Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1

Journal of Biological Chemistry

Volumn 280, Issue 26, 2005, Pages 25048-25059

  McLaughlin, Joseph N ^b   Shen, Lixin ^b   Holinstat, Michael ^b   Brooks, Joshua D ^b   DiBenedetto, Emmanuele ^b   Hamm, Heidi E ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CALCIUM; CELLS; CHELATION; ENZYME INHIBITION; MATHEMATICAL MODELS; MOLECULAR STRUCTURE; TOXIC MATERIALS;

AGONIST PEPTIDE SIGNALING; METALLOPROTEINASE; PHARMACOLOGICAL DIFFERENCES; THROMBIN;

PROTEINS;

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CALCIUM; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; ILOMASTAT; LIGAND; MATRIX METALLOPROTEINASE INHIBITOR; PEPTIDE DERIVATIVE; PERTUSSIS TOXIN; PHOSPHOLIPASE C; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; RHO FACTOR; RHO KINASE; THROMBIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; HUMAN; HUMAN CELL; MATHEMATICAL MODEL; MONOLAYER CULTURE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ACTINS; ADENOSINE DIPHOSPHATE; AMIDES; CALCIUM; CELLS, CULTURED; CHELATING AGENTS; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; EGTAZIC ACID; ELECTRIC IMPEDANCE; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; LIGANDS; MATRIX METALLOPROTEINASES; MICROCIRCULATION; MODELS, BIOLOGICAL; MODELS, THEORETICAL; PEPTIDES; PERTUSSIS TOXIN; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RECEPTOR, PAR-1; SIGNAL TRANSDUCTION; THROMBIN; TIME FACTORS;

EID: 21644449969     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M414090200     Document Type: Article

References (113)

