-
1
-
-
0035687018
-
Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease
-
R. Abraham, A. Myers, F. Wavrant-DeVrieze, M.L. Hamshere, H.V. Thomas, H. Marshal, D. Compton, G. Spurlock, D. Turic, B. Hoogendoorn, J.M. Kwon, R.C. Petersen, E. Tangalos, J. Norton, J.C. Morris, R. Bullock, D. Liolitsa, S. Lovestone, J. Hardy, A. Goate, M. O'Donovan, J. Williams, M.J. Owen and L. Jones, Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease, Hum Genet. 109 (2001), 646-652.
-
(2001)
Hum. Genet.
, vol.109
, pp. 646-652
-
-
Abraham, R.1
Myers, A.2
Wavrant-DeVrieze, F.3
Hamshere, M.L.4
Thomas, H.V.5
Marshal, H.6
Compton, D.7
Spurlock, G.8
Turic, D.9
Hoogendoorn, B.10
Kwon, J.M.11
Petersen, R.C.12
Tangalos, E.13
Norton, J.14
Morris, J.C.15
Bullock, R.16
Liolitsa, D.17
Lovestone, S.18
Hardy, J.19
Goate, A.20
O'Donovan, M.21
Williams, J.22
Owen, M.J.23
Jones, L.24
more..
-
2
-
-
0032727808
-
Angiotensin converting enzyme and endothelial nitric oxide synthase DNA polymorphisms and late onset Alzheimer's disease
-
R. Alvarez, V. Alvarez, C.H. Lahoz, C. Martinez, J. Pena, J.M. Sanchez, L.M. Guisasola, J. Salas-Puig, G. Moris, J.A. Vidal, R. Ribacoba, B.B. Menes, D. Uria and E. Coto, Angiotensin converting enzyme and endothelial nitric oxide synthase DNA polymorphisms and late onset Alzheimer's disease, J Neurol Neurosurg Psychiatry 67 (1999), 733-736.
-
(1999)
J. Neurol. Neurosurg. Psychiatry
, vol.67
, pp. 733-736
-
-
Alvarez, R.1
Alvarez, V.2
Lahoz, C.H.3
Martinez, C.4
Pena, J.5
Sanchez, J.M.6
Guisasola, L.M.7
Salas-Puig, J.8
Moris, G.9
Vidal, J.A.10
Ribacoba, R.11
Menes, B.B.12
Uria, D.13
Coto, E.14
-
3
-
-
0029852887
-
Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloidbeta peptide (1-40)
-
J.R. Backstrom, G.P. Lim, M.J. Cullen and Z.A. Tokes, Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloidbeta peptide (1-40), J Neurosci. 16 (1996), 7910-7919.
-
(1996)
J. Neurosci.
, vol.16
, pp. 7910-7919
-
-
Backstrom, J.R.1
Lim, G.P.2
Cullen, M.J.3
Tokes, Z.A.4
-
4
-
-
0026597204
-
Characterization of neutral proteinases from Alzheimer-affected and control brain specimens: Identification of calcium-dependent metalloproteinases from the hippocampus
-
J.R. Backstrom, C.A. Miller and Z.A. Tokes, Characterization of neutral proteinases from Alzheimer-affected and control brain specimens: Identification of calcium-dependent metalloproteinases from the hippocampus, J. Neurochem. 58 (1992), 983-992.
-
(1992)
J. Neurochem.
, vol.58
, pp. 983-992
-
-
Backstrom, J.R.1
Miller, C.A.2
Tokes, Z.A.3
-
5
-
-
0034711206
-
Degradation of amylin by insulin-degrading enzyme
-
R.G. Bennett, W.C. Duckworth and F.G. Hamel, Degradation of amylin by insulin-degrading enzyme, J. Biol. Chem. 275 (2000), 36621-36625.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 36621-36625
-
-
Bennett, R.G.1
Duckworth, W.C.2
Hamel, F.G.3
-
6
-
-
0034704198
-
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q
-
L. Bertram, D. Blacker, K. Mullin, D. Keeney, J. Jones, S. Basu, S. Yhu, M.G. McInnis, R.C. Go, K. Vekrellis, D.J. Selkoe, A.J. Saunders and R.E. Tanzi, Evidence for genetic linkage of Alzheimer's disease to chromosome 10q, Science 290 (2000), 2302-2303.
