Can flies shed light on our own age-related memory impairment?

Ageing Research Reviews

Volumn 4, Issue 1, 2005, Pages 83-101

  Horiuchi, Junjiro ^a,b   Saitoe, Minoru ^a,b  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Age related memory impairment (AMI); Aging; Drosophila; Memory

Indexed keywords

CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; NIMODIPINE; RAPAMYCIN; SOMATOMEDIN;

AGING; CALORIC RESTRICTION; COGNITION; DROSOPHILA; FLY; MEMORY; MEMORY DISORDER; NONHUMAN; OXIDATIVE STRESS; REVIEW;

EID: 11144313147     PISSN: 15681637     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arr.2004.10.001     Document Type: Short Survey

References (117)

1. M.E. Bach, M. Barad, H. Son, M. Zhuo, Y.F. Lu, R. Shih, I. Mansuy, R.D. Hawkins, and E.R. Kandel Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway Proc. Natl. Acad. Sci. U.S.A. 96 1999 5280 5285
2. M. Barad, R. Bourtchouladze, D.G. Winder, H. Golan, and E. Kandel Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory Proc. Natl. Acad. Sci. U.S.A. 95 1998 15020 15025
3. C.A. Barnes, and B.L. McNaughton An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses Behav. Neurosci. 99 1985 1040 1048
4. A. Bartke, J.C. Wright, J.A. Mattison, D.K. Ingram, R.A. Miller, and G.S. Roth Extending the lifespan of long-lived mice Nature 414 2001 412
5. T. Beck, and M.N. Hall The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors Nature 402 1999 689 692
6. A. Bhattacharya, S.S. Lakhman, and S. Singh Modulation of L-type calcium channels in Drosophila via a pituitary adenylyl cyclase-activating polypeptide (PACAP)-mediated pathway J. Biol. Chem. 279 2004 37291 37297
7. G. Blander, and L. Guarente The sir2 family of protein deacetylases Annu. Rev. Biochem. 73 2004 417 435
8. T. Blank, I. Nijholt, M.J. Kye, J. Radulovic, and J. Spiess Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits Nat. Neurosci. 6 2003 911 912
9. R.H. Brown Jr. Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice Cell 80 1995 687 692
10. A. Brunet, A. Bonni, M.J. Zigmond, M.Z. Lin, P. Juo, L.S. Hu, M.J. Anderson, K.C. Arden, J. Blenis, and M.E. Greenberg Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor Cell 96 1999 857 868
11. A. Brunet, L.B. Sweeney, J.F. Sturgill, K.F. Chua, P.L. Greer, Y. Lin, H. Tran, S.E. Ross, R. Mostoslavsky, and H.Y. Cohen Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase Science 303 2004 2011 2015
12. A. Casadio, K.C. Martin, M. Giustetto, H. Zhu, M. Chen, D. Bartsch, C.H. Bailey, and E.R. Kandel A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis Cell 99 1999 221 237
13. H. Chen Gene expression by the anterior pituitary gland: effects of age and caloric restriction Mol. Cell Endocrinol. 222 2004 21 31
14. D.J. Clancy, D. Gems, E. Hafen, S.J. Leevers, and L. Partridge Dietary restriction in long-lived dwarf flies Science 296 2002 319
15. D.J. Clancy, D. Gems, L.G. Harshman, S. Oldham, H. Stocker, E. Hafen, S.J. Leevers, and L. Partridge Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein Science 292 2001 104 106
16. H.Y. Cohen, C. Miller, K.J. Bitterman, N.R. Wall, B. Hekking, B. Kessler, K.T. Howitz, M. Gorospe, R. de Cabo, and D.A. Sinclair Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase Science 305 2004 390 392
17. K.T. Coschigano, D. Clemmons, L.L. Bellush, and J.J. Kopchick Assessment of growth parameters and life span of GHR/BP gene-disrupted mice Endocrinology 141 2000 2608 2613
18. C.W. Cotman, E. Head, B.A. Muggenburg, S. Zicker, and N.W. Milgram Brain ageing in the canine: a diet enriched in antioxidants reduces cognitive dysfunction Neurobiol. Aging 23 2002 809 818
19. H. Daitoku, M. Hatta, H. Matsuzaki, S. Aratani, T. Ohshima, M. Miyagishi, T. Nakajima, and A. Fukamizu Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity Proc. Natl. Acad. Sci. U.S.A. 101 2004 10042 10047
20. N. Das, R.L. Levine, W.C. Orr, and R.S. Sohal Selectivity of protein oxidative damage during aging in Drosophila melanogaster Biochem. J. 360 2001 209 216
