-
1
-
-
0344764944
-
Cyclin-dependent protein kinases
-
J.R. Woodgett. Oxford: IRL Press
-
Gould K.L. Cyclin-dependent protein kinases. Woodgett J.R. Protein kinases. 1994;149-176 IRL Press, Oxford.
-
(1994)
Protein Kinases
, pp. 149-176
-
-
Gould, K.L.1
-
2
-
-
0030561427
-
Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control
-
Lew D.J., Kornbluth S. Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control. Curr Opin Cell Biol. 8:1996;795-804.
-
(1996)
Curr Opin Cell Biol
, vol.8
, pp. 795-804
-
-
Lew, D.J.1
Kornbluth, S.2
-
3
-
-
0028931265
-
Principles of CDK regulation
-
Morgan D.O. Principles of CDK regulation. Nature. 374:1995;131-134.
-
(1995)
Nature
, vol.374
, pp. 131-134
-
-
Morgan, D.O.1
-
4
-
-
0031743063
-
Polo-like kinases: Positive regulators of cell division from start to finish
-
Nigg E.A. Polo-like kinases: positive regulators of cell division from start to finish. Curr Opin Cell Biol. 10:1998;776-783.
-
(1998)
Curr Opin Cell Biol
, vol.10
, pp. 776-783
-
-
Nigg, E.A.1
-
5
-
-
0032004973
-
The role of Cdk7 in CAK function, a retro-retrospective
-
Harper J.W., Elledge S.J. The role of Cdk7 in CAK function, a retro-retrospective. Genes Dev. 12:1998;285-289.
-
(1998)
Genes Dev
, vol.12
, pp. 285-289
-
-
Harper, J.W.1
Elledge, S.J.2
-
6
-
-
0031743256
-
Mitotic DNA damage and replication checkpoints in yeast
-
Rhind N., Russell P. Mitotic DNA damage and replication checkpoints in yeast. Curr Opin Cell Biol. 10:1998;749-758.
-
(1998)
Curr Opin Cell Biol
, vol.10
, pp. 749-758
-
-
Rhind, N.1
Russell, P.2
-
7
-
-
0029808466
-
Cell cycle checkpoints: Preventing an identity crisis
-
Elledge S.J. Cell cycle checkpoints: preventing an identity crisis. Science. 274:1996;1664-1672.
-
(1996)
Science
, vol.274
, pp. 1664-1672
-
-
Elledge, S.J.1
-
8
-
-
0032004942
-
S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe
-
Lindsay H.D., Griffiths D.J., Edwards R.J., Christensen P.U., Murray J.M., Osman F., Walworth N., Carr A.M. S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe. Genes Dev. 12:1998;382-395.
-
(1998)
Genes Dev
, vol.12
, pp. 382-395
-
-
Lindsay, H.D.1
Griffiths, D.J.2
Edwards, R.J.3
Christensen, P.U.4
Murray, J.M.5
Osman, F.6
Walworth, N.7
Carr, A.M.8
-
9
-
-
0033552873
-
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
-
Blasina A., de Weyer I.V., Laus M.C., Luyten W., Parker A.E., McGowan C.H. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. Curr Biol. 9:1999;1-10.
-
(1999)
Curr Biol
, vol.9
, pp. 1-10
-
-
Blasina, A.1
De Weyer, I.V.2
Laus, M.C.3
Luyten, W.4
Parker, A.E.5
McGowan, C.H.6
-
10
-
-
0032484084
-
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
-
Matsuoka S., Huang M., Elledge S.J. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science. 282:1998;1893-1897.
-
(1998)
Science
, vol.282
, pp. 1893-1897
-
-
Matsuoka, S.1
Huang, M.2
Elledge, S.J.3
-
11
-
-
0026568213
-
Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes
-
Ookata K., Hisanaga S., Okano T., Tachibana K., Kishimoto T. Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes. EMBO J. 11:1992;1763-1772.
