Inhibition of α-ketoglutarate dehydrogenase complex promotes cytochrome C release from mitochondria, caspase-3 activation, and necrotic cell death

Journal of Neuroscience Research

Volumn 74, Issue 2, 2003, Pages 309-317

  Huang, Hsueh Meei ^a   Ou, Hsiu Chong ^b   Xu, Hui ^a   Chen, Huan Lian ^b   Fowler, Corinne ^a   Gibson, Gary E ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

keto methyl n valeric acid; Caspase 3; Cell death; Cyclosporin A; Cytochrome c; Membrane potential; Mitochondria; Mitochondrial permeability transition pore; Reactive oxygen species

Indexed keywords

ALPHA KETO BETA METHYL N VALERIC ACID; CASPASE 3; CYCLOSPORIN A; CYTOCHROME C; LACTATE DEHYDROGENASE; OXOGLUTARATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE;

ANIMAL CELL; ARTICLE; BRAIN METABOLISM; CELL DEATH; CELL FUNCTION; CITRIC ACID CYCLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; GENE TRANSLOCATION; HISTOCHEMISTRY; INHIBITION KINETICS; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CASPASE 3; CASPASES; CELL DEATH; CELL MEMBRANE PERMEABILITY; CHROMATIN; CYCLOSPORINE; CYTOCHROMES C; ION CHANNELS; KETO ACIDS; KETOGLUTARATE DEHYDROGENASE COMPLEX; L-LACTATE DEHYDROGENASE; MATRIX METALLOPROTEINASES; MEMBRANE POTENTIALS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; NECROSIS; NEURODEGENERATIVE DISEASES; NEURONS; PC12 CELLS; PROTEIN TRANSPORT; RATS; REACTIVE OXYGEN SPECIES;

EID: 0141481850     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10756     Document Type: Article

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