Surviving hypoxia without really dying

Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Volumn 126, Issue 4, 2000, Pages 481-490

  Boutilier, R G ^a   St Pierre, J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Anoxia; ATP turnover; Hypoxia; Ion channels; Membranes; Metabolism; Mitochondria

Indexed keywords

ADENOSINE TRIPHOSPHATE; OXYGEN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ADAPTATION; ANOXIA; ENERGY CONSUMPTION; HYPOXIA; ION TRANSPORT; ISCHEMIA; MEMBRANE PERMEABILITY; MITOCHONDRIAL RESPIRATION; OXIDATIVE PHOSPHORYLATION; REVIEW;

MAMMALIA; VERTEBRATA;

EID: 0034253515     PISSN: 10956433     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1095-6433(00)00234-8     Document Type: Review

References (45)

1. 2+ concentrations. J. Exp. Biol. 201:1998;1141-1152.
2. Boutilier R.G., Donohoe P.H., Tattersall G.J., West T.G. Hypometabolic homeostasis in overwintering aquatic amphibians. J. Exp. Biol. 200:1997;387-400.
3. Buc-Calderon P., Lefebvre V., Steenbrugge M. Inhibition of protein synthesis in isolated hepatocytes as an immediate response to oxygen limitation. Hochachka P.W., Lutz P.L., Sick T., Rosenthal M., van den Thillart G. Surviving Hypoxia. 1993;271-280 CRC Press, Boca Raton, FL.
4. +-ATPase and constant membrane potential in hepatocytes: support for channel arrest. Am. J. Physiol. 265:1993;R1020-R1025.
5. Buck L.T., Land S.C., Hochahcka P.W. Anoxia-tolerant hepatocytes: model system for study of reversible metabolic suppression. Am. J. Physiol. 265:1993;R49-R56.
6. 2 sensor. J. Biol. Chem. 273:1998;3320-3326.
7. Bunn H.F., Poyton R.O. Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev. 76:1996;839-885.
8. Bunn H.F., Gu J., Huang L.E., Park J.-W., Zhu H. Erythropoietin: a model system for studying oxygen-dependent gene regulation. J. Exp. Biol. 201:1998;1197-1201.
9. Buttgereit F., Brand M.D. A hierarchy of ATP-consuming processes in mammalian cells. Biochem. J. 312:1995;163-167.
10. Chandel N.S., Maltepe E., Goldwasser E., Mathieu C.E., Simon M.C., Schumacker P.T. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc. Natl. Acad. Sci. USA. 95:1998;11715-11720.
11. Chih C., Rosenthal M., Sick T. Ion leakage is reduced during anoxia in turtle brain: a potential survival strategy. Am. J. Physiol. 257:1989;R1562-R1564.
12. Doll C.J., Hochachka P.W., Hand S.C. A microcalorimetric study of turtle cortical slices: insights into brain metabolic depression. J. Exp. Biol. 191:1994;141-153.
13. Donohoe P.H., Boutilier R.G. The protective effects of metabolic rate depression in hypoxic cold submerged frogs. Respir. Physiol. 111:1998;325-336.
14. Donohoe P.H., West T.G., Boutilier R.G. Respiratory and metabolic correlates of aerobic metabolic rate reduction in overwintering frogs. Am. J. Physiol. 43:1998;R704-R710.
15. Donohoe, P.H., West, T.G., Boutilier, R.G., 2000. Factors effecting membrane permeability and ionic homeostasis in the cold-submerged frog. J. Exp. Biol. 203, 405-414.
16. Ehleben W., Bölling B., Merten E., Porwol T., Strohmaier A.R., Acker H. Cytochromes and oxygen radicals as putative members of the oxygen sensing pathway. Respir. Physiol. 114:1998;25-36.
17. Goldberg M.A., Dunning S.P., Bunn H.F. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science. 242:1988;1412-1415.
18. + channels. Annu. Rev. Physiol. 59:1997;23-43.
19. Hansen A.J. Effect of anoxia on ion distribution in the brain. Physiol. Rev. 65:1985;101-148.
20. Heuch G. Hibernating myocardium. Physiol. Rev. 78:1998;1055-1085.
21. Hochachka P.W. Defence strategies against hypoxia and hypothermia. Science. 231:1986;234-241.