-
(1992)
EMBO J
, vol.11
, pp. 1763-1772
-
-
Ookata, K.1
Hisanaga, S.2
Okano, T.3
Tachibana, K.4
Kishimoto, T.5
-
12
-
-
0026014878
-
Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport
-
Pines J., Hunter T. Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J Cell Biol. 115:1991;1-17.
-
(1991)
J Cell Biol
, vol.115
, pp. 1-17
-
-
Pines, J.1
Hunter, T.2
-
13
-
-
0027244234
-
Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
-
Heald R., McLoughlin M., McKeon F. Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. Cell. 74:1993;463-474.
-
(1993)
Cell
, vol.74
, pp. 463-474
-
-
Heald, R.1
McLoughlin, M.2
McKeon, F.3
-
14
-
-
0029019737
-
Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus
-
Jackman M., Firth M., Pines J. Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus. EMBO J. 14:1995;1646-1654.
-
(1995)
EMBO J
, vol.14
, pp. 1646-1654
-
-
Jackman, M.1
Firth, M.2
Pines, J.3
-
15
-
-
0028123264
-
Identification of a novel vertebrate cyclin: Cyclin B3 shares properties with both A- And B-type cyclins
-
Gallant P., Nigg E.A. Identification of a novel vertebrate cyclin: cyclin B3 shares properties with both A- and B-type cyclins. EMBO J. 13:1994;595-605.
-
(1994)
EMBO J
, vol.13
, pp. 595-605
-
-
Gallant, P.1
Nigg, E.A.2
-
16
-
-
0025331088
-
The roles of Drosophila cyclins A and B in mitotic control
-
Lehner C.F., O'Farrell P.H. The roles of Drosophila cyclins A and B in mitotic control. Cell. 61:1990;535-547.
-
(1990)
Cell
, vol.61
, pp. 535-547
-
-
Lehner, C.F.1
O'Farrell, P.H.2
-
17
-
-
0005203182
-
Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B
-
Jacobs H.W., Knoblich J.A., Lehner C.F. Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B. Genes Dev. 12:1998;3741-3751.
-
(1998)
Genes Dev
, vol.12
, pp. 3741-3751
-
-
Jacobs, H.W.1
Knoblich, J.A.2
Lehner, C.F.3
-
18
-
-
0032516023
-
Cyclin B2-null mice develop normally and are fertile whereas cyclin B1- null mice die in utero
-
Brandeis M., Rosewell I., Carrington M., Crompton T., Jacobs M.A., Kirk J., Gannon J., Hunt T. Cyclin B2-null mice develop normally and are fertile whereas cyclin B1- null mice die in utero. Proc Natl Acad Sci USA. 95:1998;4344-4349.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 4344-4349
-
-
Brandeis, M.1
Rosewell, I.2
Carrington, M.3
Crompton, T.4
Jacobs, M.A.5
Kirk, J.6
Gannon, J.7
Hunt, T.8
-
19
-
-
0032544440
-
Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis
-
Mitotic phosphorylation of GM130, which is important for Golgi fragmentation, is shown to require Cdc2. Both Cdc2-cyclin B1 and Cdc2-cyclin B2, but not S-phase CDK complexes, are capable of phosphorylating GM130.
-
Lowe M., Rabouille C., Nakamura N., Watson R., Jackman M., Jamsa E., Rahman D., Pappin D.J., Warren G. Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis. Cell. 94:1998;783-793. Mitotic phosphorylation of GM130, which is important for Golgi fragmentation, is shown to require Cdc2. Both Cdc2-cyclin B1 and Cdc2-cyclin B2, but not S-phase CDK complexes, are capable of phosphorylating GM130.
-
(1998)
Cell
, vol.94
, pp. 783-793
-
-
Lowe, M.1
Rabouille, C.2
Nakamura, N.3
Watson, R.4
Jackman, M.5
Jamsa, E.6
Rahman, D.7
Pappin, D.J.8
Warren, G.9
-
20
-
-
0031053117
-
The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex
-
The kinase Myt1 which phosphorylates Cdc2 on Thr14 is shown to localize to the endoplasmic reticulum and Golgi apparatus.
