Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species

Biochemical Journal

Volumn 357, Issue 1, 2001, Pages 107-115

  Lafleur, M A ^a   Hollenberg, M D ^a   Atkinson, S J ^a   Knauper V ^a   Murphy, G ^a   Edwards, D R ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Angiogenesis; Gelatinase A; Proteinase; Proteinase inhibitors; Thrombosis

Indexed keywords

BIODIVERSITY; BIOLOGICAL MEMBRANES; CATALYSIS; CELL CULTURE; ENZYME INHIBITION;

NEOVASCULARIZATION;

BIOCHEMISTRY;

1,10 PHENANTHROLINE; CONCANAVALIN A; EDETIC ACID; ENZYME PRECURSOR; G PROTEIN COUPLED RECEPTOR; GELATINASE A; HIRUDIN; HYDROXAMIC ACID; LEUPEPTIN; MESSENGER RNA; METALLOPROTEINASE INHIBITOR; NEUROTRANSMITTER RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PROMATRIX METALLOPROTEINASE 2; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 4; THROMBIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 4; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MEMBRANE BINDING; NEOVASCULARIZATION (PATHOLOGY); PRIORITY JOURNAL; PROTEIN DEGRADATION; THROMBOGENESIS; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

CELLS, CULTURED; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ENZYME PRECURSORS; GELATINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; KINETICS; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; METALLOENDOPEPTIDASES; MOLECULAR WEIGHT; OLIGOPEPTIDES; PROTEASE INHIBITORS; RECEPTORS, THROMBIN; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TETRADECANOYLPHORBOL ACETATE; THROMBIN; TIME FACTORS; TRANSCRIPTION, GENETIC; UMBILICAL VEINS;

EID: 0035396863     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3570107     Document Type: Article

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