-
(2000)
Science
, vol.290
, pp. 2302-2303
-
-
Bertram, L.1
Blacker, D.2
Mullin, K.3
Keeney, D.4
Jones, J.5
Basu, S.6
Yhu, S.7
McInnis, M.G.8
Go, R.C.9
Vekrellis, K.10
Selkoe, D.J.11
Saunders, A.J.12
Tanzi, R.E.13
-
7
-
-
0035103358
-
The multiple paradoxs of presenilins
-
F. Checler, The multiple paradoxs of presenilins, J. Neurochem. 76 (2001), 1621-1627.
-
(2001)
J. Neurochem.
, vol.76
, pp. 1621-1627
-
-
Checler, F.1
-
8
-
-
0034667518
-
Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization
-
V. Chesneau, K. Vekrellis, M.R. Rosner and D.J. Selkoe, Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization, Biochem. J. 351 (2000), 509-516.
-
(2000)
Biochem. J.
, vol.351
, pp. 509-516
-
-
Chesneau, V.1
Vekrellis, K.2
Rosner, M.R.3
Selkoe, D.J.4
-
9
-
-
0033962798
-
Gender-specific association of the angiotensin converting enzyme gene with Alzheimer's disease
-
F. Crawford, L. Abdullah, J. Schinka, Z. Suo, M. Gold, R. Duara and M. Mullan, Gender-specific association of the angiotensin converting enzyme gene with Alzheimer's disease, Neurosci. Lett. 280 (2000), 215-219.
-
(2000)
Neurosci. Lett.
, vol.280
, pp. 215-219
-
-
Crawford, F.1
Abdullah, L.2
Schinka, J.3
Suo, Z.4
Gold, M.5
Duara, R.6
Mullan, M.7
-
10
-
-
0024062933
-
Insulin degradation: Mechanisms, products, and significance
-
WC Duckworth. Insulin degradation: Mechanisms, products, and significance, Endocr Rev. 9 (1988), 319-345.
-
(1988)
Endocr. Rev.
, vol.9
, pp. 319-345
-
-
Duckworth, W.C.1
-
11
-
-
0035816707
-
Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme
-
E.A. Eckman, D.K. Reed and C.B. Eckman, Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme, J Biol Chem. 276 (2001), 24540-24548.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 24540-24548
-
-
Eckman, E.A.1
Reed, D.K.2
Eckman, C.B.3
-
12
-
-
0034703979
-
Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
-
N. Ertekin-Taner, N. Graff-Radford, L.H. Younkin, C. Eckman, M. Baker, J. Adamson, J. Ronald, J. Blangero, M. Hutton and S.G. Younkin, Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees, Science 290 (2000), 2303-2304.
-
(2000)
Science
, vol.290
, pp. 2303-2304
-
-
Ertekin-Taner, N.1
Graff-Radford, N.2
Younkin, L.H.3
Eckman, C.4
Baker, M.5
Adamson, J.6
Ronald, J.7
Blangero, J.8
Hutton, M.9
Younkin, S.G.10
-
13
-
-
12944310975
-
Association between angiotensin-converting enzyme and Alzheimer disease
-
L.A. Farrer, T. Sherbatich, S.A. Keryanov, G.I. Korovaitseva, E.A. Rogaeva, S. Petruk, S. Premkumar, Y. Moliaka, Y.Q. Song, Y. Pei, C. Sato, N.D. Selezneva, S. Voskresenskaya, V. Golimbet, S. Sorbi, R. Duara, S. Gavrilova, P.H. St George-Hyslop and E.I. Rogaev, Association between angiotensin-converting enzyme and Alzheimer disease, Arch Neurol. 57 (2000), 210-214.
-
(2000)
Arch. Neurol.
