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Volumn 74, Issue 1, 2000, Pages 114-124

Metabolic impairment elicits brain cell type-selective changes in oxidative stress and cell death in culture

Author keywords

Ketoglutarate dehydrogenase complex; Astrocytes; Cell culture; Endothelial cells; Inflammation; Microglia; Neurons; Oxidative stress; Thiamine deficiency

Indexed keywords

AMPROLIUM; OXOGLUTARATE DEHYDROGENASE; THIAMINE;

EID: 0033985184     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0740114.x     Document Type: Article
Times cited : (27)

References (65)
  • 2
    • 0030744704 scopus 로고    scopus 로고
    • Thiamine may indirectly act as an antioxidant
    • Bakker S. J. L., Heine R. J., and Gans R. O. B. (1997) Thiamine may indirectly act as an antioxidant. Diabetologia 40, 741-742.
    • (1997) Diabetologia , vol.40 , pp. 741-742
    • Bakker, S.J.L.1    Heine, R.J.2    Gans, R.O.B.3
  • 3
    • 0019216477 scopus 로고
    • Trophic interactions between astroglial cells and hippocampal neurons in culture
    • Banker G. A. (1980) Trophic interactions between astroglial cells and hippocampal neurons in culture. Science 209, 809-810.
    • (1980) Science , vol.209 , pp. 809-810
    • Banker, G.A.1
  • 4
    • 0030273295 scopus 로고    scopus 로고
    • Mitochondria, free radicals, and neurodegeneration
    • Beal M. F. (1996) Mitochondria, free radicals, and neurodegeneration. Curr. Opin. Neurobiol. 6, 661-666.
    • (1996) Curr. Opin. Neurobiol. , vol.6 , pp. 661-666
    • Beal, M.F.1
  • 5
    • 0032498922 scopus 로고    scopus 로고
    • Xanthine oxidase-derived superoxide causes reoxygenation injury of ischemic cerebral endothelial cells
    • Beetsch J. W., Park T. S., Dugan L. L., Shah A. R., and Gidday J. M. (1998) Xanthine oxidase-derived superoxide causes reoxygenation injury of ischemic cerebral endothelial cells. Brain Res. 786, 89-95.
    • (1998) Brain Res. , vol.786 , pp. 89-95
    • Beetsch, J.W.1    Park, T.S.2    Dugan, L.L.3    Shah, A.R.4    Gidday, J.M.5
  • 6
    • 0028334654 scopus 로고
    • Mechanism of thiamine transport in neuroblastoma cells: Inhibition of a high affinity carrier by sodium channel activators and dependence of thiamine uptake on membrane potential and intracellular ATP
    • Bettendorff L. and Wins P. (1994) Mechanism of thiamine transport in neuroblastoma cells: inhibition of a high affinity carrier by sodium channel activators and dependence of thiamine uptake on membrane potential and intracellular ATP. J. Biol. Chem. 269, 14379-14385.
    • (1994) J. Biol. Chem. , vol.269 , pp. 14379-14385
    • Bettendorff, L.1    Wins, P.2
  • 7
    • 0028934399 scopus 로고
    • Thiamine deficiency in cultured neuroblastoma cells: Effect on mitochondrial function and peripheral benzodiazepine receptors
    • Bettendorff L., Goessens G., Sluse F., Wins P., Bureau M., Laschet J., and Grisar T. (1995a) Thiamine deficiency in cultured neuroblastoma cells: effect on mitochondrial function and peripheral benzodiazepine receptors. J. Neurochem. 64, 2013-2021.
    • (1995) J. Neurochem. , vol.64 , pp. 2013-2021
    • Bettendorff, L.1    Goessens, G.2    Sluse, F.3    Wins, P.4    Bureau, M.5    Laschet, J.6    Grisar, T.7
  • 8
    • 0028971633 scopus 로고
    • Thiamine deficiency-induced partial necrosis and mitochondrial uncoupling in neuroblastoma cells are rapidly reversed by addition of thiamine
    • Bettendorff L., Sluse F., Goessens G., Wins P., and Grisar T. (1995b) Thiamine deficiency-induced partial necrosis and mitochondrial uncoupling in neuroblastoma cells are rapidly reversed by addition of thiamine. J. Neurochem. 65, 2178-2184.
