 2 RECEPTOR; PROTEIN TYROSINE KINASE; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; BACULOVIRUS; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; GENE EXPRESSION SYSTEM; LEUKEMIA; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0032981804     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199909167389     Document Type: Article

References (50)

1. Ihle JN and Kerr IM. (1995) Jaks and STATs in signaling by the cytokine receptor superfamily. Trends Genet. 11:69-74.
2. Darnell JE, Jr., Kerr IM and Stark GR. (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421.
3. Briscoe J, Rogers NC, Witthuhn BA, Watling D, Harpur AG, Wilks AF, Stark GR, Ihle JN and Kerr IM. (1996) Kinase-negative mutants of Jak1 can sustain interferon-gamma-inducible gene expression but not an antiviral state. EMBO J 15:799-809.
4. Nosaka T, van Deursen JM, Tripp RA, Thierfelder WE, Witthuhn BA, McMickle AP, Doherty PC, Grosveld GC and Ihle JN. (1995) Defective lymphoid development in mice lacking Jak3 [published erratum appears in Science 271:17]. Science 270:800-802.
5. Zhuang H, Patel SV, He TC, Sonsteby SK, Niu Z and Wojchowski DM. (1994) Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2. J. Biol. Chem. 269:21411-21414.
6. Thomis DC, Gurniak CB, Tivol E, Sharpe AH and Berg LJ. (1995) Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270:794-797.
7. Park SY, Saijo K, Takahashi T, Osawa M, Arase H, Hirayama N, Miyake K, Nakauchi H, Shirasawa T and Saito T. (1995) Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. J. Biol. Chem. 270:30829-30836.
8. Greenland AC, Morales MO, Viviano BL, Yan H, Krolewski J and Schreiber RD. (1995) STAT recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process. Immunity 2:677-687.
9. Stahl N, Farruggella TJ, Boulton TG, Zhong Z, Darnell JE, Jr. and Yancopoulos GD. (1995) Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267:1349-1353.
10. Yamanaka Y, Nakajima K, Fukada T, Hibi M and Hirano T. (1996) Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for STAT3 activation. EMBO J 15:1557-1565.
11. Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M and McKnight SL. (1994) An interleukin-4-induced transcription factor: IL-4 STAT. Science 265:1701-1706.
12. Friedmann MC, Migone TS, Russell SM and Leonard WJ. (1996) Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation. Proc. Natl. Acad. Sci. U.S.A., 93:2077-2082.
13. Fujii H, Nakagawa Y, Schindler U, Kawahara A, Mori H, Gouilleux F, Groner B, Ihle JN, Minami Y, Miyazaki T and et al. (1995) Activation of STATS by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission. Proc. Natl. Acad. Sci. U.S.A. 92:5482-5486.
14. Quelle FW, Wang D, Nosaka T, Thierfelder WE, Stravopodis D, Weinstein Y and Ihle JN. (1996) Erythropoietin induces activation of STATS through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol. Cell. Biol. 16:1622-1631.
15. Gobert S, Chretien S, Gouilleux F, Muller O, Pallard C, Dusanter-Fourt I, Groner B, Lacombe C, Gisselbrecht S and Mayeux P. (1996) Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STATS activation. EMBO J 15:2434-2441.
16. Behrmann I, Janzen C, Gerhartz C, Schmitz-Van de Leur H, Hermanns H, Heesel B, Graeve L, Horn F, Tavernier J and Heinrich PC. (1997) A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation. J. Biol. Chem. 272:5269-5274.
17. Nelson BH, Lord JD and Greenberg PD. (1996) A membrane-proximal region of the interleukin-2 receptor gamma c chain sufficient for Jak kinase activation and induction of proliferation in T cells. Mol. Cell. Biol. 16:369-375.
18. Nelson BH, McIntosh BC, Rosencrans LL and Greenberg PD. (1997) Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation. Proc. Natl Acad. Sci. U.S.A. 94:1878-1883.
19. Chen M, Cheng A, Chen YQ, Hymel A, Hanson EP, Kimmel L, Minami Y, Taniguchi T, Changelian PS and O'Shea JJ. (1997) The amino terminus of Jak3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals. Proc. Natl. Acad. Sci. U.S.A. 94:6910-6915.
20. Quelle FW, Thierfelder W, Witthuhn BA, Tang B, Cohen S and Ihle JN. (1995) Phosphorylation and activation of the DNA binding activity of purified STAT1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor. J. Biol. Chem. 270:20775-20780.
21. Park OK, Schaefer TS and Nathans D. (1996) In vitro activation of STAT3 by epidermal growth factor receptor kinase. Proc. Natl. Acad. Sci. U.S.A. 93:13704-13708.
22. Fujitani Y, Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K and Hirano T. (1997) An alternative pathway for STAT activation that is mediated by the direct interaction between Jak and STAT. Oncogene. 14:751-761.
23. Takeshita T, Arita T, Higuchi M, Asao H, Endo K, Kuroda H, Tanaka N, Murata K, Ishii N and Sugamura K. (1997) STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction. Immunity 6:449-457.
24. Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S and Yoshimura A. (1997) A new protein containing an SH2 domain that inhibits Jak kinases. Nature 387:921-924.
25. Witthuhn BA, Silvennoinen O, Miura O, Lai KS, Cwik C, Liu ET and Ihle JN. (1994) Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature. 370:153-157.
26. Feng J, Witthuhn BA, Matsuda T, Kohlhuber F, Kerr IM and Ihle JN. (1997) Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop. Mol. Cell. Bid. 17:2497-2501.
27. Hubbard SR, Wei L, Ellis L and Hendrickson WA. (1994) Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature 372:746-754.
28. Kotenko SV, Izotova LS, Pollack BP, Mariano TM, Donnelly RJ, Mutukumaran G, Cook JR, Garotta G, Silvennoinen O, Ihle JN and Pestka S. (1995) Interaction between the components of the interferon gamma receptor complex. J. Biol. Chem. 270:20915-20921.
29. Sakatsume M, Igarashi K, Winestock KD, Garotta G, Larner AC and Finbloom DS. (1995) The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors. J Biol. Chem. 270:17528-17534.
30. Kaplan DH, Greenlund AC, Tanner JW, Shaw AS and Schreiber RD. (1996) Identification of an interferon-gamma receptor alpha chain sequence required for Jak-1 binding. J. Biol. Chem. 271:9-12.
31. Blank U, Ra C, Miller L, White K, Metzger H and Kinet J. (1989) Complete structure and expression in transfected cells of high affinity IgE receptor. Nature 336:187-189.
32. Clevers H, Alarcon B, Willeman T and Terhorst C. (1988) The T cell receptor/CD3 complex: a dynamic protein ensemble. Ann. Rev. Immunol. 6:629-662.
33. Taniguchi T. (1995) Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268:251-255.
34. Asao H, Takeshita T, Nakamura M, Nagata K and Sugamura K. (1990) Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75. J. Exp. Med. 171:2183.
35. Asao H, Kumaki S, Takeshita T, Nakamura M and Sugamura K. (1992) IL-2-dependent in vivoand in vitro tyrosine phosphorylation of IL-2 receptor gamma chain. FEBS Lett. 304:141-145.
36. Miyazaki T and Taniguchi T. (1996) Coupling of the IL2 receptor complex with non-receptor protein tyrosine kinases. Cancer Surveys 27:139-163.
37. Taniguchi T and Minami Y. (1993) The IL2/IL2 receptor system: A current overview. Cell 73:5-8.
38. Evans GA, Goldsmith MA, Johnston JA, Xu W, Weiler SR, Erwin R, Howard OM, Abraham RT, O'Shea JJ, Greene WC and Farrar WL (1995) Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require She phosphorylation or receptor association. J. Biol. Chem. 270:28858-28863.
39. Gaffen SL, Lai SY, Ha M, Liu X, Hennighausen L, Greene WC and Goldsmith MA. (1996) Distinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversity. J. Biol. Chem. 271:21381-21390.
40. Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O and el al. (1994) Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID. Science 266:1042-1045.
41. Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN and et al. (1994) Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 266:1045-1047.
42. Johnston JA, Kawamura M, Kirken RA, Chen YQ, Blake TB, Shibuya K, Qrtaldo JR, McVicar DW and O'Shea JJ. (1994) Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 370:151-153.
43. Fujiwara H, Hanissian Sh, Tsytsykova A and Geha Rs. (1997) Homodimerization of the human interleukin 4 receptor alpha chain induces C-epsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain. Proc. Natl. Acad. Sci. U.S.A. 94:5866-5871.
44. Chen XH, Patel BK, Wang LM, Frankel M, Ellmore N, Flavell RA, LaRochelle WJ and Pierce JH. (1997) Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and STAT6 signaling molecules. J. Biol. Chem. 272:6556-6560.
45. Burfoot MS, Rogers NC, Watling D, Smith JM, Pons S, Paonessaw G, Pellegrini S, White MF and Kerr IM. (1997) Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons. J. Biol. Chem. 272:24183-24190.
46. Kawahara A, Minami Y, Miyazaki T, Ihle JN and Taniguchi T. (1995) Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction. Proc. Natl. Acad. Sci. U.S.A. 92:8724-8728.
47. Harrison DA, Binari R, Nahreini TS, Gilman M and Perrimon N. (1995) Activation of a Drosophila Janus kinase (Jak) causes hematopoietic neoplasia and developmental defects. EMBO J 14:2857-2865.
48. Luo H, Rose P, Barber D, Hanratty WP, Lee S, Roberts TM, D'Andrea AD and Dearolf CR. (1997) Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-STAT pathways. Mol. Cell Biol. 17:1562-1571.
49. Luo H, Hanratty WP and Dearolf CR. (1995) An amino acid substitution in the Drosophila hopTum-1 Jak kinase causes leukemia-like hematopoietic defects. EMBO J. 14:1412-1420.
50. Shuai K, Halpern J, Tenhoeve J, Rao XP and Sawyers CL. (1996) Constitutive activation of STATS by the Bcr-Abl oncogene in chronic myelogenous leukemia. Oncogene 13:247-254.