Growth factor-induced phosphoinositide 3-OH kinase/Akt phosphorylation in smooth muscle cells: Induction of cell proliferation and inhibition of cell death

Cardiovascular Research

Volumn 48, Issue 1, 2000, Pages 148-157

  Jung, Frank ^a   Haendeler, Judith ^a   Goebel, Christine ^a   Zeiher, Andreas M ^a   Dimmeler, Stefanie ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Apoptosis; Growth factors; Protein kinases; Signal transduction; Smooth muscle

Indexed keywords

GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; SOMATOMEDIN C;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; ENZYME ACTIVATION; GENE OVEREXPRESSION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANALYSIS OF VARIANCE; ANIMAL; AORTA; APOPTOSIS; CELL DIVISION; CELLS, CULTURED; FLOW CYTOMETRY; GROWTH SUBSTANCES; INSULIN; INSULIN-LIKE GROWTH FACTOR I; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RATS; SIGNAL TRANSDUCTION; STIMULATION, CHEMICAL; SUPPORT, NON-U.S. GOV'T;

EID: 0033780948     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(00)00152-8     Document Type: Article

References (60)

1. Gabbiani G., Kocher O., Bloom W.S., Vandekerckhove J., Weber K. Actin expression in smooth muscle cells of rat aortic intimal thickening, human atheromatous plaque, and cultured rat aortic media. J Clin Invest. 73:1984;148-152.
2. Hanke H., Strohschneider T., Oberhoff M., Betz E., Karsch K.R. Time course of smooth muscle cell proliferation in the intima and media of arteries following experimental angioplasty. Circ Res. 67:1990;651-659.
3. Clowes A.W., Clowes M.M., Fingerle J., Reidy M.A. Kinetics of cellular proliferation after arterial injury. V. Role of acute distension in the induction of smooth muscle proliferation. Lab Invest. 60:1989;360-364.
4. Clowes A.W., Clowes M.M., Fingerle J., Reidy M.A. Regulation of smooth muscle cell growth in injured artery. J Cardiovasc Pharmacol. 14:(Suppl 6):1989;S12-S15.
5. Bochaton P.M.L., Gabbiani F., Redard M., Desmouliere A., Gabbiani G. Apoptosis participates in cellularity regulation during rat aortic intimal thickening. Am J Pathol. 146:1995;1059-1064.
6. Isner J.M., Kearney M., Bortman S., Passeri J. Apoptosis in human atherosclerosis and restenosis. Circulation. 91:1995;2703-2711.
7. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 362:1993;801-809.
8. Rao G.N., Berk B.C. Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression. Circ Res. 70:1992;593-599.
9. Jawien A., Bowen-Pope D.F., Lindner V., Schwartz S.M., Clowes A.W. Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty. J Clin Invest. 89:1992;507-511.
10. Nabel E.G., Shum L., Pompili V.J., et al. Direct gene transfer of transforming growth factor beta-1 into arteries stimulates fibrocellular hyperplasia. Proc Natl Acad Sci USA. 90:1993;10759-10763.
11. Lindner V., Lappi D.A., Baird A., Majack R.A., Reidy M.A. Role of basic fibroblast growth factor in vascular lesion formation. Circ Res. 68:1991;106-113.
12. Duff J.L., Marrero M.B., Paxton W.G., et al. Angiotensin II signal transduction and the mitogen-activated protein kinase pathway. Cardiovasc Res. 30:1995;511-517.
13. Sturgill T.W., Ray L.B., Erikson E., Maller J.L. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. Nature. 334:1988;715-718.
14. Denhardt D.T. Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signaling. Biochem J. 318:1996;729-747.
15. Khwaja A., Rodriguez-Viciana P., Wennstrom S., Warne P.H., Downward J. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16:1997;2783-2793.
16. Franke T.F., Kaplan D.R., Cantley L.C. PI3K: downstream AKTion blocks apoptosis. Cell. 88:1997;435-437.
17. Kennedy S.G., Wagner A.J., Conzen S.D., et al. The PI3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 11:1997;701-713.
18. Klippel A., Kavanaugh W.M., Pot D., Williams L.T. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. Mol Cell Biol. 17:1997;338-344.
19. Stephens L., Anderson K., Stokoe D., et al. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science. 279:1998;710-714.
20. Downward J. Lipid-regulated kinases: some common themes at last. Science. 279:1998;673-674.
21. Burgering B.M., Coffer P.J. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature. 376:1995;599-602.
22. Cross D.A., Alessi D.R., Cohen P., Andjelkovich M., Hemmings B.A. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 378:1995;785-789.
23. Datta S.R., Dudek H., Tao X., et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 91:1997;231-241.
24. del Peso L., Gonzalez-Garcia M., Page C., Herrera R., Nunez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science. 278:1997;687-689.
25. Bai H., Pollman M.J., Inishi Y., Gibbons G.H. Regulation of vascular smooth muscle cell apoptosis; modulation of Bad by a phosphatidylinositol 3-kinase-dependent pathway. Circ Res. 85:1999;229-237.
26. Ferns G.A., Stewart L.A., Anggard E.E. Arterial response to mechanical injury: balloon catheter de-endothelialization. Atherosclerosis. 92:1992;89-104.
27. Hearse D.J., Maxwell L., Saldanha C., Gavin J.B. The myocardial vasculature during ischemia and reperfusion: a target for injury and protection. J Mol Cell Cardiol. 25:1993;759-800.
28. Dudek H., Datta S.R., Franke T.F., et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science. 275:1997;661-665.
29. Parrizas M., Saltiel A.R., LeRoith D. Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways. J Biol Chem. 272:1997;154-161.