    • (1995) J. Neurochem. , vol.65 , pp. 2178-2184
    • Bettendorff, L.1    Sluse, F.2    Goessens, G.3    Wins, P.4    Grisar, T.5
  • 10
    • 84937174490 scopus 로고
    • Pathophysiology of the Alzheimer's syndrome
    • Blass J. P. (1993) Pathophysiology of the Alzheimer's syndrome. Neurology 43 (Suppl. 4), S25-S38.
    • (1993) Neurology , vol.43 , Issue.SUPPL. 4
    • Blass, J.P.1
  • 11
    • 0028952832 scopus 로고
    • Effect of peroxynitrite on the mitochondrial respiratory chain: Differential susceptibility of neurons and astrocytes in primary culture
    • Bolaños J. P., Heales S. J. R., Land J. M., and Clark J. B. (1995) Effect of peroxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurons and astrocytes in primary culture. J. Neurochem. 64, 1965-1972.
    • (1995) J. Neurochem. , vol.64 , pp. 1965-1972
    • Bolaños, J.P.1    Heales, S.J.R.2    Land, J.M.3    Clark, J.B.4
  • 12
    • 0027226219 scopus 로고
    • Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination
    • Brewer G. J., Torricelli J. R., Evege E. K., and Price P. J. (1993) Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J. Neurosci. Res. 35, 567-576.
    • (1993) J. Neurosci. Res. , vol.35 , pp. 567-576
    • Brewer, G.J.1    Torricelli, J.R.2    Evege, E.K.3    Price, P.J.4
  • 13
    • 84990616618 scopus 로고
    • Pathophysiological mechanisms responsible for the reversible (thiamine-responsive) and irreversible (thiamine non-responsive) neurological symptoms of Wernicke's encephalopathy
    • Butterworth R. F. (1993) Pathophysiological mechanisms responsible for the reversible (thiamine-responsive) and irreversible (thiamine non-responsive) neurological symptoms of Wernicke's encephalopathy. Drug Alcohol Rev. 12, 315-322.
    • (1993) Drug Alcohol Rev. , vol.12 , pp. 315-322
    • Butterworth, R.F.1
  • 14
    • 0027131501 scopus 로고
    • Thiamine-dependent enzyme changes in the brains of alcoholics: Relationship to the Wernicke-Korsakoff syndrome
    • Butterworth R. F., Kril J. J., and Harper C. G. (1993) Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke-Korsakoff syndrome. Alcohol Clin. Exp. Res. 71, 1084-1088.
    • (1993) Alcohol Clin. Exp. Res. , vol.71 , pp. 1084-1088
    • Butterworth, R.F.1    Kril, J.J.2    Harper, C.G.3
  • 16
    • 0031830710 scopus 로고    scopus 로고
    • Induction of nitric oxide synthase and microglial responses precede selective cell death induced by chronic impairment of oxidative metabolism
    • Calingasan N. Y., Park L. C. H., Calo L. L., Trifiletti R. R., Gandy S. E., and Gibson G. E. (1998) Induction of nitric oxide synthase and microglial responses precede selective cell death induced by chronic impairment of oxidative metabolism. Am. J. Pathol. 153, 599-610.
    • (1998) Am. J. Pathol. , vol.153 , pp. 599-610
    • Calingasan, N.Y.1    Park, L.C.H.2    Calo, L.L.3    Trifiletti, R.R.4    Gandy, S.E.5    Gibson, G.E.6
  • 17
    • 0032849357 scopus 로고    scopus 로고
    • Oxidative stress is associated with region-specific neuronal death during thiamine deficiency
    • Calingasan N. Y., Chun W. J., Park L. C. H., Uchida K., and Gibson G. E. (1999) Oxidative stress is associated with region-specific neuronal death during thiamine deficiency. J. Neuropathol. Exp. Neurol. 58, 946-958.
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 946-958
    • Calingasan, N.Y.1    Chun, W.J.2    Park, L.C.H.3    Uchida, K.4    Gibson, G.E.5
  • 18
    • 0029549426 scopus 로고
    • A cautionary note on the use of the TUNEL stain to determine apoptosis
    • Charriaut-Marlangue C. and Ben-Ari Y. (1995) A cautionary note on the use of the TUNEL stain to determine apoptosis. Neuroreport 7, 61-64.