, vol.57
, pp. 210-214
-
-
Farrer, L.A.1
Sherbatich, T.2
Keryanov, S.A.3
Korovaitseva, G.I.4
Rogaeva, E.A.5
Petruk, S.6
Premkumar, S.7
Moliaka, Y.8
Song, Y.Q.9
Pei, Y.10
Sato, C.11
Selezneva, N.D.12
Voskresenskaya, S.13
Golimbet, V.14
Sorbi, S.15
Duara, R.16
Gavrilova, S.17
St George-Hyslop, P.H.18
Rogaev, E.I.19
-
14
-
-
0024454036
-
An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin
-
J.V. Garcia, B.D. Gehm and M.R. Rosner, An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin, J. Cell Biol. 109 (1989), 1301-1307.
-
(1989)
J. Cell Biol.
, vol.109
, pp. 1301-1307
-
-
Garcia, J.V.1
Gehm, B.D.2
Rosner, M.R.3
-
15
-
-
0025809406
-
Regulation of insulin, epidermal growth factor, and transforming growth factor-alpha levels by growth factor-degrading enzymes
-
B.D. Gehm and M.R. Rosner, Regulation of insulin, epidermal growth factor, and transforming growth factor-alpha levels by growth factor-degrading enzymes, Endocrinology 128 (1991), 1603-1610.
-
(1991)
Endocrinology
, vol.128
, pp. 1603-1610
-
-
Gehm, B.D.1
Rosner, M.R.2
-
16
-
-
0029061685
-
Neutral endopeptidase can hydrolyze beta-amyloid(1-40) but shows no effect on beta-amyloid precursor protein metabolism
-
S. Howell, J. Nalbantogluand and P. Crine, Neutral endopeptidase can hydrolyze beta-amyloid(1-40) but shows no effect on beta-amyloid precursor protein metabolism, Peptides 16 (1995), 647-652.
-
(1995)
Peptides
, vol.16
, pp. 647-652
-
-
Howell, S.1
Nalbantogluand, J.2
Crine, P.3
-
17
-
-
0035930538
-
Angiotensin-converting enzyme degrades Alzheimer Amyloid beta-Peptide (Aβ); retards Aβ aggregation, deposition, fibril formation; and inhibits cytotoxicity
-
J. Hu, A. Igarashi, M. Kamata and H. Nakagawa, Angiotensin-converting enzyme degrades Alzheimer amyloid beta-Peptide (Aβ); retards Aβ aggregation, deposition, fibril formation; and inhibits cytotoxicity, J. Biol. Chem. 276 (2001), 47863-47868.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47863-47868
-
-
Hu, J.1
Igarashi, A.2
Kamata, M.3
Nakagawa, H.4
-
18
-
-
0032706653
-
Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population
-
J. Hu, F. Miyatake, Y. Aizu, H. Nakagawa, S. Nakamura, A. Tamaoka, R. Takahash, K. Urakami and M. Shoji, Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population, Neurosci Lett. 277 (1999), 65-67.
-
(1999)
Neurosci. Lett.
, vol.277
, pp. 65-67
-
-
Hu, J.1
Miyatake, F.2
Aizu, Y.3
Nakagawa, H.4
Nakamura, S.5
Tamaoka, A.6
Takahash, R.7
Urakami, K.8
Shoji, M.9
-
19
-
-
0035947207
-
Metabolic regulation of brain Abeta by neprilysin
-
N. Iwata, S. Tsubuki, Y. Takaki, K. Shirotani, B. Lu, N.P Gerard, C. Gerard, E. Hama, H.J. Lee and T.C. Saido, Metabolic regulation of brain Abeta by neprilysin, Science 292 (2001), 1550-1552.
-
(2001)
Science
, vol.292
, pp. 1550-1552
-
-
Iwata, N.1
Tsubuki, S.2
Takaki, Y.3
Shirotani, K.4
Lu, B.5
Gerard, N.P.6
Gerard, C.7
Hama, E.8
Lee, H.J.9
Saido, T.C.10
-
20
-
-
0033621739
-
Identification of the major Abetal-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
-
N. Iwata, S. Tsubuki, Y. Takaki, K. Watanabe, M. Sekiguchi, E. Hosoki, M. Kawashima-Morishima, H.J. Lee, E. Hama, Y. Sekine-Aizawa and T.C. Saido, Identification of the major Abetal-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition, Nat. Med. 6 (2000), 143-150.
