Inhibition of the α-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes by a putative aberrant metabolite of serotonin, tryptamine-4,5-dione

Chemical Research in Toxicology

Volumn 15, Issue 10, 2002, Pages 1242-1247

  Jiang, Xiang Rong ^a   Dryhurst, Glenn ^a  

^a UNIVERSITY OF OKLAHOMA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ANTIOXIDANT; METHAMPHETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTOXIN; NITRIC OXIDE; OXOGLUTARATE DEHYDROGENASE; PEROXYNITRITE; PYRUVATE DEHYDROGENASE COMPLEX; SEROTONIN; SUPEROXIDE; TRYPTAMINE 4,5 DIONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; COMPLEX FORMATION; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; METABOLITE; NEUROTOXICITY; NONHUMAN; OXIDATION; RAT; SEROTONINERGIC NERVE CELL; SYNTHESIS;

ANIMALS; BRAIN; CENTRAL NERVOUS SYSTEM STIMULANTS; ENZYME INHIBITORS; INDOLEQUINONES; KETOGLUTARATE DEHYDROGENASE COMPLEX; MALE; METHAMPHETAMINE; MITOCHONDRIA; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; PYRUVATE DEHYDROGENASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; TRYPTAMINES;

ANIMALIA;

EID: 0036801419     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx020029b     Document Type: Article

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