21. M.A. Davare, and J.W. Hell Increased phosphorylation of the neuronal L-type Ca(2+) channel Ca(v)1.2 during aging Proc. Natl. Acad. Sci. U.S.A. 100 2003 16018 16023
22. Davenport, R.J., 2004. Growing pains. Sci. Aging Knowl. Environ. 2004 (30), ns5
23. R.L. Davis, J. Cherry, B. Dauwalder, P.L. Han, and E. Skoulakis The cyclic AMP system and Drosophila learning Mol. Cell Biochem. 149-150 1995 271 278
24. R.A. Deyo, K.T. Straube, and J.F. Disterhoft Nimodipine facilitates associative learning in aging rabbits Science 243 1989 809 811
25. W. Duan, J. Lee, Z. Guo, and M.P. Mattson Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury J. Mol. Neurosci. 16 2001 1 12
26. Y. Dudai, Y.N. Jan, D. Byers, W.G. Quinn, and S. Benzer Dunce, a mutant of Drosophila deficient in learning Proc. Natl. Acad. Sci. U.S.A. 73 1976 1684 1688
27. K. Eckles-Smith, D. Clayton, P. Bickford, and M.D. Browning Caloric restriction prevents age-related deficits in LTP and in NMDA receptor expression Brain Res. Mol. Brain Res. 78 2000 154 162
28. P. Fabrizio, F. Pozza, S.D. Pletcher, C.M. Gendron, and V.D. Longo Regulation of longevity and stress resistance by Sch9 in yeast Science 292 2001 288 290
29. M.B. Feany, and W.G. Quinn A neuropeptide gene defined by the Drosophila memory mutant amnesiac Science 268 1995 869 873
30. K. Flurkey, J. Papaconstantinou, R.A. Miller, and D.E. Harrison Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production Proc. Natl. Acad. Sci. U.S.A. 98 2001 6736 6741
31. T.C. Foster, and C.M. Norris Age-associated changes in Ca(2+)-dependent processes: relation to hippocampal synaptic plasticity Hippocampus 7 1997 602 612
32. T.C. Foster, K.M. Sharrow, J.R. Masse, C.M. Norris, and A. Kumar Calcineurin links Ca2+ dysregulation with brain aging J. Neurosci. 21 2001 4066 4073
33. Y. Geinisman, O. Ganeshina, R. Yoshida, R.W. Berry, J.F. Disterhoft, and M. Gallagher Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum Neurobiol. Aging 25 2004 407 416
34. H.F. Guo, I. The, F. Hannan, A. Bernards, and Y. Zhong Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides Science 276 1997 795 798
35. M. Hayashi, F. Mistunaga, K. Ohira, and K. Shimizu Changes in BDNF-immunoreactive structures in the hippocampal formation of the aged macaque monkey Brain Res. 918 2001 191 196
36. S.L. Helfand, and B. Rogina Genetics of aging in the fruit fly, Drosophila melanogaster Annu. Rev. Genet. 37 2003 329 348
37. Y. Honda, and S. Honda Oxidative stress and life span determination in the nematode Caenorhabditis elegans Ann. NY Acad. Sci. 959 2002 466 474
38. Y.Y. Huang, X.C. Li, and E.R. Kandel cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase Cell 79 1994 69 79
39. D.S. Hwangbo, B. Gersham, M.P. Tu, M. Palmer, and M. Tatar Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body Nature 429 2004 562 566
40. F.B. Johnson, D.A. Sinclair, and L. Guarente Molecular biology of aging Cell 96 1999 291 302
41. P. Kapahi, B.M. Zid, T. Harper, D. Koslover, V. Sapin, and S. Benzer Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway Curr. Biol. 14 2004 885 890
42. F. Karege, C. Lambercy, M. Schwald, T. Steimer, and M. Cisse Differential changes of cAMP-dependent protein kinase activity and 3H-cAMP binding sites in rat hippocampus during maturation and aging Neurosci. Lett. 315 2001 89 92
43. F. Karege, M. Schwald, C. Lambercy, J.J. Murama, M. Cisse, and A. Malafosse A non-radioactive assay for the cAMP-dependent protein kinase activity in rat brain homogenates and age-related changes in hippocampus and cortex Brain Res. 903 2001 86 93
44. M. Keaney, F. Matthijssens, M. Sharpe, J. Vanfleteren, and D. Gems Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans Free Radic. Biol. Med. 37 2004 239 250
45. B.A. Kinney, C.J. Meliska, R.W. Steger, and A. Bartke Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters Horm. Behav. 39 2001 277 284