-
(2000)
Nat. Med.
, vol.6
, pp. 143-150
-
-
Iwata, N.1
Tsubuki, S.2
Takaki, Y.3
Watanabe, K.4
Sekiguchi, M.5
Hosoki, E.6
Kawashima-Morishima, M.7
Lee, H.J.8
Hama, E.9
Sekine-Aizawa, Y.10
Saido, T.C.11
-
21
-
-
0032924870
-
Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease
-
PG. Kehoe, C. Russ, S. McIlory, H. Williams, P. Holmans, C. Holmes, D. Liolitsa, D. Vahidassr, J. Powell, B. McGleenon, M. Liddell, R. Plomin, K. Dynan, N. Williams, J. Neal, N.J. Cairns, G. Wilcock, P. Passmore, S. Lovestone, J. Williams and M.J. Owen, Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease, Nat. Genet. 21 (1999), 71-72.
-
(1999)
Nat. Genet.
, vol.21
, pp. 71-72
-
-
Kehoe, P.G.1
Russ, C.2
McIlory, S.3
Williams, H.4
Holmans, P.5
Holmes, C.6
Liolitsa, D.7
Vahidassr, D.8
Powell, J.9
McGleenon, B.10
Liddell, M.11
Plomin, R.12
Dynan, K.13
Williams, N.14
Neal, J.15
Cairns, N.J.16
Wilcock, G.17
Passmore, P.18
Lovestone, S.19
Williams, J.20
Owen, M.J.21
more..
-
22
-
-
0022895350
-
Regulatory peptide metabolism at cell surfaces: The key role of endopeptidase-24.11
-
A.J. Kenny, Regulatory peptide metabolism at cell surfaces: The key role of endopeptidase-24.11, Biomed Biochim Acta. 45 (1986), 1503-1513.
-
(1986)
Biomed. Biochim. Acta
, vol.45
, pp. 1503-1513
-
-
Kenny, A.J.1
-
23
-
-
0028928084
-
In vitro stimulation of tissue-type plasminogen activator by alzheimer amyloid beta-peptide analogues
-
I.B. Kingston, M.J. Castro and S. Anderson, In vitro stimulation of tissue-type plasminogen activator by alzheimer amyloid beta-peptide analogues, Nat. Med 1 (1995), 138-142.
-
(1995)
Nat. Med.
, vol.1
, pp. 138-142
-
-
Kingston, I.B.1
Castro, M.J.2
Anderson, S.3
-
24
-
-
0021111565
-
A high molecular weight metalloendoprotease from the cytosol of mammalian cells
-
R.J. Kirschner and A.L. Goldberg, A high molecular weight metalloendoprotease from the cytosol of mammalian cells, J. Biol. Chem. 258 (1983), 967-976.
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 967-976
-
-
Kirschner, R.J.1
Goldberg, A.L.2
-
25
-
-
0028176821
-
Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
-
I.V. Kurochkin and S. Goto, Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme, FEBS Lett. 345 (1994), 33-37.
-
(1994)
FEBS Lett.
, vol.345
, pp. 33-37
-
-
Kurochkin, I.V.1
Goto, S.2
-
26
-
-
0029005248
-
Neprilysin: Assay methods, purification, and characterization
-
C. Li and L.B. Hersh, Neprilysin: Assay methods, purification, and characterization, Methods Enzymol. 248 (1995), 253-263.
-
(1995)
Methods Enzymol.
, vol.248
, pp. 253-263
-
-
Li, C.1
Hersh, L.B.2
-
27
-
-
0022877471
-
An immunohistochemical study of endopeptidase-24.11 ("enkephalinase") in the pig nervous system
-
R. Matsas, A.J. Kenny and A.J. Turner, An immunohistochemical study of endopeptidase-24.11 ("enkephalinase") in the pig nervous system, Neuroscience 18 (1986), 91-1012.