    • (1995) Neuroreport , vol.7 , pp. 61-64
    • Charriaut-Marlangue, C.1    Ben-Ari, Y.2
  • 19
    • 0029245289 scopus 로고
    • A potential role for apoptosis in neurodegeneration in Alzheimer's disease
    • Cotman C. W. and Anderson A. J. (1995) A potential role for apoptosis in neurodegeneration in Alzheimer's disease. Mol. Neurobiol. 10, 19-45.
    • (1995) Mol. Neurobiol. , vol.10 , pp. 19-45
    • Cotman, C.W.1    Anderson, A.J.2
  • 20
    • 0025814980 scopus 로고
    • Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
    • Esterbauer H., Shaur R. J., and Zollner H. (1991) Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic. Biol. Med. 11, 81-128.
    • (1991) Free Radic. Biol. Med. , vol.11 , pp. 81-128
    • Esterbauer, H.1    Shaur, R.J.2    Zollner, H.3
  • 21
    • 0023732664 scopus 로고
    • Reduced activities of thiamine-dependent enzymes in brains and peripheral tissues of Alzheimer's patients
    • Gibson G. E., Sheu K. F. R., Baker A. C., Carlson K. C., Harding B., Perrino P., and Blass J. P. (1988) Reduced activities of thiamine-dependent enzymes in brains and peripheral tissues of Alzheimer's patients. Arch. Neurol. 45, 838-840.
    • (1988) Arch. Neurol. , vol.45 , pp. 838-840
    • Gibson, G.E.1    Sheu, K.F.R.2    Baker, A.C.3    Carlson, K.C.4    Harding, B.5    Perrino, P.6    Blass, J.P.7
  • 22
    • 0024552754 scopus 로고
    • Regionally selective alterations in enzymatic activities and metabolic fluxes during thiamin deficiency
    • Gibson G., Nielsen P., Mykytyn V., Carlson K., and Blass J. (1989) Regionally selective alterations in enzymatic activities and metabolic fluxes during thiamin deficiency. Neurochem. Res. 14, 17-24.
    • (1989) Neurochem. Res. , vol.14 , pp. 17-24
    • Gibson, G.1    Nielsen, P.2    Mykytyn, V.3    Carlson, K.4    Blass, J.5
  • 24
    • 0342677338 scopus 로고
    • Biochemical changes in thiamine deficiencies
    • Gubler C. J., Fujiwara M., and Dreyfus P. M., eds, Wiley Interscience, New York
    • Gubler C. J. (1976) Biochemical changes in thiamine deficiencies, in Thiamine (Gubler C. J., Fujiwara M., and Dreyfus P. M., eds), pp. 121-139. Wiley Interscience, New York.
    • (1976) Thiamine , pp. 121-139
    • Gubler, C.J.1
  • 25
    • 0032104137 scopus 로고    scopus 로고
    • Brain inflammatory response induced by intracerebroventricular infusion of lipopolysaccharide: An immunohistochemical study
    • Hauss-Wegrzyniak B., Lukovic L., Bigaud M., and Stoeckel M. E. (1998) Brain inflammatory response induced by intracerebroventricular infusion of lipopolysaccharide: an immunohistochemical study. Brain Res. 794, 211-224.
    • (1998) Brain Res. , vol.794 , pp. 211-224
    • Hauss-Wegrzyniak, B.1    Lukovic, L.2    Bigaud, M.3    Stoeckel, M.E.4
  • 28
    • 0032506040 scopus 로고    scopus 로고
    • Selective inactivation of α-ketoglutarate dehydrogenase and pyruvate dehydrogenase: Reaction of lipoic acid with 4-hydroxy-2-nonenal
    • Humphries K. M. and Szweda L. I. (1998) Selective inactivation of α-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal. Biochemistry 37, 15835-15841.
    • (1998) Biochemistry , vol.37 , pp. 15835-15841
    • Humphries, K.M.1    Szweda, L.I.2
  • 29
    • 0030754962 scopus 로고    scopus 로고
    • 4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes
    • Keller J. N., Mark R. J., Bruce A. J., Blanc E. M., Rothstein J. D., Uchida K., and Mattson M. P. (1997) 4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes. Neuroscience 80, 685-696.
