Characterization of a cholesterol response element (CRE) in the promoter of the cholesteryl ester transfer protein gene: Functional role of the transcription factors SREBP-1 a, -2, and YY1

Journal of Lipid Research

Volumn 40, Issue 7, 1999, Pages 1284-1293

  Gauthier, Benoit ^a   Robb, Malcolm ^a   Gaudet, Francois ^b   Ginsburg, Geoffrey S ^b   McPherson, Ruth ^a  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Gene expression; Lipid transfer protein; Liposarcoma cells; Reverse cholesterol transport; Sterol regulatory element

Indexed keywords

25 HYDROXYCHOLESTEROL; CHOLESTEROL; CHOLESTEROL ESTER TRANSFER PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIPID; LUCIFERASE; MESSENGER RNA; TRANSCRIPTION FACTOR;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC TRANSFECTION; HAMSTER; HUMAN; HUMAN CELL; LIPOSARCOMA; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TANDEM REPEAT; TRANSACTIVATION; TUMOR CELL LINE;

ANIMALS; CARRIER PROTEINS; CCAAT-ENHANCER-BINDING PROTEINS; CHOLESTEROL; CHOLESTEROL ESTER TRANSFER PROTEINS; CRICETINAE; DNA; DNA-BINDING PROTEINS; ERYTHROID-SPECIFIC DNA-BINDING FACTORS; GLYCOPROTEINS; HUMANS; HYDROXYCHOLESTEROLS; LIPIDS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED; YY1 TRANSCRIPTION FACTOR; ZINC FINGERS;