-
(1986)
Neuroscience
, vol.18
, pp. 91-1012
-
-
Matsas, R.1
Kenny, A.J.2
Turner, A.J.3
-
28
-
-
0031044352
-
Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: Involvement of insulin-degrading enzyme
-
J.R. McDermott and A.M. Gibson, Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: Involvement of insulin-degrading enzyme, Neurochem. Res. 22 (1997), 49-56.
-
(1997)
Neurochem. Res.
, vol.22
, pp. 49-56
-
-
McDermott, J.R.1
Gibson, A.M.2
-
29
-
-
0034551718
-
Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques
-
A. Mukherjee, E. Song, M. Kihiko-Ehmann, J.P. Goodman Jr, J.S. Pyrek, S. Estus and L.B. Hersh, Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques, J. Neurosci. 20 (2000), 8745-8749.
-
(2000)
J. Neurosci.
, vol.20
, pp. 8745-8749
-
-
Mukherjee, A.1
Song, E.2
Kihiko-Ehmann, M.3
Goodman J.P., Jr.4
Pyrek, J.S.5
Estus, S.6
Hersh, L.B.7
-
30
-
-
0025987157
-
Atrial natriuretic peptide (ANP) is a high-affinity substrate for rat insulin-degrading enzyme
-
D. Muller, H. Baumeister, F. Buck and D. Richter, Atrial natriuretic peptide (ANP) is a high-affinity substrate for rat insulin-degrading enzyme, Eur. J. Biochem. 202 (1991), 285-292.
-
(1991)
Eur. J. Biochem.
, vol.202
, pp. 285-292
-
-
Muller, D.1
Baumeister, H.2
Buck, F.3
Richter, D.4
-
31
-
-
0026471959
-
Rat insulin-degrading enzyme: Cleavage pattern of the natriuretic peptide hormones ANP, BNP, and CNP revealed by HPLC and mass spectrometry
-
D. Muller, C. Schulze, H. Baumeister, E Buck and D. Richter, Rat insulin-degrading enzyme: cleavage pattern of the natriuretic peptide hormones ANP, BNP, and CNP revealed by HPLC and mass spectrometry, Biochemistry 31 (1992), 11138-11143.
-
(1992)
Biochemistry
, vol.31
, pp. 11138-11143
-
-
Muller, D.1
Schulze, C.2
Baumeister, H.3
Buck, E.4
Richter, D.5
-
32
-
-
0034704197
-
Susceptibility locus for Alzheimer's disease on chromosome 10
-
A. Myers, P. Holmans, H. Marshall, J. Kwon, D. Meyer, D. Ramic, S. Shears, J. Booth, EW. DeVrieze, R. Crook, M. Hamshere, R. Abraham, N. Tunstall, F. Rice, S. Carty, S. Lillystone, P. Kehoe, V. Rudrasingham, L. Jones, S. Lovestone, J. Perez-Tur, J. Williams, M.J. Owen, J. Hardy and A.M. Goate, Susceptibility locus for Alzheimer's disease on chromosome 10, Science 290 (2000), 2304-2305.
-
(2000)
Science
, vol.290
, pp. 2304-2305
-
-
Myers, A.1
Holmans, P.2
Marshall, H.3
Kwon, J.4
Meyer, D.5
Ramic, D.6
Shears, S.7
Booth, J.8
DeVrieze, E.W.9
Crook, R.10
Hamshere, M.11
Abraham, R.12
Tunstall, N.13
Rice, F.14
Carty, S.15
Lillystone, S.16
Kehoe, P.17
Rudrasingham, V.18
Jones, L.19
Lovestone, S.20
Perez-Tur, J.21
Williams, J.22
Owen, M.J.23
Hardy, J.24
Goate, A.M.25
more..
-
33
-
-
0033828644
-
The ACE gene and Alzheimer's disease susceptibility
-
Y. Narain, A. Yip, T. Murphy, C. Brayne, D. Easton, J.G. Evans, J. Xuereb, N. Cairns, M.M. Esiri, R.A. Furlong and D.C. Rubinsztein, The ACE gene and Alzheimer's disease susceptibility, J. Med. Genet. 37 (2000), 695-697.
