Abnormalities of mitochondrial enzymes in Alzheimer disease

Journal of Neural Transmission

Volumn 105, Issue 8-9, 1998, Pages 855-870

  Gibson, G E ^a,b   Sheu, K F R ^a,b   Blass, J P ^a,b  

^a BURKE MEDICAL RESEARCH INSTITUTE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

ketoglutarate dehydrogenase; Alzheimer's disease; Cytochrome oxidase; Mitochondria; Neurodegenerative disease; Pyruvate dehydrogenase

Indexed keywords

BRAIN ENZYME; CYTOCHROME C OXIDASE; MITOCHONDRIAL ENZYME; PYRUVATE DEHYDROGENASE COMPLEX;

ALZHEIMER DISEASE; ARTICLE; BRAIN METABOLISM; ENZYME ACTIVITY; HUMAN; MITOCHONDRIAL RESPIRATION; NEUROPATHOLOGY; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

ALZHEIMER DISEASE; ELECTRON TRANSPORT COMPLEX IV; HUMANS; KETOGLUTARATE DEHYDROGENASE COMPLEX; MITOCHONDRIA; OXIDATIVE STRESS; PYRUVATE DEHYDROGENASE COMPLEX;

EID: 0031737226     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020050099     Document Type: Article

References (78)

1. Ali G, Wasco W, Cai X, Szabo P, Sheu K-FR, Cooper AJ, Gaston SM, Gusella JF, Tanzi R, Blass JP (1994) Isolation, cloning, and localization of the gene for the E2k component of the human α-ketoglutarate dehydrogenase complex. Somat Cell Mol Genet 20: 99-105
2. Bauer J, Plaschke K, Martin E, Bardenheuer HJ, Hoyer S (1997) Causes and consequences of neuronal energy deficit in sporadic Alzheimer's disease. Ann NY Acad Sci 826: 379-381
3. Blass JP (1993a) Pathophysiology of the Alzheimer syndrome. Neurol 43 [Suppl 4]: S25-S38
4. Blass JP (1993h) Metabolic alterations common to neural and non-neural cells in Alzheimer's disease. Hippocampus 3: 45-54
5. Blass JP (1996) Alzheimer's disease: melting pot or mosaic? Alz Dis Rev 1: 1720
6. Blass JP (1997) Cerebral metabolic impairments. In: Alzheimer's disease: cause(s), diagnosis, treatment, and care. CRC Press, New York, pp 187-206
7. Blass JP, Sheu K-FR, Piacentini S. Sorbi (1997a) Inherent abnormalities in oxidative metabolism in AD: interaction with vascular abnormalities. Ann NY Acad Sci 826: 382-385
8. Blass JP, Gibson GE, Hoyer SE (1997b) Metabolism of the aging brain. Adv Cell Aging Gerontol 2: 109-128
9. Blum-Degen D, Frölich L, Hoyer S, Riederer P (1995) Altered regulation of brain glucose metabolism as a cause of neurodegenerative disorders? J Neural Transm [Suppl] 46: 139-147
10. Bolanos JP, Almeida A, Stewart V, Peuchen S, Land JM, Clark JB, Heales SJ (1997) Nitric oxide-mediated mitochondrial damage in the brain: mechanisms and implications for neurodegenerative diseases. J Neurochem 68: 2227-2240
11. Brown AM, Sheu K-FR, Haroutunian V, Mohs R, Blass JP (1998) Abnormalities of mitochondrial COl gene in Alzheimer's disease brain. J Neurochem 70 [Suppl]: S48A
12. Bruce AJ, Malfroy B, Baudry M (1996) beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger. Proc Natl Acad Sci (USA) 93: 2312-2316
13. Butterworth RF, Besnard AM (1990) Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease. Metab Brain Dis 5: 179-184
14. Chandrasekaran K, Hatanpaa K, Brady DR, Rapoport SI (1996) Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimers disease. Exp Neurol 142: 80-88
15. Cooper AJL, Sheu K-FR, Blass JP (1996) Normal glutamate metabolism in Alzheimer's disease fibroblasts deficient in α-ketoglutarate dehydrogenase activity. Dev Neurosci 18: 499-504
16. Craft S, Zallen G, Baker LD (1992) Glucose and memory in milde senile dementia of the Alzheimer type. J Clin Exp Neuropsych 14: 253-267
17. Cruts M, van Dujin CM, Backhovens H, Van den Broeck M, Wehnert A, Serneels S, Sherrington R, Hutton M, Hardy J, St George-Hyslop PH, Hofm A, Van Broeckhoven C (1998) Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease. Hum Mol Genet 7: 43-51