1. Berg, K. A., Maayani, S., Goldfarb, J., Scaramellini, C., Leff, P., and Clarke, W. P. (1998) Mol. Pharmacol. 54, 94-104
2. Kurrasch-Orbaugh, D. M., Watts, V. J., Barker, E. L., and Nichols, D. E. (2003) J. Pharmacol. Exp. Ther. 304, 229-237
3. Ebersole, B. J., Visiers, I., Weinstein, H., and Sealfon, S. C. (2003) Mol. Pharmacol. 63, 36-43
4. Ghanouni, P., Gryczynski, Z., Steenhuis, J. J., Lee, T. W., Farrens, D. L., Lakowicz, J. R., and Kobilka, B. K. (2001) J. Biol. Chem. 276, 24433-24436
5. Mottola, D. M., Kilts, J. D., Lewis, M. M., Connery, H. S., Walker, Q. D., Jones, S. R., Booth, R. G., Hyslop, D. K., Piercey, M., Wightman, R. M., Lawler, C. P., Nichols, D. E., and Mailman, R. B. (2002) J. Pharmacol. Exp. Ther. 301, 1166-1178
6. Kilts, J. D., Connery, H. S., Arrington, E. G., Lewis, M. M., Lawler, C. P., Oxford, G. S., O'Malley, K. L., Todd, R. D., Blake, B. L., Nichols, D. E., and Mailman, R. B. (2002) J. Pharmacol. Exp. Ther. 301, 1179-1189
7. Robb, S., Cheek, T. R., Hannan, F. L., Hall, L. M., Midgley, J. M., and Evans, P. D. (1994) EMBO J. 13, 1325-1330
8. Kenakin, T. (2004) Trends Pharmacol. Sci. 25, 186-192
9. Hermans, E. (2003) Pharmacol. Ther. 99, 25-44
10. Andrade-Gordon, P., Derian, C. K., Maryanoff, B. E., Zhang, H. C., Addo, M. F., Cheung, W., Damiano, B. P., D'Andrea, M. R., Darrow, A. L., de Garavilla, L., Eckardt, A. J., Giardino, E. C., Haertlein, B. J., and McComsey, D. F. (2001) J. Pharmacol. Exp. Ther. 298, 34-42
11. Hollenberg, M. D., and Saifeddine, M. (2001) Can. J. Physiol. Pharmacol. 79, 439-442
12. Nystedt, S., Emilsson, K., Wahlestedt, C., and Sundelin, J. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 9208-9212
13. Hirano, K., and Kanaide, H. (2003) J. Atheroscler. Thromb. 10, 211-225
14. Ishihara, H., Connolly, A. J., Zeng, D., Kahn, M. L., Zheng, Y. W., Timmons, C., Tram, T., and Coughlin, S. R. (1997) Nature 386, 502-506
15. O'Brien, P. J., Prevost, N., Molino, M., Hollinger, M. K., Woolkalis, M. J., Woulfe, D. S., and Brass, L. F. (2000) J. Biol. Chem. 275, 13502-13509
16. Schmidt, V. A., Nierman, W. C., Maglott, D. R., Cupit, L. D., Moskowitz, K. A., Wainer, J. A., and Bahou, W. F. (1998) J. Biol. Chem. 273, 15061-15068
17. Nakanishi-Matsui, M., Zheng, Y. W., Sulciner, D. J., Weiss, E. J., Ludeman, M. J., and Coughlin, S. R. (2000) Nature 404, 609-613
18. Barr, A. J., Brass, L. F., and Manning, D. R. (1997) J. Biol. Chem. 272, 2223-2229
19. Vanhauwe, J. F., Thomas, T. O., Minshall, R. D., Tiruppathi, C., Li, A., Gilchrist, A., Yoon, E. J., Malik, A. B., and Hamm, H. E. (2002) J. Biol. Chem. 277, 34143-34149
20. Malik, A. B., and Fenton, J. W., Jr. (1992) Semin. Thromb. Hemostasis 18, 193-199
21. Rabiet, M. J., Plantier, J. L., and Dejana, E. (1994) Br. Med. Bull. 50, 936-945
22. Rabiet, M. J., Plantier, J. L., Rival, Y., Genoux, Y., Lampugnani, M. G., and Dejana, E. (1996) Arterioscler. Thromb. Vasc. Biol. 16, 488-496
23. Kozasa, T., Jiang, X., Hart, M. J., Sternweis, P. M., Singer, W. D., Gilman, A. G., Bollag, G., Sternweis, P. C., Sharma, S., elMasry, N., Qiu, R. G., McCabe, P., and Polakis, P. (1998) Science 280, 2109-2111
24. Fukuhara, S., Chikumi, H., and Gutkind, J. S. (2000) FEBS Lett. 485, 183-188
25. Fukuhara, S., Murga, C., Zohar, M., Igishi, T., and Gutkind, J. S. (1999) J. Biol. Chem. 274, 5868-5879
