메뉴 건너뛰기




Volumn 16, Issue 3, 2005, Pages 1513-1526

Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; METHYLNITRONITROSOGUANIDINE; NITROSOUREA DERIVATIVE; PROTEIN CDC25C; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

EID: 14844331767     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E04-02-0089     Document Type: Article
Times cited : (78)

References (74)
  • 1
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham, R. T. (2001). Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15, 2177-2196.
    • (2001) Genes Dev. , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 2
    • 0037064053 scopus 로고    scopus 로고
    • ATM is activated in response to N-methyl-N′-nitro-N- nitrosoguanidine-induced DNA alkylation
    • Adamson, A. W., Kim, W. J., Shangary, S., Baskaran, R., and Brown, K. D. (2002). ATM is activated in response to N-methyl-N′-nitro-N- nitrosoguanidine-induced DNA alkylation. J. Biol. Chem. 277, 38222-38229.
    • (2002) J. Biol. Chem. , vol.277 , pp. 38222-38229
    • Adamson, A.W.1    Kim, W.J.2    Shangary, S.3    Baskaran, R.4    Brown, K.D.5
  • 3
    • 8944230189 scopus 로고    scopus 로고
    • Loss of DNA mismatch repair in acquired resistance to cisplatin
    • Aebi, S., et al. (1996). Loss of DNA mismatch repair in acquired resistance to cisplatin. Cancer Res. 56, 3087-3090.
    • (1996) Cancer Res. , vol.56 , pp. 3087-3090
    • Aebi, S.1
  • 4
    • 0034326802 scopus 로고    scopus 로고
    • Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation
    • Ahn, J. Y., Schwarz, J. K., Piwnica-Worms, H., and Canman, C. E. (2000). Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Res. 60, 5934-5936.
    • (2000) Cancer Res. , vol.60 , pp. 5934-5936
    • Ahn, J.Y.1    Schwarz, J.K.2    Piwnica-Worms, H.3    Canman, C.E.4
  • 5
    • 0035281565 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated is essential during adult neurogenesis
    • Alien, D. M., et al. (2001). Ataxia telangiectasia mutated is essential during adult neurogenesis. Genes Dev. 15, 554-566.
    • (2001) Genes Dev. , vol.15 , pp. 554-566
    • Alien, D.M.1
  • 7
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through rntermolecular autophosphorylation and dimer dissociation
    • Bakkenist, C. J., and Kastan, M. B. (2003). DNA damage activates ATM through rntermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 8
    • 0032496322 scopus 로고    scopus 로고
    • Replication checkpoint enforced by kinases Cds1 and Chk1
    • Boddy, M. N., Furnari, B., Mondesert, O., and Russell, P. (1998). Replication checkpoint enforced by kinases Cds1 and Chk1. Science 280, 909-912.
    • (1998) Science , vol.280 , pp. 909-912
    • Boddy, M.N.1    Furnari, B.2    Mondesert, O.3    Russell, P.4
  • 9
    • 0027502938 scopus 로고
    • Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage
    • Branch, P., Aquilina, G., Bignami, M., and Karran, P. (1993). Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature 362, 652-654.
    • (1993) Nature , vol.362 , pp. 652-654
    • Branch, P.1    Aquilina, G.2    Bignami, M.3    Karran, P.4
  • 10
    • 0033616828 scopus 로고    scopus 로고
    • A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
    • Brown, A. L., Lee, C. H., Schwarz, J. K., Mitiku, N., Piwnica-Worms, H., and Chung, J. H. (1999). A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc. Natl. Acad. Sci. USA 96, 3745-3750.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3745-3750
    • Brown, A.L.1    Lee, C.H.2    Schwarz, J.K.3    Mitiku, N.4    Piwnica-Worms, H.5    Chung, J.H.6
  • 13
    • 0033566082 scopus 로고    scopus 로고
    • Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
    • Chaturvedi, P., et al. (1999). Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene 18, 4047-4054.