46. B.A. Kinney-Forshee, N.E. Kinney, R.W. Steger, and A. Bartke Could a deficiency in growth hormone signaling be beneficial to the aging brain? Physiol. Behav. 80 2004 589 594
47. K. Kirby, J. Hu, A.J. Hilliker, and J.P. Phillips RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress Proc. Natl. Acad. Sci. U.S.A. 99 2002 16162 16167
48. T.B. Kirkwood, and S.N. Austad Why do we age? Nature 408 2000 233 238
49. G.N. Landis, D. Abdueva, D. Skvortsov, J. Yang, B.E. Rabin, J. Carrick, S. Tavare, and J. Tower Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster Proc. Natl. Acad. Sci. U.S.A. 101 2004 7663 7668
50. P.A. Lapchak, D.M. Araujo, K.D. Beck, C.E. Finch, S.A. Johnson, and F. Hefti BDNF and trkB mRNA expression in the hippocampal formation of aging rats Neurobiol. Aging 14 1993 121 126
51. J. Lee, K.B. Seroogy, and M.P. Mattson Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice J. Neurochem. 80 2002 539 547
52. W. Li, T. Tully, and D. Kalderon Effects of a conditional Drosophila PKA mutant on olfactory learning and memory Learn. Mem. 2 1996 320 333
53. N. Libina, J.R. Berman, and C. Kenyon Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan Cell 115 2003 489 502
54. S.J. Lin, P.A. Defossez, and L. Guarente Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae Science 289 2000 2126 2128
55. Y.J. Lin, L. Seroude, and S. Benzer Extended life-span and stress resistance in the Drosophila mutant methuselah Science 282 1998 943 946
56. J. Liu, E. Head, A.M. Gharib, W. Yuan, R.T. Ingersoll, T.M. Hagen, C.W. Cotman, and B.N. Ames Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-l-carnitine and/or R-alpha-lipoic acid Proc. Natl. Acad. Sci. U.S.A. 99 2002 2356 2361
57. R. Liu, I.Y. Liu, X. Bi, R.F. Thompson, S.R. Doctrow, B. Malfroy, and M. Baudry Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics Proc. Natl. Acad. Sci. U.S.A. 100 2003 8526 8531
58. M.S. Livingstone, P.P. Sziber, and W.G. Quinn Loss of calcium/calmodulin responsiveness in adenylate cyclase of rutabaga, a Drosophila learning mutant Cell 37 1984 205 215
59. V.D. Longo The Ras and Sch9 pathways regulate stress resistance and longevity Exp. Gerontol. 38 2003 807 811
60. T. Lu, Y. Pan, S.Y. Kao, C. Li, I. Kohane, J. Chan, and B.A. Yankner Gene regulation and DNA damage in the ageing human brain Nature 429 2004 883 891
61. K.R. Magnusson Influence of diet restriction on NMDA receptor subunits and learning during aging Neurobiol. Aging 22 2001 613 627
62. R.C. Malenka, and M.F. Bear LTP and LTD: an embarrassment of riches Neuron 44 2004 5 21
63. A.L. Markowska Life-long diet restriction failed to retard cognitive aging in Fischer-344 rats Neurobiol. Aging 20 1999 177 189
64. A.L. Markowska, M. Mooney, and W.E. Sonntag Insulin-like growth factor-1 ameliorates age-related behavioral deficits Neuroscience 87 1998 559 569
65. K.C. Martin, A. Casadio, H. Zhu, E. Yaping, J.C. Rose, M. Chen, C.H. Bailey, and E.R. Kandel Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage Cell 91 1997 927 938
66. S. Matsuyama, A. Matsumoto, H. Hashimoto, N. Shintani, and A. Baba Impaired long-term potentiation in vivo in the dentate gyrus of pituitary adenylate cyclase-activating polypeptide (PACAP) or PACAP type 1 receptor-mutant mice Neuroreport 14 2003 2095 2098
67. M.P. Mattson, W. Duan, and Z. Guo Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms J. Neurochem. 84 2003 417 431
68. S. Melov Mitochondrial oxidative stress. Physiologic consequences and potential for a role in aging Ann. NY Acad. Sci. 908 2000 219 225
69. S. Melov, S.R. Doctrow, J.A. Schneider, J. Haberson, M. Patel, P.E. Coskun, K. Huffman, D.C. Wallace, and B. Malfroy Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics J. Neurosci. 21 2001 8348 8353
70. S. Melov, J.A. Schneider, B.J. Day, D. Hinerfeld, P. Coskun, S.S. Mirra, J.D. Crapo, and D.C. Wallace A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase Nat. Genet. 18 1998 159 163
