UCN-01 inhibits p53 up-regulation and abrogates γ-radiation-induced G2-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1

Cancer Research

Volumn 62, Issue 20, 2002, Pages 5743-5748

  Yu, Qiang ^a   La Rose, JiHyun ^a   Zhang, Hongliang ^a   Takemura, Haruyuki ^a   Kohn, Kurt W ^a   Pommier, Yves ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYSTAUROSPORINE; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; PHOSPHOTRANSFERASE; PROTEIN DERIVATIVE; PROTEIN P21; PROTEIN P53; SERINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; COLON CARCINOMA; CONTROLLED STUDY; DNA DAMAGE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; GAMMA RADIATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NULL ALLELE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIOSENSITIZATION; TUMOR SUPPRESSOR GENE; UPREGULATION;

ALKALOIDS; ANTINEOPLASTIC AGENTS; APOPTOSIS; COLONIC NEOPLASMS; ENZYME ACTIVATION; ENZYME INHIBITORS; G2 PHASE; GAMMA RAYS; HUMANS; MITOSIS; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; STAUROSPORINE; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 0037108873     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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