-
Liu F., Stanton J.J., Wu Z., Piwnica-Worms H. The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. Mol Cell Biol. 17:1997;571-583. The kinase Myt1 which phosphorylates Cdc2 on Thr14 is shown to localize to the endoplasmic reticulum and Golgi apparatus.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 571-583
-
-
Liu, F.1
Stanton, J.J.2
Wu, Z.3
Piwnica-Worms, H.4
-
21
-
-
0029937532
-
Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells
-
Gabrielli B.G., De Souza C.P., Tonks I.D., Clark J.M., Hayward N.K., Ellem K.A. Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells. J Cell Sci. 109:1996;1081-1093.
-
(1996)
J Cell Sci
, vol.109
, pp. 1081-1093
-
-
Gabrielli, B.G.1
De Souza, C.P.2
Tonks, I.D.3
Clark, J.M.4
Hayward, N.K.5
Ellem, K.A.6
-
22
-
-
0032528290
-
MPF localization is controlled by nuclear export
-
In this study, real-time imaging of GFP-tagged cyclin B1 in HeLa cells revealed that cyclin B1 shuttles in and out of the nucleus during interphase. Leptomycin B, a specific inhibitor of CRM1 (exportin 1), blocks nuclear export of cyclin B1 indicating that CRM1 is required for the export process. The NES is localized within the cyclin B1 cytoplasmic retention signal, and mutations in the NES abolish export.
-
Hagting A., Karlsson C., Clute P., Jackman M., Pines J. MPF localization is controlled by nuclear export. EMBO J. 17:1998;4127-4138. In this study, real-time imaging of GFP-tagged cyclin B1 in HeLa cells revealed that cyclin B1 shuttles in and out of the nucleus during interphase. Leptomycin B, a specific inhibitor of CRM1 (exportin 1), blocks nuclear export of cyclin B1 indicating that CRM1 is required for the export process. The NES is localized within the cyclin B1 cytoplasmic retention signal, and mutations in the NES abolish export.
-
(1998)
EMBO J
, vol.17
, pp. 4127-4138
-
-
Hagting, A.1
Karlsson, C.2
Clute, P.3
Jackman, M.4
Pines, J.5
-
24
-
-
0032528001
-
Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1
-
••], to glutamic acid residues results in impaired nuclear export. The cyclin B1 CRS mutants have a reduced affinity for CRM1 suggesting that phosphorylation of cyclin B1 CRS serine residues blocks CRM1 binding and subsequent nuclear export.
-
••], to glutamic acid residues results in impaired nuclear export. The cyclin B1 CRS mutants have a reduced affinity for CRM1 suggesting that phosphorylation of cyclin B1 CRS serine residues blocks CRM1 binding and subsequent nuclear export.
-
(1998)
Genes Dev
, vol.12
, pp. 2131-2143
-
-
Yang, J.1
Bardes, E.S.2
Moore, J.D.3
Brennan, J.4
Powers, M.A.5
Kornbluth, S.6
-
25
-
-
0033601783
-
Nuclear import of Cdk/cyclin complexes: Identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1
-
Moore J.D., Yang J., Truant R., Kornbluth S. Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1. J Cell Biol. 144:1999;213-224.
-
(1999)
J Cell Biol
, vol.144
, pp. 213-224
-
-
Moore, J.D.1
Yang, J.2
Truant, R.3
Kornbluth, S.4
-
26
-
-
0027933911
-
The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B
-
Pines J., Hunter T. The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. EMBO J. 13:1994;3772-3781.
-
(1994)
EMBO J
, vol.13
, pp. 3772-3781
-
-
Pines, J.1
Hunter, T.2
-
27
-
-
0031028382
-
Nuclear localization of cyclin B1 mediates its biological activity and is regulated by phosphorylation
-
Glu mutant, which mimics cyclin B1 phosphorylated at the CRS serines, is slightly more potent than wild-type cyclin B1 in promoting oocyte maturation.
