Myosin light chain kinase: Functional domains and structural motifs

Acta Physiologica Scandinavica

Volumn 164, Issue 4, 1998, Pages 471-482

  Stull, James T ^a   Lin, P J ^a   Krueger, J K ^b   Trewhella, J ^b   Zhi, G ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

Actin; Calcium; Calmodulin; Kinase; Myosin light chain kinase; Smooth muscle

Indexed keywords

CALMODULIN; MYOSIN ADENOSINE TRIPHOSPHATASE; MYOSIN LIGHT CHAIN KINASE; PROTEIN KINASE;

AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CONFERENCE PAPER; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; MYOFILAMENT; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; STRUCTURE ACTIVITY RELATION; THIN FILAMENT;

EID: 0032436268     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-201X.1998.tb10699.x     Document Type: Conference Paper

References (69)

1. Adelstein, R.S. & Klee, C.B. 1981. Purification and characterization of smooth muscle myosin light chain kinase. J Biol Chem 256, 7501-7509.
2. Babu, Y.S., Bugg, C.E. & Cook, W.J. 1988. Structure of calmodulin refined at 2.2 A resolution. J Mol Biol 204, 191-204.
3. Babu, Y.S., Sack, J.S., Greenhough, T.J., Bugg, C.E., Means, A.R. & Cook, W.J. 1985. Three-dimensional structure of calmodulin. Nature 315, 37-40.
4. Barth, A., Martin, S.R. & Bayley, P.M. 1998. Specificity and symmetry in the interaction of calmodulin domains with the skeletal muscle myosin light chain kinase target sequence. J Biol Chem 273, 2174-2181.
5. Bayley, P.M., Findlay, W.A. & Martin, S.R. 1996. Target recognition by calmodulin: Dissecting the kinetics and affinity of interaction using short peptide sequences. Protein: Sci 5, 1215-1228.
6. Collinge, M., Matrisian, P.E., Zimmer, W.E., et al. 1992. Structure and expression of a calcium-binding protein gene contained within a calmodulin-regulated protein kinase gene. Mol Cell Biol 12, 2359-2371.
7. Findlay, W.A., Gradwell, M.J. & Bayley, P.M. 1995. Role of the N-terminal region of the skeletal muscle myosin light chain kinase target sequence in its interaction with calmodulin. Protein Sci 4, 2375-2382.
8. Finn, B.E., Evenas, J., Waltho, J.P., Thulin, E. & Forsén, S. 1995. Calcium-induced structural changes and domain autonomy in calmodulin. Nature Structural Biol 2, 777-783.
9. Fisher, S.A. & Ikebe, M. 1995. Developmental and tissue distribution of expression of nonmuscle and smooth muscle isoforms of myosin light chain kinase. Biochem Biophys Res Commun 217, 696-703.
10. Fitzsimons, D.P., Herring, B.P., Stull, J.T. & Gallagher, P.J. 1992. Identification of basic residues involved in activation and calmodulin binding of rabbit smooth muscle myosin light chain kinase. J Biol Chem 267, 23903-23909.
11. Gallagher, P.J. & Herring, B.P. 1991. The C-terminus of the smooth muscle myosin light chain kinase is expressed as an independent protein, telokin. J Biol Chem 266, 23945-23952.
12. Gallagher, P.J., Herring, B.P., Griffin, S.A. & Stull, J.T. 1991. Molecular characterization of a mammalian smooth muscle myosin light chain kinase. J Biol Chem 266, 23936-23944.
13. Gallagher, P.J., Herring, B.P. & Stull, J.T. 1997. Myosin light chain kinases (review). J Muscle Res Cell Motil 18, 1-16.
14. Gallagher, P.J., Herring, B.P., Trafny, A., Sowadski, J. & Stull, J.T. 1994. A molecular, mechanism for autoinhibition of myosin light chain kinases. J Biol Chem 269, 26578-26582.
15. Gao, Z.-H., Zhi, G., Herring, B.P., et al. 1995. Photoaffinity labeling of a peptide substrate to myosin light chain kinase. J Biol Chem 270, 10125-10135.
16. George, S.E., VanBerkum, M.F., Ono, T., et al. 1990. Chimeric calmodulin-cardiac troponin C proteins differentially activate calmodulin target enzymes. J Biol Chem 265, 9228-9235.
17. Goldberg, J., Nairn, A.C. & Kuriyan, J. 1996. Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I. Cell 84, 887.
18. Hartshorne, D.J. 1987. Biochemistry of the contractile process in smooth muscle. In: L.R. Johnson (ed) Physiology of the Gastrointestinal Tract, pp. 423-482. Raven Press, New York.
19. Hayakawa, K., Okagaki, T., Higashi-Fujime, S. & Kohama, K. 1994. Bundling of actin filaments by myosin light chain kinase from smooth muscle. Biochem Biopbys Res Commun 199, 786-791.
