Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease

Lancet

Volumn 347, Issue 9000, 1996, Pages 509-512

  Wragg, Michelle ^a   Hutton, Mike ^b   Talbot, Chris ^a   Goate, Alison ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E4;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; CAUCASIAN; CONTROLLED STUDY; DEMENTIA; DIAGNOSTIC ACCURACY; DNA POLYMORPHISM; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; GENOTYPE; HOMOZYGOSITY; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL;

EID: 0030028429     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(96)91140-X     Document Type: Article

References (17)

1. Sherrington R, Rogaev E, Liang Y, et al. Cloning of a gene bearing mis-sense mutations in early-onset familial Alzheimer's disease. Nature 1995; 375: 754-60.
2. Clark RF, Hutton M, Fuldner R, et al. The structure of the chromosome 14 Alzheimer's disease gene, presenilin 1 (PS-1) and identification of six novel mutations in early onset AD families. Nature Genet 1995; 11: 219-22.
3. Wasco W, Pettingell W, Jondro P3 et al. Familial Alzheimer's chromosome 14 mutations. Nature Med 1995; 1: 848.
4. Cruts M, Backhovens H, Wang S-Y, et al. Molecular genetic analysis of familial early onset Alzheimer's disease linked to chromosome 14q24.3. Hum Mol Genet 1995; 4: 2363-72.
5. Schellenberg G, Payami H, Wijsman E, et al. Chromosome 14 and late onset familial Alzheimer's disease. Am J Hum Genet 1993; 53: 619-28.
6. Corder E, Saunders A, Strittmatter W, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993; 261: 921-23.
7. Corder E, Saunders A, Risch N, et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nature Genet 1994; 7: 180-83.
8. Talbot C, Lendon C, Craddock N, Shears S, Morris JC, Goate A. Protection against Alzheimer's disease with apoE ∈2. Lancet 1994; 343: 1432-33.
9. Kamboh MI, Narambir D, Sanghera K, Ferrell R, DeKosky S. APOE4-associated Alzheimer's disease risk is modified by α1-antichymotrypsin polymorphism. Nature Genet 1995; 10: 486-88.
10. Talbot CJ, Houlden H, Craddock N, et al. Polymorphism in AACT gene may lower age of onset of Alzheimer's disease. NeuroReport (in press).
11. Houlden H, Crook R, Duff K, et al. Confirmation that the apolipoprotein E4 allele is associated with late onset familial Alzheimer's disease. Neurodegeneration 1993; 2: 283-86.
12. Hutton M, Busfield F, Wragg M, et al. Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease. NeuroReport (in press).
13. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-44.
14. Berg L, Morris JC. Alzheimer's disease. In: Terry RD, Katzman R, Bick K, eds. Alzheimer's disease. New York: Raven Press, 1994: 9-21.
15. Rogaev EI, Sherrington R, Rogaeva E, et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 1995; 376: 775-78.
16. Perez-Tur J, Froelich S, Prihar G, et al. A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene. NeuroReport (in press).
17. Wisniewski T, Palha JA, Ghiso J, Frangione B. S182 protein in Alzheimer's disease neuritic plaques. Lancet 1995; 346: 1366.