    • (1997) Neuroscience , vol.80 , pp. 685-696
    • Keller, J.N.1    Mark, R.J.2    Bruce, A.J.3    Blanc, E.M.4    Rothstein, J.D.5    Uchida, K.6    Mattson, M.P.7
  • 30
    • 0030986669 scopus 로고    scopus 로고
    • Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis
    • Kruman I., Bruce-Keller A. J., Bredesen D., Waeg G., and Mattson M. P. (1997) Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J. Neurosci. 17, 5089-5100.
    • (1997) J. Neurosci. , vol.17 , pp. 5089-5100
    • Kruman, I.1    Bruce-Keller, A.J.2    Bredesen, D.3    Waeg, G.4    Mattson, M.P.5
  • 31
    • 0030992519 scopus 로고    scopus 로고
    • Increased cerebral free radical production during thiamine deficiency
    • Langlais P. J., Anderson G., Guo S. X., and Bondy S. C. (1997) Increased cerebral free radical production during thiamine deficiency. Metab. Brain Dis. 12, 137-143.
    • (1997) Metab. Brain Dis. , vol.12 , pp. 137-143
    • Langlais, P.J.1    Anderson, G.2    Guo, S.X.3    Bondy, S.C.4
  • 32
    • 0000454477 scopus 로고
    • Astroglia in culture
    • Banker G. and Goslin K., eds, MIT Press, Cambridge
    • Levison S. W. and McCarthy K. D. (1991) Astroglia in culture, in Culturing Nerve Cells (Banker G. and Goslin K., eds), pp. 309-355. MIT Press, Cambridge.
    • (1991) Culturing Nerve Cells , pp. 309-355
    • Levison, S.W.1    McCarthy, K.D.2
  • 33
    • 0027501851 scopus 로고
    • Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats
    • Linnik M. D., Zobrist R. H., and Hatfield M. D. (1993) Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 24, 2002-2008.
    • (1993) Stroke , vol.24 , pp. 2002-2008
    • Linnik, M.D.1    Zobrist, R.H.2    Hatfield, M.D.3
  • 34
    • 0027976087 scopus 로고
    • Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: Evidence that astrocytes play an important role in antioxidative processes in the brain
    • Makar T. K., Nedergaard M., Preuss A., Gelbard A. S., Perumal A. S., and Cooper A. J. L. (1994) Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain. J. Neurochem. 62, 45-53.
    • (1994) J. Neurochem. , vol.62 , pp. 45-53
    • Makar, T.K.1    Nedergaard, M.2    Preuss, A.3    Gelbard, A.S.4    Perumal, A.S.5    Cooper, A.J.L.6
  • 35
    • 0029884010 scopus 로고    scopus 로고
    • Brain protein and α-ketoglutarate dehydrogenase complex activity in Alzheimer's disease
    • Mastrogiacomo F., Lindsay J. G., Bettendorft L., Rice J., and Kish S. J. (1996) Brain protein and α-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. Ann. Neurol. 39, 592-598.
    • (1996) Ann. Neurol. , vol.39 , pp. 592-598
    • Mastrogiacomo, F.1    Lindsay, J.G.2    Bettendorft, L.3    Rice, J.4    Kish, S.J.5
  • 36
    • 0031001373 scopus 로고    scopus 로고
    • Apoptosis is restricted to the thalamus in thiamine-deficient rats
    • Matsushima K., MacManus J. P., and Hakim A. M. (1997) Apoptosis is restricted to the thalamus in thiamine-deficient rats. Neuroreport 8, 867-870.
    • (1997) Neuroreport , vol.8 , pp. 867-870
    • Matsushima, K.1    MacManus, J.P.2    Hakim, A.M.3
  • 37
    • 0025118878 scopus 로고
    • Glia protect hippocampal neurons against excitatory amino acid-induced degeneration: Involvement of fibroblast growth factor
    • Mattson M. P. and Rychlik B. (1990) Glia protect hippocampal neurons against excitatory amino acid-induced degeneration: involvement of fibroblast growth factor. Int. J. Dev. Neurosci. 8, 399-415.
    • (1990) Int. J. Dev. Neurosci. , vol.8 , pp. 399-415
    • Mattson, M.P.1    Rychlik, B.2
  • 39
    • 0030839255 scopus 로고    scopus 로고
    • Pathobiology of lipopolysaccharide
    • Mayeux P. R. (1997) Pathobiology of lipopolysaccharide. J. Toxicol. Environ. Health 51, 415-435.