20. Heidorn, D.B., Seeger, P.A., Rokop, S.K., et al. 1989. Changes in the structure of calmodulin induced by a peptide based on the calmodulin-binding domain of myosin light chain kinase. Biochemistry 28, 6757-6764.
21. Heidorn, D.B. & Trewhella, J. 1988. Comparison of the crystal and solution structures of calmodulin and troponin C. Biochemistry 27, 909-915.
22. Herring, B. P. & Smith, A.F. 1996. Telokin expression is mediated by a smooth muscle cell-specific promoter. Am J Physiol 39, C1656-C1665.
23. Holden, H.M., Ito, M., Hartshorne, D.J. & Rayment, I. 1992. X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2,8 Å resolution. J Mol Biol 227, 840-851.
24. Hu, S.-H., Parker, M.W., Lel, J.Y., et al. 1994. Insights into autoregulation from the crystal structure of twitchin kinase. Nature 369, 581-584.
25. 2-terminal domain of the regulatory light chain on the regulation of smooth muscle myosin. J Biol Chem 269, 28173-28180.
26. Ikura, M., Clore, G.M., Gronenborn, A.M., et al. 1992. Solution structure of a calmodulin-target peptide complex by multidimensional NMR. Science 256, 632-638.
27. Ito, M., Pierce, P.R., Allen, R.E. & Hartshorne, D.J. 1989. Effect of monoclonal antibodies on the properties of smooth muscle myosin. Biochemistry 28, 5567-5572.
28. Kamm, K.H. & Stull, J.T. 1985. Myosin phosphorylation, force, and maximal shortening velocity in neurally stimulated tracheal smooth muscle. Am J Physiol 249, C238-C247.
29. Kanoh, S., Ito, M., Niwa, E., et al. 1993. Actin-binding peptide from smooth muscle myosin light chain kinase. Biochemistry 32, 8902-8907.
30. Kemp, B.E. & Pearson, R.B. 1991. Intrasteric regulation of protein kinases and phosphatases. Biochim Biopbys Acta 1094, 67-76.
31. Kennelly, P.J. & Krebs, E.G. 1991. Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J Biol Chem 266, 15555-15558.
32. Kennelly, P.J., Leng, J. & Marchand, P. 1992. The MgATP-binding site on chicken gizzard myosin light chain kinase remains open and functionally competent during the calmodulin-dependent activation-inactivation cycle of the enzyme. Biochemistry 31, 5394-5399.
33. Knighton, D.R., Pearson, R.B., Sowadski, J.M., et al. 1992. Structural basis of the intrasteric regulation of myosin light chain kinases. Science 258, 130-135.
34. Knighton, D.R., Zheng, J.H., Ten Eyck, L.F., Xuong, N.H., Taylor, S.S. & Sowadski, J.M. 1991. Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science 253, 414-420.
35. Krueger, J.K., Olah, G.A., Rokop, S.E., Zhi, G., Stull, J.T. & Trewhella, J. 1997. Structures of calmodulin and a functional myosin light chain kinase in the activated complex: a neutron scattering study. Biochemistry 36, 6017-6023.
36. Krueger, J.K., Padre, R.C. & Stull, J.T. 1995. Intrasteric regulation of myosin light chain kinase. J Biol Chem 270, 16848-16853.
37. Kuboniwa, H., Tjandra, N., Grzesiek, S., Ren, H., Klee, C.B. & Bax, A. 1995. Solution structure of calcium-free calmodulin. Nature Structural Biol 2, 768-776.
38. Lin, P.-J., Luby-Phelps, K. & Stull, J.T. 1997. Binding of myosin light chain kinase to cellular actin-myosin filaments. J Biol Chem 212, 7412-7420.
39. Matsushima, S., Huang, Y.P., Dudas, C.V., Guerriero, V. Jr. & Hartshorne, D.J. 1994. Mutants of smooth muscle myosin light chain kinase at tryptophan 800. Biochem Biophys Res Commun 202, 1329-1336.
40. Meador, W.E., Means, A.R. & Quiocho, F.A. 1992. Target enzyme recognition by calmodulin: 2.4 Å structure of a calmodulin-peptide complex. Science 257, 1251-1255.
41. 1 calmodulin on its target proteins. Biochim Biophys Acta 845, 533-539.
42. Olah, G.A., Mitchell, R.W., Sosnoski, D., Walsh, D.A. & Trewhella, J. 1993. Solution structure of the cAMP-dependent protein kinase catalytic subunit and its contraction upon binding the protein kinase inhibitor peptide. Biochemistry 32, 3649-3657.
43. Olsen, D.B. & Eckstein, F. 1990. High-efficiency oligonucleotide-directed plasmid mutagenesis. Prof Natl Acad Sci USA 87, 1451-1455.
44. 2+ binding and implications for kinase activation. Protein Sci 6, 794-807.