EID: 0032805208     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Tall, A. 1995. Plasma lipid transfer proteins. Annu. Rev. Biochem. 64: 235-257.
2. Marotti, K. R., C. K. Castle, T. P. Boyle, A. H. Lin, R. W. Murray, and G. W. Melchior. 1993. Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein. Nature. 364: 73-75.
3. Jiang, X. C., P. Moulin, E. Quinet, I. J. Goldberg, L. K. Yacoub, L. B. Agellon, D. Compton, R. Schnitzer-Polokoff, and A. R. Tall. 1991. Mammalian adipose tissue and muscle are major sources of lipid transfer protein mRNA. J. Biol. Chem. 266: 4631-4639.
4. Radeau, T., P. Lau, M. Robb, M. McDonnell, G. Ailhaud, and R. McPherson. 1995. Cholesteryl ester transfer protein (CETP) mRNA abundance in human adipose tissue: relationship to cell size and membrane cholesterol content. J. Lipid Res. 36: 2552-2561.
5. Radeau, T., M. Robb, P. Lau, J. Borthwick, and R. McPherson. 1998. Relationship of adipose tissue cholesteryl ester transfer protein (CETP) mRNA to plasma concentrations of CETP in human. Atherosclerosis. 139: 369-376.
6. Quinet, E. M., P. Huerta, D. Nancoo, A. R. Tall, Y. L. Marcel, and R. McPherson. 1993. Adipose tissue cholesteryl ester transfer protein mRNA in response to probucol treatment: cholesterol and species dependence. J. Lipid Res. 34: 845-852.
7. Benoist, F., M. McDonnell, P. Lau, R. Milne, and R. McPherson. 1997. Cholesteryl ester transfer protein mediates selective uptake of high density lipoprotein cholesteryl esters by human adipose tissue. J. Biol. Chem. 272: 23572-23577.
8. Richardson, M. A., D. T. Berg, P. A. Johnston, D. McClure, and B. W. Grinnell. 1996. Human liposarcoma cell line, SW872, secretes cholesteryl ester transfer protein in response to cholesterol. J. Lipid Res. 37: 1162-1166.
9. Gaudet, F., and G. S. Ginsburg. 1995. Transcriptional regulation of the cholesteryl ester transfer protein gene by the orphan nuclear hormone receptor apolipoprotein AI regulatory protein-1. J. Biol. Chem. 270: 29916-29922.
10. Higuchi, R. 1990. PCR Protocols. A Guide to Methods and Applications. M. A. Innis, D. H. Gelfand, J. J. Sninsky, and T. J. White, editors. Academic Press, San Diego, 177-183.
11. Schumaker, V. N., and D. L. Puppione. 1986. Sequential flotation ultracentrifugation. Methods Enzymol. 128: 155-170.
12. Blackhart, B. D., Z. Yao, and B. McCarthy. 1990. An expression system for human apolipoprotein B100 in a rat hepatoma cell line. J. Biol. Chem. 265: 8358-8360.
13. Bushmeyer, S., K. Park, and M. L. Atchison. 1995. Characterization of functional domains within the multifunctional transcription factor, YY1. J. Biol. Chem. 270: 30213-30220.
14. Vallett, S. M., H. B. Sanchez, J. M. Rosenfeld, and T. F. Osborne. 1996. A direct role for the sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene. J. Biol. Chem. 271: 12247-12253.
15. Juge-Aubry, C., A. Pernin, T. Favez, A. G. Burger, W. Wahli, C. A. Meier, and B. Desvergne. 1997. DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5′-flanking region. J. Biol. Chem. 272: 25252-25259.
16. Molden, J., Y. Chang, Y. You, P. S. Moore, and M. A. Goldsmith. 1997. A Kaposi's sarcoma-associated herpes virus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit. J. Biol. Chem. 272: 19625-19631.
17. Roder, K., S. S. Wolf, K-F. Beck, and M. Schweizer. 1997. Cooperative binding of NF-Y and Sp1 at the DNase I-hypersensitive site, fatty acid synthase insulin-responsive element 1, located at -500 in the rat fatty acid synthase promoter. J. Biol. Chem. 272: 21616-21624.
18. Paradis, P., W. R. MacLellan, N. S. Belaguli, R. J. Schwartz, and M. D. Schneider. 1996. Serum response factor mediates AP-1-dependent induction of the skeletal β-actin promoter in ventricular myocytes. J. Biol. Chem. 271: 10827-10833.
19. Zhang, X. Y., Z-Q. Chen, Z. Wang, W. Mohan, and S-P. Tam. 1996. Protein-DNA interactions at a drug-responsive element of the human apolipoprotein A-I gene. J. Biol. Chem. 271: 27152-27160.
20. Oliveira, H. C. F., R. A. Chouinard, L. B. Agellon, C. Bruce, L. M. Ma, A. Walsh, J. L. Breslow, and A. R. Tall. 1996. Human cholesteryl ester transfer protein gene proximal promoter contains dietary cholesterol positive responsive elements and mediates expression in small intestine and periphery while predominant liver and spleen expression is controlled by 5′-distal sequences. Cis-acting sequences mapped in transgenic mice. J. Biol. Chem. 271: 31831-31838.
21. Osborne, T. F., M. K. Bennett, and K. Rhee. 1992. Red 25, a protein that binds specifically to the sterol regulatory region in the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J. Biol. Chem. 267: 18973-18982.
22. Magaña, M. M., and T. F. Osborne. 1996. Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter. J. Biol. Chem. 271: 32689-32694.
23. Yang, W-M., C. Inouye, Y. Zeng, D. Bearss, and E. Seto. 1996. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc. Natl. Acad. Sci. USA. 93: 12845-12850.
24. Ericsson, J., S. M. Jackson, J. B. Kim, B. M. Spiegelman, and P. A. Edwards. 1997. Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1-and sterol regulatory element-binding protein-responsive gene. J. Biol. Chem. 272: 7298-7305.
25. Brown, M. S., and J. L. Goldstein. 1997. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 89: 331-340.
26. Sanchez, H. B., L. Yieh, and T. F. Osborne. 1995. Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene. J. Biol. Chem. 270: 1161-1169.
27. Jackson, S. M., J. Ericsson, T. F. Osborne, and P. A. Edwards. 1995. NF-Y has a novel role in sterol-dependent transcription of two cholesterogenic genes. J. Biol. Chem. 270: 21445-21448.
28. Ericsson, J., S. M. Jackson, and P. A. Edwards. 1996. Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene. J. Biol. Chem. 271: 24359-24364.
29. Yokoyama, C., X. Wang, M. R. Briggs, A. Admon, J. Wu, X. X. Hua, J. L. Goldstein, and M. S. Brown. 1993. SREBP-1, that controls transcription of the low density lipoprotein receptor gene. Cell. 75: 187-197.
30. Hua, X. X., C. Yokoyama, J. Wu, M. R. Briggs, M. S. Brown, J. L. Goldstein, and X. Wang. 1993. SREBP-2, a second a basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc. Natl. Acad. Sci. USA. 90: 11603-11607.
31. Ericsson, J., S. M. Jackson, B. C. Lee, and P. A. Edwards. 1996. Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl synthase gene. Proc. Natl. Acad. Sci. USA. 93: 945-950.
32. Kim, J. B., and B. M. Spiegelman. 1996. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes. Dev. 10: 1096-1107.
33. Kim, J. B., H. M. Wright, M. Wright, and B. M. Spiegelman. 1998. ADD1/SREBP1 activates PPARγ through the production of endogenous ligand. Proc. Natl. Acad. Sci. USA. 95: 4333-4337.
34. Shimomura, I., H. Shimano, J. D. Horton, J. L. Goldstein, and M. S. Brown. 1997. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J. Clin. Invest. 99: 838-845.
35. Shimano, H., I. Shimomura, R. E. Hammer, J. Herz, J. L. Goldstein, M. S. Brown, and J. D. Horton. 1997. Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. J. Clin. Invest. 100: 2115-2124.
36. Shimano, H., J. D. Horton, R. E. Hammer, I. Shimomura, M. S. Brown, and J. L. Goldstein. 1996. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J. Clin. Invest. 98: 1575-1584.
37. Sheng, Z., H. Otani, M. S. Brown, and J. L. Goldstein. 1995. Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc. Natl. Acad. Sci. USA. 92: 935-938.
38. Shimano, H., J. D. Horton, I. Shimomura, R. E. Hammer, M. S. Brown, and J. L. Goldstein. 1997. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J. Clin. Invest. 99: 846-854.