    • (1997) J. Toxicol. Environ. Health , vol.51 , pp. 415-435
    • Mayeux, P.R.1
  • 40
    • 0003139218 scopus 로고
    • Thiamine deficiency and cerebral metabolism
    • McCandless D. W., ed, Plenum Press, New York
    • McCandless D. W. (1985) Thiamine deficiency and cerebral metabolism, in Cerebral Energy Metabolism and Metabolic Encephalopathy (McCandless D. W., ed), pp. 335-351. Plenum Press, New York.
    • (1985) Cerebral Energy Metabolism and Metabolic Encephalopathy , pp. 335-351
    • McCandless, D.W.1
  • 41
    • 0014341180 scopus 로고
    • Encephalopathy of thiamine deficiency: Studies of intracerebral mechanisms
    • McCandless D. W. and Schenker S. (1968) Encephalopathy of thiamine deficiency: studies of intracerebral mechanisms. J. Clin. Invest. 47, 2268-2280.
    • (1968) J. Clin. Invest. , vol.47 , pp. 2268-2280
    • McCandless, D.W.1    Schenker, S.2
  • 42
    • 0028176592 scopus 로고
    • An immunohistochemical study on α-ketoglutarate dehydrogenase complex in Parkinson's disease
    • Mizuno Y., Matuda S., Yoshino H., Mori H., Hattori N., and Ikebe S. I. (1994) An immunohistochemical study on α-ketoglutarate dehydrogenase complex in Parkinson's disease. Ann. Neurol. 35, 204-210.
    • (1994) Ann. Neurol. , vol.35 , pp. 204-210
    • Mizuno, Y.1    Matuda, S.2    Yoshino, H.3    Mori, H.4    Hattori, N.5    Ikebe, S.I.6
  • 43
    • 0021061819 scopus 로고
    • Rapid colorimetric assay of cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T. (1983) Rapid colorimetric assay of cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 44
    • 0029872690 scopus 로고    scopus 로고
    • Novel insight into molecular mechanism of endotoxin shock: Biochemical analysis of LPS receptor signaling in a cell-free system targeting NF-kappaB and regulation of cytokine production/action through beta2 integrin in vivo
    • Mukaida N., Ishikawa Y., Ikeda N., Fujioka N., Watanabe S., Kuno K., and Matsushima K. (1996) Novel insight into molecular mechanism of endotoxin shock: biochemical analysis of LPS receptor signaling in a cell-free system targeting NF-kappaB and regulation of cytokine production/action through beta2 integrin in vivo. J. Leukoc. Biol. 59, 145-151.
    • (1996) J. Leukoc. Biol. , vol.59 , pp. 145-151
    • Mukaida, N.1    Ishikawa, Y.2    Ikeda, N.3    Fujioka, N.4    Watanabe, S.5    Kuno, K.6    Matsushima, K.7
  • 45
    • 0017487289 scopus 로고
    • The large apparent work capability of the blood-brain barrier: A study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat
    • Oldendorf W. H., Cornford M. E., and Brown W. J. (1977) The large apparent work capability of the blood-brain barrier: a study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat. Ann. Neurol. 1, 409-417.
    • (1977) Ann. Neurol. , vol.1 , pp. 409-417
    • Oldendorf, W.H.1    Cornford, M.E.2    Brown, W.J.3
  • 46
    • 0029909010 scopus 로고    scopus 로고
    • Neuroprotection by the metabolic antioxidant alpha-lipoic acid
    • Packer L., Tritschler H. J., and Wessel K. (1997) Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic. Biol. Med. 22, 359-378.
    • (1997) Free Radic. Biol. Med. , vol.22 , pp. 359-378
    • Packer, L.1    Tritschler, H.J.2    Wessel, K.3
  • 47
    • 25544447113 scopus 로고    scopus 로고
    • Effects of thiamine deficiency on cerebellar granule cell metabolism and viability
    • Pannunzio P., Hazell A. S., and Butterworth R. F. (1999) Effects of thiamine deficiency on cerebellar granule cell metabolism and viability. (Abstr.) J. Neurochem. 73 (Suppl.), S12C.
    • (1999) J. Neurochem. , vol.73 , Issue.SUPPL.
    • Pannunzio, P.1    Hazell, A.S.2    Butterworth, R.F.3
  • 48
    • 0033048258 scopus 로고    scopus 로고
    • Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia
    • Park L. C. H., Zhang H., Sheu K. F. R., Calingasan N. Y., Kristal B. S., Lindsay J. G., and Gibson G. E. (1999) Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia. J. Neurochem. 72, 1948-1958.