26. Jackson, M., Song, W., Liu, M. Y., Jin, L., Dykes-Hoberg, M., Lin, C. I., Bowers, W. J., Federoff, H. J., Sternweis, P. C., and Rothstein, J. D. (2001) Nature 410, 89-93
27. Wojciak-Stothard, B., and Ridley, A. J. (2002) Vasc. Pharmacol. 39, 187-199
28. Tiruppathi, C., Minshall, R. D., Paria, B. C., Vogel, S. M., and Malik, A. B. (2002) Vasc. Pharmacol. 39, 173-185
29. Borbiev, T., Verin, A. D., Shi, S., Liu, F., and Garcia, J. G. (2001) Am. J. Physiol. 280, L983-L990
30. van Nieuw Amerongen, G. P., van Delft, S., Vermeer, M. A., Collard, J. G., and van Hinsbergh, V. W. (2000) Circ. Res. 87, 335-340
31. Bogatcheva, N. V., Garcia, J. G., and Verin, A. D. (2002) Biochemistry (Mosc.) 67, 75-84
32. Scarborough, R. M., Naughton, M. A., Teng, W., Hung, D. T., Rose, J., Vu, T. K., Wheaton, V. I., Turck, C. W., and Coughlin, S. R. (1992) J. Biol. Chem. 267, 13146-13149
33. Garcia, J. G., Patterson, C., Bahler, C., Aschner, J., Hart, C. M., and English, D. (1993) J. Cell. Physiol. 156, 541-549
34. Blackhart, B., Emilsson, K., Nguyen, D., Teng, W., Martelli, A., Nystedt, S., Sundelin, J., and Scarborough, R. (1996) J. Biol. Chem. 271, 16466-16471
35. Vouret-Craviari, V., Van Obberghen-Schilling, E., Rasmussen, U. B., Pavirani, A., Lecocq, J. P., and Pouyssegur, J. (1992) Mol. Biol. Cell 3, 95-102
36. Vouret-Craviari, V., Van Obberghen-Schilling, E., Scimeca, J. C., Van Obberghen, E., and Pouyssegur, J. (1993) Biochem. J. 289, 209-214
37. Blackhart, B. D., Ruslim-Litrus, L., Lu, C. C., Alves, V. L., Teng, W., Scarborough, R. M., Reynolds, E. E., and Oksenberg, D. (2000) Mol. Pharmacol. 58, 1178-1187
38. Hollenberg, M. D. (2000) Mol. Pharmacol. 58, 1175-1177
39. Al-Ani, B., Wijesuriya, S. J., and Hollenberg, M. D. (2002) J. Pharmacol. Exp. Ther. 302, 1046-1054
40. Riewald, M., and Ruf, W. (March, 2005) J. Biol. Chem. 10.1074/jbc.M500747200
41. Tiruppathi, C., Malik, A. B., Del Vecchio, P. J., Keese, C. R., and Giaever, I. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 7919-7923
42. McCarthy, S. A., and Bicknell, R. (1992) J. Biol. Chem. 267, 21617-21622
43. Kim, J. A., Kang, Y. S., Lee, S. H., Lee, E. H., and Lee, Y. S. (2001) J. Cell. Biochem. 81, 93-101
44. Rajagopalan-Gupta, R. M., Rasenick, M. M., and Hunzicker-Dunn, M. (1997) Mol. Endocrinol. 11, 538-549
45. Harrell, P. C., McCawley, L. J., Fingleton, B., McIntyre, J. O., and Matrisian, L. M. (2005) Exp. Cell Res. 303, 308-320
46. Mohammed, F. F., Smookler, D. S., Taylor, S. E., Fingleton, B., Kassiri, Z., Sanchez, O. H., English, J. L., Matrisian, L. M., Au, B., Yeh, W. C., and Khokha, R. (2004) Nat. Genet. 36, 969-977
47. Ren, X. D., Kiosses, W. B., and Schwartz, M. A. (1999) EMBO J. 18, 578-585
48. Bohm, S. K., Kong, W., Bromme, D., Smeekens, S. P., Anderson, D. C., Connolly, A., Kahn, M., Nelken, N. A., Coughlin, S. R., Payan, D. G., and Bunnett, N. W. (1996) Biochem. J. 314, 1009-1016
49. Hollenberg, M. D., Saifeddine, M., Al-Ani, B., and Kawabata, A. (1997) Can. J. Physiol. Pharmacol. 75, 832-841
50. Faruqi, T. R., Weiss, E. J., Shapiro, M. J., Huang, W., and Coughlin, S. R. (2000) J. Biol. Chem. 275, 19728-19734
51. Cupit, L. D., Schmidt, V. A., and Bahou, W. F. (1999) Trends Cardiovasc. Med. 9, 42-48