18. Curti D, Rognoni F, Gasparini L, Cattaneo A, Paolillo M, Racchi M, Zani L, Bianchetti A, Trabucchi M, Bergamaschi S, Govoni S (1997) Oxidative metabolism in cultured fibroblasts derived from sporadic Alzheimer's disease (AD) patients. Neurosci Lett 236: 13-16
19. Davis RE, Herrnstadt C, Ghosh SS, Fahey E, Shinobu LA, Balasko D, Thal LJ, Beal MF, Howell N, Parker WD (1997) Mutations in mitochondrial cytochrome C oxidase genes segregate with late onset Alzheimer's disease. Proc Natl Acad Sci USA 94: 4526-4531
20. Farrer LA, Adrienne-Cupples L, Haines JL, Hyman B, Kukull WA, Mayeux R, Mayers RH, Pericek-Vance MA, Risch N, van Dujin CM, for the APOE and Alzheimer Disease Meta Analysis Consortium (1997) Effects of age, sex, and ethnicity on the association between Apolipoprotein E genotype and Alzheimer's disease. A meta-analysis. J Am Med Assoc 278: 1349-1356
21. Gibson GE, Sheu K-FR, Blass JP, Baker A, Carlson KC, Harding B, Perrino P (1988) Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease. Arch Neurol 45: 836-840
22. Gibson GE, Zhang H, Sheu KF-R, Bogdanovich N, Lannfelt L, Vestling M, Cowburn RF (1997) Oxidative enzymes in Alzheimer's disease neurodegeneration. Soc Neurosci 23: 637.5
23. Goodman Y, Mattson MP (1994) Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury. Exp Neurol 128: 1-12
24. Goodman Y, Steiner MR, Steiner SM, Mattson MP (1994) Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta-peptide toxicity, and attenuates free radical and calcium accumulation. Brain Res 654: 171-176
25. Haycock JW, Jones P, Harris JB, Mantle D (1996) Differential susceptibility of human skeletal muscle proteins to free radical induced oxidative damage: a histochemical, immunocytochemical and electron microscopical study in vitro. Acta Neuropathol 92: 331-340
26. Hirano M, Shtilbans A, Mayeux R, Davidson MM, DiMauro S, Knowles JA, Schon EA (1997) Apparent mtDNA heteroplasmy in Alzheimer's disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes. Proc Natl Acad Sci USA 94: 14894-14899
27. Hoyer S (1996) Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease. Acta Neurol Scand [Suppl] 165: 18-24
28. Hoyer S (1997) Models of Alzheimer's disease: cellular and molecular aspects. J Neural Transm [Suppl] 49: 11-21
29. Hutchin TP, Heath PR, Pearson RCA, Sinclair AJ (1997) Mitochondrial DNA mutations in Alzheimer's disease. Biochem Biophys Res Comm 241: 221-225
30. Imahori K, Uchida T (1997) Physiology and pathology of tau protein kinases in relation to Alzheimer's disease. J Biochem 121: 179-88
31. Kish SJ (1997) Brain energy metabolizing enzymes in Alzheimer's disease: alpha-ketoglutarate dehydrogenase complex and cytochrome oxidase. Ann NY Acad Sci 826: 218-228
32. Kish SJ, Bergeron C, Rajput A, Dozic S, Mastrogiacomo F, Chang F, Wilson JM, DiStefano LM, Nobrega JN (1992) Brain cytochrome oxidase in Alzheimer's disease. J Neurochem 59: 776-779
33. Kristal BS, Jackson CT, Chung HY, Matsuda M, Nguyen HD, Yu BP (1997) Defects at center P underlie diabetes-associated mitochondrial dysfunction. Free Rad Biol Med 22: 823-833
34. Kumar U, Dunlop DM, Richardson JS (1994) The acute neurotoxic effect of beta-amyloid on mature cultures of rat hippocampal neurons is attenuated by the antioxidant U-78517F. Int J Neurosci 79: 185-190
35. Manning CA, Ragozzino ME, Gold PE (1993) Glucose enhancement of memory in patients with probable dementia of the Alzheimer's type. Neurobiol Aging 14: 523-528
36. Markesbery WR (1997) Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med 23: 134-147
37. Mastrogiacomo F, Bergeron C, Kish SJ (1994) Brain α-ketoglutarate dehydrogenase activity in Alzheimer's disease. J Neurochem 61: 2007-2014
38. Mastrogiacomo F, Lindsay JG, Bettendorf L, Rice J, Kish SJ (1996) Brain protein and α-ketoglutarate dehydrogenase complex activity in Alzheimer's disease brain. Ann Neurol 39: 592-598
