Deletion of β-catenin impairs T cell development

Nature Immunology

Volumn 4, Issue 12, 2003, Pages 1177-1182

  Xu, Youyuan ^a   Banerjee, Daliya ^b   Huelsken, Joerg ^c   Birchmeier, Walter ^c   Sen, Jyoti Misra ^a,d  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BRANDEIS UNIVERSITY   (United States)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CD3 ANTIGEN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ARTICLE; CELL MATURATION; CONTROLLED STUDY; GENE DELETION; MICROENVIRONMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROLYMPHOCYTE; SIGNAL TRANSDUCTION; SPLEEN LYMPHOCYTE; T LYMPHOCYTE; THYMOCYTE; THYMUS; TISSUE SPECIFICITY;

ANIMALS; BETA CATENIN; CELL DIFFERENTIATION; CYTOSKELETAL PROTEINS; FLOW CYTOMETRY; GENE DELETION; IMMUNE SYSTEM; IMMUNITY, CELLULAR; MICE; MICE, TRANSGENIC; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL; SPLEEN; T-LYMPHOCYTES; TRANS-ACTIVATORS;

EID: 0346121607     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni1008     Document Type: Article

References (35)

1. Sen, J. Signals for T cell maturation Cell. Mol. Biol. 47, 197-215 (2001).
2. Anderson, G. & Jenkinson, E.J. Lymphostromal interactions in thymic development and function. Nat. Res. Immunol. 1, 31-40 (2001).
3. Petrie, H.T. Role of thymic structure and stromal composition in steady-state postnatal T cell production. Immunol. Rev. 189, 8-19 (2002).
4. Borowski, C. et al. On the brink of becoming a T cell, Curr. Opin. Immunol. 2, 200-206 (2002).
5. Hoffman, E.S. et al. Productive T-cell receptor β-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev. 10, 948-962 (1996).
6. Moore, T.A. & Zlotnik, A.T. T cell lineage commitment and cytokine responses of thymic progenitors. Blood 86, 1850-1860 (1995).
7. Di Santo, J.P. et al. Common cytokine receptor γ chain and the pre-TCR provide independent but critically overlapping signals in early αβ T cell development. J. Exp. Med. 189, 563-574 (1999).
8. Mulroy, T.M., McMahon, J.A., Burakoff, S.J., McMahon, A.P. & Sen, J. Wnt-1 and Wnt-4 regulate thymic cellularity. Eur. J. Immunol. 32, 967-971 (2002).
9. Petrie, H.T., Tourigny, M., Burtrum, D.B. & Livac, F. Precursor thymocyte proliferation and differentiation are controlled by signals unrelated to the pre-TCR. J. Immunol. 165, 3094-3098 (2000).
10. Singer, A. New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision. Curr. Opin. Immunol. 2, 207-215 (2002).
11. Germain, R.N. T-cell development and CD4-CD8 lineage decision. Nat. Rev. Immunol. 2, 309-322 (2002).
12. Liu, C. et al. Control of β-catenin phosphorylation degradation by dual kinase mechanism. Cell 108, 837-847, (2002).
13. Schwarz-Romond, T. et al. The ankyrin repeat protein Diversin recruits Casein kinase I epsilon to the β-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev. 16, 2073-2084 (2002).
14. Behhrens, J. et al. Functional interaction of β-catenin with the transcription factor LEF-1. Nature 382, 638-642 (1996).
15. Bienz, M. & Clevers H. Armadillo/β-catenin signals in the nucleus - proof beyond a reasonable doubt? Nat. Cell Biol. 5, 179-182 (2003).
16. Verbeek, S. et al. An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature 6517, 70-4 (1995).
17. Okamura, R.M. et al. Redundant regulation of T cell differentiation and TCRα gene expression by the transcription factors LEF-1 and TCF-1. Immunity 1, 11-20 (1998).
18. + thymocyte survival. Nat. Immunol. 2, 691-697 (2001).
19. Hsu, W., Shakya, R. & Costantini, F. Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice. J. Cell Biol. 155, 1055-1064 (2001).
20. Staal, F.J. et al. Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Eur. J. Immunol. 1, 285-93 (2001).
21. Muller, K.M., Luedecker, C.J., Udey, M.C. & Farr, A.G. Involvement of E-cadherin in thymus organogenesis and thymocyte maturation. Immunity 3, 257-264 (1997).
22. Gounari, F. et al. Somatic activation of β-catenin bypasses pre-TCR signaling and TCR signaling in thymocyte development. Nat. Immunol. 9, 863-869, (2001).
23. Xu, Y. & Sen, J. β-Catenin expression in thymocytes accelerates thymic involution. Eur. J. Immunol. 33, 12-18 (2003).
24. Huelsken, J. et al. Requirement for β-catenin in anterior-posterior axis formation in mice. J. Cell Biol. 148, 567-578 (2000).
25. Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G. & Birchmeier, W. β-Catenin controls hair follicle morhphogenesis and stem cell differentiation in the skin. Cell 105, 533-545 (2001).
26. Lee, P.P. et al. B. A critical role for Dnmt1 and DNA methylation in T cell development, function and survival. Immunity 15, 763-774 (2001).
27. Shimizu, C. et al. Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity. Int. Immunol. 1, 105-117 (2001).
28. Dudley, E.C., Petrie, H.T., Shah, L.M., Owen, M.J. & Hayday, A.C. T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice. Immunity 2, 83-93 (1994).
29. Wolfer, A., Wilson, A., Nemir, M., MacDonald, H.R. & Radtke, F. Inactivation of Notch-1 impairs VDJβ rearrangement and allows pre-TCR independent survival of early αβ lineage thymocytes. Immunity 16, 869-879 (2002).
30. Varas, A. et al. The role of morphogens in T cell development. Trends Immunol. 24, 197-206 (2003).
31. Zamoyska, R. et al. The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation. Imm. Rev. 191, 107-118 (2003).
32. Mulroy, T.M., Xu, Y. & Sen, J. β-Catenin signals enhance generation of mature T cells. Int. Immunol. 15, 1-10 (2003).
33. Christian S.L., Sims P.V. & Gold, M.R. The B cell antigen receptor regulates the transcriptional activator β-catenin via protein kinase C-mediated inhibition of glycogen synthase kinase-3. J. Immunol. 169, 758-769 (2002).
34. Monick, M.M. et al. Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of β-catenin. J. Immunol. 166, 4713-4720 (2001).
35. Sellin, J.H., Umar, S., Xiao, J. & Morris, A.P. Increased β-catenin expression and nuclear translocation accompany hyperproliferation in vivo. Cancer Res. 61, 2899-2906 (2001).