Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation

Journal of Applied Physiology

Volumn 98, Issue 2, 2005, Pages 722-731

  Gerasimovskaya, Evgenia V ^a   Tucker, Doug A ^a   Stenmark, Kurt R ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Environmental stress; Oxygen sensing; Protein synthesis; Pulmonary hypertension; Vascular remodeling

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN S6; RAPAMYCIN; S6 KINASE;

ANIMAL CELL; ANIMAL TISSUE; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FETUS; FIBROBLAST; HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PULMONARY ARTERY; PULMONARY HYPERTENSION; REVIEW;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CATTLE; CELL HYPOXIA; CELL PROLIFERATION; CELLS, CULTURED; ENZYME ACTIVATION; FIBROBLASTS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PULMONARY ARTERY; SIGNAL TRANSDUCTION;

EID: 12344288653     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00715.2004     Document Type: Review

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