-
(2000)
J. Med. Genet.
, vol.37
, pp. 695-697
-
-
Narain, Y.1
Yip, A.2
Murphy, T.3
Brayne, C.4
Easton, D.5
Evans, J.G.6
Xuereb, J.7
Cairns, N.8
Esiri, M.M.9
Furlong, R.A.10
Rubinsztein, D.C.11
-
34
-
-
0034644836
-
Regulation of APP cleavage by α-, β-, and γ-secretases
-
J. Nunan and D.H. Small, Regulation of APP cleavage by α-, β-, and γ-secretases, FEBS Lett. 483 (2000), 6-10.
-
(2000)
FEBS Lett.
, vol.483
, pp. 6-10
-
-
Nunan, J.1
Small, D.H.2
-
35
-
-
0033612161
-
Angiotensin converting enzyme deletion allele in different kinds of dementia disorders
-
B. Palumbo, D. Cadini, G. Nocentini, E. Filipponi, M.L. Fravolini and U. Senin, Angiotensin converting enzyme deletion allele in different kinds of dementia disorders, Neurosci Lett. 267 (1999), 97-100.
-
(1999)
Neurosci Lett.
, vol.267
, pp. 97-100
-
-
Palumbo, B.1
Cadini, D.2
Nocentini, G.3
Filipponi, E.4
Fravolini, M.L.5
Senin, U.6
-
36
-
-
0034038036
-
Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains
-
A. Perez, L. Morelli, J.C. Cresto and E.M. Castano, Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains, Neurochem. Res. 25 (2000), 247-255.
-
(2000)
Neurochem. Res.
, vol.25
, pp. 247-255
-
-
Perez, A.1
Morelli, L.2
Cresto, J.C.3
Castano, E.M.4
-
37
-
-
0013642132
-
Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex
-
W.Q. Qiu, W. Borth, Z. Ye, C. Haass, D.B Teplow and D.J. Selkoe, Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex, J. Biol. Chem. 271 (1996), 8443-8451.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 8443-8451
-
-
Qiu, W.Q.1
Borth, W.2
Ye, Z.3
Haass, C.4
Teplow, D.B.5
Selkoe, D.J.6
-
38
-
-
0000398342
-
Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation
-
W.Q. Qiu, D.M. Walsh, Z. Ye, K. Vekrellis, J. Zhang, M.B. Podlisny, M.R. Rosner, A. Safavi, L.B. Hersh and D.J. Selkoe, Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation, J. Biol. Chem. 273 (1998), 32730-32738.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 32730-32738
-
-
Qiu, W.Q.1
Walsh, D.M.2
Ye, Z.3
Vekrellis, K.4
Zhang, J.5
Podlisny, M.B.6
Rosner, M.R.7
Safavi, A.8
Hersh, L.B.9
Selkoe, D.J.10
-
39
-
-
1842367306
-
Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells
-
W.Q. Qiu, Z. Ye, D. Kholodenko, P. Seubert and D.J. Selkoe, Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells, J. Biol. Chem. 272 (1997), 6641-6646.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 6641-6646
-
-
Qiu, W.Q.1
Ye, Z.2
Kholodenko, D.3
Seubert, P.4
Selkoe, D.J.5
-
40
-
-
0029843563
-
Identification of gamma-endorphin-generating enzyme as insulin-degrading enzyme
-
A. Safavi, B.C. Miller, L. Cottam and L.B. Hersh, Identification of gamma-endorphin-generating enzyme as insulin-degrading enzyme, Biochemistry 35 (1996), 14318-14325.
-
(1996)
Biochemistry
, vol.35
, pp. 14318-14325
-
-
Safavi, A.1
Miller, B.C.2
Cottam, L.3
Hersh, L.B.4
-
41
-
-
0028170818
-
Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease
-
D.J. Selkoe, Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease, Annu Rev Cell Biol. 10 (1994), 373-403.
-
(1994)
Annu. Rev. Cell Biol.
