Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia

Journal of Neurochemistry

Volumn 72, Issue 5, 1999, Pages 1948-1958

  Park, Larry C H ^a   Zhang, Hui ^a   Sheu, Kwan Fu Rex ^a   Calingasan, Noel Y ^a   Kristal, Bruce S ^a   Lindsay, J Gordon ^b   Gibson, Gary E ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Ketoglutarate dehydrogenase complex; Azide; Metabolic impairment; Mitochondrial complex IV; Nitric oxide; Peroxynitrite; Reactive oxygen species

Indexed keywords

CYTOCHROME C OXIDASE; LIPOPOLYSACCHARIDE; MITOCHONDRIAL ENZYME; NITRIC OXIDE; OXOGLUTARATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; ENERGY METABOLISM; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME SUBUNIT; IMMUNOREACTIVITY; INFLAMMATION; METABOLIC DISORDER; MICROGLIA; MOUSE; NERVE DEGENERATION; NEWBORN; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

ANIMALS; AZIDES; CELL SURVIVAL; CELLS, CULTURED; ENZYME ACTIVATION; GLUTAMATE DEHYDROGENASE; INFLAMMATION; KETOGLUTARATE DEHYDROGENASE COMPLEX; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICROGLIA; MITOCHONDRIA; NITRATES; NITRIC OXIDE; OXIDATIVE STRESS; OXIDOREDUCTASES; OXYGEN CONSUMPTION; REACTIVE OXYGEN SPECIES; TYROSINE;

ANIMALIA;

EID: 0033048258     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0721948.x     Document Type: Article

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