Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene

Journal of Clinical Investigation

Volumn 100, Issue 8, 1997, Pages 2115-2124

  Shimano, Hitoshi ^a   Shimomura, Iichiro ^a   Hammer, Robert E ^a   Herz, Joachim ^a   Goldstein, Joseph L ^a,b   Brown, Michael S ^a   Horton, Jay D ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cholesterol; Fatty acids; Low density lipoprotein; Sterol regulatory element binding proteins; Targeted homologous recombination

Indexed keywords

BINDING PROTEIN; CHOLESTEROL; COMPLEMENTARY DNA; FATTY ACID; LIPID BINDING PROTEIN; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL SYNTHESIS; FEMALE; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030829812     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119746     Document Type: Article

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