    • (1999) Oncogene , vol.18 , pp. 4047-4054
    • Chaturvedi, P.1
  • 14
    • 0034646228 scopus 로고    scopus 로고
    • Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis
    • Christensen, P. U., Bentley, N. J., Martinho, R. G., Nielsen, O., and Carr, A. M. (2000). Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis. Proc. Natl. Acad. Sci. USA 97, 2579-2584.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2579-2584
    • Christensen, P.U.1    Bentley, N.J.2    Martinho, R.G.3    Nielsen, O.4    Carr, A.M.5
  • 15
    • 0032472330 scopus 로고    scopus 로고
    • Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
    • Cliby, W. A., Roberts, C. J., Cimprich, K. A., Stringer, C. M., Lamb, J. R., Schreiber, S. L., and Friend, S. H. (1998). Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J. 17, 159-169.
    • (1998) EMBO J. , vol.17 , pp. 159-169
    • Cliby, W.A.1    Roberts, C.J.2    Cimprich, K.A.3    Stringer, C.M.4    Lamb, J.R.5    Schreiber, S.L.6    Friend, S.H.7
  • 16
    • 0032974109 scopus 로고    scopus 로고
    • Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site
    • Dalal, S. N., Schweitzer, C. M., Gan, J., and DeCaprio, J. A. (1999). Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site. Mol. Cell. Biol. 19, 4465-4479.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 4465-4479
    • Dalal, S.N.1    Schweitzer, C.M.2    Gan, J.3    Decaprio, J.A.4
  • 17
    • 0025196019 scopus 로고
    • Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents
    • Dolan, M. E., Moschel, R. C., and Pegg, A. E. (1990). Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc. Natl. Acad. Sci. USA 87, 5368-5372.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 5368-5372
    • Dolan, M.E.1    Moschel, R.C.2    Pegg, A.E.3
  • 18
    • 2642554558 scopus 로고    scopus 로고
    • Mutations in the nucleotide-binding domain of MutS homologs uncouple cell death from cell survival
    • Drotschmann, K., Topping, R .P., Clodfelter, J. E., and Salsbury, F. R. (2004). Mutations in the nucleotide-binding domain of MutS homologs uncouple cell death from cell survival. DNA Repair 3, 729-742.
    • (2004) DNA Repair , vol.3 , pp. 729-742
    • Drotschmann, K.1    Topping, R.P.2    Clodfelter, J.E.3    Salsbury, F.R.4
  • 19
    • 0033607055 scopus 로고    scopus 로고
    • hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage
    • Duckett, D. R., Bronstein, S. M., Taya, Y., and Modrich, P. (1999). hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage. Proc. Natl. Acad. Sci. USA 96, 12384-12388.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 12384-12388
    • Duckett, D.R.1    Bronstein, S.M.2    Taya, Y.3    Modrich, P.4
  • 20
    • 0029665878 scopus 로고    scopus 로고
    • Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct
    • Duckett, D. R., Drummond, J. T., Murchie, A. I., Reardon, J. T., Sancar, A., Lilley, D. M., and Modrich, P. (1996). Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct. Proc. Natl. Acad. Sci. USA 93, 6443-6447.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 6443-6447
    • Duckett, D.R.1    Drummond, J.T.2    Murchie, A.I.3    Reardon, J.T.4    Sancar, A.5    Lilley, D.M.6    Modrich, P.7
  • 21
    • 0035848819 scopus 로고    scopus 로고
    • The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
    • Falck, J., Mailand, N., Syljuasen, R. G., Bartek, J., and Lukas, J. (2001). The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410, 842-847.
    • (2001) Nature , vol.410 , pp. 842-847
    • Falck, J.1    Mailand, N.2    Syljuasen, R.G.3    Bartek, J.4    Lukas, J.5
  • 22
    • 0036510055 scopus 로고    scopus 로고
    • The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways
    • Falck, J., Petrini, J. H., Williams, B. R., Lukas, J., and Bartek, J. (2002). The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat. Genet. 30, 290-294.