39. Molina JA, Debustos F, Jimenezjimenez FJ, Benitoleon J, Gasalla T, Ortipareja M, Vela L, Bermejo F, Martin MA, Campos Y, Arenas J (1997) Respiratory chain enzyme activities in isolated mitochondria of lymphocytes from patients with Alzheimer's disease. Neurol 48: 636-638
40. Nakano K, Takase C, Sakamoto T, Nakagawa S, Inazawa J, Ohta S, Matuda S (1994) Isolation, characterization, and structural organization of the gene and pseudogene for the dihydrolipoyl succinyltransferase component of the human 2-oxoglutarate dehydrogenase complex. Eur J Biochem 224: 179-189
41. Nakano K, Ohta S, Nishimaki K, Miki K, Matsuda S (1997) Alzheimer's disease and DLST genotype. Lancet 350: 1367-1368
42. Park CH, Calingasan NY, Sheu KF-R, Kristal BS, Zhang H, Gibson GE (1998) Oxidative stress compromises inflammatory responses and a key mitochondrial enzyme in microglia. J Neurochem 70S: S57B
43. Parker WD, Parks JK (1995) Cytochrome c oxidase in Alzheimer's disease brain: purification and characterization. Neurol 45: 482-486
44. Parker WD, Filley CM, Parks JK (1990) Cytochrome oxidase deficiency in Alzheimer's disease. Neurol 42: 1246-1247
45. Perry EK, Perry RH, Tomlinson G, Blessed G, Gibson PH (1980) Coenzyme - A acetylating enzymes in Alzheimer disease: possible cholinergic "compartment" of pyruvate dehydrogenase. Neurosci Lett 18: 105-110
46. Peterson C, Goldman JE (1986) Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors. Proc Natl Acad Sci USA 83: 2758-2762
47. Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, Minoshima S, Thibodeau SN, Osborne D (1996) Preclinical evidence of Alzheimer's disease in persons homozygous for the ∈ 4 allele for apolipoprotein E. N Engl J Med 33: 752-758
48. Richardson JS, Zhou Y, Kumar U (1996) Free radicals in the neurotoxic actions of betaamyloid. Ann NY Acad Sci 777: 362-367
49. Rubinsztein DC (1997) The genetics of Alzheimer's disease. Prog Neurobiol 52: 447-454
50. Scherer SW, Otulakowski G, Robinson BH, Tsui L-C (1991) Localization of the human dihydrolipoamide dehydrogenase gene (DLD) to 7q31 → q32. Cytogenet Cell Genet 56: 176-177
51. Schoonen WG, Wanamarta AH, van der Klei-van Moorsel JM, Jakobs C, Joenje H (1990a) Hyperoxia-induced clonogenic killing of HeLa cells associated with respiratory failure and selective inactivation of Krebs cycle enzymes. Mutat Res 237: 173-181
52. Schoonen WG, Wanamarta AH, van der Klei-van Moorsel JM, Jakobs C, Joenje H (1990b) Respiratory failure and stimulation of glycolysis in Chinese hamster ovary cells exposed to normobaric hyperoxia. J Biol Chem 265: 1118-11124
53. Schoonen WG, Wanamarta AH, van der Klei-van Moorsel JM, Jakobs C, Joenje H (1991) Characterization of oxygen-resistant Chinese hamster ovary cells. III. Relative resistance of succinate and alpha-ketoglutarate dehydrogenases to hyperoxic inactivation. Free Radic Biol Med 10: 111-118
54. Sheehan JP, Swerdlow RH, Miller SW, Davis RE, Parks JK, Parker WD, Tuttle JB (1997) Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease. J Neurosci 17: 4612-4622
55. Sheu KFR, Kim Y-T, Blass JP, Weksler ME (1985) An immunochemical study of pyruvate dehydrogenase deficit in Alzheimer's disease brain. Ann Neurol 17: 444-449
56. Sheu K-FR, Cooper AJ, Koike K, Koike M, Lindsay JG, Blass JP (1994) Abnormality of the α-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease. Ann Neurol 35: 312-318
57. Sheu K-FR, Sarkar P, Wasco W, Tanzi RE, Blass JP (1996) A gene locus of dihydrolipoyl succinyltransferase (DLST) is associated with Alzheimer's disease. J Neurochem 66: [Suppl 1] S10B
58. Sheu K-FR, Brown A, Blass JP (1997) α-Ketoacid dehydrogenase complexes in inborn errors of metabolism and neurodegeneration. J Neurochem 69: S2