    • (1999) J. Neurochem. , vol.72 , pp. 1948-1958
    • Park, L.C.H.1    Zhang, H.2    Sheu, K.F.R.3    Calingasan, N.Y.4    Kristal, B.S.5    Lindsay, J.G.6    Gibson, G.E.7
  • 49
    • 0025520484 scopus 로고
    • Interrelationship between the thiamine content, thiamine diphosphate-dependent enzyme activity and reduced glutathione level in the rat liver
    • Parkhomenko I. M., Chernysh I., Protasova Z. S., and Donchenko G. V. (1990) Interrelationship between the thiamine content, thiamine diphosphate-dependent enzyme activity and reduced glutathione level in the rat liver [in Russian]. Ukrainskii Biokhimicheskii Zhurnal 62, 52-58.
    • (1990) Ukrainskii Biokhimicheskii Zhurnal , vol.62 , pp. 52-58
    • Parkhomenko, I.M.1    Chernysh, I.2    Protasova, Z.S.3    Donchenko, G.V.4
  • 50
    • 0030014522 scopus 로고    scopus 로고
    • Thiamine pyrophosphate-requiring enzymes are altered during pyrithiamine-induced thiamine deficiency in cultured human lymphoblasts
    • Pekovich S. R., Martin P. R., and Singleton C. K. (1996) Thiamine pyrophosphate-requiring enzymes are altered during pyrithiamine-induced thiamine deficiency in cultured human lymphoblasts. J. Nutr. 126, 1791-1798.
    • (1996) J. Nutr. , vol.126 , pp. 1791-1798
    • Pekovich, S.R.1    Martin, P.R.2    Singleton, C.K.3
  • 51
    • 0026079562 scopus 로고
    • Domains, motifs, and linkers in 2-oxo acid dehydrogenase multienzyme complexes: A paradigm in the design of a multifunctional protein
    • Perham R. N. (1991) Domains, motifs, and linkers in 2-oxo acid dehydrogenase multienzyme complexes: a paradigm in the design of a multifunctional protein. Biochemistry 30, 8501-8512.
    • (1991) Biochemistry , vol.30 , pp. 8501-8512
    • Perham, R.N.1
  • 52
    • 0030940277 scopus 로고    scopus 로고
    • Metabolic and permeability changes caused by thiamine deficiency in immortalized rat brain microvessel endothelial cells
    • Romero I. A., Rist R. J., Aleshaiker A., and Abbott N. J. (1997) Metabolic and permeability changes caused by thiamine deficiency in immortalized rat brain microvessel endothelial cells. Brain Res. 756, 133-140.
    • (1997) Brain Res. , vol.756 , pp. 133-140
    • Romero, I.A.1    Rist, R.J.2    Aleshaiker, A.3    Abbott, N.J.4
  • 53
    • 0027421350 scopus 로고
    • Maintenance of neuronal glutathione by glial cells
    • Sagara J., Miura K., and Bannai S. (1993) Maintenance of neuronal glutathione by glial cells. J. Neurochem. 61, 1672-1676.
    • (1993) J. Neurochem. , vol.61 , pp. 1672-1676
    • Sagara, J.1    Miura, K.2    Bannai, S.3
  • 54
    • 0030020028 scopus 로고    scopus 로고
    • Neurofibrillary tangles of Guam parkinson-dementia are associated with reactive microglia and complement proteins
    • Schwab C., Steele J. C., and McGeer P. L. (1996) Neurofibrillary tangles of Guam parkinson-dementia are associated with reactive microglia and complement proteins. Brain Res. 707, 196-205.
    • (1996) Brain Res. , vol.707 , pp. 196-205
    • Schwab, C.1    Steele, J.C.2    McGeer, P.L.3
  • 55
    • 0016776962 scopus 로고
    • Glycolytic metabolism in cultured cells of the nervous system. III. The effects of thiamine deficiency and pyrithiamine on the C-6 glioma and C-1300 neuroblastoma cell lines
    • Schwartz J. P., Lust W. D., Shirazawa R., and Passoneau J. V. (1975) Glycolytic metabolism in cultured cells of the nervous system. III. The effects of thiamine deficiency and pyrithiamine on the C-6 glioma and C-1300 neuroblastoma cell lines. Mol. Cell. Biochem. 9, 73-78.