    • (2002) Nat. Genet. , vol.30 , pp. 290-294
    • Falck, J.1    Petrini, J.H.2    Williams, B.R.3    Lukas, J.4    Bartek, J.5
  • 23
    • 0022971473 scopus 로고
    • Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N′-nitro-N-nitrosoguanidine
    • Goldmacher, V. S., Cuzick, R. A., Jr., and Thilly, W. G. (1986). Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N′-nitro-N-nitrosoguanidine. J. Biol. Chem. 262, 12462-12471.
    • (1986) J. Biol. Chem. , vol.262 , pp. 12462-12471
    • Goldmacher, V.S.1    Cuzick Jr., R.A.2    Thilly, W.G.3
  • 24
    • 0034053130 scopus 로고    scopus 로고
    • The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
    • Graves, P. R., Yu, L., Schwarz, J. K., Gales, J., Sausville, E. A., O'Connor, P. M., and Piwnica-Worms, H. (2000). The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J. Biol. Chem. 275, 5600-5605.
    • (2000) J. Biol. Chem. , vol.275 , pp. 5600-5605
    • Graves, P.R.1    Yu, L.2    Schwarz, J.K.3    Gales, J.4    Sausville, E.A.5    O'Connor, P.M.6    Piwnica-Worms, H.7
  • 25
    • 0028245682 scopus 로고
    • DNA mismatch binding and incision at modified guanine bases by extracts of mammalian cells: Implications for tolerance to DNA methylation damage
    • Griffin, S., Branch, P., Xu, Y. Z., and Karran, P. (1994). DNA mismatch binding and incision at modified guanine bases by extracts of mammalian cells: implications for tolerance to DNA methylation damage. Biochemistry 33, 4787-4793.
    • (1994) Biochemistry , vol.33 , pp. 4787-4793
    • Griffin, S.1    Branch, P.2    Xu, Y.Z.3    Karran, P.4
  • 26
    • 0032528290 scopus 로고    scopus 로고
    • MPF localization is controlled by nuclear export
    • Hagting, A., Karlsson, C., Clute, P., Jackman, M., and Pines, J. (1998). MPF localization is controlled by nuclear export. EMBO J. 17, 4127-4138.
    • (1998) EMBO J. , vol.17 , pp. 4127-4138
    • Hagting, A.1    Karlsson, C.2    Clute, P.3    Jackman, M.4    Pines, J.5
  • 27
    • 0028568315 scopus 로고
    • Cell cycle control and cancer
    • Hartwell, L. H., and Kastan, M. B. (1994). Cell cycle control and cancer. Science 266, 1821-1828.
    • (1994) Science , vol.266 , pp. 1821-1828
    • Hartwell, L.H.1    Kastan, M.B.2
  • 28
    • 0242663968 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents
    • Hirose, Y., Katayama, M., Stokoe, D., Haas-Kogan, D. A., Berger, M. S., and Pieper, R. O. (2003). The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents. Mol. Cell. Biol. 23, 8306-8315.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8306-8315
    • Hirose, Y.1    Katayama, M.2    Stokoe, D.3    Haas-Kogan, D.A.4    Berger, M.S.5    Pieper, R.O.6
  • 29
    • 2942568163 scopus 로고    scopus 로고
    • N-Methyl-N′-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA
    • Jaiswal, A. S., Multani, A. S., Pathak, S., and Narayan, S. (2004). N-Methyl-N′-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA. Mol. Cancer 3, 3.
    • (2004) Mol. Cancer , vol.3 , pp. 3
    • Jaiswal, A.S.1    Multani, A.S.2    Pathak, S.3    Narayan, S.4
  • 30
    • 0038054343 scopus 로고    scopus 로고
    • The Chk2 tumor suppressor is not required for p53 responses in human cancer cells
    • Jallepalli, P. V., Lengauer, C., Vogelstein, B., and Bunz, F. (2003). The Chk2 tumor suppressor is not required for p53 responses in human cancer cells. J. Biol. Chem. 278, 20475-20479.