-
Glu mutant, which mimics cyclin B1 phosphorylated at the CRS serines, is slightly more potent than wild-type cyclin B1 in promoting oocyte maturation.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 502-507
-
-
Li, J.1
Meyer, A.N.2
Donoghue, D.J.3
-
28
-
-
0025092622
-
Distinct nuclear and spindle pole body population of cyclin-cdc2 in fission yeast
-
Alfa C.E., Ducommun B., Beach D., Hyams J.S. Distinct nuclear and spindle pole body population of cyclin-cdc2 in fission yeast. Nature. 347:1990;680-682.
-
(1990)
Nature
, vol.347
, pp. 680-682
-
-
Alfa, C.E.1
Ducommun, B.2
Beach, D.3
Hyams, J.S.4
-
29
-
-
0032578006
-
A role for NIMA in the nuclear localization of cyclin B in Aspergillus nidulans
-
Wu L., Osmani S.A., Mirabito P.M. A role for NIMA in the nuclear localization of cyclin B in Aspergillus nidulans. J Cell Biol. 141:1998;1575-1587.
-
(1998)
J Cell Biol
, vol.141
, pp. 1575-1587
-
-
Wu, L.1
Osmani, S.A.2
Mirabito, P.M.3
-
30
-
-
0032213216
-
Nuclear RNA export
-
Stutz F., Rosbash M. Nuclear RNA export. Genes Dev. 12:1998;3303-3319.
-
(1998)
Genes Dev
, vol.12
, pp. 3303-3319
-
-
Stutz, F.1
Rosbash, M.2
-
31
-
-
0032535244
-
Polo-like kinases: A team that plays throughout mitosis
-
Glover D.M., Hagan I.M., Tavares A.A.M. Polo-like kinases: a team that plays throughout mitosis. Genes Dev. 12:1998;3777-3787.
-
(1998)
Genes Dev
, vol.12
, pp. 3777-3787
-
-
Glover, D.M.1
Hagan, I.M.2
Tavares, A.A.M.3
-
32
-
-
0029821131
-
Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts
-
Kumagai A., Dunphy W.G. Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts. Science. 273:1996;1377-1380.
-
(1996)
Science
, vol.273
, pp. 1377-1380
-
-
Kumagai, A.1
Dunphy, W.G.2
-
33
-
-
0031806809
-
Activated polo-like kinase Plx1 is required at multiple points during mitosis in Xenopus laevis
-
2/M delay consistent with a role for Plx upstream of Cdc25C. Cdc25C injection also results in Plx activation suggesting the existence of a positive-feedback loop.
-
2/M delay consistent with a role for Plx upstream of Cdc25C. Cdc25C injection also results in Plx activation suggesting the existence of a positive-feedback loop.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 4262-4271
-
-
Qian, Y.W.1
Erikson, E.2
Li, C.3
Maller, J.L.4
-
34
-
-
0031850551
-
2/M-phase transition of the cell cycle in Xenopus eggs
-
Antibody-mediated interference and immunodepletion of Plx in a Xenopus extract system is shown to result in a failure to accumulate hyperphosphorylated Cdc25C and active Cdc2-cyclin B1. Active Cdc2-cyclin B1 triggers Plx activation indicating the existence of a positive-feedback loop.
-
2/M-phase transition of the cell cycle in Xenopus eggs. J Cell Sci. 111:1998;1751-1757. Antibody-mediated interference and immunodepletion of Plx in a Xenopus extract system is shown to result in a failure to accumulate hyperphosphorylated Cdc25C and active Cdc2-cyclin B1. Active Cdc2-cyclin B1 triggers Plx activation indicating the existence of a positive-feedback loop.
-
(1998)
J Cell Sci
, vol.111
, pp. 1751-1757
-
-
Abrieu, A.1
Brassac, T.2
Galas, S.3
Fisher, D.4
Labbe, J.C.5
Doree, M.6
-
35
-
-
0032573383
-
Purification and cloning of a protein kinase that phosphorylates and activates the polo-like kinase Plx1
-
Qian Y.W., Erikson E., Maller J.L. Purification and cloning of a protein kinase that phosphorylates and activates the polo-like kinase Plx1. Science. 282:1998;1701-1704.