22. Hochachka P.W., Buck L., Doll C., Land S. Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack. Proc. Natl. Acad. Sci. USA. 93:1996;9493-9498.
23. Ju Y.-K., Saint D.A., Gage P.W. Hypoxia increases persistent sodium current in rat ventricular myocytes. J. Physiol. 497:1996;337-347.
24. Krnjevic K. Membrane current activation and inactivation during hypoxia in hippocampal neurons. Hochachka P.W., Lutz P.L., Sick T., Rosenthal M., van den Thillart G. Surviving Hypoxia. 1993;365-388 CRC Press, Boca Raton, FL.
25. + homeostasis in anoxia-tolerant and anoxia-intolerant hepatocytes. Am. J. Physiol. 273:1997;R307-R316.
26. 2+ flux via second-messenger pathways in anoxia-tolerant hepatocytes. J. Appl. Physiol. 82:1997;776-783.
27. Lisa F.D., Menabò R., Canton M., Petronilli V. The role of mitochondria in the salvage and the injury of the ischemic myocardium. Biochim. Biophys. Acta. 1366:1998;69-78.
28. Lutz P.L., Nilsson G.E. Contrasting strategies for anoxic brain survival - glycolysis up or down. J. Exp. Biol. 200:1997;411-419.
29. Lutz P.L., McMahon P., Rosenthal M., Sick T.J. Relationships between aerobic and anaerobic energy production in turtle brain in situ. Am. J. Physiol. 247:1984;R740-R744.
30. Peréz-Pinzón M., Rosenthal M., Sick T., Lutz P., Pablo J., Mash D. Down-regulation of sodium channels during anoxia: a putative survival strategy of turtle brain. Am. J. Physiol. 262:1992;R712-R715.
31. Pullman M.E., Monroy G.C. A naturally occurring inhibitor of mitochondrial adenosine-triphosphatase. J. Biol. Chem. 238:1963;3762-3769.
32. Schumacker P., Chandel N., Agusti A.G.N. Oxygen conformance of cellular respiration in hepatocytes. Am. J. Physiol. 265:1993;L395-L402.
33. Srinivas V., Zhu X., Salceda S., Nakamura R., Caro J. Hypoxia-inducible factor 1a (HIF-1a) is a non-heme iron protein. J. Biol. Chem. 273:1998;18019-18022.
34. Rolfe D.F.S., Brown G.C. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol. Rev. 77:1997;731-758.
35. Rouslin W. Protonic inhibition of the mitochondrial oligomycin-sensitive adenosine 5′-triphosphatase in ischemic and autolysing cardiac muscle. Possible mechanism for the mitigation of ATP hydrolysis under non-energising conditions. J. Biol. Chem. 258:1983;9657-9661.
36. Rouslin W. Factors affecting the loss of mitochondrial function during zero-flow ischemia (autolysis) in slow and fast heart-rate hearts. J. Mol. Cell. Cardiol. 20:1988;999-1007.
37. Rouslin W. Regulation of the mitochondrial ATPase in situ in cardiac muscle: role of the inhibitor subunit. J. Bioenerg. Biomembr. 23:1991;873-888.
38. + symport. J. Biol. Chem. 264:1989;15224-15229.
39. Rouslin W., Broge C.W. Regulation of the mitochondrial adenosine 5′-triphosphatase in situ during ischemia and in vitro in intact and sonicated mitochondria from slow and fast heart-rate hearts. Arch. Biochem. Biophys. 280:1990;103-111.
40. 1 function in situ in uncoupler-challenged ischemic rabbit, rat, and pigeon hearts. J. Biol. Chem. 271:1996;23638-23641.
41. Rouslin W., Broge C.W., Grupp I.L. ATP depletion and mitochondrial functional loss during ischemia in slow and fast heart-rate hearts. Am. J. Physiol. 259:1990;H1759-H1766.
42. 1, in the tissues of several slow and fast heart-rate homeothermic species and in two poikilotherms. J. Bioenerg. Biomembr. 27:1995;117-125.
43. Wegener G., Krause U. Environmental and exercise anaerobiosis in frogs. Hochachka P.W., Lutz P.L., Sick T., Rosenthal M., van den Thillart G. Surviving Hypoxia. 1993;217-236 CRC Press, Boca Raton, FL.
44. + channels in isolated guinea pig cardiac myocytes. Science. 238:1987;67-69.
45. West T.G., Boutilier R.G. Metabolic suppression in anoxic frog muscle. J. Comp. Physiol. B. 168:1998;273-280.