    • (2003) J. Biol. Chem. , vol.278 , pp. 20475-20479
    • Jallepalli, P.V.1    Lengauer, C.2    Vogelstein, B.3    Bunz, F.4
  • 31
    • 0023821527 scopus 로고
    • O6-Methylguanine-DNA methyltransferase-defective human cell mutant: O6-methylguanine, DNA strand breaks and cytotoxicity
    • Kalamegham, R., Warmels-Rodenhiser, S., MacDonald, H., and Ebisuzaki, K. (1988). O6-Methylguanine-DNA methyltransferase-defective human cell mutant: O6-methylguanine, DNA strand breaks and cytotoxicity. Carcinogenesis 9, 1749-1753.
    • (1988) Carcinogenesis , vol.9 , pp. 1749-1753
    • Kalamegham, R.1    Warmels-Rodenhiser, S.2    MacDonald, H.3    Ebisuzaki, K.4
  • 32
    • 0026750738 scopus 로고
    • Self-destruction and tolerance in resistance of mammalian cells to alkylation damage
    • Karran, P., and Bignami, M. (1992). Self-destruction and tolerance in resistance of mammalian cells to alkylation damage. Nucleic Acids Res. 20, 2933-2940.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 2933-2940
    • Karran, P.1    Bignami, M.2
  • 33
  • 34
    • 0027292234 scopus 로고
    • An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair
    • Kat, A., Thilly, W. G., Fang, W. H., Longley, M. J., Li, G. M., and Modrich, P. (1993). An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc. Natl. Acad. Sci. USA 90, 6424-6428.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6424-6428
    • Kat, A.1    Thilly, W.G.2    Fang, W.H.3    Longley, M.J.4    Li, G.M.5    Modrich, P.6
  • 35
    • 0028177687 scopus 로고
    • G1 arrest and cell-cycle-dependent clastogenesis in UV-irradiated human fibroblasts
    • Kaufmann, W. K., and Wilson, S. J. (1994). G1 arrest and cell-cycle-dependent clastogenesis in UV-irradiated human fibroblasts. Mutat, Res. 314, 67-76.
    • (1994) Mutat, Res. , vol.314 , pp. 67-76
    • Kaufmann, W.K.1    Wilson, S.J.2
  • 36
    • 0027936057 scopus 로고
    • Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation
    • Koi, M., Umar, A., Chauhan, D. P., Cherian, S. P., Carethers, J, M., Kunkel, T. A., and Boland, C. R. (1994). Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res. 54, 4308-4312.
    • (1994) Cancer Res. , vol.54 , pp. 4308-4312
    • Koi, M.1    Umar, A.2    Chauhan, D.P.3    Cherian, S.P.4    Carethers, J.M.5    Kunkel, T.A.6    Boland, C.R.7
  • 38
    • 9144227402 scopus 로고    scopus 로고
    • An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
    • Lin, D. P., et al. (2004). An Msh2 point mutation uncouples DNA mismatch repair and apoptosis. Cancer Res. 64, 517-522.
    • (2004) Cancer Res. , vol.64 , pp. 517-522
    • Lin, D.P.1
  • 39
    • 0020340071 scopus 로고
    • Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase
    • Lindahl, T., Demple, B., and Robins, P. (1982). Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase. EMBO J. 1, 1359-1363.
    • (1982) EMBO J. , vol.1 , pp. 1359-1363
    • Lindahl, T.1    Demple, B.2    Robins, P.3
  • 40
    • 0033067558 scopus 로고    scopus 로고
    • Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-Cyclin B1 complexes
    • Liu, F., Rothblum-Oviatt, C., Ryan, C. E., and Piwnica-Worms, H. (1999). Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-Cyclin B1 complexes. Mol. Cell. Biol. 19, 5113-5123.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5113-5123
    • Liu, F.1    Rothblum-Oviatt, C.2    Ryan, C.E.3    Piwnica-Worms, H.4
  • 41
    • 17644432403 scopus 로고    scopus 로고
    • Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
    • Liu, Q., et al. (2000). Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev. 14, 1448-1459.