-
(1998)
Science
, vol.282
, pp. 1701-1704
-
-
Qian, Y.W.1
Erikson, E.2
Maller, J.L.3
-
36
-
-
0032473568
-
The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae
-
Shirayama M., Zachariae W., Ciosk R., Nasmyth K. The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae. EMBO J. 17:1998;1336-1349.
-
(1998)
EMBO J
, vol.17
, pp. 1336-1349
-
-
Shirayama, M.1
Zachariae, W.2
Ciosk, R.3
Nasmyth, K.4
-
37
-
-
0031713341
-
A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae
-
Jaspersen S.L., Charles J.F., Tinker-Kulberg R.L., Morgan D.O. A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol Biol Cell. 9:1998;2803-2817.
-
(1998)
Mol Biol Cell
, vol.9
, pp. 2803-2817
-
-
Jaspersen, S.L.1
Charles, J.F.2
Tinker-Kulberg, R.L.3
Morgan, D.O.4
-
38
-
-
0032560029
-
The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae
-
Charles J.F., Jaspersen S.L., Tinker-Kulberg R.L., Hwang L., Szidon A., Morgan D.O. The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae. Curr Biol. 8:1998;497-507.
-
(1998)
Curr Biol
, vol.8
, pp. 497-507
-
-
Charles, J.F.1
Jaspersen, S.L.2
Tinker-Kulberg, R.L.3
Hwang, L.4
Szidon, A.5
Morgan, D.O.6
-
39
-
-
0032053785
-
The fission yeast SPB component cut12 links bipolar spindle formation to mitotic control
-
+ encodes a novel SPB component that is required for bipolar spindle formation. The cut12-1 mutation is allelic to the cdc25-22 suppressor stf1-1, and thus provides a genetic link between the cdc2p/cdc13p activation and spindle assembly pathways.
-
+ encodes a novel SPB component that is required for bipolar spindle formation. The cut12-1 mutation is allelic to the cdc25-22 suppressor stf1-1, and thus provides a genetic link between the cdc2p/cdc13p activation and spindle assembly pathways.
-
(1998)
Genes Dev
, vol.12
, pp. 927-942
-
-
Bridge, A.J.1
Morphew, M.2
Bartlett, R.3
Hagan, I.M.4
-
40
-
-
0025134785
-
Stf1: Non-wee mutations epistatic to cdc25 in the fission yeast Schizosaccharomyces pombe
-
Hudson J.D., Feilotter H., Young P.G. stf1: non-wee mutations epistatic to cdc25 in the fission yeast Schizosaccharomyces pombe. Genetics. 126:1990;309-315.
-
(1990)
Genetics
, vol.126
, pp. 309-315
-
-
Hudson, J.D.1
Feilotter, H.2
Young, P.G.3
-
41
-
-
0032555899
-
A morphogenesis checkpoint monitors the actin cytoskeleton in yeast
-
2delay is shown to be mediated through Swe1p. This study also indicates that the checkpoint is triggered in cells that have already formed a bud, indicating that checkpoint activation can occur following proper establishment of bud polarity.
-
2delay is shown to be mediated through Swe1p. This study also indicates that the checkpoint is triggered in cells that have already formed a bud, indicating that checkpoint activation can occur following proper establishment of bud polarity.
-
(1998)
J Cell Biol
, vol.142
, pp. 1487-1499
-
-
McMillan, J.N.1
Sia, R.A.L.2
Lew, D.J.3
-
42
-
-
0029906773
-
Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast
-
Sia R.A., Herald H.A., Lew D.J. Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast. Mol Biol Cell. 7:1996;1657-1666.
-
(1996)
Mol Biol Cell
, vol.7
, pp. 1657-1666
-
-
Sia, R.A.1
Herald, H.A.2
Lew, D.J.3
-
43
-
-
0032538796
-
Control of Swe1p degradation by the morphogenesis checkpoint
-
2/M in S. cerevisiae to promote Cdc28p-Clb activation.
