Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase

Journal of Biological Chemistry

Volumn 277, Issue 12, 2002, Pages 10064-10072

  Gazaryan, Irina G ^a   Krasnikov, Boris F ^b   Ashby, Gillian A ^c   Thorneley, Roger N F ^a   Kristal, Bruce S ^a   Brown, Abraham M ^a,d  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b JOHN INNES CENTRE   (United Kingdom)

^c Department of Neuroscience ^*  (United States)

^d BURKE MEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; ELECTRONS; ENZYMES; HYDROGEN PEROXIDE;

RESPIRATION;

BIOCHEMISTRY;

DIHYDROLIPOAMIDE DEHYDROGENASE; FLAVINE ADENINE NUCLEOTIDE; HYDROGEN PEROXIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXIDOREDUCTASE; OXOGLUTARATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SUPEROXIDE; THIOL DERIVATIVE; ZINC;

ARTICLE; CALCIUM TRANSPORT; DISULFIDE BOND; ELECTRON TRANSPORT; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; INTERNALIZATION; MITOCHONDRIAL RESPIRATION; MOLECULAR MODEL; PRIORITY JOURNAL; STEADY STATE;

ANIMALS; DIHYDROLIPOAMIDE DEHYDROGENASE; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; KINETICS; MODELS, CHEMICAL; MYOCARDIUM; NAD; OXYGEN; OXYGEN CONSUMPTION; PROTEIN BINDING; PROTEIN DISULFIDE REDUCTASE (GLUTATHIONE); REACTIVE OXYGEN SPECIES; SUBSTRATE SPECIFICITY; SWINE; TIME FACTORS; ZINC;

SUS SCROFA;

EID: 0037155880     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M108264200     Document Type: Article

References (36)