Correction of hypermutability, N-Methyl-N'-nitro-N-nitrosoguanidine resistance, and defective dna mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6

Cancer Research

Volumn 57, Issue 18, 1997, Pages 3949-3955

  Umar, Asad ^a   Koi, Minoru ^a   Risinger, John I ^a,b   Glaab, Warren E ^a,b   Tindall, Kenneth R ^a,b   Kolodner, Richard D ^d   Boland, C Richard ^c   Barrett, J Carl ^a,b   Kunkel, Thomas A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; METHYLNITRONITROSOGUANIDINE;

ALLELE; ARTICLE; BASE MISPAIRING; CELL KILLING; CHROMOSOME 2; DNA NICK TRANSLATION; DNA SEQUENCE; EXCISION REPAIR; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; TUMOR CELL CULTURE; TUMOR RESISTANCE;

CELL FUSION; CHROMOSOMES, HUMAN, PAIR 2; DNA REPAIR; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; HUMANS; METHYLNITRONITROSOGUANIDINE; MICROSATELLITE REPEATS; MUTAGENESIS; MUTS HOMOLOG 2 PROTEIN; PROTO-ONCOGENE PROTEINS; SEQUENCE DELETION; TUMOR CELLS, CULTURED;

EID: 0030776227     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Kolodner, R. Biochemistry and genetics of eukaryotic mismatch repair. Genes Dev., 10: 1433-1442, 1996.
2. Umar, A., and Kunkel, T. A. DNA replication fidelity, mismatch repair and genome instability in cancer cells. Eur. J. Biochem., 238: 297-307, 1996.
3. Modrich, P., and Lahue, R. Mismatch repair in replication fidelity, genetic recombination and cancer biology. Annu. Rev. Biochem., 65: 101-133, 1996.
4. Drummond, J. T., Li, G-M., Longley, M. J., and Modrich, P. Mismatch recognition by an hMSH2-GTBP heterodimer and differential repair defects in tumor cells. Science (Washington DC), 268: 1909-1912, 1995.
5. Iaccarino, I., Palombo, F., Drummond, J., Totty, N. F., Hsuan, J. J., Modrich, P., and Jiricny, J. MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2. Curr. Biol., 6: 484-486, 1996.
6. Holmes, J., Clark, S. J., and Modrich, P. Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. Proc. Natl. Acad. Sci. USA, 87: 5837-5841, 1990.
7. Thomas, D. C., Roberts, J. D., and Kunkel, T. A. Heterduplex repair in extracts of human HeLa cells. J. Biol. Chem., 266: 3744-3751, 1991.
8. Fang, W-H., and Modrich, P. Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction. J. Biol. Chem., 268: 11838-11844, 1993.
9. 4-methylthymine, or the cisplatin-d(GpG) adduct. Proc. Natl. Acad. Sci. USA, 93: 6443-6447, 1996.
10. Li, G-M., Wang, H., and Romano, L. J. Human MutSα specifically binds to DNA containing aminofluorene and acetylaminofluorene adducts. J. Biol. Chem., 271: 24084-24088, 1996.
11. Mu, D., Tursun, M., Duckett, D. R., Drummond, J. T., Modrich, P., and Sancar, A. Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems. Mol. Cell. Biol., 17: 760-769, 1997.
12. Mello, J. A., Acharya, S., Fishel, R., and Essigmann, J. M. The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin. Chem. Biol., 3: 579-589, 1996.
13. 2 cell cycle checkpoint. Cancer Res., 55: 3721-3725, 1995.
14. Kat, A., Thilly, W. G., Fang, W., Longley, M. J., Li, G. M., and Modrich, P. An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc. Natl. Acad. Sci. USA, 90: 6424-6428, 1993.
15. Koi, M., Umar, A., Chauhan, D. P., Cherian, S. P., Carethers, J. M., Kunkel, T. A., and Boland, C. R. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N′-methyl-N-nitro-N-nitrosoguanidine tolerance in colon tumor cells with a homozygous hMLH1 mutation. Cancer Res., 54: 4308-4312, 1994.
