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Volumn 43, Issue 2, 2003, Pages 129-135

Deficits in a tricarboxylic acid cycle enzyme in brains from patients with Parkinson's disease

Author keywords

Oxidative stress; Parkinson's disease; Ketoglutarate dehydrogenase

Indexed keywords

BRAIN ENZYME; GLUTAMATE DEHYDROGENASE; MITOCHONDRIAL ENZYME; OXOGLUTARATE DEHYDROGENASE; PROTEIN SUBUNIT;

EID: 0344838535     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(02)00225-5     Document Type: Article
Times cited : (96)

References (40)
  • 1
    • 0033624419 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease
    • Albers D.S., Beal M.F. Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. J. Neural. Transm. Suppl. 59:2000;133-154.
    • (2000) J. Neural. Transm. , Issue.SUPPL. 59 , pp. 133-154
    • Albers, D.S.1    Beal, M.F.2
  • 3
    • 0025650037 scopus 로고
    • Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease
    • Butterworth R.F., Besnard A.M. Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease. Metab. Brain. Dis. 5:1990;179-184.
    • (1990) Metab. Brain. Dis. , vol.5 , pp. 179-184
    • Butterworth, R.F.1    Besnard, A.M.2
  • 4
    • 0032904412 scopus 로고    scopus 로고
    • An evaluation of the role of mitochondria in neurodegenerative diseases: Mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration
    • Cassarino D.S., Bennett J.P. Jr. An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration. Brain Res. Brain Res. Rev. 29:1999;1-25.
    • (1999) Brain Res. Brain Res. Rev. , vol.29 , pp. 1-25
    • Cassarino, D.S.1    Bennett J.P., Jr.2
  • 5
    • 0032525344 scopus 로고    scopus 로고
    • Downregulation of oxidative phosphorylation in Alzheimer disease: Loss of cytochrome oxidase subunit mRNA in the hippocampus and entorhinal cortex
    • Chandrasekaran K., Hatanpaa K., Brady D.R., Stoll J., Rapoport S.I. Downregulation of oxidative phosphorylation in Alzheimer disease: loss of cytochrome oxidase subunit mRNA in the hippocampus and entorhinal cortex. Brain Res. 796:1998;13-19.
    • (1998) Brain Res. , vol.796 , pp. 13-19
    • Chandrasekaran, K.1    Hatanpaa, K.2    Brady, D.R.3    Stoll, J.4    Rapoport, S.I.5
  • 6
    • 0034079858 scopus 로고    scopus 로고
    • Oxidative stress, mitochondrial respiration, and Parkinson's disease
    • Cohen G. Oxidative stress, mitochondrial respiration, and Parkinson's disease. Ann. N. Y. Acad. Sci. 899:2000;112-120.
    • (2000) Ann. N. Y. Acad. Sci. , vol.899 , pp. 112-120
    • Cohen, G.1
  • 7
    • 0032970763 scopus 로고    scopus 로고
    • Function of the cerebellum in Parkinsonian rest tremor and Holmes' tremor
    • Deuschl G., Wilms H., Krack P., Wurker M., Heiss W.D. Function of the cerebellum in Parkinsonian rest tremor and Holmes' tremor. Ann. Neurol. 46:1999;126-128.
    • (1999) Ann. Neurol. , vol.46 , pp. 126-128
    • Deuschl, G.1    Wilms, H.2    Krack, P.3    Wurker, M.4    Heiss, W.D.5
  • 11
    • 0023732664 scopus 로고
    • Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease
    • Gibson G.E., Sheu K.F., Blass J.P., Baker A., Carlson K.C., Harding B., Perrino P. Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease. Arch. Neurol. 45:1988;836-840.
    • (1988) Arch. Neurol. , vol.45 , pp. 836-840
    • Gibson, G.E.1    Sheu, K.F.2    Blass, J.P.3    Baker, A.4    Carlson, K.C.5    Harding, B.6    Perrino, P.7
  • 14