52. Rasmussen, U. B., Cachet, C., Schlesinger, Y., Hanau, D., Ohlmann, P., Van Obberghen-Schilling, E., Pouyssegur, J., Cazenave, J. P., and Pavirani, A. (1993) J. Biol. Chem. 268, 14322-14328
53. Negrescu, E. V., deq Uintana, K. L., and Siess, W. (1995) J. Biol. Chem. 270, 1057-1061
54. Bauer, M., Retzer, M., Wilde, J. I., Maschberger, P., Essler, M., Aepfelbacher, M., Watson, S. P., and Siess, W. (1999) Blood 94, 1665-1672
55. Bauer, M., Maschberger, P., Quek, L., Briddon, S. J., Dash, D., Weiss, M., Watson, S. P., and Siess, W. (2001) Thromb. Haemostasis 85, 331-340
56. Otterdal, K., Pedersen, T. M., and Solum, N. O. (2001) Thromb. Res. 103, 411-420
57. Dorsam, R. T., Kim, S., Jin, J., and Kunapuli, S. P. (2002) J. Biol. Chem. 277, 47588-47595
58. Quinton, T. M., Murugappan, S., Kim, S., Jin, J., and Kunapuli, S. P. (2004) J Thromb. Haemostasis 2, 978-984
59. Lum, H., and Malik, A. B. (1996) Can. J. Physiol. Pharmacol. 74, 787-800
60. Gohla, A., Offermanns, S., Wilkie, T. M., and Schultz, G. (1999) J. Biol. Chem. 274, 17901-17907
61. Hart, M. J., Jiang, X., Kozasa, T., Roscoe, W., Singer, W. D., Gilman, A. G., Sternweis, P. C., Bollag, G., Sternweis, P. M., Sharma, S., elMasry, N., Qiu, R. G., McCabe, P., and Polakis, P. (1998) Science 280, 2112-2114
62. Cocks, T. M., and Moffatt, J. D. (2000) Trends Pharmacol Sci. 21, 103-108
63. Runnels, L. W., and Scarlata, S. F. (1998) Biochemistry 37, 15563-15574
64. Stam, J. C., Michiels, F., van der Kammen, R. A., Moolenaar, W. H., and Collard, J. G. (1998) EMBO J. 17, 4066-4074
65. Mehta, D., Ahmmed, G. U., Paria, B. C., Holinstat, M., Voyno-Yasenetskaya, T., Tiruppathi, C., Minshall, R. D., and Malik, A. B. (2003) J. Biol. Chem. 278, 33492-33500
66. Schaeffer, P., Riera, E., Dupuy, E., and Herbert, J. M. (1997) Biochem. Pharmacol. 53, 487-491
67. Herbert, J. M., Dupuy, E., Laplace, M. C., Zini, J. M., Bar Shavit, R., and Tobelem, G. (1994) Biochem. J. 303, 227-231
68. Sower, L. E., Payne, D. A., Meyers, R., and Carney, D. H. (1999) Exp. Cell Res. 247, 422-431
69. Seymour, M. L., Zaidi, N. F., Hollenberg, M. D., and MacNaughton, W. K. (2003) Am. J. Physiol. 284, C1185-C1192
70. Behzadian, M. A., Wang, X. L., Windsor, L. J., Ghaly, N., and Caldwell, R. B. (2001) Investig. Ophthalmol. Vis. Sci. 42, 853-859
71. Lafleur, M. A., Hollenberg, M. D., Atkinson, S. J., Knauper, V., Murphy, G., and Edwards, D. R. (2001) Biochem. J. 357, 107-115
72. Zhong, H., Wade, S. M., Woolf, P. J., Linderman, J. J., Traynor, J. R., and Neubig, R. R. (2003) J. Biol. Chem. 278, 7278-7284
73. Hofer, T., Venance, L., and Giaume, C. (2002) J. Neurosci. 22, 4850-4859
74. De Young, G. W., and Keizer, J. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 9895-9899
75. Lemon, G., Gibson, W. G., and Bennett, M. R. (2003) J. Theor. Biol. 223, 93-111
76. Nystedt, S., Emilsson, K., Larsson, A. K., Strombeck, B., and Sundelin, J. (1995) Eur. J. Biochem. 232, 84-89
77. Klarenbach, S. W., Chipiuk, A., Nelson, R. C., Hollenberg, M. D., and Murray, A. G. (2003) Circ. Res. 92, 272-278
78. Stull, J. T., Lin, P. J., Krueger, J. K., Trewhella, J., and Zhi, G. (1998) Acta Physiol Scand. 164, 471-482
79. Adelstein, R. S., Conti, M. A., and Pato, M. D. (1980) Ann. N. Y. Acad. Sci. 356, 142-150
80. Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., Iwamatsu, A., and Kaibuchi, K. (1996) Science 273, 245-248
