LEF1-mediated regulation of delta-like1 links Wnt and Notch signaling in somitogenesis

Genes and Development

Volumn 18, Issue 22, 2004, Pages 2718-2723

  Galceran, Juan ^a,c   Sustmann, Claudio ^a,b   Hsu, Shu Chi ^a   Folberth, Stephanie ^a,b   Grosschedl, Rudolf ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^c INSTITUTO DE NEUROCIENCIAS   (Spain)

Author keywords

Dll1; LEF1 TCF; Notch; Somitogenesis; Wnt

Indexed keywords

BETA GALACTOSIDASE; LYMPHOID ENHANCER FACTOR 1; NOTCH RECEPTOR; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DELTA LIKE1 GENE; EMBRYO; EMBRYO PATTERN FORMATION; FIBROBLAST; GENE; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENE TARGETING; IN VITRO STUDY; IN VIVO STUDY; MESODERM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SOMITE; SOMITOGENESIS; TRANSGENE; VERTEBRATE;

ANIMALS; BETA CATENIN; BETA-GALACTOSIDASE; BODY PATTERNING; CELLS, CULTURED; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; EMBRYO; FIBROBLASTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; HUMANS; LAC OPERON; LYMPHOID ENHANCER-BINDING FACTOR 1; MEMBRANE PROTEINS; MESODERM; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTATION; NIH 3T3 CELLS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; SOMITES; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; WNT PROTEINS;

ANIMALIA; VERTEBRATA;

EID: 8644219672     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1249504     Document Type: Article

References (37)