    • 0032767876 scopus 로고    scopus 로고
    • Mechanisms underlying gait disturbance in Parkinson's disease: A single photon emission computed tomography study
    • Hanakawa T., Katsumi Y., Fukuyama H., Honda M., Hayashi T., Kimura J., Shibasaki H. Mechanisms underlying gait disturbance in Parkinson's disease: a single photon emission computed tomography study. Brain. 122:1999;1271-1282.
    • (1999) Brain , vol.122 , pp. 1271-1282
    • Hanakawa, T.1    Katsumi, Y.2    Fukuyama, H.3    Honda, M.4    Hayashi, T.5    Kimura, J.6    Shibasaki, H.7
  • 15
    • 0021921539 scopus 로고
    • The patients dying after long terminal phase have acidotic brains: Implications for biochemical measurements on autopsy tissue
    • Hardy J.A., Wester P., Winblad B., Gezelius C., Bring G., Eriksson A. The patients dying after long terminal phase have acidotic brains: implications for biochemical measurements on autopsy tissue. J. Neural. Transm. 61:1985;253-264.
    • (1985) J. Neural. Transm. , vol.61 , pp. 253-264
    • Hardy, J.A.1    Wester, P.2    Winblad, B.3    Gezelius, C.4    Bring, G.5    Eriksson, A.6
  • 16
    • 0025942723 scopus 로고
    • Immunohistochemical studies on complexes I, II, and IV of mitochondria in Parkinson's disease, and IV of mitochondria in Parkinson's disease
    • Hattori N., Tanaka M., Ozawa T., Mizuno Y. Immunohistochemical studies on complexes I, II, and IV of mitochondria in Parkinson's disease, and IV of mitochondria in Parkinson's disease. Ann. Neurol. 30:1991;563-571.
    • (1991) Ann. Neurol. , vol.30 , pp. 563-571
    • Hattori, N.1    Tanaka, M.2    Ozawa, T.3    Mizuno, Y.4
  • 17
    • 0032563567 scopus 로고    scopus 로고
    • Secondary inhibition of 2-ketoglutarate dehydrogenase complex by MPTP
    • Joffe G.T., Parks J.K., Parker W.D. Jr. Secondary inhibition of 2-ketoglutarate dehydrogenase complex by MPTP. NeuroReport. 9:1998;2781-2783.
    • (1998) NeuroReport , vol.9 , pp. 2781-2783
    • Joffe, G.T.1    Parks, J.K.2    Parker W.D., Jr.3
  • 19
    • 0030297851 scopus 로고    scopus 로고
    • A simplified and rapid procedure for in situ hybridization on human, flash-frozen, post-mortem brain and its combination with immunohistochemistry
    • Kingsbury A.E., Bray E.L., Foster O.J. A simplified and rapid procedure for in situ hybridization on human, flash-frozen, post-mortem brain and its combination with immunohistochemistry. J. Neurosci. Methods. 69:1996;213-227.
    • (1996) J. Neurosci. Methods , vol.69 , pp. 213-227
    • Kingsbury, A.E.1    Bray, E.L.2    Foster, O.J.3
  • 21
    • 0034909015 scopus 로고    scopus 로고
    • Metabolic enzyme expression in dopaminergic neurons in Parkinson's disease: An in situ hybridization study
    • Kingsbury A.E., Cooper M., Schapira A.H., Foster O.J. Metabolic enzyme expression in dopaminergic neurons in Parkinson's disease: an in situ hybridization study. Ann. Neurol. 50:2001;142-149.
    • (2001) Ann. Neurol. , vol.50 , pp. 142-149
    • Kingsbury, A.E.1    Cooper, M.2    Schapira, A.H.3    Foster, O.J.4
  • 22
    • 0021166308 scopus 로고
    • Cerebellar norepinephrine in patients with Parkinson's disease and control subjects
    • Kish S.J., Shannak K.S., Rajput A.H., Gilbert J.J., Hornykiewicz O. Cerebellar norepinephrine in patients with Parkinson's disease and control subjects. Arch. Neurol. 41:1984;612-614.
    • (1984) Arch. Neurol. , vol.41 , pp. 612-614