, vol.10
, pp. 373-403
-
-
Selkoe, D.J.1
-
42
-
-
0035950225
-
Clearing the brain's amyloid cobwebs
-
D.J. Selkoe, Clearing the brain's amyloid cobwebs, Neuron. 32 (2001), 177-180.
-
(2001)
Neuron
, vol.32
, pp. 177-180
-
-
Selkoe, D.J.1
-
43
-
-
0031550507
-
Overexpression of insulin degrading enzyme: Cellular localization and effects on insulin signaling
-
K.A. Seta and R.A. Roth, Overexpression of insulin degrading enzyme: Cellular localization and effects on insulin signaling, Biochem. Biophys. Res. Commun. 231 (1997), 167-171.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.231
, pp. 167-171
-
-
Seta, K.A.1
Roth, R.A.2
-
44
-
-
0035877747
-
Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases
-
K. Shirotani, S. Tsubuki, N. Iwata, Y. Takaki, W. Harigaya, K. Maruyama, S. Kiryu-Seo, H. Kiyama, H. Iwata, T. Tomita, T. Iwatsubo and T.C. Saido, Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases, J Biol Chem. 276 (2001), 1895-21901.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 1895-21901
-
-
Shirotani, K.1
Tsubuki, S.2
Iwata, N.3
Takaki, Y.4
Harigaya, W.5
Maruyama, K.6
Kiryu-Seo, S.7
Kiyama, H.8
Iwata, H.9
Tomita, T.10
Iwatsubo, T.11
Saido, T.C.12
-
45
-
-
0035107460
-
The role of presenilins in γ-secretase activity: Catalyst or cofactor?
-
D.H. Small, The role of presenilins in γ-secretase activity: Catalyst or cofactor? J. Neurochem. 76 (2001), 1612-1614.
-
(2001)
J. Neurochem.
, vol.76
, pp. 1612-1614
-
-
Small, D.H.1
-
46
-
-
0034530036
-
Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain
-
Y. Takaki, N. lwata, S. Tsubuki, S. Taniguchi, S. Toyoshima, B. Lu, N.P. Gerard, C. Gerard, H.J. Lee, K. Shirotani and TC. Saido, Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain, J Biochem (Tokyo) 128 (2000), 897-902.
-
(2000)
J. Biochem. (Tokyo)
, vol.128
, pp. 897-902
-
-
Takaki, Y.1
Lwata, N.2
Tsubuki, S.3
Taniguchi, S.4
Toyoshima, S.5
Lu, B.6
Gerard, N.P.7
Gerard, C.8
Lee, H.J.9
Shirotani, K.10
Saido, T.C.11
-
47
-
-
18544410708
-
The plasmin system is induced by and degrades amyloid-beta aggregates
-
H.M. Tucker, M. Kihiko, J.N. Caldwell, S. Wright, T. Kawarabayashi, D. Price, D. Walker, S. Scheff, J.P. McGillis, R.E. Rydel and S. Estus, The plasmin system is induced by and degrades amyloid-beta aggregates, J. Neurosci. 20 (2000), 3937-3946.
-
(2000)
J. Neurosci.
, vol.20
, pp. 3937-3946
-
-
Tucker, H.M.1
Kihiko, M.2
Caldwell, J.N.3
Wright, S.4
Kawarabayashi, T.5
Price, D.6
Walker, D.7
Scheff, S.8
McGillis, J.P.9
Rydel, R.E.10
Estus, S.11
-
48
-
-
0033788789
-
Tissue plasminogen activator requires plasminogen to modulate amyloid-beta neurotoxicity and deposition
-
H.M. Tucker, M. Kihiko-Ehmann, S. Wright, R.E. Rydel and S. Estus, Tissue plasminogen activator requires plasminogen to modulate amyloid-beta neurotoxicity and deposition, J. Neurochem. 75 (2000), 2172-2177.
-
(2000)
J. Neurochem.
, vol.75
, pp. 2172-2177
-
-
Tucker, H.M.1
Kihiko-Ehmann, M.2
Wright, S.3
Rydel, R.E.4
Estus, S.5
-
49
-
-
0030032386
-
Molecular pharmacology of endothelin converting enzymes
-
A.J. Turner and L.J. Murphy, Molecular pharmacology of endothelin converting enzymes, Biochem. Pharmacol 51 (1996), 91-102.