    • (2000) Genes Dev. , vol.14 , pp. 1448-1459
    • Liu, Q.1
  • 43
    • 0026035524 scopus 로고
    • mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2
    • Lundgren, K., Walworth, N., Booher, R., Dembski, M., Kirschner, M., and Beach, D. (1991). mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell 64, 1111-1122.
    • (1991) Cell , vol.64 , pp. 1111-1122
    • Lundgren, K.1    Walworth, N.2    Booher, R.3    Dembski, M.4    Kirschner, M.5    Beach, D.6
  • 45
    • 0036847320 scopus 로고    scopus 로고
    • Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability
    • Mailand, N., Podtelejnikov, A. V., Groth, A., Mann, M., Bartek, J., and Lukas, J. (2002). Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability. EMBO J. 21, 5911-5920.
    • (2002) EMBO J. , vol.21 , pp. 5911-5920
    • Mailand, N.1    Podtelejnikov, A.V.2    Groth, A.3    Mann, M.4    Bartek, J.5    Lukas, J.6
  • 46
    • 0032484084 scopus 로고    scopus 로고
    • Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
    • Matsuoka, S., Huang, M., and Elledge, S. J. (1998). Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282, 1893-1897.
    • (1998) Science , vol.282 , pp. 1893-1897
    • Matsuoka, S.1    Huang, M.2    Elledge, S.J.3
  • 48
    • 0030198880 scopus 로고    scopus 로고
    • The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin
    • Mello, J. A., Acharya, S., Fishel, R., and Essigmann, J. M. (1996). The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin. Chem. Biol. 3, 579-589.
    • (1996) Chem. Biol. , vol.3 , pp. 579-589
    • Mello, J.A.1    Acharya, S.2    Fishel, R.3    Essigmann, J.M.4
  • 49
    • 0032910170 scopus 로고    scopus 로고
    • Regulating the onset of mitosis
    • Ohi, R., and Gould, K. L. (1999). Regulating the onset of mitosis. Curr. Opin. Cell Biol. 11, 267-273.
    • (1999) Curr. Opin. Cell Biol. , vol.11 , pp. 267-273
    • Ohi, R.1    Gould, K.L.2
  • 51
    • 0028350601 scopus 로고
    • Mutation of a mutL homolog in hereditary colon cancer
    • Papadopoulos, N., et al. (1994). Mutation of a mutL homolog in hereditary colon cancer. Science 263, 1625-1629.
    • (1994) Science , vol.263 , pp. 1625-1629
    • Papadopoulos, N.1
  • 53
    • 0030611095 scopus 로고    scopus 로고
    • Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
    • Peng, C. Y., Graves, P. R., Thoma, R. S., Wu, Z., Shaw, A. S., and Piwnica-Worms, H. (1997). Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277, 1501-1505.
    • (1997) Science , vol.277 , pp. 1501-1505
    • Peng, C.Y.1    Graves, P.R.2    Thoma, R.S.3    Wu, Z.4    Shaw, A.S.5    Piwnica-Worms, H.6
  • 54
    • 0015137966 scopus 로고
    • Extension of the pre-DNA synthetic phase of the cell cycle as a consequence of DNA alkylation in Chinese hamster cells: A possible mechanism of DNA repair
    • Plant, J. E., and Roberts, J. J. (1971). Extension of the pre-DNA synthetic phase of the cell cycle as a consequence of DNA alkylation in Chinese hamster cells: a possible mechanism of DNA repair. Chem. Biol. Interact. 3, 343-351.
    • (1971) Chem. Biol. Interact. , vol.3 , pp. 343-351
    • Plant, J.E.1    Roberts, J.J.2
  • 55
    • 0030867582 scopus 로고    scopus 로고
    • Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
    • Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., and Elledge, S. J. (1997). Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 277, 1497-1501.
    • (1997) Science , vol.277 , pp. 1497-1501
    • Sanchez, Y.1    Wong, C.2    Thoma, R.S.3    Richman, R.4    Wu, Z.5    Piwnica-Worms, H.6    Elledge, S.J.7
  • 57
    • 2442670292 scopus 로고    scopus 로고
    • Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase
    • Stojic, L., Mojas, N., Cejka, P., Di Pietro, M., Ferrari, S., Marra, G., and Jiricny, J. (2004). Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase. Genes Dev. 18, 1331-1344.