    • Kish, S.J.1    Shannak, K.S.2    Rajput, A.H.3    Gilbert, J.J.4    Hornykiewicz, O.5
  • 23
    • 0031891886 scopus 로고    scopus 로고
    • Association between the gene encoding the E2 subunit of the alpha-ketoglutarate dehydrogenase complex and Parkinson's disease
    • Kobayashi T., Matsumine H., Matuda S., Mizuno Y. Association between the gene encoding the E2 subunit of the alpha-ketoglutarate dehydrogenase complex and Parkinson's disease. Ann. Neurol. 43:1998;120-123.
    • (1998) Ann. Neurol. , vol.43 , pp. 120-123
    • Kobayashi, T.1    Matsumine, H.2    Matuda, S.3    Mizuno, Y.4
  • 24
    • 0022454117 scopus 로고
    • The subcellular localization of glutamate dehydrogenase (GDH): Is GDH a marker for mitochondria in brain?
    • Lai J.C., Sheu K.F., Kim Y.T., Clarke D.D., Blass J.P. The subcellular localization of glutamate dehydrogenase (GDH): Is GDH a marker for mitochondria in brain? Neurochem. Res. 11:1986;733-744.
    • (1986) Neurochem. Res. , vol.11 , pp. 733-744
    • Lai, J.C.1    Sheu, K.F.2    Kim, Y.T.3    Clarke, D.D.4    Blass, J.P.5
  • 25
    • 0032457506 scopus 로고    scopus 로고
    • Time-dependent effects of levodopa on regional brain dopamine metabolism and lipid peroxidation
    • Loeffler D.A., LeWitt P.A., Juneau P.L., Camp D.M., Arnold L.A., Hyland K. Time-dependent effects of levodopa on regional brain dopamine metabolism and lipid peroxidation. Brain Res. Bull. 47:1998;663-667.
    • (1998) Brain Res. Bull. , vol.47 , pp. 663-667
    • Loeffler, D.A.1    LeWitt, P.A.2    Juneau, P.L.3    Camp, D.M.4    Arnold, L.A.5    Hyland, K.6
  • 26
    • 0027332651 scopus 로고
    • Brain alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease
    • Mastrogiacomo F., Bergeron C., Kish S.J. Brain alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. J. Neurochem. 61:1993;2007-2014.
    • (1993) J. Neurochem. , vol.61 , pp. 2007-2014
    • Mastrogiacomo, F.1    Bergeron, C.2    Kish, S.J.3
  • 28
    • 0028989810 scopus 로고
    • Inhibition of alpha-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    • McNaught K.S., Altomare C., Cellamare S., Carotti A., Thull U., Carrupt P.A., Testa B., Jenner P., Marsden C.D. Inhibition of alpha-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). NeuroReport. 6:1995;1105-1108.
    • (1995) NeuroReport , vol.6 , pp. 1105-1108
    • McNaught, K.S.1    Altomare, C.2    Cellamare, S.3    Carotti, A.4    Thull, U.5    Carrupt, P.A.6    Testa, B.7    Jenner, P.8    Marsden, C.D.9
  • 29
    • 0028176592 scopus 로고
    • An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's disease
    • Mizuno Y., Matuda S., Yoshino H., Mori H., Hattori N., Ikebe S. An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's disease. Ann. Neurol. 35:1994;204-210.
    • (1994) Ann. Neurol. , vol.35 , pp. 204-210
    • Mizuno, Y.1    Matuda, S.2    Yoshino, H.3    Mori, H.4    Hattori, N.5    Ikebe, S.6
  • 31
    • 0033048258 scopus 로고    scopus 로고
    • Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia
    • Park L.C.H., Zhang H., Sheu K.F., Calingasan N.Y., Kristal B.S., Lindsay J.G., Gibson G.E. Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia. J. Neurochem. 72:1999;1948-1958.
    • (1999) J. Neurochem. , vol.72 , pp. 1948-1958
    • Park, L.C.H.1    Zhang, H.2    Sheu, K.F.3    Calingasan, N.Y.4    Kristal, B.S.5    Lindsay, J.G.6    Gibson, G.E.7
  • 32