1. Adams, R.H., Betz, H., and Puschel, A.W. 1996. A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis. Mech. Dev. 57: 33-45.
2. Aulehla, A., Wehrle, C., Brand-Saberi, B., Kemler, R., Gossler, A., Kanzler, B., and Herrmann, B.G. 2003. Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev. Cell 4: 395-406.
3. Beckers, J., Caron, A., Hrabé de Angelis, M., Hans, S., Campos-Ortega, J. A., and Gossler, A. 2000. Distinct regulatory elements direct Delta1 expression in the nervous system and paraxial mesoderm of transgenic mice. Mech. Dev. 95: 23-34.
4. Biben, C., Stanley, E., Fabri, L., Kotecha, S., Rhinn, M., Drinkwater, C., Lab, M., Wang, C.C. Nash, A., Hilton, D., et al. 1998. Murine cerberus homologue mCer-1: A candidate anterior patterning molecule. Dev. Biol. 194: 135-151.
5. Conlon, R.A., Reaume, A.G., and Rossant, J. 1995. Notch1 is required for the coordinate segmentation of somites. Development 121: 1533-1545.
6. Cordes, R., Schuster-Gossler, K., Serth, K., and Gossler, A. 2003. Specification of vertebral identity is coupled to Notch signaling and the segmentation clock. Development 131: 1221-1233.
7. del Barco Barrantes, I., Elia, A.J., Wunsch, K., Hrabe de Angelis, M., Mak, T.W., Rossant, R., Conlon, R.A., Gossler, A., and de la Pompa, J.L. 1999. Interaction between L-fringe and Notch signaling in the regulation of boundary formation and posterior identity in the presomitic mesoderm of the mouse. Curr. Biol. 9: 470-480.
8. Evrard, Y.A., Luri, Y., Aulehla, A., Gan, L., and Johnson, R.L. 1998. Lunatic fringe is an essential mediator of somite segmentation and patterning. Nature 394: 377-381.
9. Frank, S.R., Schroeder, M., Fernandez, P., Taubert, S. and Amati, B. 2001. Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes & Dev. 15: 2069-2082.
10. -/- mice. Genes & Dev. 13: 709-717.
11. Galceran, J., Miyashita-Lin, E.M., Devaney, E., Rubenstein, J.L.R., and Grosschedl, R. 2000. Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF-1. Development 127: 469-482.
12. Galceran, J., Hsu, S.-C., and Grosschedl, R. 2001. Rescue of a Wnt mutation by an activated form of LEF-1: Regulation of maintenance but not initiation of Brachyury expression. Proc. Natl. Acad. Sci. 98: 8668-8673.
13. Greco, T.L., Takada, S., Newhouse, M.M., McMahon, J.A., McMahon, A.P., and Camper, S.A. 1996. Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes & Dev. 10: 313-324.
14. Hofmann, M., Schuster-Gossler, K., Watabe-Rudolph, M., Aulehla, A., Herrmann, E.G., and Gossler, A. 2004. WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos. Genes & Dev. (this issue).
15. Hrabe de Angelis, M., Mc Intyre, J., and Gossler, A. 1997. Maintenance of somite borders in mice requires the Delta homologue Dll1. Nature 386: 717-721.
16. Hsu, S.-C., Galceran, J., and Grosschedl, R. 1998. Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with β-catenin. Mol. Cell. Biol. 18: 4807-4818.
17. Ikeya, M. and Takada, S. 2001. Wnt3a is required for somite specification along the anterioposterior axis of the mouse embryo and for the regulation of cdx-1 expression. Mech. Dev. 103: 27-33.
18. Kothary, R., Clapoff, S., Darling, S., Perry, M. D., Moran, L.A., and Rossant, J. 1989. Inducible expression of an hsp68-lacZ hybrid gene in transgenic mice. Development 105: 707-714.
19. Kratochwil, K., Galceran, J., Tontsch, S., Roth, W., and Grosschedl, R. 2002. FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1/mice. Genes & Dev. 16: 3173-3185.
20. Labbe, E., Letamendia, A., and Attisano, L. 2000. Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-β and wnt pathways. Proc. Natl. Acad. Sci. 97: 8358-8363.
21. Neidhardt, L., Kispert, A., and Herrmann, B. 1997. A mouse gene of the paired-related homeobox class expressed in the caudal somite compartment and in the developing vertebral column, kidney and nervous system. Dev. Genes Evol 207: 330-339.
22. Nishita, M., Hashimoto, M.K., Ogata, S., Laurent, M.N., Ueno, N., Shibuya, H., and Cho, K.W. 2000. Interaction between Wnt and TGF-β signalling pathways during formation of Spemann's organizer. Nature 403: 781-785.
23. No, D., Yao, T.P., and Evans, R.M. 1996. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc. Natl. Acad. Sci. 93: 3346-3351.
24. Oosterwegel, M., van de Wetering, M., Timmerman, J., Kruisbeek, A., Destree, O., Meijlink, F., and Clevers, H. 1993. Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis. Development 118: 439-448.
25. Pourquié, O. 2001. Vertebrate somitogenesis. Annu. Rev. Cell Dev. Biol. 17: 311-350.
26. -. 2003. The segmentation clock: Converting embryonic time into spatial pattern. Science 301: 328-330.
27. Saga, Y. and Takeda, H. 2001. The making of the somite: Molecular events in vertebrate segmentation. Nat. Rev. Genet. 2: 835-845.
28. Saga, Y., Hata, N., Koseki, H., and Taketo, M.M. 1997. Mesp2: A novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes & Dev. 11: 1827-1839.
29. Takada, S., Stark, K.L., Shea, M.J., Vassileva, G., McMahon, J.A., and McMahon, A.P. 1994. Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes & Dev. 8: 103-128.
30. Takahashi, Y., Inoue, T., Gossler, A., and Saga, Y. 2003. Feedback loops comprising DII1, DII3, and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites. Development 130: 4259-4268.
31. van Genderen, C., Okamura, R., Fariñas, I., Quo, R., Parslow, T., Bruhn, L., and Grosschedl, R. 1994. Development of several organs that require inductive epithelial mesenchymal interactions is impaired in LEF-1 deficient mice. Genes & Dev. 8: 2691-2703.
32. van Noort, M. and devers, H. 2002. TCF transcription factors, mediators of Wnt-signaling in development and cancer. Dev. Biol. 244: 1-8.
33. Verbeek, S., Izon, D., Hofhuis, F., Robanus-Maandag, E., te Riele, H., van de Wetering, M., Oosterwegel, M., Wilson, A., MacDonald, H.R., and Clevers, H. 1995. An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature 374: 70-74.
34. White, P.D., Farkas, D.R., McFadden, E.E., and Chapman, D.L. 2003. Defective somite patterning in mouse embryos with reduced levels of Tbx6. Development 120: 1681-1690.
35. Yamaguchi, T.P., Takada, S., Yoshikawa, Y., Wu, N., and McMahon, A.P. 1999. T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes & Dev. 13: 3185-3190.
36. Yoshikawa, Y., Fujimori, T., McMahon, A.P., and Takada, S. 1997. Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. Dev. Biol. 183: 234-242.
37. Zhang, N. and Gridley, T. 1998. Defects in somite formation in lunatic fringe-deficient mice. Nature 394: 374-377.