Endogenous mitochondrial oxidative stress: Neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice

Journal of Neurochemistry

Volumn 88, Issue 3, 2004, Pages 657-667

  Hinerfeld, Douglas ^a   Traini, Mathew D ^b   Weinberger, Ron P ^b   Cochran, Bruce ^a   Doctrow, Susan R ^c   Harry, Jenny ^b   Melov, Simon ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b Proteome Systems Ltd   (Australia)

^c Eukarion Inc   (United States)

Author keywords

Antioxidant; Mitochondria; Neurodegeneration; Oxidative stress; Proteomics; Superoxide dismutase

Indexed keywords

ACONITATE HYDRATASE; ANTIOXIDANT; CITRATE SYNTHASE; CYTOCHROME C OXIDASE; HYDROGEN PEROXIDE; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL PROTEIN; OXOGLUTARATE DEHYDROGENASE; PARAQUAT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RESPIRATORY COMPLEX 1; RESPIRATORY COMPLEX 2; RESPIRATORY COMPLEX 3; RESPIRATORY COMPLEX 5; SUPEROXIDE DISMUTASE; TRICARBOXYLIC ACID; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BEHAVIOR DISORDER; BRAIN CELL; BRAIN SPONGIOSIS; CELL DEATH; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIFFERENTIAL DISPLAY; DISEASE MODEL; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME SPECIFICITY; INHIBITION KINETICS; MITOCHONDRIAL DNA DISORDER; MOUSE; NERVE DEGENERATION; NEUROLOGIC DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; NULL ALLELE; OXIDATIVE STRESS; PARKINSON DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROTEOMICS; RESPIRATORY CHAIN; SENSITIVITY ANALYSIS;

ANIMALS; ANTIOXIDANTS; CEREBRAL CORTEX; ELECTRON TRANSPORT; MICE; MICE, KNOCKOUT; MITOCHONDRIA; NERVE DEGENERATION; OXIDATIVE STRESS; PROTEOMICS; SUPEROXIDE DISMUTASE;

ANIMALIA;

EID: 0942298545     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.02195.x     Document Type: Article

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