30. Kulik G., Klippel A., Weber M.J. Anti-apoptotic signaling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol. 17:1997;1595-1606.
31. Dimmeler S., Assmus B., Hermann C., Haendeler J., Zeiher A.M. Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis. Circ Res. 83:1998;334-341.
32. Bennett M.R., Evan G.I., Schwartz S.M. Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques. J Clin Invest. 95:1995;2266-2274.
33. Walker L.N., Bowen-Pope D.F., Ross R., Reidy M.A. Production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury. Proc Natl Acad Sci USA. 83:1986;7311-7315.
34. Gibbons G.H., Pratt R.E., Dzau V.J. Vascular smooth muscle cell hypertrophy vs. hyperplasia: autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II. J Clin Invest. 90:1992;456-461.
35. Rampalli A.M., Zelenka P.S. Insulin regulates expression of c-fos and c-jun and suppresses apoptosis of lens epithelial cells. Cell Growth Differ. 6:1995;945-953.
36. Force T., Bonventre J.V. Growth factors and mitogen-activated protein kinases. Hypertension. 31:(2):1998;152-161.
37. Wang Y., Rose P.M., Webb M.L., Dunn M.J. Endothelins stimulate mitogen-activated protein kinase cascade through either ETA or ETB. Am J Physiol. 267:1994;C1130-C1135.
38. Liao D.F., Monia B., Dean N., Berk B.C. Protein kinase C-zeta mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells. J Biol Chem. 272:1997;6146-6150.
39. Kim S., Izumi Y., Yano M., et al. Angiotensin blockade inhibits activation of mitogen-activated protein kinases in rat balloon-injured artery. Circulation. 97:1998;1731-1737.
40. Andjelkovic M., Jakubowicz T., Cron P., et al. Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci USA. 93:1996;5699-5704.
41. Franke T.F., Yang S.I., Chan T.O., et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell. 81:1995;727-736.
42. Pukac L., Huangpu J., Karnovsky M.J. Platelet-derived growth factor-BB, insulin-like growth factor-I, and phorbol ester activate different signaling pathways for stimulation of vascular smooth muscle cell migration. Exp Cell Res. 242:1998;548-560.
43. Peruzzi F., Prisco M., Dews M., et al. Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Mol Cell Biol. 19:1999;7203-7215.
44. Cospedal R., Abedi H., Zachary I. Platelet-derived growth factor-BB (PDGF-BB) regulation of migration and focal adhesion kinase phosphorylation in rabbit aortic vascular smooth muscle cells: roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinases. Cardiovasc Res. 41:1999;708-721.
45. Zimmermann S., Moelling K. Phosphorylation and regulation of Raf by Akt (protein kinase B). Science. 286:1999;1741-1744.
46. Pugazhenthi S., Miller E., Sable C., et al. Insulin-like growth factor-I induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein. J Biol Chem. 274:1999;27529-27535.
47. Scheid M.P., Duronio V. Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation. Proc Natl Acad Sci USA. 95:1998;7439-7444.
48. 2-induced apoptosis of human endothelial cells by modulation of the glutathione redox cycle and nitric oxide synthase. Arterioscler Thromb Vasc Biol. 17:1997;3588-3592.
49. Cardone M.H., Roy N., Stennicke H.R., et al. Regulation of cell death protease caspase-9 by phosphorylation. Science. 282:1998;1318-1321.
50. Neshat M.S., Raitano A.B., Wang H.G., Reed J.C., Sawyers C.L. The survival function of the bcr-Abl oncogene is mediated by bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf. Mol Cell Biol. 20:2000;1179-1186.
51. Higaki M., Shimokado K. Phosphatidylinositol 3-kinase is required for growth factor-induced amino acid uptake by vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 19:1999;2127-2132.
52. Imai Y., Clemmons D.R. Roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in stimulation of vascular smooth muscle cell migration and deoxyribonucleic acid synthesis by insulin-like growth factor-I. Endocrinology. 140:1999;4228-4235.
53. Hayashi K., Takahashi M., Kimura K., et al. Changes in the balance of phosphoinositide 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38MAPK) determine a phenotype of visceral and vascular smooth muscle cells. J Cell Biol. 145:1999;727-740.
54. Skorski T., Bellacosa A., Nieborowska-Skorska M., et al. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO J. 16:1997;6151-6161.
55. Muise-Helmericks R.C., Grimes H.L., Bellacosa A., et al. Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-Kinase/Akt-dependent pathway. J Biol Chem. 273:1998;29864-29872.
56. Diehl J.A., Cheng M., Roussel M.F., Sherr C.J. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 12:1998;3499-3511.
57. Gille H., Downward J. Multiple ras effector pathways contribute to G[1] cell cycle progression. J Biol Chem. 274:1999;22033-22040.
58. Weng L.P., Smith W.M., Dahia P.L., et al. PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death. Cancer Res. 59:1999;5808-5814.
59. Paramio J.M., Navarro M., Segrelles C., Gomez-Casero E., Jorcano J.L. PTEN tumor suppressor is linked to the cell cycle control through the retinoblastoma protein. Oncogene. 18:1999;7462-7468.
60. Suzuki E., Nagata D., Yoshizumi M., et al. Re-entry into the cell cycle of contact-inhibited vascular endothelial cells by a phosphatase inhibitor. Possible involvement of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. J Biol Chem. 275:2000;3637-3644.