    • (1975) Mol. Cell. Biochem. , vol.9 , pp. 73-78
    • Schwartz, J.P.1    Lust, W.D.2    Shirazawa, R.3    Passoneau, J.V.4
  • 57
    • 0029040824 scopus 로고
    • The intracellular component of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction is specifically inhibited by β-amyloid peptides
    • Shearman M. S., Hawtin S. R., and Tailor V. J. (1995) The intracellular component of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction is specifically inhibited by β-amyloid peptides. J. Neurochem. 65, 218-227.
    • (1995) J. Neurochem. , vol.65 , pp. 218-227
    • Shearman, M.S.1    Hawtin, S.R.2    Tailor, V.J.3
  • 58
    • 0028387219 scopus 로고
    • Abnormality of the a-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease
    • Sheu K. P. R., Cooper A. J. L., Koike K., Koike M., Lindsay J. G., and Blass J. P. (1994) Abnormality of the a-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease. Ann. Neurol. 35, 312-318.
    • (1994) Ann. Neurol. , vol.35 , pp. 312-318
    • Sheu, K.P.R.1    Cooper, A.J.L.2    Koike, K.3    Koike, M.4    Lindsay, J.G.5    Blass, J.P.6
  • 59
    • 0031891606 scopus 로고    scopus 로고
    • Immunochemical characterization of the deficiency of the a-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain
    • Sheu K. F. R., Calingasan N. Y., Lindsay J. G., and Gibson G. E. (1998) Immunochemical characterization of the deficiency of the a-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain. J. Neurochem. 70, 1143-1150.
    • (1998) J. Neurochem. , vol.70 , pp. 1143-1150
    • Sheu, K.F.R.1    Calingasan, N.Y.2    Lindsay, J.G.3    Gibson, G.E.4
  • 60
    • 0033105776 scopus 로고    scopus 로고
    • Detective high-affinity thiamine transporter leads to cell death in thiamine-responsive megaloblastic anemia syndrome fibroblasts
    • Stagg A. R., Fleming J. C., Baker M. A., Sakamoto M., Cohen J., and Neufeld E. J. (1999) Detective high-affinity thiamine transporter leads to cell death in thiamine-responsive megaloblastic anemia syndrome fibroblasts. J. Clin. Invest. 103, 723-729.
    • (1999) J. Clin. Invest. , vol.103 , pp. 723-729
    • Stagg, A.R.1    Fleming, J.C.2    Baker, M.A.3    Sakamoto, M.4    Cohen, J.5    Neufeld, E.J.6
  • 61
    • 0029927343 scopus 로고    scopus 로고
    • Metabolic coupling between glia and neurons
    • Tsacopoulos M. and Magistretti P. J. (1996) Metabolic coupling between glia and neurons. J. Neurosci. 16, 877-885.
    • (1996) J. Neurosci. , vol.16 , pp. 877-885
    • Tsacopoulos, M.1    Magistretti, P.J.2
  • 62
    • 0027946778 scopus 로고
    • Michael addition-type 4-hydroxy-2-nonenal adducts in modified low-density lipoproteins: Markers for atherosclerosis
    • Uchida K., Toyokuni S., Nishikawa K., Kawakishi S., Oda H., Hiai H., and Stadtman E. R. (1994) Michael addition-type 4-hydroxy-2-nonenal adducts in modified low-density lipoproteins: markers for atherosclerosis. Biochemistry 33, 12487-12494.
    • (1994) Biochemistry , vol.33 , pp. 12487-12494
    • Uchida, K.1    Toyokuni, S.2    Nishikawa, K.3    Kawakishi, S.4    Oda, H.5    Hiai, H.6    Stadtman, E.R.7
  • 64
    • 0018102130 scopus 로고
    • Early edematous lesion of pyrithiamine induced acute thiamine deficient encephalopathy in the mouse
    • Watanabe I. and Kanabe S. (1978) Early edematous lesion of pyrithiamine induced acute thiamine deficient encephalopathy in the mouse. J. Neuropathol. Exp. Neurol. 37, 401-413.
    • (1978) J. Neuropathol. Exp. Neurol. , vol.37 , pp. 401-413
    • Watanabe, I.1    Kanabe, S.2


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