45. Persechini, A., Gansz, K.J. & Paresi, R.J. 1996. Activation of myosin light chain kinase and nitric oxide synthase activities by engineered calmodulins with duplicated or exchanged EF hand pairs. Biochemistry 35, 224-228.
46. Persechini, A., McMillan, K. & Leakey, P. 1994. Activation of myosin light chain kinase and nitric oxide synthase activities by calmodulin fragments. J Biol Chem 269, 16148-16154.
47. Potier, M.-C., Chelot, E., Pekarsky, Y., Gardiner, K., Rossier, J. & Turnell, W.G. 1995. The human myosin light chain kinase (MLCK) from hippocampus: Cloning, sequencing, expression, and localization to 3qcen-q21. Genomics 29, 562-570.
48. Rüegg, J.C. 1986. Calcium in Muscle Activation. Springer, Berlin, 1-300
49. Rüegg, J.C., Pfitzer, G., Zimmer, M. & Hofmann, F. 1984. The calmodulin fraction responsible for contraction in an intestinal smooth muscle. FEBS Lett 170, 383-386.
50. Sato, M., Ye, L.-H. & Kohama, K. 1995. Myosin light chain kinase from vascular smooth muscle inhibits the ATP-dependent interaction between actin and myosin by binding to actin. J Biol Chem 118, 1-3.
51. Sellers, J.R. & Pato, M.D. 1984. The binding of smooth muscle myosin light chain kinase and phosphatases to actin and myosin. J Biol Chem 259, 7740-7746.
52. Shirinsky, V.P., Vorotnikov, A.V., Birukov, K.G., et al. 1993. A kinase-related protein stabilizes unphosphorylated smooth muscle myosin minifilaments in the presence of ATP. J Biol Chem 268, 16578-16583.
53. Somlyo, A.P., Devine, C.F. & Somlyo, A.V. 1973. Filament organization in vertebrate smooth muscle. Philos Trans R Soc Lond 265, 223-229.
54. Somlyo, A.P. & Somlyo, A.V. 1994. Signal transducrion and regulation in smooth muscle. Nature 372, 231-236.
55. Strynadka, N.C. & James, M.N. 1988. Two trifluoperazine-binding sites on calmodulin predicted from comparative molecular modeling with troponin-C. Proteins 3, 1-17.
56. Stull, J.T., Nunnally, M.H. & Michnoff, C.H. 1986. Calmodulin-dependent protein kinases. In: E.G. Krebs & P.D. Boyer (eds), The Enzymes, pp. 113-166, Academic Press, New York.
57. Su, Z., Fan, D. & George, S.E. 1994. Role of domain 3 of calmodulin in activation of calmodulin-stimulated phosphodiesterase and smooth muscle myosin light chain kinase. J Biol Chem 269, 16761-16765.
58. Sweeney, H.L., Bowman, B.F. & Stull, J.T. 1993. Myosin light chain phosphorvlation in vertebrate striated muscle: regulation and function. Am J Physiol 264, C1085-C1095.
59. Tanaka, M., Ikebe, R., Matsuura, M. & Ikebe, M. 1995. Pseudosubstrate sequence may not be critical for autoinhibition of smooth muscle myosin light chain kinase. EMBO J 14, 2839-2846.
60. 2+ sensitivity of light chain phosphorylation within smooth muscle cells. J Biol Chem 269, 9912-9920.
61. Trinick, J. 1994. Titin and nehulin: protein rulers in muscle? TBS 19, 405-409.
62. VanBerkum, M.F. & Means, A.R. 1991. Three amino acid substitutions in domain I or calmodulin prevent the activation of chicken smooth muscle myosin light chain kinase. J Biol Chem 266, 21488-21495.
63. Watterson, D.M., Collinge, M., Lukas, T.J., et al. 1995. Multiple gene products are produced from a novel protein kinase transcription region. FEBS Lett 373, 217-220.
64. Wu, Y.Y., Haystead, T.A.J., Nakamura, A., Somlyo, A.V. & Somlyo, A.P. 1998. Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin. J Biol Chem 273, 11362-11369.
65. Ye, L.-H., Hayakawa, K., Kishi, H., et al. 1997. The structure and function of the actin-binding domain of myosin light chain kinase of smooth muscle. J Biol Chem 272, 32182-32189.
66. Zhang, M., Tanaka, T. & Ikura, M. 1995. Calcium-induced contornvational transition revealed by the solution structure of APO calmodulin. Nature Structural Biol 2, 758-767.
67. 2+ /calmodulin-dependent protein kinases. J Biol Chem 273, 8951-8957.
68. Zhi, G., Herring, B.P. & Stull, J.T. 1994. Structural requirements for phosphorylation of myosin regulatory light chain from smooth muscle. J Biol Chem 269, 24723-24727.
69. Zimmerman, B., Somloy, A.V., Ellis-Davies, G.C.R., Kaplan, J.H. & Somlyo, A.P. 1995. Kinetics of prephosphorylation reactions and myosin light chain phosphorylation in smooth muscle. Flash photolysis studies with caged, calcium and caged ATP. J Biol Chem 270, 23966-23974.