81. Majumdar, M., Seasholtz, T. M., Goldstein, D., de Lanerolle, P., and Brown, J. H. (1998) J. Biol. Chem. 273, 10099-10106
82. Majumdar, M., Seasholtz, T. M., Buckmaster, C., Toksoz, D., and Brown, J. H. (1999) J. Biol. Chem. 274, 26815-26821
83. Preissner, K. T., Nawroth, P. P., and Kanse, S. M. (2000) J. Pathol. 190, 360-372
84. Lafay, M., Laguna, R., Le Bonniec, B. F., Lasne, D., Aiach, M., and Rendu, F. (1998) Thromb. Haemostasia 79, 848-852
85. Maruyama, I., and Shigeta, K. (1994) Rinsho Ketsueki 35, 234-237
86. Al-Ani, B., Hansen, K. K., and Hollenberg, M. D. (2004) Mol. Pharmacol. 65, 149-156
87. Cuatrecasas, P., and Hollenberg, M. D. (1976) Adv. Protein Chem. 30, 251-451
88. de Haen, C. (1976) J. Theor. Biol. 58, 383-400
89. Boeynaems, J. M., and Dumont, J. E. (1977) Mol. Cell. Endocrinol. 7, 33-47
90. Seifert, R., Wenzel-Seifert, K., Gether, U., and Kobilka, B. K. (2001) J. Pharmacol. Exp. Ther. 297, 1218-1226
91. Peleg, G., Ghanouni, P., Kobilka, B. K., and Zare, R. N. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 8469-8474
92. Swaminath, G., Xiang, Y., Lee, T. W., Steenhuis, J., Parnot, C., and Kobilka, B. K. (2004) J. Biol. Chem. 279, 686-691
93. Gay, E. A., Urban, J. D., Nichols, D. E., Oxford, G. S., and Mailman, R. B. (2004) Mol. Pharmacol. 66, 97-105
94. Hains, M. D., Siderovski, D. P., and Harden, T. K. (2004) Methods Enzymol. 389, 71-88
95. Bhalla, U. S., and Iyengar, R. (2001) Novartis Found. Symp. 239, 4-15, 45-51
96. Verin, A. D., Patterson, C. E., Day, M. A., and Garcia, J. G. (1995) Am. J. Physiol. 269, L99-L108
97. Hao, N., Yildirim, N., Wang, Y., Elston, T. C., and Dohlman, H. G. (2003) J. Biol. Chem. 278, 46506-46515
98. Ishida, A., Shigeri, Y., Taniguchi, T., and Kameshita, I. (2003) Pharmacol. Ther. 100, 291-305
99. Pitcher, J. A., Freedman, N. J., and Lefkowitz, R. J. (1998) Annu. Rev. Biochem. 67, 653-692
100. Ishii, K., Hein, L., Kobilka, B., and Coughlin, S. R. (1993) J. Biol. Chem. 268, 9780-9786
101. Hansen, K. K., Saifeddine, M., and Hollenberg, M. D. (2004) Immunology 112, 183-190
102. Kruse, H. J., Mayerhofer, C., Siess, W., and Weber, P. C. (1995) Am. J. Physiol. 268, C36-C44
103. Faraut, B., Barbier, J., Ravel-Chapuis, A., Doyennette, M. A., Jandrot-Perrus, M., Verdiere-Sahuque, M., Schaeffer, L., Koenig, J., and Hantai, D. (2003) J. Cell. Physiol. 196, 105-112
104. Ahn, H.-S., Foster, C., Boykow, G., Arik, L., Smith-Torhan, A., Hesk, D., and Chatterjee, M. (1997) Mol. Pharmacol. 51, 350-356
105. Parry, M. A., Myles, T., Tschopp, J., and Stone, S. R. (1996) Biochem. J. 320, 335-341
106. Goldsack, N. R., Chambers, R. C., Dabbagh, K., and Laurent, G. J. (1998) Int. J. Biochem. Cell Biol. 30, 641-646
107. Biddlecome, G. H., Berstein, G., and Ross, E. M. (1996) J. Biol. Chem. 271, 7999-8007
108. Mukhopadhyay, S., and Ross, E. M. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 9539-9544
109. Ross, E. M., and Wilkie, T. M. (2000) Annu. Rev. Biochem. 69, 795-827
110. Blank, J., Brattain, K., and Exton, J. (1992) J. Biol. Chem. 267, 23069-23075
111. Singer, W., Miller, R., and Sternweis, P. (1994) J. Biol. Chem. 269, 19796-19802
112. Yamamoto, K., Kondo, J., Hishida, T., Teranishi, Y., and Takai, Y. (1988) J. Biol. Chem. 263, 9926-9932
113. Tiruppathi, C., Lum, H., Andersen, T. T., Fenton, J. W., Jr., and Malik, A. B. (1992) Am. J. Physiol. 263, L595-C601