59. Sheu K-FR, Brown AM, Haroutunian V, Kristal BS, Thaler H, Lesser M, Kalaria RN, Relkin NR, Mohs MC, Lilius L, Lannfelt L, Blass JP (1998a) Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population. Ann Neurol (in press)
60. Sheu K-FR, Lilius L, Brown AM, Kristal B, Haratounian V, Mohs R, Relkin N, Kalaria R, Basun H, Wahlund LO, Viitanen M, Lannfelt L, Blass JP (1998b) Polymorphisms of the DLST gene associate with late-onset and with familial Alzheimer's disease. Neurobiol Aging 19(45): 1226 (Abstract)
61. Simonian SA, Hyman BT (1994) Functional alterations in Alzheimer's disease: selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation. J Neuropathol Exp Neurol 53: 508-512
62. 14C]glucose by tissue prisms from human neocortex. Biochem J 196: 867-876
63. 14C]glucose in vitro in human neocortex. J Neurochem 41: 1329-1334
64. Sims NR, Finegan JM, Blass JP (1987a) Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease. Ann Neurol 21: 509-510
65. Sims NR, Finegan JM, Blass JP, Bowen DM, Neary D (1987b) Mitochondrial function in brain tissue in primary degenerative dementia. Brain Res 436: 30-38
66. Small GW, Mazziotta JC, Collins MT, Baxter LR, Phelps ME, Mandelkern MA, Kaplan A, Larue A, Adamson CF, Chang L (1995) Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease. J Am Med Assoc 273: 942-947
67. Sorbi S, Amaducci L, Blass JP, Bird ED (1982) Pyruvate dehydrogenase complex and choline acetyltransferase in aging and dementia. In: Giacobini E et al. (eds) The again brain: cellular and molecular mechanisms of aging in the nervous system. Raven Press, New York, pp 223-229
68. Sorbi S, Bird ED, Blass JP (1983) Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain. Ann Neurol 13: 72-78
69. Swerdlow RH, Parks JK, Cassarino DS, Maguire DJ, Aguire RS, Bennett JP, Davis RE, Parker WD (1997) Cybrids in Alzheimer's disease: a cellular model of the disease? Neurol 49: 918-925
70. Szabo P, Cai X, Ali G, Blass JP (1994) Localization of the gene (OGDH) coding for the Elk component of the α-ketoglutarate dehydrogenase complex to chromosome 7p13-p11.2. Genomics 20: 324-326
71. Tirmenstein MA, Mathias PI, Snawder JE, Wey HE, Toraason M (1997) Antimony-induced alterations in thiol homeostasis and adenine nucleotide status in cultured cardiac myocytes. Toxicology 119: 203-211
72. Tomiyama T, Shoji A, Kataoka K, Suwa Y, Asano S, Kaneko H, Endo N (1996) Inhibition of amyloid beta protein aggregation and neurotoxicity by rifampicin. Its possible function as a hydroxyl radical scavenger. J Biol Chem 271: 6839-6844
73. Van Zuylen AJ, Bosnian GJCGM, Ruitenbeck W, Kalmouth PJ, DeGrip WJ (1992) No evidence for reduced thrombocyte cytochrome oxidase in Alzheimer disease. Neurol 42: 1246-1247
74. Wallace DC, Stugard C, Murdock D, Schurr T, Brown MD (1997) Ancient mtDNA sequences in the human nuclear genome: a potential source of errors in identifying pathogenic mutations. Proc Natl Acad Sci USA 94: 14900-14905
75. 13C NMR spectroscopy may indicate compartmentation and mitochondrial heterogeneity. Neurosci Lett 185: 24-28
76. Wong-Riley M, Antuono P, Ho KC, Egan R, Hevner R, Liebl W, Huang Z, Rachel R, Jones J (1997) Cytochrome oxidase in Alzheimer's disease: biochemical, histochemical, and immunohistochemical analyses of the visual and other systems. Vision Res 37: 3593-3608
77. Yates CM, Butterworth J, Tennant MC, Gordan A (1990) Enzyme activities in relation to pH and lactate in post-mortem brain in Alzheimer-type and other dementias. J Neurochem 55: 444-449
78. Yatin S, Aksenov M, Carney J, Butterfield DA (1997) Alzheimer's amyloid β-peptide (25-35) free radical oxidative modification of neuronal proteins. Neurosci Abstr 23: 634.14