    • (2004) Genes Dev. , vol.18 , pp. 1331-1344
    • Stojic, L.1    Mojas, N.2    Cejka, P.3    Di Pietro, M.4    Ferrari, S.5    Marra, G.6    Jiricny, J.7
  • 58
    • 0025922083 scopus 로고
    • Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein
    • Strausfeld, U., Labbe, J. C., Fesquet, D., Cavadore, J. C., Picard, A., Sadhu, K., Russell, P., and Doree, M. (1991). Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein. Nature 351, 242-245.
    • (1991) Nature , vol.351 , pp. 242-245
    • Strausfeld, U.1    Labbe, J.C.2    Fesquet, D.3    Cavadore, J.C.4    Picard, A.5    Sadhu, K.6    Russell, P.7    Doree, M.8
  • 59
    • 0030776227 scopus 로고    scopus 로고
    • Correction of hypermutability, N-methyl-N′-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6
    • Umar, A., Koi, M., Risinger, J. I., Glaab, W. E., Tindall, K. R., Kolodner, R. D., Boland, C. R., Barrett, J. C., and Kunkel, T. A. (1997). Correction of hypermutability, N-methyl-N′-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6. Cancer Res. 57, 3949-3955.
    • (1997) Cancer Res. , vol.57 , pp. 3949-3955
    • Umar, A.1    Koi, M.2    Risinger, J.I.3    Glaab, W.E.4    Tindall, K.R.5    Kolodner, R.D.6    Boland, C.R.7    Barrett, J.C.8    Kunkel, T.A.9
  • 60
    • 0037294545 scopus 로고    scopus 로고
    • Phosphorylation of the cyclin b1 cytoplasmic retention sequence by mitogen-activated protein kinase and Plx
    • Walsh, S., Margolis, S. S., and Kornbluth, S. (2003). Phosphorylation of the cyclin b1 cytoplasmic retention sequence by mitogen-activated protein kinase and Plx. Mol. Cancer Res. 1, 280-289.
    • (2003) Mol. Cancer Res. , vol.1 , pp. 280-289
    • Walsh, S.1    Margolis, S.S.2    Kornbluth, S.3
  • 62
    • 0347364654 scopus 로고    scopus 로고
    • MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation
    • Wang, Y., and Qin, J. (2003). MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc. Natl. Acad. Sci. USA
    • (2003) Proc. Natl. Acad. Sci. USA
    • Wang, Y.1    Qin, J.2
  • 63
    • 0032560556 scopus 로고    scopus 로고
    • Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control
    • Wright, J. A., Keegan, K. S., Herendeen, D. R., Bentley, N. J., Carr, A. M., Hoekstra, M. F., and Concannon, P. (1998). Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control. Proc. Natl. Acad. Sci. USA 95, 7445-7450.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7445-7450
    • Wright, J.A.1    Keegan, K.S.2    Herendeen, D.R.3    Bentley, N.J.4    Carr, A.M.5    Hoekstra, M.F.6    Concannon, P.7
  • 64
    • 0037484271 scopus 로고    scopus 로고
    • Chk1 Mediates S and G2 Arrests through Cdc25A Degradation in Response to DNA-damaging Agents
    • Xiao, Z., Chen, Z., Gunasekera, A. H., Sowin, T. J., Rosenberg, S. H., Fesik, S., and Zhang, H. (2003). Chk1 Mediates S and G2 Arrests through Cdc25A Degradation in Response to DNA-damaging Agents. J. Biol. Chem. 278, 21767-21773.