16. Karran, P., and Bignami, M. DNA damage tolerance, mismatch repair and genome instability. BioEssays, 16: 833-839, 1994.
17. Risinger, J. R., Umar, A., Barrett, J. C., and Kunkel, T. A. A hPMS2 mutant cell line is defective in strand-specific mismatch repair. J. Biol. Chem., 270: 18183-18186, 1995.
18. Branch, P., Hampson, R., and Karran, P. DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines. Cancer Res., 55: 2304-2309, 1995.
19. Aebi, S., Kurdi-Haidar, B., Gordon, R., Cenni, B., Zheng, H., Fink, D., Christen, R. D., Boland, C. R., Koi, M., Fishel, R., and Howell, S. B. Loss of DNA mismatch repair in acquired resistance to cisplatin. Cancer Res., 56: 3087-3090, 1996.
20. Drummond, J. T., Anthoney, A., Brown, R., and Modrich, P. Cisplatin and adriamycin resistance are associated with MutLα and mismatch repair deficiency in an ovarian tumor cell line. J. Biol. Chem., 271: 19645-19648, 1996.
21. Swann, P. F., Waters, T. R., Moulton, D. C., Xu, Y-Z., Zheng, Q., Edwards, M., and Mace, R. Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine. Science (Washington DC), 273: 1109-1111, 1996.
22. Papadopoulos, N., Nicolaides, N. C., Liu, B., Parsons, R. E., Lengauer, C., Palombo, F., D'Arrigo, Markowitz, S., Willson, J. K. V., Kinzler, K. W., Jiricny, J., and Vogelstein, B. Mutations of GTBP in genetically unstable cells. Science (Washington DC), 268: 1915-1917, 1995.
23. Shibata, D., Peinado, M. A., Ionov, Y., Malkhosyan, S., and Perucho, M. Genomic instability in repeated sequences is an early somatic event on colorectal tumorigenesis that persists after transformation. Nat. Genet., 6: 273-281, 1995.
24. Bhattacharyya, N. P., Skandalis, A., Ganesh, A., Groden, J. A., and Meuth, M. Mutator phenotypes in human colorectal carcinoma cell lines. Proc. Natl. Acad. Sci. USA, 91: 6319-6323, 1994.
25. Bhattacharyya, N. P., Ganesh, A., Phear, G., Richards, B., Skandalis, A., and Meuth, M. Molecular analysis of mutations in mutator colorectal carcinoma cell lines. Hum. Mol. Genet., 4: 2057-2064, 1996.
26. Malkhosyan, S., McCarty, A., Sawai, H., and Perucho, M. Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype. Mutat. Res., 316: 249-259, 1996.
27. Phear, G., Bhattacharyya, N. P., and Meuth, M. Loss of heterozygosity and base pair substitution at the APRT locus in mismatch-repair-proficient and -deficient colorectal carcinoma cell lines. Mol. Cell. Biol., 16: 6516-6523, 1996.
28. Glaab, W. E., and Tindall, K. R. Mutation rate at the HPRT locus in human cancer cell lines with specific mismatch-repair gene defects. Carcinogenesis (Lond.), 18: 1-8, 1997.
29. Umar, A., Boyer, J. C., Thomas, D. C., Nguyen, D. C., Risinger, J. I., Boyd, J., Ionov, Y., Perucho, M., and Kunkel, T. A. Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J. Biol. Chem., 269: 14367-14370, 1994.
30. Boyer, J. C., Umar, A., Risinger, J. I., Lipford, R., Kane, M., Yin, S., Barrett, J. C., Kolodner, R. D., and Kunkel, T. A. Microsatellite instability, mismatch repair deficiency and genetic defects in human cancer cell lines. Cancer Res., 55: 6063-6070, 1995.
31. da Costa, L. T., Liu B., El-Deiry, W., Hamilton, S. R., Kinzler, K. W., Vogelstein, B., Markowitz, S., Willson, J. K. V., de la Chapelle, A., Downey, K. M., and So, A. G. Polymerase δ variants in RER colorectal tumours. Nat. Genet., 9: 10-11, 1995.