71. M. Montminy Transcriptional regulation by cyclic AMP Annu. Rev. Biochem. 66 1997 807 822
72. C.T. Murphy, S.A. McCarroll, C.I. Bargmann, A. Fraser, R.S. Kamath, J. Ahringer, H. Li, and C. Kenyon Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans Nature 424 2003 277 283
73. C.M. Norris, S. Halpain, and T.C. Foster Alterations in the balance of protein kinase/phosphatase activities parallel reduced synaptic strength during aging J. Neurophysiol. 80 1998 1567 1570
74. C.M. Norris, S. Halpain, and T.C. Foster Reversal of age-related alterations in synaptic plasticity by blockade of L-type Ca2+ channels J. Neurosci. 18 1998 3171 3179
75. C.M. Norris, D.L. Korol, and T.C. Foster Increased susceptibility to induction of long-term depression and long-term potentiation reversal during aging J. Neurosci. 16 1996 5382 5392
76. S. Ogg, S. Paradis, S. Gottlieb, G.I. Patterson, L. Lee, H.A. Tissenbaum, and G. Ruvkun The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans Nature 389 1997 994 999
77. K. Oguro, N. Oguro, T. Kojima, S.Y. Grooms, A. Calderone, X. Zheng, M.V. Bennett, and R.S. Zukin Knockdown of AMPA receptor GluR2 expression causes delayed neurodegeneration and increases damage by sublethal ischemia in hippocampal CA1 and CA3 neurons J. Neurosci. 19 1999 9218 9227
78. W.C. Orr, and R.S. Sohal Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster Science 263 1994 1128 1130
79. M.H. Oster, P.J. Fielder, N. Levin, and M.J. Cronin Adaptation of the growth hormone and insulin-like growth factor-I axis to chronic and severe calorie or protein malnutrition J. Clin. Invest. 95 1995 2258 2265
80. T.L. Parkes, A.J. Elia, D. Dickinson, A.J. Hilliker, J.P. Phillips, and G.L. Boulianne Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons Nat. Genet. 19 1998 171 174
81. T.L. Parkes, K. Kirby, J.P. Phillips, and A.J. Hilliker Transgenic analysis of the cSOD-null phenotypic syndrome in Drosophila Genome 41 1998 642 651
82. N.M. Porter, O. Thibault, V. Thibault, K.C. Chen, and P.W. Landfield Calcium channel density and hippocampal cell death with age in long-term culture J. Neurosci. 17 1997 5629 5639
83. B.P. Ramos, S.G. Birnbaum, I. Lindenmayer, S.S. Newton, R.S. Duman, and A.F. Arnsten Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline Neuron 40 2003 835 845
84. P.R. Rapp, and M. Gallagher Preserved neuron number in the hippocampus of aged rats with spatial learning deficits Proc. Natl. Acad. Sci. U.S.A. 93 1996 9926 9930
85. B. Raught, A.-C. Gingras, and N. Sonenberg The target of rapamycin (TOR) protieins Proc. Natl. Acad. Sci. U.S.A. 98 2001 7037 7044
86. B. Rogina, S.L. Helfand, and S. Frankel Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction Science 298 2002 1745
87. B. Rogina, R.A. Reenan, S.P. Nilsen, and S.L. Helfand Extended life-span conferred by cotransporter gene mutations in Drosophila Science 290 2000 2137 2140
88. J.R. Rohde, and M.E. Cardenas The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation Mol. Cell Biol. 23 2003 629 635
89. A.R. Saltiel, and C.R. Kahn Insulin signalling and the regulation of glucose and lipid metabolism Nature 414 2001 799 806
90. J.N. Sampayo, M.S. Gill, and G.J. Lithgow Oxidative stress and aging - the use of superoxide dismutase/catalase mimetics to extend lifespan Biochem. Soc. Trans. 31 2003 1305 1307
91. J.N. Sampayo, A. Olsen, and G.J. Lithgow Oxidative stress in Caenorhabditis elegans: protective effects of superoxide dismutase/catalase mimetics Aging Cell 2 2003 319 326
92. R. Sattler, Z. Xiong, W.Y. Lu, J.F. MacDonald, and M. Tymianski Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicity J. Neurosci. 20 2000 22 33
93. M. Sauvage, P. Brabet, F. Holsboer, J. Bockaert, and T. Steckler Mild deficits in mice lacking pituitary adenylate cyclase-activating polypeptide receptor type 1 (PAC1) performing on memory tasks Brain Res. Mol. Brain Res. 84 2000 79 89