-
2/M in S. cerevisiae to promote Cdc28p-Clb activation.
-
(1998)
EMBO J
, vol.17
, pp. 6678-6688
-
-
Sia, R.A.1
Bardes, E.S.2
Lew, D.J.3
-
45
-
-
0033555685
-
Nim1-related kinases coordinate cell cycle progression with the organization of the peripheral cytoskeleton in yeast
-
2/M delay. An intriguing possibility that this study raises is that actin and septin dynamics may be coupled, and that the morphogenesis checkpoint may be triggered by defects in septin function.
-
2/M delay. An intriguing possibility that this study raises is that actin and septin dynamics may be coupled, and that the morphogenesis checkpoint may be triggered by defects in septin function.
-
(1999)
Genes Dev
, vol.13
, pp. 176-187
-
-
Barral, Y.1
Parra, M.2
Bidlingmaier, S.3
Snyder, M.4
-
47
-
-
0031792832
-
The protein kinase cdr2, related to nim1/cdr1 mitotic inducer, regulates the onset of mitosis in fission yeast
-
Kanoh J., Russell P. The protein kinase cdr2, related to nim1/cdr1 mitotic inducer, regulates the onset of mitosis in fission yeast. Mol Biol Cell. 9:1998;3321-3334.
-
(1998)
Mol Biol Cell
, vol.9
, pp. 3321-3334
-
-
Kanoh, J.1
Russell, P.2
-
48
-
-
0032476582
-
The septins are required for the mitosis-specific activation of the Gin4 kinase
-
The authors report that Gin4p binds septins and requires septin function for activity. Cells with septin mutations are shown to display an elongated bud phenotype - similar to cells with gin4 mutations - indicating that mitotic delay results from loss of septin function.
-
Carroll C.W., Altman R., Schieltz D., Yates J.R., Kellogg D. The septins are required for the mitosis-specific activation of the Gin4 kinase. J Cell Biol. 143:1998;709-717. The authors report that Gin4p binds septins and requires septin function for activity. Cells with septin mutations are shown to display an elongated bud phenotype - similar to cells with gin4 mutations - indicating that mitotic delay results from loss of septin function.
-
(1998)
J Cell Biol
, vol.143
, pp. 709-717
-
-
Carroll, C.W.1
Altman, R.2
Schieltz, D.3
Yates, J.R.4
Kellogg, D.5
-
49
-
-
0032476712
-
Role of the yeast Gin4p protein kinase in septin assembly and the relationship between septin assembly and septin function
-
Gin4p is shown to interact genetically and physically with septins, and colocalize with septins at the bud neck. In addition, the authors demonstrate that deletion of GIN4 leads to aberrant septin organization and cell morphology.
-
Longtine M.S., Fares H., Pringle J.R. Role of the yeast Gin4p protein kinase in septin assembly and the relationship between septin assembly and septin function. J Cell Biol. 143:1998;719-736. Gin4p is shown to interact genetically and physically with septins, and colocalize with septins at the bud neck. In addition, the authors demonstrate that deletion of GIN4 leads to aberrant septin organization and cell morphology.
-
(1998)
J Cell Biol
, vol.143
, pp. 719-736
-
-
Longtine, M.S.1
Fares, H.2
Pringle, J.R.3
-
50
-
-
0032484097
-
Coupling of mitosis to the completion of S phase through Cdc34-mediated degradation of Wee1
-
This report shows that Wee1 proteolysis, which is dependent upon the activity of Cdc34, is required in a Xenopus extract system to allow timely entry into mitosis. Wee1 is shown to be stabilized in extracts treated with the DNA replication inhibitor aphidicolin.
-
Michael W.M., Newport J. Coupling of mitosis to the completion of S phase through Cdc34-mediated degradation of Wee1. Science. 282:1998;1886-1889. This report shows that Wee1 proteolysis, which is dependent upon the activity of Cdc34, is required in a Xenopus extract system to allow timely entry into mitosis. Wee1 is shown to be stabilized in extracts treated with the DNA replication inhibitor aphidicolin.