-
(1996)
Biochem. Pharmacol.
, vol.51
, pp. 91-102
-
-
Turner, A.J.1
Murphy, L.J.2
-
50
-
-
0033621048
-
Plasmin cleavage of the amyloid β-protein: Alteration of secondary structure and stimulation of tissue plasminogen activator activity
-
W.E. Van Nostrand and M. Porter, Plasmin Cleavage of the Amyloid β-Protein: Alteration of secondary Structure and Stimulation of tissue Plasminogen Activator Activity, Biochemistry 38 (1999), 11570-11575.
-
(1999)
Biochemistry
, vol.38
, pp. 11570-11575
-
-
Van Nostrand, W.E.1
Porter, M.2
-
51
-
-
0034161516
-
Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme
-
K. Vekrellis, Z. Ye, W.Q. Qiu, D. Walsh, D. Hartley, V. Chesneau, M.R. Rosner and D.J. Selkoe, Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme, J. Neurosci. 20 (2000), 1657-1665.
-
(2000)
J. Neurosci.
, vol.20
, pp. 1657-1665
-
-
Vekrellis, K.1
Ye, Z.2
Qiu, W.Q.3
Walsh, D.4
Hartley, D.5
Chesneau, V.6
Rosner, M.R.7
Selkoe, D.J.8
-
52
-
-
0035106128
-
Presenilin and γ-secretase: Structure meets function
-
M.S. Wolfe, Presenilin and γ-secretase: Structure meets function, J. Neurochem. 76 (2001), 1615-1620.
-
(2001)
J. Neurochem.
, vol.76
, pp. 1615-1620
-
-
Wolfe, M.S.1
-
53
-
-
0036551587
-
Secretase as a target for Alzheimer's disease
-
M.S. Wolfe, Secretase as a target for Alzheimer's disease, Curr Top Med Chem. 2 (2002), 371-383.
-
(2002)
Curr. Top. Med. Chem.
, vol.2
, pp. 371-383
-
-
Wolfe, M.S.1
-
54
-
-
0033603328
-
Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation
-
R. Yamin, E.G. Malgeri, J.A. Sloane, W.T. McGraw and C.R. Abraham, Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation, J. Biol. Chem. 274 (1999), 18777-18784.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 18777-18784
-
-
Yamin, R.1
Malgeri, E.G.2
Sloane, J.A.3
McGraw, W.T.4
Abraham, C.R.5
-
55
-
-
0034576764
-
Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han Chinese
-
J.D. Yang, G. Feng, J. Zhang, Z.X. Lin, T. Shen, G. Breen, D. St Clair and L. He. Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han Chinese, Neurosci. Lett. 295 (2000), 41-44.
-
(2000)
Neurosci. Lett.
, vol.295
, pp. 41-44
-
-
Yang, J.D.1
Feng, G.2
Zhang, J.3
Lin, Z.X.4
Shen, T.5
Breen, G.6
St Clair, D.7
He, L.8
-
56
-
-
0035846826
-
Reduced neprilysin in high plaque areas of Alzheimer brain: A possible relationship to deficient degradation of beta-amyloid peptide
-
K. Yasojima, H. Akiyama, E.G. McGeer and P.L. McGeer, Reduced neprilysin in high plaque areas of Alzheimer brain: A possible relationship to deficient degradation of beta-amyloid peptide, Neurosci. Lett. 297 (2001), 97-100.
-
(2001)
Neurosci. Lett.
, vol.297
, pp. 97-100
-
-
Yasojima, K.1
Akiyama, H.2
McGeer, E.G.3
McGeer, P.L.4
-
57
-
-
0035900189
-
Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain
-
K. Yasojima, E.G. McGeer and P.L. McGeer, Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain, Brain Res. 919 (2001), 115-121.
-
(2001)
Brain Res.
, vol.919
, pp. 115-121
-
-
Yasojima, K.1
McGeer, E.G.2
McGeer, P.L.3
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