Tethered ligand-derived peptides of proteinase-activated receptor 3 (PAR3) activate PAR1 and PAR2 in Jurkat T cells

Immunology

Volumn 112, Issue 2, 2004, Pages 183-190

  Hansen, Kristina K ^a   Saifeddine, Mahmoud ^a   Hollenberg, Morley D ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Enzymes: proteases, proteinases; Proteins: peptides, tethered ligands, VAV 1; Signalling: calcium, PARs, tyrosine phosphorylation; T cells: Jurkat cells

Indexed keywords

LIGAND; PEPTIDE DERIVATIVE; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; SERYLLEUCYLISOLEUCYLGLYCYLLYSYLVALYLASPARTYLGLYCYLTHREONYLSERINE; SERYLPHENYLALANYLLEUCYLLEUCYLARGINYLASPARAGINYLPROLYLASPARAGINYLASPARTYL LYS INE; THREONYLPHENYLALANYLARGINYLGLYCYLALANYLPROLYLPROLYLASPARAGINYLSERYLPHENY LAL ANINE; THROMBIN; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; CALCIUM SIGNALING; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; JURKAT CELLS; LIGANDS; MICE; PEPTIDE FRAGMENTS; RECEPTOR, PAR-1; RECEPTOR, PAR-2; RECEPTORS, THROMBIN; T-LYMPHOCYTES; TRYPSIN;

EID: 2542609847     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2004.01870.x     Document Type: Article

References (26)

1. Hollenberg MD, Compton SJ. International Union of Pharmacology. XXVIII. Proteinase-activated receptors. Pharmacol Rev 2002; 54:203-17.
2. Déry O, Corvera CU, Steinhoff M, Bunnett NW. Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am J Physiol 1998; 274:C1429-52.
3. Coughlin SR. Thrombin signalling and protease-activated receptors. Nature 2000; 407:258-64.
4. Blackhart BD, Emilsson K, Nguyen D, Teng W, Martelli AJ, Nystedt S, Sundelin J, Scarborough RM. Ligand cross-reactivity within the protease-activated receptor family. J Biol Chem 1996; 271:16466-71.
5. Hollenberg MD, Saifeddine M, Al-Ani B, Kawabata A. Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides. Can J Physiol Pharmacol 1997; 75:832-41.
6. 1-targeted ligands. J Pharmacol Exper Ther 1999; 288:358-70.
7. Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin SR. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 1997; 386:502-6.
8. 4 activation by thrombin. Nature 2000; 404:609-13.
9. Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin SR. Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature 2001; 413:74-8.
10. Hung DT, Vu TK, Wheaton VI, Ishii K, Coughlin SR. Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation. J Clin Invest 1992; 89:1350-3.
11. Brass LF, Vassallo RR Jr, Belmonte E, Ahuja M, Cichowski K, Hoxie JA. Structure and function of the human platelet thrombin receptor: studies using monoclonal antibodies directed against a defined domain within the receptor N terminus. J Biol Chem 1992; 267:13795-8.
12. Tordai A, Fenton JW II, Andersen T, Gelfand EW. Functional thrombin receptors on human T lymphoblastoid cells. J Immunol 1993; 150:4876-86.
13. Mari B, Imbert V, Belhacene N et al. Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production. J Biol Chem 1994; 269:8517-23.
14. 2+ mobilization in human T cell lines through interaction with different protease-activated receptors. FASEB J 1996; 10:309-16.
15. Bar-Shavit R, Maoz M, Yongjun Y, Groysman M, Dekel I, Katzav S. Signalling pathways induced by protease-activated receptors and integrins in T cells. Immunology 2002; 105: 35-46.
16. Fischer KD, Tedford K, Penninger JM. Vav links antigen-receptor signaling to the actin cytoskeleton. Semin Immunol 1998; 10:317-27.
17. Turner M, Billadeau DD. VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nat Rev Immunol 2002; 2:476-86.
18. 2) by human mast cell tryptase. Br J Pharmacol 2001; 134:705-18.
19. Saifeddine M, Al-Ani B, Cheng C, Wang L, Hollenberg MD. Rat proteinase-activated receptor-2 (PAR-2). cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. Br J Pharmacol 1996; 118:521-30.
20. 2-derived peptide ligands. J Pharmacol Exper Ther 1999; 290:753-60.
21. Minta A, Kao JP, Tsien RY. Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores. J Biol Chem 1989; 264:8171-8.
22. Kao JP, Harootunian AT, Tsien RY. Photochemically generated cytosolic calcium pulses and their detection by fluo-3. J Biol Chem 1989; 264:8179-84.
23. Al-Ani B, Saifeddine M, Kawabata A, Hollenberg MD. Proteinase activated receptor 2: role of extracellular loop 2 for ligand-mediated activation. Br J Pharmacol 1999; 128:1105-13.
24. Compton SJ, Cairns JA, Palmer KJ, Al-Ani B, Hollenberg MD, Walls AF. A polymorphic protease-activated receptor 2 (PAR2) displaying reduced sensitivity to trypsin and differential responses to PAR agonists. J Biol Chem 2000; 275:39207-12.
25. Kahn ML, Zheng YW, Huang W et al. A dual thrombin receptor system for platelet activation. Nature 1998; 394:690-4.
26. Vergnolle N, Wallace JL, Bunnett NW, Hollenberg MD. Protease-activated receptors in inflammation, neuronal signaling and pain. Trends Pharmacol Sci 2001; 22:146-52.