Oxidative α-ketoglutarate dehydrogenase inhibition via subtle elevations in monoamine oxidase B levels results in loss of spare respiratory capacity: Implications for Parkinson's disease

Journal of Biological Chemistry

Volumn 278, Issue 47, 2003, Pages 46432-46439

  Kumar, M Jyothi ^a   Nicholls, David G ^a   Andersen, Julie K ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CATALYSIS; DISEASES; HYDROGEN PEROXIDE; NEUROLOGY; OXIDATION; OXYGEN; TOXIC MATERIALS;

NEURODEGENERATION;

ENZYME INHIBITION;

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CATALASE; HYDROGEN PEROXIDE; OXOGLUTARATE DEHYDROGENASE; TRICARBOXYLIC ACID;

AGING; ARTICLE; BRAIN; CELL STRAIN; CORRELATION ANALYSIS; ENZYME ACTIVITY; GENETIC ENGINEERING; IN VITRO STUDY; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; OXIDATION; OXYGEN CONSUMPTION; PARKINSON DISEASE; PRIORITY JOURNAL;

AGING; ANIMALS; CELL RESPIRATION; DOXYCYCLINE; GENE EXPRESSION REGULATION; HUMANS; KETOGLUTARATE DEHYDROGENASE COMPLEX; MITOCHONDRIAL DISEASES; MONOAMINE OXIDASE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PARKINSON DISEASE; PC12 CELLS; RATS; TRANSFECTION;

GYMNOMYZA SAMOENSIS; PARKINSONIA;

EID: 0344443765     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306378200     Document Type: Article

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