    • (2003) J. Biol. Chem. , vol.278 , pp. 21767-21773
    • Xiao, Z.1    Chen, Z.2    Gunasekera, A.H.3    Sowin, T.J.4    Rosenberg, S.H.5    Fesik, S.6    Zhang, H.7
  • 65
    • 0036146085 scopus 로고    scopus 로고
    • Two molecularly distinct g(2)/m checkpoints are induced by ionizing irradiation
    • Xu, B., Kim, S. T., Lim, D. S., and Kastan, M. B. (2002). Two molecularly distinct g(2)/m checkpoints are induced by ionizing irradiation. Mol. Cell. Biol. 22, 1049-1059.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1049-1059
    • Xu, B.1    Kim, S.T.2    Lim, D.S.3    Kastan, M.B.4
  • 66
    • 0032528001 scopus 로고    scopus 로고
    • Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1
    • Yang, J., Bardes, E. S., Moore, J. D., Brennan, J., Powers, M. A., and Kornbluth, S. (1998). Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1. Genes Dev. 12, 2131-2143.
    • (1998) Genes Dev. , vol.12 , pp. 2131-2143
    • Yang, J.1    Bardes, E.S.2    Moore, J.D.3    Brennan, J.4    Powers, M.A.5    Kornbluth, S.6
  • 67
    • 0035793643 scopus 로고    scopus 로고
    • Combinatorial control of cyclin B1 nuclear trafficking through phosphorylation at multiple sites
    • Yang, J., Song, H., Walsh, S., Bardes, E. S., and Kornbluth, S. (2001). Combinatorial control of cyclin B1 nuclear trafficking through phosphorylation at multiple sites. J. Biol. Chem. 276, 3604-3609.
    • (2001) J. Biol. Chem. , vol.276 , pp. 3604-3609
    • Yang, J.1    Song, H.2    Walsh, S.3    Bardes, E.S.4    Kornbluth, S.5
  • 68
    • 0037108873 scopus 로고    scopus 로고
    • UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1
    • Yu, Q., La Rose, J., Zhang, H., Takemura, H., Kohn, K. W., and Pommier, Y. (2002). UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation- induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1. Cancer Res. 62, 5743-5748.
    • (2002) Cancer Res. , vol.62 , pp. 5743-5748
    • Yu, Q.1    La Rose, J.2    Zhang, H.3    Takemura, H.4    Kohn, K.W.5    Pommier, Y.6
  • 69
    • 0019506288 scopus 로고
    • Cell death, chromosome damage and mitotic delay in normal human, ataxia telangiectasia and retinoblastoma fibroblasts after x-irradiation
    • Zampetti-Bosseler, F., and Scott, D. (1981). Cell death, chromosome damage and mitotic delay in normal human, ataxia telangiectasia and retinoblastoma fibroblasts after x-irradiation. Int. J. Radiat. Biol. Relat. Stud Phys. Chem. Med. 39, 547-558.
    • (1981) Int. J. Radiat. Biol. Relat. Stud Phys. Chem. Med. , vol.39 , pp. 547-558
    • Zampetti-Bosseler, F.1    Scott, D.2
  • 70
    • 0034967556 scopus 로고    scopus 로고
    • ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
    • Zhao, H., and Piwnica-Worms, H. (2001). ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol. Cell. Biol. 22, 4129-4139.
    • (2001) Mol. Cell. Biol. , vol.22 , pp. 4129-4139
    • Zhao, H.1    Piwnica-Worms, H.2
  • 71
    • 0037069326 scopus 로고    scopus 로고
    • Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints
    • Zhao, H., Watkins, J. L., and Piwnica-Worms, H. (2002). Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proc. Natl. Acad. Sci. USA 99, 14795-14800.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14795-14800
    • Zhao, H.1    Watkins, J.L.2    Piwnica-Worms, H.3
  • 73
    • 0028152615 scopus 로고
    • DNA replication arrest and tolerance to DNA methylation damage
    • Zhukovskaya, N., Branch, P., Aquilina, G., and Karran, P. (1994). DNA replication arrest and tolerance to DNA methylation damage. Carcinogenesis 15, 2189-2194.
    • (1994) Carcinogenesis , vol.15 , pp. 2189-2194
    • Zhukovskaya, N.1    Branch, P.2    Aquilina, G.3    Karran, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.