-
(1998)
Science
, vol.282
, pp. 1886-1889
-
-
Michael, W.M.1
Newport, J.2
-
51
-
-
0032190082
-
Replication checkpoint requires phosphorylation of the phosphatase cdc25 by cds1 or chk1
-
Zeng Y., Forbes K.C., Wu Z., Moreno S., Piwnica-Worms H., Enoch T. Replication checkpoint requires phosphorylation of the phosphatase cdc25 by cds1 or chk1. Nature. 395:1998;507-510.
-
(1998)
Nature
, vol.395
, pp. 507-510
-
-
Zeng, Y.1
Forbes, K.C.2
Wu, Z.3
Moreno, S.4
Piwnica-Worms, H.5
Enoch, T.6
-
52
-
-
0032496322
-
Replication checkpoint enforced by kinases cds1 and chk1
-
Boddy M.N., Furnari B., Mondesert O., Russell P. Replication checkpoint enforced by kinases cds1 and chk1. Science. 280:1998;909-912.
-
(1998)
Science
, vol.280
, pp. 909-912
-
-
Boddy, M.N.1
Furnari, B.2
Mondesert, O.3
Russell, P.4
-
53
-
-
0030867582
-
Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
-
Sanchez Y., Wong C., Thoma R.S., Richman R., Wu Z., Piwnica-Worms H., Elledge S.J. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science. 277:1997;1497-1501.
-
(1997)
Science
, vol.277
, pp. 1497-1501
-
-
Sanchez, Y.1
Wong, C.2
Thoma, R.S.3
Richman, R.4
Wu, Z.5
Piwnica-Worms, H.6
Elledge, S.J.7
-
54
-
-
0031906844
-
14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts
-
This study demonstrates that 14-3-3 proteins bind Cdc25 that is phosphorylated on Ser287. This interaction is required to prevent entry into mitosis in the presence of unreplicated or damaged DNA. Importantly, the authors show that binding of 14-3-3 proteins to Cdc25 has only modest affects on the ability of Cdc25 to dephosphorylate Cdc2 that is phosphorylated on Tyr15.
-
Kumagai A., Yakowec P.S., Dunphy W.G. 14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts. Mol Biol Cell. 9:1998;345-354. This study demonstrates that 14-3-3 proteins bind Cdc25 that is phosphorylated on Ser287. This interaction is required to prevent entry into mitosis in the presence of unreplicated or damaged DNA. Importantly, the authors show that binding of 14-3-3 proteins to Cdc25 has only modest affects on the ability of Cdc25 to dephosphorylate Cdc2 that is phosphorylated on Tyr15.
-
(1998)
Mol Biol Cell
, vol.9
, pp. 345-354
-
-
Kumagai, A.1
Yakowec, P.S.2
Dunphy, W.G.3
-
55
-
-
0030611095
-
2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
-
2 arrest in the presence of unreplicated or damaged DNA. The authors propose that Ser216 phosphorylation and binding to 14-3-3 proteins prevent Cdc25C from interacting with Cdc2 since Cdc25C activity is not detectably affected by either Ser216 phosphorylation or binding to 14-3-3 proteins.
-
2 arrest in the presence of unreplicated or damaged DNA. The authors propose that Ser216 phosphorylation and binding to 14-3-3 proteins prevent Cdc25C from interacting with Cdc2 since Cdc25C activity is not detectably affected by either Ser216 phosphorylation or binding to 14-3-3 proteins.
-
(1997)
Science
, vol.277
, pp. 1501-1505
-
-
Peng, C.Y.1
Graves, P.R.2
Thoma, R.S.3
Wu, Z.4
Shaw, A.S.5
Piwnica-Worms, H.6
-
56
-
-
0025234351
-
Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast
-
Moreno S., Nurse P., Russell P. Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast. Nature. 344:1990;549-552.