94. J. Song, L. Wu, Z. Chen, R.A. Kohanski, and L. Pick Axons guided by insulin receptor in Drosophila visual system Science 300 2003 502 505
95. W.E. Sonntag, C. Lynch, P. Thornton, A. Khan, S. Bennett, and R. Ingram The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing J. Anat. 197 Pt 4 2000 575 585
96. W.E. Sonntag, C.D. Lynch, P.T. Cooney, and P.M. Hutchins Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1 Endocrinology 138 1997 3515 3520
97. K.T. Straube, R.A. Deyo, J.R. Moyer Jr., and J.F. Disterhoft Dietary nimodipine improves associative learning in aging rabbits Neurobiol. Aging 11 1990 659 661
98. T. Tamura, A.S. Chiang, N. Ito, H.P. Liu, J. Horiuchi, T. Tully, and M. Saitoe Aging specifically impairs amnesiac-dependent memory in Drosophila Neuron 40 2003 1003 1011
99. G. Telegdy, and K. Kokavszky The action of pituitary adenylate cyclase activating polypeptide (PACAP) on passive avoidance learning. The role of transmitters Brain Res. 874 2000 194 199
100. O. Thibault, R. Hadley, and P.W. Landfield Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity J. Neurosci. 21 2001 9744 9756
101. O. Thibault, and P.W. Landfield Increase in single L-type calcium channels in hippocampal neurons during aging Science 272 1996 1017 1020
102. P.L. Thornton, R.L. Ingram, and W.E. Sonntag Chronic [d-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory J. Gerontol. A Biol. Sci. Med. Sci. 55 2000 B106 B112
103. T. Tully, T. Preat, S.C. Boynton, and M. Del Vecchio Genetic dissection of consolidated memory in Drosophila Cell 79 1994 35 47
104. T. Tully, and W.G. Quinn Classical conditioning and retention in normal and mutant Drosophila melanogaster J. Comp. Physiol. [A] 157 1985 263 277
105. H. Van Remmen, Y. Ikeno, M. Hamilton, M. Pahlavani, N. Wolf, S.R. Thorpe, N.L. Alderson, J.W. Baynes, C.J. Epstein, and T.T. Huang Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging Physiol. Genomics 16 2003 29 37
106. T. Vellai, K. Takacs-Vellai, Y. Zhang, A.L. Kovacs, L. Orosz, and F. Muller Genetics: influence of TOR kinase on lifespan in C. elegans Nature 426 2003 620
107. S. Waddell, J.D. Armstrong, T. Kitamoto, K. Kaiser, and W.G. Quinn The amnesiac gene product is expressed in two neurons in the Drosophila brain that are critical for memory Cell 103 2000 805 813
108. D.C. Wallace, and S. Melov Radicals r'aging Nat. Genet. 19 1998 105 106
109. H. Wang, G.D. Ferguson, V.V. Pineda, P.E. Cundiff, and D.R. Storm Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP Nat. Neurosci. 7 2004 635 642
110. M.J. Webster, C.S. Weickert, M.M. Herman, and J.E. Kleinman BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortex Brain Res. Dev. Brain Res. 139 2002 139 150
111. J.G. Wood, B. Rogina, S. Lavu, K. Howitz, S.L. Helfand, M. Tatar, and D. Sinclair Sirtuin activators mimic caloric restriction and delay ageing in metazoans Nature 430 2004 686 689
112. W. Wu, J.D. Cogan, R.W. Pfaffle, J.S. Dasen, H. Frisch, S.M. O'Connell, S.E. Flynn, M.R. Brown, P.E. Mullis, and J.S. Parks Mutations in PROP1 cause familial combined pituitary hormone deficiency Nat. Genet. 18 1998 147 149
113. L.J. Yan, W.C. Orr, and R.S. Sohal Identification of oxidized proteins based on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, immunochemical detection, isoelectric focusing, and microsequencing Anal. Biochem. 263 1998 67 71
114. S. Yanai, Y. Okaichi, and H. Okaichi Long-term dietary restriction causes negative effects on cognitive functions in rats Neurobiol. Aging 25 2004 325 332
115. J.C. Yin, M. Del Vecchio, H. Zhou, and T. Tully CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila Cell 81 1995 107 115
116. J.C. Yin, J.S. Wallach, M. Del Vecchio, E.L. Wilder, H. Zhou, W.G. Quinn, and T. Tully Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila Cell 79 1994 49 58
117. S. Zou, S. Meadows, L. Sharp, L.Y. Jan, and Y.N. Jan Genome-wide study of aging and oxidative stress response in Drosophila melanogaster Proc. Natl. Acad. Sci. U.S.A. 97 2000 13726 13731