    • 0035576822 scopus 로고    scopus 로고
    • Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy
    • Park L.C.H., Albers D.S., Xu H., Lindsay J.G., Beal M.F., Gibson G.E. Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy. J. Neurosci. Res. 66:2001;1028-1034.
    • (2001) J. Neurosci. Res. , vol.66 , pp. 1028-1034
    • Park, L.C.H.1    Albers, D.S.2    Xu, H.3    Lindsay, J.G.4    Beal, M.F.5    Gibson, G.E.6
  • 33
    • 0024848034 scopus 로고
    • Abnormalities of the electron transport chain in idiopathic Parkinson's disease
    • Parker W.D. Jr., Boyson S.J., Parks J.K. Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann. Neurol. 26:1989;719-723.
    • (1989) Ann. Neurol. , vol.26 , pp. 719-723
    • Parker W.D., Jr.1    Boyson, S.J.2    Parks, J.K.3
  • 34
    • 0344521192 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative damage in Parkinson's disease
    • Beal, M.F., Nowell, N., Bodis-Wollner, I. (Eds.). Wiley, New York
    • Schapira, A.H.V., 1997. Mitochondrial dysfunction and oxidative damage in Parkinson's disease. In: Beal, M.F., Nowell, N., Bodis-Wollner, I. (Eds.), Mitochondria & Free Radicals in Neurodegenerative Disease. Wiley, New York, pp. 343-360.
    • (1997) Mitochondria & Free Radicals in Neurodegenerative Disease , pp. 343-360
    • Schapira, A.H.V.1
  • 36
    • 0025012215 scopus 로고
    • Hyperoxia-induced clonogenic killing of HeLa cells associated with respiratory failure and selective inactivation of Krebs cycle enzymes
    • Schoonen W.G., Wanamarta A.H., van der Klei-van Moorsel J.M., Jakobs C., Joenje H. Hyperoxia-induced clonogenic killing of HeLa cells associated with respiratory failure and selective inactivation of Krebs cycle enzymes. Mutat. Res. 237:1990;173-181.
    • (1990) Mutat. Res. , vol.237 , pp. 173-181
    • Schoonen, W.G.1    Wanamarta, A.H.2    Van der Klei-van Moorsel, J.M.3    Jakobs, C.4    Joenje, H.5
  • 37
    • 0033787328 scopus 로고    scopus 로고
    • Oxidative metabolites of 5-S-cysteinyldopamine inhibit the alpha-ketoglutarate dehydrogenase complex: Possible relevance to the pathogenesis of Parkinson's disease
    • Shen X.M., Li H., Dryhurst G. Oxidative metabolites of 5-S-cysteinyldopamine inhibit the alpha-ketoglutarate dehydrogenase complex: possible relevance to the pathogenesis of Parkinson's disease. J. Neural Transm. 107:2000;959-978.
    • (2000) J. Neural Transm. , vol.107 , pp. 959-978
    • Shen, X.M.1    Li, H.2    Dryhurst, G.3
  • 38
    • 0031891606 scopus 로고    scopus 로고
    • Immunochemical characterization of the deficiency of the alpha-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain
    • Sheu K.F., Calingasan N.Y., Lindsay J.G., Gibson G.E. Immunochemical characterization of the deficiency of the alpha-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain. J. Neurochem. 70:1998;1143-1150.
    • (1998) J. Neurochem. , vol.70 , pp. 1143-1150
    • Sheu, K.F.1    Calingasan, N.Y.2    Lindsay, J.G.3    Gibson, G.E.4
  • 40
    • 0032569826 scopus 로고    scopus 로고
    • Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia
    • Terwel D., Bothmer J., Wolf E., Meng F., Jolles J. Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia. J. Neurol. Sci. 161:1998;47-56.
    • (1998) J. Neurol. Sci. , vol.161 , pp. 47-56
    • Terwel, D.1    Bothmer, J.2    Wolf, E.3    Meng, F.4    Jolles, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.