-
(1990)
Nature
, vol.344
, pp. 549-552
-
-
Moreno, S.1
Nurse, P.2
Russell, P.3
-
57
-
-
0033552943
-
Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
-
This paper shows that the nuclear localization of fission yeast cdc25p is regulated by DNA damage. Following DNA damage, cdc25p is probably phosphorylated directly by chk1p, which creates a binding site for the 14-3-3 protein rad24p. The authors demonstrate that the rad24p-cdc25p complex is exported to the cytoplasm in a crm1p-dependent manner via a NES that is located within rad24p.
-
Lopez-Girona A., Furnari B., Mondesert O., Russell P. Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature. 397:1999;172-175. This paper shows that the nuclear localization of fission yeast cdc25p is regulated by DNA damage. Following DNA damage, cdc25p is probably phosphorylated directly by chk1p, which creates a binding site for the 14-3-3 protein rad24p. The authors demonstrate that the rad24p-cdc25p complex is exported to the cytoplasm in a crm1p-dependent manner via a NES that is located within rad24p.
-
(1999)
Nature
, vol.397
, pp. 172-175
-
-
Lopez-Girona, A.1
Furnari, B.2
Mondesert, O.3
Russell, P.4
-
58
-
-
0028101138
-
14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast
-
Ford J.C., al-Khodairy F., Fotou E., Sheldrick K.S., Griffiths D.J., Carr A.M. 14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast. Science. 265:1994;533-535.
-
(1994)
Science
, vol.265
, pp. 533-535
-
-
Ford, J.C.1
Al-Khodairy, F.2
Fotou, E.3
Sheldrick, K.S.4
Griffiths, D.J.5
Carr, A.M.6
-
59
-
-
0031749011
-
Nuclear localization of cyclin B1 controls mitotic entry after DNA damage
-
2 delay after irradiation.
-
2 delay after irradiation.
-
(1998)
J Cell Biol
, vol.141
, pp. 875-885
-
-
Jin, P.1
Hardy, S.2
Morgan, D.O.3
-
60
-
-
0030921428
-
The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation-induced damage in human cells
-
Blasina A., Paegle E.S., McGowan C.H. The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation-induced damage in human cells. Mol Biol Cell. 8:1997;1013-1023.
-
(1997)
Mol Biol Cell
, vol.8
, pp. 1013-1023
-
-
Blasina, A.1
Paegle, E.S.2
McGowan, C.H.3
-
62
-
-
0031775652
-
Entry into mitosis without Cdc2 kinase activation
-
Gowdy P.M., Anderson H.J., Roberge M. Entry into mitosis without Cdc2 kinase activation. J Cell Sci. 111:1998;3401-3410.
-
(1998)
J Cell Sci
, vol.111
, pp. 3401-3410
-
-
Gowdy, P.M.1
Anderson, H.J.2
Roberge, M.3
-
63
-
-
0031655993
-
A phosphorylation site mutant of Schizosaccharomyces pombe cdc2p fails to promote the metaphase to anaphase transition
-
Gould K.L., Feoktistova A., Fleig U. A phosphorylation site mutant of Schizosaccharomyces pombe cdc2p fails to promote the metaphase to anaphase transition. Mol Gen Genet. 259:1998;437-448.
-
(1998)
Mol Gen Genet
, vol.259
, pp. 437-448
-
-
Gould, K.L.1
Feoktistova, A.2
Fleig, U.3
-
64
-
-
0028998815
-
Subcellular localisation of human wee1 kinase is regulated during the cell cycle
-
Baldin V., Ducommun B. Subcellular localisation of human wee1 kinase is regulated during the cell cycle. J Cell Sci. 108:1995;2425-2432.
-
(1995)
J Cell Sci
, vol.108
, pp. 2425-2432
-
-
Baldin, V.1
Ducommun, B.2
-
65
-
-
0028089946
-
Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)
-
Tassan J.P., Schultz S.J., Bartek J., Nigg E.A. Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase). J Cell Biol. 127:1994;467-478.
-
(1994)
J Cell Biol
, vol.127
, pp. 467-478
-
-
Tassan, J.P.1
Schultz, S.J.2
Bartek, J.3
Nigg, E.A.4
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