32. Chung, D. W., Zhang, J., Tan, C. K., Davie, E. W., So, A. G., and Downey, K. M. Primary structure of the catalytic subunit of human DNA polymerase δ and chromosomal location of the gene. Proc. Natl. Acad. Sci. USA, 88: 11197-11201, 1991.
33. Thomas, D. C., Umar, A., and Kunkel, T. A. Measurement of heteroduplex repair in human cell extracts. In: E. C. Friedberg (ed.), Methods: A Companion to Methods in Enzymology, Vol. 7, pp. 187-197. New York: Academic Press, 1995.
34. Koi, M., Morita, H., Yamada, H., Satoh, H., Barrett, J. C., and Oshimura, M. Normal human chromosome 11 suppresses tumorigenicity of human cervical tumor cell line SiHa. Mol. Carcinog., 2: 12-21, 1989.
35. Liu, B., Parsons, R., Hamilton, S. R., Peterson, G. M., Lynch, H. T. Watson, P., Markowitz, S., Willson, J., Green, J., de la Chapelle, A., Kinzler, K. W., and Vogelstein, B. hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds. Cancer Res., 54: 4590-4594, 1994.
36. Roberts, J. D., and Kunkel, T. A. Fidelity of DNA replication in human cells. Methods Mol. Genet., 2: 295-313, 1993.
37. Chen, T. R., Dorotinsky, C. S., McGuire, L. J., Macy, M. L., and Hay, R. J. DLD-1 and HCT-15 cell lines derived separately from colorectal carcinomas have totally different chromosome changes but the same genetic origin. Cancer Genet. Cytogenet., 81: 103-108, 1995.
38. Risinger, J. L., Umar, A., Boyd, J., Berchuck, A., Kunkel, T. A., and Barrett, J. C. Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Nat. Genet., 14: 102-105, 1996.
39. Marsischky, G. T., Filosi, N., Kane, M. F., and Kolodner, R. Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair. Genes Dev., 10: 407-420, 1996.
40. Johnson, R. E., Kovvali, G. K., Prakash, L., and Prakash, S. Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability. J. Biol. Chem., 271: 7285-7288, 1996.
41. Strand, M., Earley, M. C., Crouse, G. F., and Petes T. D. Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA, 92: 10418-10421, 1995.
42. Morisawa, T. The results of primary culture of endometrial adenocarcinoma and characterization of its established line. J. Jpn. Soc. Clin. Cytol., 26: 433-442, 1987.
43. Hager, J. C., Gold, D. V., Barbosa, J. A., Fligiel, Z., Miller, F., and Dexter, D. L. N,N-dimethylformamide-induced modulation of organ- and tumor-associated markers in cultured human colon carcinoma cells. J. Natl. Cancer Inst. (Bethesda), 64: 439-446, 1980.
44. Dexter, D. L., Barbosa, J. A., and Calabresi, P. N,N-dimethylformamide-induced alteration of cell culture characteristics and loss of tumorigenicity in cultured human colon carcinoma cells. Cancer Res., 39: 1020-1025, 1979.
45. Joyce, C. M., and Steitz, T. A. Function and structure relationships in DNA polymerases. Annu. Rev. Biochem., 63: 777-822, 1994.
46. Derbyshire, V., Grindley, N. D. F., and Joyce, C. M. The 3′-5′ exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction. EMBO J., 10: 17-24, 1991.
47. Soengas, M. S., Esteban, J. A., Lázaro, J. M., Bernad, A., Blasco, M. A., Salas, M., and Blanco, L. Site-directed mutagenesis at the Exo III motif of ø29 DNA polymerase: overlapping structural domains for the 3′ -5′ exonuclease and strand-displacement activities. EMBO J., 11: 4227-4237, 1992.
48. Blanco, L., Bernad, A., and Salas, M. Evidence favoring the hypothesis of a conserved 3′-5′ exonuclease active site in DNA-dependent DNA polymerases. Gene (Amst.), 112: 139-144, 1992.